Cited by 68Genetically Modified Organisms ResearchCarcinogens and Genotoxicity AssessmentAgricultural safety and regulations

Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean

Malatesta, Manuela, Caporaloni, Chiara, Rossi, Luigia, Battistelli, Serafina, Rocchi, Marco B. L., Tonucci, Francesco, Gazzanelli, Giancarlo·2002·Journal of Anatomy

Abstract

No direct evidence that genetically modified (GM) food may represent a possible danger for health has been reported so far; however, the scientific literature in this field is quite poor. Therefore, we investigated the possible effects of a diet containing GM soybean on mouse exocrine pancreas by means of ultrastructural, morphometrical and immunocytochemical analyses. Our observations demonstrate that, although no structural modification occurs in pancreatic acinar cells of mice fed on GM soybean, quantitative changes of some cellular constituents take place in comparison to control animals. In particular, a diet containing significant amount of GM food seems to influence the zymogen synthesis and processing.

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Crossref · 10.1046/j.0021-8782.2002.00103.x

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Authors
Malatesta, M., Caporaloni, C., Rossi, L., Battistelli, S., Rocchi, M. B. L., Tonucci, F., & Gazzanelli, G.
Affiliations
  • University of Urbino (IT)
  • Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche (IT)
Corresponding author
Malatesta, Manuela
Venue
Journal of Anatomy
Publisher
Wiley
Published
2002-10-25
Volume
201
Issue
5
Pages
409-415
ISSN
  • 0021-8782 (ISSN-L)
  • 1469-7580
OpenAlex
W2135551353
Cited by
68
References
25
Citations by year
2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 2
FWCI
1.26
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Anatomy (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutional Research information system (University of Urbino) (submittedVersion)
Funders
Johnson and Johnson
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Keywords
transgenic soybean, pancreatic acinar cells, exocrine pancreas, ultrastructure, zymogen activation, GM food safety, mice
MeSH terms
alpha-Amylases, Animals, Cell Nucleus, Female, Golgi Apparatus, Image Processing, Computer-Assisted, Mice, Inbred Strains, Microscopy, Electron, Pancreas, Glycine max, Spectrophotometry, Endoplasmic Reticulum, Rough, Secretory Vesicles, Food, Genetically Modified, Mice

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