Regulatory circuits controlling white versus brown adipocyte differentiation

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works

Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators

Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

Watanabe, M., Houten, S. M., Mataki, C., Christoffolete, M. A., Kim, B. W., Sato, H., Messaddeq, N., Harney, J. W., Ezaki, O., Kodama, T., et al. (2006) · Nature · doi:10.1038/nature04330 · Cited by 2,220 · see citing works

Metabolic control through the PGC-1 family of transcription coactivators

Lin, J., Handschin, C., & Spiegelman, B. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.004 · Cited by 2,130 · see citing works

PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro

Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081 · see citing works

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943 · see citing works

Transcriptional regulation of adipogenesisPreprint

Rosen, E. D., Walkey, C. J., Puigserver, P., & Spiegelman, B. M. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 1,902 · see citing works

Inhibition of Adipogenesis by Wnt Signaling

Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

Um, S. H., Frigerio, F., Watanabe, M., Picard, F., Joaquin, M., Sticker, M., Fumagalli, S., Allegrini, P. R., Kozma, S. C., Auwerx, J., et al. (2004) · Nature · doi:10.1038/nature02866 · Cited by 1,677 · see citing works

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649 · see citing works

C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint

Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497 · see citing works

The Sir2 Family of Protein Deacetylases

Blander, G., & Guarente, L. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073651 · Cited by 1,496 · see citing works

CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440 · see citing works

Cholesterol and Bile Acid Metabolism Are Impaired in Mice Lacking the Nuclear Oxysterol Receptor LXRα

Peet, D. J., Turley, S. D., Ma, W., Janowski, B. A., Lobaccaro, J. A., Hammer, R. E., & Mangelsdorf, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81432-4 · Cited by 1,428 · see citing works

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296 · see citing works

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

Fingar, D. C., & Blenis, J. (2004) · Oncogene · doi:10.1038/sj.onc.1207542 · Cited by 1,250 · see citing works

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

Kelly, D. P., & Scarpulla, R. C. (2004) · Genes & Development · doi:10.1101/gad.1177604 · Cited by 1,243 · see citing works

Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide

Nisoli, E., Clementi, E., Paolucci, C., Cozzi, V., Tonello, C., Sciorati, C., Bracale, R., Valerio, A., Francolini, M., Moncada, S., et al. (2003) · Science · doi:10.1126/science.1079368 · Cited by 1,243 · see citing works

Steroid receptor coactivator-1 is a histone acetyltransferase

Spencer, T. E., Jenster, G. W., Burcin, M. M., Allis, C. D., Zhou, J., Mizzen, C. A., McKenna, N. J., Oñate, S. A., Tsai, S. Y., Tsai, M., et al. (1997) · Nature · doi:10.1038/38304 · Cited by 1,242 · see citing works

Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice

Lin, J., Wu, P.-H., Tarr, P. T., Lindenberg, K. S., St-Pierre, J., Zhang, C.-Y., Mootha, V. K., Jäger, S., Vianna, C. R., Reznick, R. M., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.013 · Cited by 1,162 · see citing works

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123 · see citing works

Regulation of Muscle Fiber Type and Running Endurance by PPARδ

Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020294 · Cited by 1,089 · see citing works

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works

SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α

Nemoto, S., Fergusson, M. M., & Finkel, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501485200 · Cited by 1,047 · see citing works

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, W., Barak, Y., Hevener, A. L., Olson, P., Liao, D., Le, J., Nelson, M. C., Ong, E. S., Olefsky, J. M., & Evans, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536828100 · Cited by 978 · see citing works

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030101 · Cited by 951 · see citing works

Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators

Smith, C. L., & O’Malley, B. W. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0023 · Cited by 931 · see citing works

Impaired Energy Homeostasis in C/EBPα Knockout Mice

Wang, N.-D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., & Darlington, G. J. (1995) · Science · doi:10.1126/science.7652557 · Cited by 929 · see citing works

IRS proteins and the common path to diabetes

White, M. F. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2001 · Cited by 925 · see citing works

Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome

Tanaka, T., Yamamoto, J., Iwasaki, S., Asaba, H., Hamura, H., Ikeda, Y., Watanabe, M., Magoori, K., Ioka, R. X., Tachibana, K., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306981100 · Cited by 832 · see citing works

Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene

Tanaka, T., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7432 · Cited by 804 · see citing works

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

Moncada, S., & Erusalimsky, J. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm762 · Cited by 789 · see citing works

βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

Bachman, E. S., Dhillon, H., Zhang, C.-Y., Cinti, S., Bianco, A. C., Kobilka, B. K., & Lowell, B. B. (2002) · Science · doi:10.1126/science.1073160 · Cited by 782 · see citing works

The Role of C/EBP Genes in Adipocyte Differentiation

Darlington, G., Ross, S. E., & MacDougald, O. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30057 · Cited by 758 · see citing works

S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Pende, M., Um, S. H., Mieulet, V., Sticker, M., Goss, V. L., Mestan, J., Mueller, M., Fumagalli, S., Kozma, S. C., & Thomas, G. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3112-3124.2004 · Cited by 743 · see citing works

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

Cavaillès, V., Dauvois, S., L’Horset, F., Lopez, G. N., Hoare, S., Kushner, P. J., & Parker, M. G. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00044.x · Cited by 740 · see citing works

Cytokine Stimulation of Energy Expenditure through p38 MAP Kinase Activation of PPARγ Coactivator-1

Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C.-Y., Krauss, S., Mootha, V. K., Lowell, B. B., & Spiegelman, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00390-2 · Cited by 732 · see citing works

An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle

Handschin, C., Rhee, J., Lin, J., Tarr, P. T., & Spiegelman, B. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232352100 · Cited by 729 · see citing works

SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes

Shi, T., Wang, F., Stieren, E., & Tong, Q. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414670200 · Cited by 712 · see citing works

Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators

Gleyzer, N., Vercauteren, K., & Scarpulla, R. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1354-1366.2005 · Cited by 711 · see citing works

The adipose organ

Cinti, S. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 690 · see citing works

ERRα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Mootha, V. K., Handschin, C., Arlow, D., Xie, X., St. Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401401101 · Cited by 688 · see citing works

Thermogenic Mechanisms and Their Hormonal Regulation

Silva, J. E. (2006) · Physiological Reviews · doi:10.1152/physrev.00009.2005 · Cited by 687 · see citing works

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

Laffitte, B. A., Repa, J. J., Joseph, S. B., Wilpitz, D. C., Kast, H. R., Mangelsdorf, D. J., & Tontonoz, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.507 · Cited by 683 · see citing works

Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Pénicaud, L., & Casteilla, L. (1992) · Journal of Cell Science · doi:10.1242/jcs.103.4.931 · Cited by 665 · see citing works

The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis

Schreiber, S., Emter, R., Hock, M. B., Knutti, D., Cardenas, J., Podvinec, M., Oakeley, E. J., & Kralli, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308686101 · Cited by 657 · see citing works

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

Uldry, M., Yang, W., St‐Pierre, J., Lin, J. D., Seale, P., & Spiegelman, B. M. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.002 · Cited by 644 · see citing works

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

Shima, H., Pende, M., Chen, Y., Fumagalli, S., THOMAS, G. V., & Kozma, S. C. (1998) · The EMBO Journal · doi:10.1093/emboj/17.22.6649 · Cited by 636 · see citing works

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605 · see citing works

Activation of PPARγ Coactivator-1 Through Transcription Factor Docking

Puigserver, P., Adelmant, G., Wu, Z., Fan, M., Xu, J., O’Malley, B. W., & Spiegelman, B. M. (1999) · Science · doi:10.1126/science.286.5443.1368 · Cited by 596 · see citing works

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593 · see citing works

Effects of peroxisome proliferator-activated receptor δ on placentation, adiposity, and colorectal cancer

Barak, Y., Liao, D., He, W., Ong, E. S., Nelson, M. C., Olefsky, J. M., Boland, R., & Evans, R. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012610299 · Cited by 586 · see citing works

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

Cederberg, A., Grønning, L. M., Åhrén, B., Taskén, K., Carlsson, P., & Enerbäck, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00474-3 · Cited by 555 · see citing works

