Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
Abstract
No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is quite poor. Therefore, we investigated the possible effects of a diet containing GM soybean on mouse exocrine pancreas by means of ultrastructural, morphometrical and immunocytochemical analyses. Our observations demonstrate that, although no structural modification occurs in pancreatic acinar cells of mice fed on GM soybean, quantitative changes of some cellular constituents take place in comparison to control animals. In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing.
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After several months of consumption of an R-tolerant soy, the liver and pancreas of mice were affected, as highlighted by disturbances in sub-nuclear structure.
“After several months of consumption of an R-tolerant soy, the liver and pancreas of mice were affected, as highlighted by disturbances in sub-nuclear structure [12–14].”
From Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerantgenetically modified maize (2014) · cites this paper as [14]
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- Authors
- Malatesta, M., Caporaloni, C., Rossi, L., Battistelli, S., Rocchi, M. B. L., Tonucci, F., & Gazzanelli, G.
- Affiliations
- University of Urbino (IT)
- Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche (IT)
- Corresponding author
- Malatesta, Manuela
- Venue
- Journal of Anatomy
- Publisher
- Wiley
- Published
- 2002-10-25
- Volume
- 201
- Issue
- 5
- Pages
- 409-415
- ISSN
- 0021-8782 (ISSN-L)
- 1469-7580
- OpenAlex
- W2135551353
- Cited by
- 68
- References
- 25
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Anatomy (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
- Funders
- Johnson and Johnson
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Keywords
- transgenic soybean, pancreatic acinar cells, exocrine pancreas, ultrastructure, zymogen activation, GM food safety, mice
- MeSH terms
- alpha-Amylases, Animals, Cell Nucleus, Female, Golgi Apparatus, Image Processing, Computer-Assisted, Mice, Inbred Strains, Microscopy, Electron, Pancreas, Glycine max, Spectrophotometry, Endoplasmic Reticulum, Rough, Secretory Vesicles, Food, Genetically Modified, Mice
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