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works

Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor

Lin, J., Puigserver, P., Donovan, J., Tarr, P., & Spiegelman, B. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100631200 · Cited by 552 · see citing works

Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells

St‐Pierre, J., Lin, J. D., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B., & Spiegelman, B. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301850200 · Cited by 543 · see citing works

Function of GATA Transcription Factors in Preadipocyte-Adipocyte Transition

Tong, Q., Dalgin, G., Xu, H., Ting, C.-N., Leiden, J. M., & Hotamışlıgil, G. S. (2000) · Science · doi:10.1126/science.290.5489.134 · Cited by 534 · see citing works

Peroxisome proliferator‐activated receptor δ controls muscle development and oxydative capability

Luquet, S., Lopez‐Soriano, J., Holst, D., Fredenrich, A., Melki, J., Rassoulzadegan, M., & Grimaldi, P. A. (2003) · The FASEB Journal · doi:10.1096/fj.03-0269fje · Cited by 509 · see citing works

Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

Laffitte, B. A., Chao, L. C., Li, J., Walczak, R., Hummasti, S., Joseph, S. B., Castrillo, A., Wilpitz, D. C., Mangelsdorf, D. J., Collins, J. L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0830671100 · Cited by 503 · see citing works

Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

Jones, J. R., Barrick, C. J., Kim, K., Lindner, J., Blondeau, B., Fujimoto, Y., Shiota, M., Kesterson, R. A., Kahn, B. B., & Magnuson, M. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306743102 · Cited by 487 · see citing works

Acquirement of brown fat cell features by human white adipocytes

Tiraby, C., Tavernier, G., Lefort, C., Larrouy, D., Bouillaud, F., Ricquier, D., & Langin, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305235200 · Cited by 474 · see citing works

Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works

Cidea-deficient mice have lean phenotype and are resistant to obesity

Zhou, Z., Toh, S. Y., Chen, Z., Guo, K., Ng, C. P., Ponniah, S., Lin, S., Hong, W., & Li, P. (2003) · Nature Genetics · doi:10.1038/ng1225 · Cited by 468 · see citing works

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

Maffei, M., Fei, H., Lee, G., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Négrel, R., Ailhaud, G. P., & Friedman, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6957 · Cited by 465 · see citing works

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation

Oishi, Y., Manabe, I., Tobe, K., Tsushima, K., Shindo, T., Fujiu, K., Nishimura, G., Maemura, K., Yamauchi, T., Kubota, N., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.11.005 · Cited by 461 · see citing works

Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone.

Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M., & Corvera, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1085-1094.2003 · Cited by 459 · see citing works

Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice

Pende, M., Kozma, S. C., Jaquet, M., Oorschot, V. M. J., Burcelin, R., MARCHAND‐BRUSTEL, Y. L., Klumperman, J., Thorens, B., & Thomas, G. W. (2000) · Nature · doi:10.1038/35050135 · Cited by 452 · see citing works

SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues

Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444 · see citing works

Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A

Cummings, D. E., Brandon, E. P., Planas, J. V., Motamed, K., Idzerda, R. L., & McKnight, G. S. (1996) · Nature · doi:10.1038/382622a0 · Cited by 418 · see citing works

The retinoblastoma gene family in differentiation and development

Lipinski, M. M., & Jacks, T. (1999) · Oncogene · doi:10.1038/sj.onc.1203244 · Cited by 404 · see citing works

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

Tsukiyama–Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A., Katsume, A., Elchebly, M., Spiegelman, B. M., et al. (2001) · Nature Medicine · doi:10.1038/nm1001-1128 · Cited by 392 · see citing works

Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse

Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J., Messaddeq, N., Wendling, O., Mark, M. P., Desvergne, B., Wahli, W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400356101 · Cited by 383 · see citing works

PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells

Andersson, U., & Scarpulla, R. C. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3738-3749.2001 · Cited by 374 · see citing works

Wnt10b Inhibits Development of White and Brown Adipose Tissues

Longo, K. A., Hahn, W. S., Kang, S., Gerin, I., Chiang, S.-H., Lucas, P. C., Opp, M. R., & MacDougald, O. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402937200 · Cited by 372 · see citing works

Proliferation, But Not Growth, Blocked by Conditional Deletion of 40 S Ribosomal Protein S6

Volarević, S., Stewart, M. J., Ledermann, B., Zilbermann, F., Terracciano, L., Montini, E., Grompe, M., Kozma, S. C., & Thomas, G. (2000) · Science · doi:10.1126/science.288.5473.2045 · Cited by 372 · see citing works

Distinct Transcriptional Profiles of Adipogenesisin Vivo and in Vitro

Soukas, A. A., Socci, N. D., Saatkamp, B. D., Novelli, S. E., & Friedman, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104421200 · Cited by 368 · see citing works

Cellular transformation by SV40 large T antigen: interaction with host proteins

Ali, S. H., & DeCaprio, J. A. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0342 · Cited by 367 · see citing works

Nuclear receptor corepressor RIP140 regulates fat accumulation

Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works

PPARγ coactivator 1β/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity.

Kamei, Y., Ohizumi, H., Fujitani, Y., Nemoto, T., Tanaka, T., Takahashi, N., Kawada, T., Miyoshi, M., Ezaki, O., & Kakizuka, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135217100 · Cited by 357 · see citing works

PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis

Li, A. C., & Glass, C. K. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400010-jlr200 · Cited by 357 · see citing works

Peroxisome Proliferator-activated Receptor α Activates Transcription of the Brown Fat Uncoupling Protein-1 Gene

Barberà, M. J., Schlüter, A., Pedraza, N., Iglesias, R., Villarroya, F., & Giralt, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006246200 · Cited by 337 · see citing works

The occurrence of brown adipose tissue in outdoor workers

Huttunen, P., Hirvonen, J., & Kinnula, V. L. (1981) · European Journal of Applied Physiology · doi:10.1007/bf00422121 · Cited by 335 · see citing works

C/EBPα is required for differentiation of white, but not brown, adipose tissue

Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 333 · see citing works

β-Adrenergic Activation of p38 MAP Kinase in Adipocytes

Cao, W., Medvedev, A. V., Daniel, K. W., & Collins, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101049200 · Cited by 327 · see citing works

Distinct Properties and Advantages of a Novel Peroxisome Proliferator-Activated Protein γ Selective Modulator

Berger, J. P., Petro, A. E., MacNaul, K. L., Kelly, L. J., Zhang, B. B., Richards, K. M., Elbrecht, A., Johnson, B. A., Zhou, G., Doebber, T. W., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0217 · Cited by 320 · see citing works

Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis

Ge, K., Guermah, M., Yuan, C., Ito, M., Wallberg, A. E., Spiegelman, B. M., & Roeder, R. G. (2002) · Nature · doi:10.1038/417563a · Cited by 319 · see citing works

T RANSCRIPTIONAL C ONTROL OF A DIPOGENESIS

Rangwala, S. M., & Lazar, M. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.535 · Cited by 319 · see citing works

E2F Repression by C/EBPα Is Required for Adipogenesis and Granulopoiesis In Vivo

Porse, B. T., Pedersen, T. Å., Xu, X., Lindberg, B. G., Wewer, U. M., Friis-Hansen, L. J., & Nerlov, C. (2001) · Cell · doi:10.1016/s0092-8674(01)00516-5 · Cited by 316 · see citing works

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK

Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., Jäeger, S., Erdjument-Bromage, H., Tempst, P., & Spiegelman, B. M. (2004) · Genes & Development · doi:10.1101/gad.1152204 · Cited by 309 · see citing works

LXRs regulate the balance between fat storage and oxidation

Kalaany, N. Y., Gauthier, K. C., Zavacki, A. M., Mammen, P. P. A., Kitazume, T., Peterson, J. A., Horton, J. D., Garry, D. J., Bianco, A. C., & Mangelsdorf, D. J. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.001 · Cited by 304 · see citing works

Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein α

Flodby, P., Barlow, C., Kylefjord, H., Åhrlund-Richter, L., & Xanthopoulos, K. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24753 · Cited by 293 · see citing works

Corepressors selectively control the transcriptional activity of PPARγ in adipocytesPreprint

Guan, H.-P., Ishizuka, T., Chui, P. C., Lehrke, M., & Lazar, M. A. (2005) · Genes & Development · doi:10.1101/gad.1263305 · Cited by 293 · see citing works

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0301964101 · Cited by 287 · see citing works

Selective disruption of PPARγ2 impairs the development of adipose tissue and insulin sensitivity

Zhang, J., Fu, M., Cui, T., Chen, X., Xu, K., Zhong, W., Xiao, Y., Floyd, D., Liang, J., Li, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403652101 · Cited by 279 · see citing works

A Unique PPARγ Ligand with Potent Insulin-Sensitizing yet Weak Adipogenic Activity

Rocchi, S., Picard, F., Vamecq, J., Gelman, L., Potier, N., Zeyer, D., Dubuquoy, L., Bac, P., Champy, M., Plunket, K. D., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00353-7 · Cited by 273 · see citing works

Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor

Knutti, D., Kressler, D., & Kralli, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171184698 · Cited by 271 · see citing works

Peroxisome Proliferator-Activated Receptors γ and α Mediate in Vivo Regulation of Uncoupling Protein (UCP-1, UCP-2, UCP-3) Gene Expression

Kelly, L. J., Vicario, P. P., Thompson, G. M., Candelore, M. R., Doebber, T. W., Ventre, J. R., Wu, M. S., Meurer, R. D., Forrest, M. J., Conner, M. W., et al. (1998) · Endocrinology · doi:10.1210/endo.139.12.6384 · Cited by 268 · see citing works

Activation of nuclear receptor coactivator PGC-1α by arginine methylationPreprint

Teyssier, C., Ma, H., Emter, R., Kralli, A., & Stallcup, M. R. (2005) · Genes & Development · doi:10.1101/gad.1295005 · Cited by 260 · see citing works

Microarray Analyses during Adipogenesis: Understanding the Effects of Wnt Signaling on Adipogenesis and the Roles of Liver X Receptor α in Adipocyte Metabolism

Ross, S. E., Erickson, R. L., Gerin, I., DeRose, P. M., Bajnok, L., Longo, K. A., Misek, D. E., Kuick, R. D., Hanash, S., Atkins, K. B., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.5989-5999.2002 · Cited by 255 · see citing works

Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression

Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M.-G., Steffensen, K. R., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3430-3444.2004 · Cited by 250 · see citing works

ADIPOCYTE DIFFERENTIATION AND LEPTIN EXPRESSION

Hwang, C.-S., Loftus, T. M., Mandrup, S., & Lane, M. D. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.231 · Cited by 247 · see citing works

The PGC-1-related Protein PERC Is a Selective Coactivator of Estrogen Receptor α

Kressler, D., Schreiber, S., Knutti, D., & Kralli, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201134200 · Cited by 239 · see citing works

β3-Adrenergic Stimulation Differentially Inhibits Insulin Signaling and Decreases Insulin-induced Glucose Uptake in Brown Adipocytes

Klein, J. C., Faßhauer, M., Ito, M., Lowell, B. B., Benito, M., & Kahn, C. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34795 · Cited by 239 · see citing works

Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes

Powelka, A. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26040 · Cited by 236 · see citing works

A Regulatory Role for RIP140 in Nuclear Receptor Activation

Treuter, E., Albrektsen, T., Johansson, L., Leers, J., & Gustafsson, J.-Α. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.6.0123 · Cited by 229 · see citing works

Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells.

Yeh, W., Bierer, B. E., & McKnight, S. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11086 · Cited by 226 · see citing works

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

Tseng, Y.-H., Butte, A. J., Kokkotou, E., Yechoor, V. K., Taniguchi, C. M., Kriauciunas, K. M., Cypess, A. M., Niinobe, M., Yoshikawa, K., Patti, M. E., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1259 · Cited by 222 · see citing works

A New Selective Peroxisome Proliferator-Activated Receptor γ Antagonist with Antiobesity and Antidiabetic Activity

Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E. J., & Wahli, W. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0036 · Cited by 214 · see citing works

Brown adipose tissue uncoupling protein content in human infants, children and adults

Lean, M. E. J., James, W. P. T., Jennings, G., & Trayhurn, P. (1986) · Clinical Science · doi:10.1042/cs0710291 · Cited by 213 · see citing works

THYROXINE 5′-DEIODINASE ACTIVITY IN BROWN ADIPOSE TISSUE

Leonard, J. L., MELLEN, S. A., & LARSEN, R. P. (1983) · Endocrinology · doi:10.1210/endo-112-3-1153 · Cited by 213 · see citing works

Characterization of the human, mouse and rat PGC1beta (peroxisome-proliferator-activated receptor-gamma co-activator 1beta) gene in vitro and in vivo

Meirhaeghe, A., Crowley, V., Lenaghan, C., Lelliott, C. J., GREEN, K., Stewart, A., Kevin, H. A. R. T., Schinner, S., Sethi, J. K., Yeo, G. S. H., et al. (2003) · Biochemical Journal · doi:10.1042/bj20030200 · Cited by 210 · see citing works

Krox20 stimulates adipogenesis via C/EBPβ-dependent and -independent mechanisms

Chen, Z., Torréns, J. I., Anand, A., Spiegelman, B. M., & Friedman, J. M. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.009 · Cited by 209 · see citing works

Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia.

Hamann, A., Flier, J. S., & Lowell, B. B. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536614 · Cited by 205 · see citing works

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α

Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199 · see citing works

The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility

White, R., Leonardsson, G., Rosewell, I. R., Jacobs, M. A., Milligan, S. R., & Parker, M. G. (2000) · Nature Medicine · doi:10.1038/82183 · Cited by 193 · see citing works

Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans

Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F., & Patsch, W. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37142-x · Cited by 191 · see citing works

Convertible adipose tissue in mice.

Lončar, D. (1991) · Cell and Tissue Research · doi:10.1007/bf00678721 · Cited by 187 · see citing works

Peroxisome Proliferator-activated Receptor δ (PPARδ)-mediated Regulation of Preadipocyte Proliferation and Gene Expression Is Dependent on cAMP Signaling*

Hansen, J., Zhang, H., Rasmussen, T. H., Petersen, R., Flindt, E., & Kristiansen, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005567200 · Cited by 187 · see citing works

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivation

Hondares, E., Mora, O., Yubero, P., de la Concepción, M. L. R., Iglesias, R., Giralt, M., & Villarroya, F. (2006) · Endocrinology · doi:10.1210/en.2006-0070 · Cited by 183 · see citing works

Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ hypomorphic mice

Koutníková, H., Cock, T., 渡辺, 光., Houten, S. M., Champy, M., Dierich, A., & Auwerx, J. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336090100 · Cited by 182 · see citing works

RIP140-Targeted Repression of Gene Expression in Adipocytes

Christian, M., Kiskinis, E., Debevec, D., Leonardsson, G., White, R., & Parker, M. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9383-9391.2005 · Cited by 181 · see citing works

Learning New Tricks from Old Dogs: β-Adrenergic Receptors Teach New Lessons on Firing Up Adipose Tissue Metabolism

Collins, S., Cao, W., & Robidoux, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0193 · Cited by 179 · see citing works

Expression of the Insulin-responsive Glucose Transporter GLUT4 in Adipocytes Is Dependent on Liver X Receptor α

Dalen, K. T., Ulven, S. M., Bamberg, K., Gustafsson, J.-Α., & Nebb, H. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302287200 · Cited by 179 · see citing works

Transcriptional Synergy and the Regulation of Ucp1 during Brown Adipocyte Induction in White Fat Depots

Xue, B., Coulter, A. A., Rim, J. S., Koza, R. A., & Kozak, L. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8311-8322.2005 · Cited by 179 · see citing works

Differential Roles of Insulin Receptor Substrates in Brown Adipocyte Differentiation

Tseng, Y.-H., Kriauciunas, K. M., Kokkotou, E., & Kahn, C. R. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1918-1929.2004 · Cited by 173 · see citing works

Essential Role of Insulin Receptor Substrate 1 in Differentiation of Brown Adipocytes

Faßhauer, M., Klein, J. C., Kriauciunas, K. M., Ueki, K., Benito, M., & Kahn, C. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.1.319-329.2001 · Cited by 171 · see citing works

On the Role of Liver X Receptors in Lipid Accumulation in Adipocytes

Juvet, L. K., Andresen, S. M., Schuster, G. U., Dalen, K. T., Tobin, K. A. R., Hollung, K., Haugen, F., Jacinto, S. M., Ulven, S. M., Bamberg, K., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2001-0210 · Cited by 169 · see citing works

A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice.

Fukui, Y., Masui, S., Osada, S., Umesono, K., & Motojima, K. (2000) · Diabetes · doi:10.2337/diabetes.49.5.759 · Cited by 168 · see citing works

LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function

Gerin, I., Dolinsky, V. W., Shackman, J. G., Kennedy, R. T., Chiang, S.-H., Burant, C., Steffensen, K. R., Gustafsson, J.-Α., & MacDougald, O. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412564200 · Cited by 167 · see citing works

Novel Roles of Liver X Receptors Exposed by Gene Expression Profiling in Liver and Adipose Tissue

Stulnig, T. M., Steffensen, K. R., Gao, H., Reimers, M., Dahlman‐Wright, K., Schuster, G. U., & Gustafsson, J.-Α. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.6.1299 · Cited by 164 · see citing works

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-803 · Cited by 164 · see citing works

Expression of Peroxisome Proliferator-activated Receptor PPARδ Promotes Induction of PPARγ and Adipocyte Differentiation in 3T3C2 Fibroblasts

Bastie, C. C., Holst, D., Gaillard, D., Jehl-Piétri, C., & Grimaldi, P. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.31.21920 · Cited by 156 · see citing works

Depressed Thermogenesis but Competent Brown Adipose Tissue Recruitment in Mice Devoid of All Hormone-Binding Thyroid Hormone Receptors

Golozoubova, V., Gullberg, H., Matthias, A., Cannon, B., Vennström, B., & Nedergaard, J. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0267 · Cited by 155 · see citing works

Activation of the Nuclear Receptor Peroxisome Proliferator-activated Receptor γ Promotes Brown Adipocyte Differentiation

Tai, T.-A. C., Jennermann, C., Brown, K. K., Oliver, B. B., MacGinnitie, M. A., Wilkison, W. O., Brown, H. R., Lehmann, J. M., Kliewer, S. A., Morris, D. C., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.47.29909 · Cited by 154 · see citing works

The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes

Wang, L., Liu, J., Saha, P., Huang, J., Chan, L., Spiegelman, B. M., & Moore, D. D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.08.010 · Cited by 150 · see citing works

Brown adipose tissue in patients with phaeochromocytoma.

Lean, M. E. J., James, W. P. T., Jennings, G., & Trayhurn, P. (1986) · PubMed · Cited by 142 · see citing works

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

Båvner, A., Sanyal, S., Gustafsson, J.-Å., & Treuter, E. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.10.005 · Cited by 142 · see citing works

Identification of a Specific Molecular Repressor of the Peroxisome Proliferator-activated Receptor γ Coactivator-1 α (PGC-1α)

Ichida, M., Nemoto, S., & Finkel, T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m210262200 · Cited by 138 · see citing works

Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs.

Champigny, O., Ricquier, D., Blondel, O., Mayers, R. M., BRISCOE, M. G., & Holloway, B. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10774 · Cited by 137 · see citing works

Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution

Kopecký, J., Hodný, Z., Rossmeisl, M., Syrový, I., & Kozak, L. P. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.5.e768 · Cited by 136 · see citing works

Novel adipocyte lines from brown fat: A model system for the study of differentiation, energy metabolism, and insulin action

Klein, J. C., Faßhauer, M., Klein, H. H., Benito, M., & Kahn, C. R. (2002) · BioEssays · doi:10.1002/bies.10058 · Cited by 136 · see citing works

Effects of Wnt Signaling on Brown Adipocyte Differentiation and Metabolism Mediated by PGC-1α

Kang, S., Bajnok, L., Longo, K. A., Petersen, R. K., Hansen, J. B., Kristiansen, K., & MacDougald, O. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.4.1272-1282.2005 · Cited by 135 · see citing works

Lipoatrophic diabetes in Irs1−/−/Irs3−/− double knockout micePreprint

Laustsen, P. G., Michael, M. D., Crute, B. E., Cohen, S. E., Ueki, K., Kulkarni, R. N., Keller, S. R., Lienhard, G. E., & Kahn, C. R. (2002) · Genes & Development · doi:10.1101/gad.1034802 · Cited by 131 · see citing works

Peroxisome Proliferator-Activated Receptor γ Agonism Increases the Capacity for Sympathetically Mediated Thermogenesis in Lean andob/obMice

Sell, H., Berger, J. P., Samson, P., Castriota, G. A., Lalonde, J., Deshaies, Y., & Richard, D. (2004) · Endocrinology · doi:10.1210/en.2004-0321 · Cited by 130 · see citing works

RIP-140 Interacts with Multiple Nuclear Receptors by Means of Two Distinct Sites

L’Horset, F., Dauvois, S., Heery, D. M., Cavaillès, V., & Parker, M. G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6029 · Cited by 129 · see citing works

β1/β2/β3‐adrenoceptor knockout mice are obese and cold‐sensitive but have normal lipolytic responses to fasting

Jimenez, M., Léger, B., Canola, K., Lehr, L., Arboit, P., Seydoux, J., Russell, A. P., Giacobino, J., Muzzin, P., & Preitner, F. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03387-2 · Cited by 126 · see citing works

Hibernoma formation in transgenic mice and isolation of a brown adipocyte cell line expressing the uncoupling protein gene.

Ross, S. R., Choy, L., Graves, R. A., Fox, N. W., SOLEVEVA, V., Klaus, S., Ricquier, D., & Spiegelman, B. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7561 · Cited by 121 · see citing works

Liver X receptors are regulators of adipocyte gene expression but not differentiation

Hummasti, S., Laffitte, B. A., Watson, M. A., Galardi, C. M., Chao, L. C., Ramamurthy, L., Moore, J. T., & Tontonoz, P. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300312-jlr200 · Cited by 120 · see citing works

Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth

Casteilla, L., Champigny, O., Bouillaud, F., Robelin, J., & Ricquier, D. (1989) · Biochemical Journal · doi:10.1042/bj2570665 · Cited by 119 · see citing works

An adipogenic cofactor bound by the differentiation domain of PPARγ

Castillo, G., Brun, R. P., Rosenfield, J. K., Hauser, S., Park, C. W., Troy, A. E., Wright, M. E., & Spiegelman, B. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.13.3676 · Cited by 119 · see citing works

Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures

Nisoli, E., Clementi, E., Tonello, C., Sciorati, C., Briscini, L., & Carruba, M. O. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702131 · Cited by 110 · see citing works

The human uncoupling protein‐1 gene (UCP1): present status and perspectives in obesity research

González‐Barroso, M. M., Ricquier, D., & Cassard, A. (2000) · Obesity Reviews · doi:10.1046/j.1467-789x.2000.00009.x · Cited by 109 · see citing works

Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance

Wang, Z., Qi, C., Krones, A., Woodring, P. J., Zhu, X., Reddy, J. K., Evans, R. M., Rosenfeld, M. G., & Hunter, T. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.002 · Cited by 103 · see citing works

C/EBPβ, When Expressed from the C/ebpα Gene Locus, Can Functionally Replace C/EBPα in Liver but Not in Adipose Tissue

Chen, S., Chen, J., Johnson, P. F., Muppala, V., & Lee, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7292-7299.2000 · Cited by 101 · see citing works

Alterations of Peroxisome Proliferator-activated Receptor δ Activity Affect Fatty Acid-controlled Adipose Differentiation

Bastie, C. C., Luquet, S. H., Holst, D., Jehl-Piétri, C., & Grimaldi, P. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006450200 · Cited by 98 · see citing works

PPARβ/δ potentiates PPARγ‐stimulated adipocyte differentiation

Matsusue, K., Peters, J. M., & Gonzalez, F. J. (2004) · The FASEB Journal · doi:10.1096/fj.04-1944fje · Cited by 97 · see citing works

Rosiglitazone and Retinoic Acid Induce Uncoupling Protein-1 (UCP-1) in a p38 Mitogen-activated Protein Kinase-dependent Manner in Fetal Primary Brown Adipocytes

Teruel, T., Hernández, R., Benito, M., & Lorenzo, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207200200 · Cited by 97 · see citing works

Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cellsPreprint

Chiu, C., Lin, W., Huang, S.-Y., & Lee, Y.-H. (2004) · Genes & Development · doi:10.1101/gad.1213104 · Cited by 96 · see citing works

Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation.

Cherington, V., Morgan, B. A., Spiegelman, B. M., & Roberts, T. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.12.4307 · Cited by 91 · see citing works

Induction of uncoupling protein in brown adipose tissue

Foellmi, L. A., Wyse, B. M., Herron, D., Nedergaard, J., & Kletzien, R. F. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00345-0 · Cited by 87 · see citing works

IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes.

Lorenzo, M., Valverde, Á. M., Teruel, T., & Benito, M. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.6.1567 · Cited by 87 · see citing works

Regulation of the Uncoupling Protein Gene (Ucp) by β1, β2, and β3-Adrenergic Receptor Subtypes in Immortalized Brown Adipose Cell Lines

Rohlfs, E. M., Daniel, K. W., Premont, R. T., Kozak, L. P., & Collins, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10723 · Cited by 85 · see citing works

Separation of Simian Virus 40 large-T-Antigen-Transforming and Origin-Binding Functions from the Ability to Block Differentiation

Cherington, V., Brown, M., Paucha, E., Louis, J. S., Spiegelman, B. M., & Roberts, T. M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.3.1380 · Cited by 84 · see citing works

Pituitary and autonomic responses to cold exposures in man

Leppäluoto, J., Pääkkönen, T., Korhonen, I., & Hassi, J. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01464.x · Cited by 83 · see citing works

Energy balance following sympathetic denervation of brown adipose tissue

Dulloo, A. G., & Miller, D. S. (1984) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y84-035 · Cited by 82 · see citing works

The Forkhead Transcription Factor FoxC2 Inhibits White Adipocyte Differentiation

Davis, K. E., Moldes, M., & Farmer, S. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402197200 · Cited by 82 · see citing works

Functional differentiation of white and brown adipocytes

Klaus, S. (1997) · BioEssays · doi:10.1002/bies.950190307 · Cited by 82 · see citing works

Differential gene expression in white and brown preadipocytes

Boeuf, S., Klingenspor, M., Hal, N. L. W. F.-V., SCHNEIDER, T., Keijer, J., & Klaus, S. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.00048.2001 · Cited by 80 · see citing works

Characterization of the novel brown adipocyte cell line hib 1b adrenergic pathways involved in regulation of uncoupling protein gene expression

Klaus, S., Choy, L., Champigny, O., Cassard, A., Ross, S. R., Spiegelman, B. M., & Ricquier, D. (1994) · Journal of Cell Science · doi:10.1242/jcs.107.1.313 · Cited by 75 · see citing works

Phosphatidylinositol 3-Kinase Is a Requirement for Insulin-Like Growth Factor I-Induced Differentiation, but not for Mitogenesis, in Fetal Brown Adipocytes

Valverde, Á. M., Lorenzo, M., Navarro, P., & Benito, M. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.5.9924 · Cited by 75 · see citing works

Metabolic Response of Mice to a Postnatal Ablation of CCAAT/Enhancer-binding Protein α

Yang, J., Croniger, C. M., Lekstrom-Himes, J. A., Zhang, P., Fenyus, M. L., Tenen, D. G., Darlington, G., & Hanson, R. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503486200 · Cited by 75 · see citing works

Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes

Bengtsson, T., Cannon, B., & Nedergaard, J. (2000) · Biochemical Journal · doi:10.1042/bj3470643 · Cited by 74 · see citing works

The effect of intermittent cold treatment on the adipose tissue of the cat

Lonćar, D., Bedrica, L., Mayer, J., Cannon, B., Nedergaard, J., Afzelius, B. A., & Švajger, A. (1986) · Journal of Ultrastructure and Molecular Structure Research · doi:10.1016/s0889-1605(86)80012-x · Cited by 74 · see citing works

Peroxisome Proliferator-activated Receptor (PPAR) γ Coactivator-1 Recruitment Regulates PPAR Subtype Specificity

Oberkofler, H., Esterbauer, H., Linnemayr, V., Strosberg, A. D., Krempler, F., & Patsch, W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200475200 · Cited by 74 · see citing works

PGC-1-related coactivator and targets are upregulated in thyroid oncocytoma

Savagner, F., Mirebeau‐Prunier, D., Jacques, C., Guyétant, S., Morgan, C., Franc, B., Reynier, P., & Malthièry, Y. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.076 · Cited by 74 · see citing works

Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue

Ulven, S. M., Dalen, K. T., Gustafsson, J.-Α., & Nebb, H. I. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400119-jlr200 · Cited by 74 · see citing works

The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance

Valverde, Á. M., Benito, M., & Lorenzo, M. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2004.01384.x · Cited by 71 · see citing works

Brown fat is essential for cold-induced thermogenesis but not for obesity resistance in aP2-Ucp mice

Stefl, B., Janovská, A., Hodný, Z., Rossmeisl, M., Horáková, M., Syrový, I., Bémová, J., Bendlová, B., & Kopecký, J. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.3.e527 · Cited by 69 · see citing works

cAMP-dependent Protein Kinase Regulates Ubiquitin-Proteasome-mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1

Hoang, T., Fenne, I. S., Cook, C., Børud, B., Bakke, M., Lien, E. A., & Mellgren, G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409746200 · Cited by 68 · see citing works

Immortal Brown Adipocytes fromp53-Knockout Mice: Differentiation and Expression of Uncoupling Proteins

Irie, Y., Asano, A., Cañas, X., Nikami, H., Aizawa, S.-I., & Saito, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9999 · Cited by 67 · see citing works

Opposite regulation of PPAR-α and -γ gene expression by both their ligands and retinoic acid in brown adipocytes

Valmaseda, A., Carmona, M. C., Barberà, M. J., Viñas, O., Mampel, T., Iglesias, R., Villarroya, F., & Giralt, M. (1999) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00081-7 · Cited by 63 · see citing works

Insulin and TNF Induce Expression of the Forkhead Transcription Factor Gene Foxc2 in 3T3-L1 Adipocytes via PI3K and ERK 1/2-Dependent Pathways

Grønning, L. M., Cederberg, A., Miura, N., Enerbäck, S., & Taskén, K. (2002) · Molecular Endocrinology · doi:10.1210/mend.16.4.0803 · Cited by 60 · see citing works

PAT5A: A Partial Agonist of Peroxisome Proliferator-Activated Receptor γ Is a Potent Antidiabetic Thiazolidinedione Yet Weakly Adipogenic

Misra, P., Chakrabarti, R., Vikramadithyan, R. K., Bulusu, G., Suresh, J., Hiriyan, J., Gershome, C., Rajjak, A., Kashireddy, P. V., Yu, S., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049791 · Cited by 60 · see citing works

Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype

Moulin, K., Truel, N., André, M., ARNAULD, E., Nibbelink, M. M., Cousin, B., Dani, C., Pénicaud, L., & Casteilla, L. (2001) · Biochemical Journal · doi:10.1042/bj3560659 · Cited by 59 · see citing works

Peroxisome-proliferator-activated receptor δ mediates the effects of long-chain fatty acids on post-confluent cell proliferation

Jehl-Piétri, C., Bastie, C. C., Gillot, I., Luquet, S. H., & Grimaldi, P. A. (2000) · Biochemical Journal · doi:10.1042/bj3500093 · Cited by 59 · see citing works

Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPβ

Carmona, M. C., Hondares, E., CONCEPCIÓN, M. L. R. D. L., Rodríguez‐Sureda, V., Peinado‐Onsurbe, J., Poli, V., Iglesias, R., Villarroya, F., & Giralt, M. (2005) · Biochemical Journal · doi:10.1042/bj20050009 · Cited by 59 · see citing works

Mitochondrial Biogenesis and Thyroid Status Maturation in Brown Fat Require CCAAT/Enhancer-binding Protein α

Carmona, M. C., Iglesias, R., Obregón, M.-J., Darlington, G., Villarroya, F., & Giralt, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201710200 · Cited by 55 · see citing works

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels

Lindgren, E., Nielsen, R., Petrovič, N., Jacobsson, A., Mandrup, S., Cannon, B., & Nedergaard, J. (2004) · Biochemical Journal · doi:10.1042/bj20031622 · Cited by 53 · see citing works

Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: requirement of IRS-1 for lipid synthesis.

Valverde, Á. M., Kahn, C. R., & Benito, M. (1999) · Diabetes · doi:10.2337/diabetes.48.11.2122 · Cited by 53 · see citing works

Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice

Melnyk, A. A., Harper, M., & Himms‐Hagen, J. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.272.4.r1088 · Cited by 52 · see citing works

Effects of Short Term Glucocorticoid Administration in Primary Hyperparathyroidism: Comparison to Sarcoidosis*

Breslau, N. A., Zerwekh, J. E., Nicar, M. J., & Pak, C. Y. C. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-4-824 · Cited by 50 · see citing works

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

Adipocytes as regulators of energy balance and glucose homeostasis

Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · see citing works

Developmental Origin of Fat: Tracking Obesity to Its Source

Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508 · see citing works

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 748 · see citing works

Ten Putative Contributors to the Obesity Epidemic

McAllister, E. J., Dhurandhar, N. V., Keith, S. W., Aronne, L. J., Barger, J., Baskin, M., Benca, R. M., Biggio, J., Boggiano, M. M., Eisenmann, J. C., et al. (2009) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390903372599 · Cited by 710 · see citing works

Cellular bioenergetics as a target for obesity therapy

Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591 · see citing works

Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex

Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works

The different shades of fat

Peirce, V. J., Carobbio, S., & Vidal‐Puig, A. (2014) · Nature · doi:10.1038/nature13477 · Cited by 414 · see citing works

Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

Bjørndal, B., Burri, L., Staalesen, V., Skorve, J., & Berge, R. K. (2011) · Journal of Obesity · doi:10.1155/2011/490650 · Cited by 372 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 322 · see citing works

Targeted deletion of<i>autophagy-related 5</i>(<i>atg5</i>) impairs adipogenesis in a cellular model and in mice

Baerga, R., Zhang, Y., Chen, P.-H., Goldman, S., & Jin, S. V. (2009) · Autophagy · doi:10.4161/auto.5.8.9991 · Cited by 304 · see citing works

Transcriptional control of brown adipocyte development and physiological function—of mice and menPreprint

Seale, P., Kajimura, S., & Spiegelman, B. M. (2009) · Genes & Development · doi:10.1101/gad.1779209 · Cited by 289 · see citing works

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 276 · see citing works

Cell line models for differentiation: preadipocytes and adipocytes

Poulos, S. P., Dodson, M. V., & Hausman, G. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010063 · Cited by 273 · see citing works

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

Pauw, A. D., Tejerina, S., Raes, M. J., Keijer, J., & Arnould, T. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.081155 · Cited by 270 · see citing works

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

Toh, S. Y., Gong, J., Du, G., Li, J. Z., Yang, S., Ye, J., Yao, H., Zhang, Y., Xue, B., Li, Q., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002890 · Cited by 267 · see citing works

Combinatorial Peptide Libraries: Mining for Cell-Binding Peptides

Gray, B. P., & Brown, K. C. (2013) · Chemical Reviews · doi:10.1021/cr400166n · Cited by 229 · see citing works

Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance

Lee, P. C., Swarbrick, M. M., & Ho, K. K. Y. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1081 · Cited by 207 · see citing works

Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications

Gómez‐Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016) · International Journal of Endocrinology · doi:10.1155/2016/1216783 · Cited by 204 · see citing works

The influence of perivascular adipose tissue on vascular homeostasis

Szasz, T., Bomfim, G. F., & Webb (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s33760 · Cited by 199 · see citing works

BAT: a new target for human obesity?

Frühbeck, G., Becerril, S., Sáinź, N., Garrastachu, P., & García‐Velloso, M. J. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.05.003 · Cited by 196 · see citing works

Diverse and Active Roles for Adipocytes During Mammary Gland Growth and Function

Hovey, R. C., & Aimo, L. (2010) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-010-9187-8 · Cited by 188 · see citing works

Cyclic AMP (cAMP)-Mediated Stimulation of Adipocyte Differentiation Requires the Synergistic Action of Epac- and cAMP-Dependent Protein Kinase-Dependent Processes

Petersen, R. K., Madsen, L., Pedersen, L. M., Hallenborg, P., Hagland, H. R., Viste, K., Døskeland, S. O., & Kristiansen, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00709-07 · Cited by 175 · see citing works

MicroRNA-26 Family Is Required for Human Adipogenesis and Drives Characteristics of Brown Adipocytes

Karbiener, M., Pisani, D. F., Frontini, A., Oberreiter, L. M., Lang, E., Vegiopoulos, A., Mössenböck, K., Bernhardt, G. A., Mayr, T., Hildner, F., et al. (2013) · Stem Cells · doi:10.1002/stem.1603 · Cited by 169 · see citing works

CIDE proteins and metabolic disorders

Gong, J., Sun, Z., & Li, P. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0bb · Cited by 167 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Aune, U. L., Ruiz, L., & Kajimura, S. (2013) · Journal of Visualized Experiments · doi:10.3791/50191 · Cited by 161 · see citing works

Fat poetry: a kingdom for PPARγ

Anghel, S. I., & Wahli, W. (2007) · Cell Research · doi:10.1038/cr.2007.48 · Cited by 156 · see citing works

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism

Schulz, T. J., & Tseng, Y.-H. (2009) · Cytokine &amp; Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.019 · Cited by 154 · see citing works

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182937 · Cited by 136 · see citing works

Adipose Triglyceride Lipase (ATGL) and Hormone-Sensitive Lipase (HSL) Deficiencies Affect Expression of Lipolytic Activities in Mouse Adipose Tissues

Morak, M., Schmidinger, H., Riesenhuber, G., Rechberger, G. N., Kollroser, M., Haemmerle, G., Zechner, R., Kronenberg, F., & Hermetter, A. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.015743 · Cited by 118 · see citing works

Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats

Liaset, B., Madsen, L., Hao, Q., Criales, G., Mellgren, G., Marschall, H., Hallenborg, P., Espe, M., Frøyland, L., & Kristiansen, K. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.01.016 · Cited by 118 · see citing works

Perspective: Does brown fat protect against diseases of aging?

Mattson, M. P. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.11.004 · Cited by 112 · see citing works

Follistatin Promotes Adipocyte Differentiation, Browning, and Energy Metabolism

Braga, M., Reddy, S. T., Vergnes, L., Pervin, S., Grijalva, V., Stout, D., David, J., Li, X., Tomasian, V., Reid, C. B., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m039719 · Cited by 111 · see citing works

miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity

Gaudet, A. D., Fonken, L. K., Gushchina, L. V., Aubrecht, T. G., Maurya, S. K., Periasamy, M., Nelson, R. J., & Popovich, P. G. (2016) · Scientific Reports · doi:10.1038/srep22862 · Cited by 111 · see citing works

Epicardial Fat: Physiological, Pathological, and Therapeutic Implications

Salazar, J. J., Luzardo, E., Mejías, J. C., Rojas, J., Ferreira, A. M., Rivas-Ríos, J. R., & Bermúdez, V. (2016) · Cardiology Research and Practice · doi:10.1155/2016/1291537 · Cited by 107 · see citing works

Liver X Receptor α Is a Transcriptional Repressor of the Uncoupling Protein 1 Gene and the Brown Fat Phenotype

Wang, H., Zhang, Y., Yehuda‐Shnaidman, E., Medvedev, A. V., Kumar, N., Daniel, K. W., Robidoux, J., Czech, M., Mangelsdorf, D. J., & Collins, S. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01479-07 · Cited by 99 · see citing works

Orexin Restores Aging-Related Brown Adipose Tissue Dysfunction in Male Mice

Sellayah, D., & Sikder, D. S. (2013) · Endocrinology · doi:10.1210/en.2013-1629 · Cited by 92 · see citing works

Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

Arias, M., Ranchal, I., Romero‐Gómez, M., & Crespo, J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151223163 · Cited by 87 · see citing works

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity

Korach-André, M., Archer, A., Barros, R. P. A., Parini, P., & Gustafsson, J.-Α. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017884108 · Cited by 82 · see citing works

IFATS Collection: Combinatorial Peptides Identify α5β1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells

Nie, J., Chang, B. H.-J., Traktuev, D. O., Sun, J. D., March, K. L., Chan, L., Sage, E. H., Pasqualini, R., Arap, W., & Kolonin, M. G. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0212 · Cited by 82 · see citing works

Genomic Profiling Reveals That Transient Adipogenic Activation Is a Hallmark of Mouse Models of Skeletal Muscle Regeneration

Lukjanenko, L., Brachat, S., Pierrel, E., Lach‐Trifilieff, E., & Feige, J. N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071084 · Cited by 80 · see citing works

Perivascular fat, AMP ‐activated protein kinase and vascular diseases

Almabrouk, T. A. M., Ewart, M., Salt, I. P., & Kennedy, S. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12479 · Cited by 80 · see citing works

Thyroid hormone transporters in health and disease: advances in thyroid hormone deiodination

Köhrle, J. (2007) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2007.04.001 · Cited by 75 · see citing works

Deficiency of TNFα Converting Enzyme (TACE/ADAM17) Causes a Lean, Hypermetabolic Phenotype in Mice

Gelling, R. W., Yan, W., Al‐Noori, S., Pardini, A. W., Morton, G. J., Ogimoto, K., Schwartz, M. W., & Dempsey, P. J. (2008) · Endocrinology · doi:10.1210/en.2008-0775 · Cited by 74 · see citing works

Chronic dietary supplementation of proanthocyanidins corrects the mitochondrial dysfunction of brown adipose tissue caused by diet-induced obesity in Wistar rats

Reguera, D. P., Quesada, H., Díaz, S., Fernández‐Iglesias, A., Arola‐Arnal, A., Bladé, C., Salvadó, M. J., & Arola, L. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002728 · Cited by 71 · see citing works

BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling

Yang, W., Thein, S., Wang, X., Bi, X., Ericksen, R. E., Xu, F., & Han, W. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt444 · Cited by 70 · see citing works

PRDM16: the interconvertible adipo-myocyte switch

Frühbeck, G., Sesma, P., & Burrell, M. A. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.01.007 · Cited by 67 · see citing works

Autophagic Degradation of Mitochondria in White Adipose Tissue Differentiation

Goldman, S. J., Zhang, Y., & Jin, S. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3777 · Cited by 66 · see citing works

Lipid Droplets Big and Small: Basic Mechanisms That Make Them All

Klemm, R. W., & Carvalho, P. (2024) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-012624-031419 · Cited by 68 · see citing works

Brown fat and obesity: the next big thing?

Stephens, M., Ludgate, M. E., & Rees, A. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04018.x · Cited by 65 · see citing works

A Diurnal Rhythm in Glucose Uptake in Brown Adipose Tissue Revealed by In Vivo PET‐FDG Imaging

van der Veen, D. R., Shao, J., Chapman, S. E., Leevy, W. M., & Duffield, G. E. (2012) · Obesity · doi:10.1038/oby.2012.78 · Cited by 65 · see citing works

Attainment of brown adipocyte features in white adipocytes of hormone-sensitive lipase null mice

Ström, K., Hansson, O., Lucas, S., Nevsten, P., Fernandez, C., Klint, C., Movérare-Skrtic, S., Sundler, F., Ohlsson, C., & Holm, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001793 · Cited by 62 · see citing works

Identification of miR-106b-93 as a negative regulator of brown adipocyte differentiation

Wu, Y., Zuo, J., Zhang, Y., Xie, Y., Hu, F., Chen, L., Liu, B., & Liu, F. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.016 · Cited by 61 · see citing works

Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity

Wang, X., & Hai, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.012 · Cited by 59 · see citing works

Activation of PPARγ induces profound multilocularization of adipocytes in adult mouse white adipose tissues

Koh, Y. J., Park, B., Park, J., Han, J., Lee, I., Park, J., & Koh, G. Y. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.12.094 · Cited by 60 · see citing works

The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function

Hallenborg, P., Feddersen, S., Madsen, L., & Kristiansen, K. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14712590802680141 · Cited by 58 · see citing works

Modulation of PGC-1 Coactivator Pathways in Brown Fat Differentiation through LRP130

Cooper, M. P., Uldry, M., Kajimura, S., Arany, Z. P., & Spiegelman, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805431200 · Cited by 57 · see citing works

A novel brown adipocyte-enriched long non-coding RNA that is required for brown adipocyte differentiation and sufficient to drive thermogenic gene program in white adipocytes

Xiong, Y., Yue, F., Jia, Z., Gao, Y., Jin, W. L., Hu, K., Zhang, Y., Zhu, D., Yang, G., & Kuang, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2018.01.008 · Cited by 56 · see citing works

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

Conte, M., Martucci, M., Sandri, M., Franceschi, C., & Salvioli, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00114 · Cited by 54 · see citing works

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1 α and UCP-1 gene expression in brown adipocytes

Muraoka, M., Fukushima, A., Viengchareun, S., Lombès, M., Kishi, F., Miyauchi, A., Kanematsu, M., Doi, J., Kajimura, J., Nakai, R., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00024.2009 · Cited by 54 · see citing works

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch

Xiang, X., He, L., Tang, H. W., Yuan, F., Xu, Y., Zhao, J., Li, Y., & Zhang, W. (2014) · Diabetes · doi:10.2337/db14-0427 · Cited by 52 · see citing works

Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-Associated Pathways

Cypess, A. M., Zhang, H., Schulz, T. J., Huang, T. L., Espinoza, D., Kristiansen, K., Unterman, T. G., & Tseng, Y. (2011) · Endocrinology · doi:10.1210/en.2011-1229 · Cited by 49 · see citing works

Role of nuclear receptor corepressor RIP140 in metabolic syndrome

Rosell, M., Jones, M. C., & Parker, M. G. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.12.016 · Cited by 52 · see citing works

Natural bioactive constituents from herbs and nutraceuticals promote browning of white adipose tissue.

Ma, P., Li, X., Wang, Y.-L., Lang, D.-Q., Liu, L., Yi, Y., Liu, Q., & Shen, C.-Y. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106175 · Cited by 47 · see citing works

Brown adipose tissue growth and development: significance and nutritional regulation

Satterfield, M. C. (2010) · Frontiers in bioscience · doi:10.2741/3807 · Cited by 46 · see citing works

Hydrolyzed Casein Reduces Diet-Induced Obesity in Male C57BL/6J Mice

Lillefosse, H. H., Tastesen, H. S., Du, Z., Ditlev, D. B., Thorsen, F., Madsen, L., Kristiansen, K., & Liaset, B. (2013) · Journal of Nutrition · doi:10.3945/jn.112.170415 · Cited by 42 · see citing works

The Genetics of Brown Adipocyte Induction in White Fat Depots

Kozak, L. P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00064 · Cited by 41 · see citing works

White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

Chung, Y. W., Ahmad, F., Tang, Y., Hockman, S. C., Kee, H. J., Berger, K., Guirguis, E., Choi, Y. H., Schimel, D., Aponte, A. M., et al. (2017) · Scientific Reports · doi:10.1038/srep40445 · Cited by 43 · see citing works

Effects of a Phosphodiesterase inhibitor on the Browning of Adipose Tissue in Mice

Seo, D. H., Shin, E., Lee, Y., Park, S., Nam, K. T., Kim, J. W., & Soo, B. (2022) · Biomedicines · doi:10.3390/biomedicines10081852 · Cited by 41 · see citing works

Ablation of the transcriptional regulator Id1 enhances energy expenditure, increases insulin sensitivity, and protects against age and diet induced insulin resistance, and hepatosteatosis

Ande, S., Klarmann, K. D., Gavrilova, O., & Keller, J. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-190892 · Cited by 41 · see citing works

Dynamic Regulation of Genes Involved in Mitochondrial DNA Replication and Transcription during Mouse Brown Fat Cell Differentiation and Recruitment

Murholm, M., Dixen, K., Qvortrup, K., Hansen, L. H. L., Amri, E., Madsen, L., Barbatelli, G., Quistorff, B., & Hansen, J. B. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008458 · Cited by 39 · see citing works

Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components

Keijer, J., & van Schothorst, E. M. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282f39f95 · Cited by 36 · see citing works

MiR-499/PRDM16 axis modulates the adipogenic differentiation of mouse skeletal muscle satellite cells

Jiang, J., Li, P., Ling, H., Xu, Z., Yi, B., & Zhu, S. (2018) · Human Cell · doi:10.1007/s13577-018-0210-5 · Cited by 35 · see citing works

Brown Fat Lipoatrophy and Increased Visceral Adiposity through a Concerted Adipocytokines Overexpression Induces Vascular Insulin Resistance and Dysfunction

Gómez‐Hernández, A., Otero, Y. F., Heras, N. D. L., Escribano, Ó., Cachofeiro, V., Lahera, V., & Benito, M. (2012) · Endocrinology · doi:10.1210/en.2011-1765 · Cited by 33 · see citing works

Integration of DIGE and Bioinformatics Analyses Reveals a Role of the Antiobesity Agent Tungstate in Redox and Energy Homeostasis Pathways in Brown Adipose Tissue

Barceló-Batllori, S., Kalko, S. G., Esteban, Y., Moreno, S., Carmona, M. C., & Gomis, R. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700198-mcp200 · Cited by 33 · see citing works

3,5‐diiodothyronine (3,5‐T2) reduces blood glucose independently of insulin sensitization in obese mice

Teixeira, S. D. S., Filgueira, C. S., Sieglaff, D. H., Benod, C. C., Villagomez, R. A., Minze, L. J., Zhang, A., Webb, P., & Nunes, M. T. (2016) · Acta Physiologica · doi:10.1111/apha.12821 · Cited by 33 · see citing works

Recent progress in the study of brown adipose tissue

Yao, X., Shan, S., Zhang, Y., & Ying, H. (2011) · Cell & Bioscience · doi:10.1186/2045-3701-1-35 · Cited by 33 · see citing works

Medium-Chain Triglyceride Activated Brown Adipose Tissue and Induced Reduction of Fat Mass in C57BL/6J Mice Fed High-fat Diet.

Zhang, Y., Xu, Q., Liu, Y. H., Zhang, X. S., Wang, J., Xiao, Y., Zhang, R. X., Xue, C., Yang, X. Y., & Xue, C. Y. (2015) · PubMed · doi:10.3967/bes2015.012 · Cited by 32 · see citing works

Grape skin extract reduces adipogenesis- and lipogenesis-related gene expression in 3T3-L1 adipocytes through the peroxisome proliferator-activated receptor-γ signaling pathway

Jeong, Y. S., Hong, J. H., Cho, K. H., & Jung, H. K. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.06.001 · Cited by 29 · see citing works

Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy

Chalfant, J. S., Smith, M. L., Hu, P., Dorey, F. J., Goodarzian, F., Fu, C. H., & Gilsanz, V. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.030650 · Cited by 28 · see citing works

The Lou/C rat: a model of spontaneous food restriction associated with improved insulin sensitivity and decreased lipid storage in adipose tissue

Veyrat‐Durebex, C., Montet, X., Vinciguerra, M., Gjinovci, A., Meda, P., Foti, M., & Rohner‐Jeanrenaud, F. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90592.2008 · Cited by 29 · see citing works

Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice

Zuo, Z., Liu, Z., Gao, T., Yin, Y., Wang, Z., Hou, Y., Fu, J., Liu, S., Wang, H., Xu, Y., et al. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.03.008 · Cited by 28 · see citing works

Brown Adipose Tissue Can Be Activated or Inhibited within an Hour before 18F‐FDG Injection: A Preliminary Study with MicroPET

Wu, C., Cheng, W., Xing, H., Dang, Y., Li, F., & Zhu, Z. (2011) · BioMed Research International · doi:10.1155/2011/159834 · Cited by 26 · see citing works

UCP1 and oxidative capacity of adipose tissue in adult ferrets (Mustela putorius furo)

Fuster, A., Oliver, P., Sánchez, J., Picó, C., & Palou, A. (2009) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2009.01.007 · Cited by 27 · see citing works

Inherent Plasticity of Brown Adipogenesis in White Fat of Mice Allows for Recovery from Effects of Post-Natal Malnutrition

Kozak, L. P., Koza, R. A., Anunciado‐Koza, R. P., Mendoza, T. M., & Newman, S. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030392 · Cited by 27 · see citing works

Proteomics in obesity research

Barceló-Batllori, S., & Gomis, R. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800178 · Cited by 27 · see citing works

Molecular pathways regulating the formation of brown‐like adipocytes in white adipose tissue

Fu, J., Li, Z., Zhang, H., Mao, Y., Wang, A., Wang, X., Zou, Z., & Zhang, X. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2600 · Cited by 26 · see citing works

Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice

Li, H., Zhang, C., Liu, J., Xie, W., Xu, W., Liang, F., Huang, K., & He, X. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220310 · Cited by 26 · see citing works

Regulation of adipocyte autophagy — The potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I

Wang, S., & Peng, D. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-131 · Cited by 27 · see citing works

Parathyroid Hormone Inhibits Fatty Infiltration and Muscle Atrophy After Rotator Cuff Tear by Browning of Fibroadipogenic Progenitors in a Rodent Model

Iio, R., Manaka, T., Takada, N., Orita, K., Nakazawa, K., Hirakawa, Y., Ito, Y. M., & Nakamura, H. (2023) · The American Journal of Sports Medicine · doi:10.1177/03635465231190389 · Cited by 25 · see citing works

ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes

Hao, Q., Hansen, J. B., Petersen, R. K., Hallenborg, P., Jørgensen, C., Cinti, S., Larsen, P. J., Steffensen, K. R., Wang, H., Collins, S., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.11.008 · Cited by 25 · see citing works

Benefits of healthy adipose tissue in the treatment of diabetes

Gunawardana, S. C. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i4.420 · Cited by 24 · see citing works

Emerging role of protein kinase C in energy homeostasis: A brief overview

Mehta, K. D. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i3.385 · Cited by 24 · see citing works

The Mixed-Lineage Kinase DLK Is a Key Regulator of 3T3-L1 Adipocyte Differentiation

Couture, J.-P., Daviau, A., Fradette, J., & Blouin, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004743 · Cited by 24 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00046.x · Cited by 23 · see citing works

Differential activity-based gel electrophoresis for comparative analysis of lipolytic and esterolytic activities

Morak, M., Schmidinger, H., Krempl, P. M., Rechberger, G. N., Kollroser, M., Birner‐Gruenberger, R., & Hermetter, A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800566-jlr200 · Cited by 23 · see citing works

Microarray Based Gene Expression Analysis of Murine Brown and Subcutaneous Adipose Tissue: Significance with Human

Baboota, R. K., Sarma, S. M., Boparai, R. K., Kondepudi, K. K., Mantri, S. S., & Bishnoi, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127701 · Cited by 23 · see citing works

Functional differentiation of white and brown adipocytes

Klaus, S. (1997) · BioEssays · doi:10.1002/bies.950190307 · Cited by 82 · see citing works

Transcriptional Regulation of Brown and White Adipogenesis

Spiegelman, B. M. (2010) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-13517-0_8 · Cited by 3 · see citing works

Differentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells

Lehr, L., Canola, K., Léger, B., & Giacobino, J.-P. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.46 · Cited by 31 · see citing works

New targets on the BATtlefield of Obesity

Kroone, C. (2013) · Utrecht University Repository (Utrecht University)

The Study of Adipose Tissue Differentiation and Development

Gulyaeva, O. (2017) · eScholarship (California Digital Library)