How safe does transgenic food need to be?

DeFrancesco, Laura

doi:10.1038/nbt.2686

Cited by 86Genetically Modified Organisms ResearchRisk Perception and ManagementAgricultural safety and regulations

How safe does transgenic food need to be?

DeFrancesco, Laura·2013·Nature Biotechnology

DOI 10.1038/nbt.2686

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Post hoc analysis of a large number of variables in a data set with a small sample size can lead to spurious conclusions.
“Post hoc analysis of a large number of variables in a data set with a small sample size can lead to spurious conclusions”
From Prevalence and impacts of genetically engineered feedstuffs on livestock populations1 (2014) · cites this paper as DeFrancesco, 2013

2 retracted

RETRACTED: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize
Séralini, G.-E., Clair, E., Mesnage, R., Gress, S., Defarge, N., Malatesta, M., Hennequin, D., & de Vendômois, J. S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.08.005 · Cited by 397 · see citing works
Retracted
Fate of transgenic DNA and evaluation of metabolic effects in goats fed genetically modified soybean and in their offsprings
Tudisco, R., Mastellone, V., Cutrignelli, M. I., Lombardi, P., Bovera, F., Mirabella, N., Piccolo, G., Calabrò, S., Avallone, L., & Infascelli, F. (2010) · animal · doi:10.1017/s1751731110000728 · Cited by 51 · see citing works
Retracted
Identification of a Brazil-Nut Allergen in Transgenic Soybeans
Nordlee, J. A., Taylor, S. L., Townsend, J. A., Thomas, L. A., & Bush, R. K. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603143341103 · Cited by 670 · see citing works
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Safety and nutritional assessment of GM plants and derived food and feed: The role of animal feeding trials
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Safety and Nutritional Assessment of GM Plants and derived food and feed: The role of animal feeding trials
(EFSA), E. F. S. A. (2008) · EFSA Journal · doi:10.2903/j.efsa.2008.1057 · Cited by 198 · see citing works
Unintended compositional changes in genetically modified (GM) crops: 20 years of research
Herman, R. A., & Price, W. D. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf400135r · Cited by 156 · see citing works
Ultrastructural Morphometrical and Immunocytochemical Analyses of Hepatocyte Nuclei from Mice Fed on Genetically Modified Soybean.
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A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation
Kılıç, A., & Akay, M. T. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.11.016 · Cited by 98 · see citing works
Ultrastructural analysis of testes from mice fed on genetically modified soybean
Vecchio, L., Cisterna, B., Malatesta, M., Martin, T., & Biggiogera, M. (2009) · European Journal of Histochemistry · doi:10.4081/920 · Cited by 95 · see citing works
A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing
Malatesta, M., Boraldi, F., Annovi, G., Baldelli, B., Battistelli, S., Biggiogera, M., & Quaglino, D. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0476-x · Cited by 88 · see citing works
Fine structural analyses of pancreatic acinar cell nuclei from mice fed on genetically modified soybean
Malatesta, M., Biggiogera, M., Manuali, E., & Rocchi, M. (2009) · European Journal of Histochemistry · doi:10.4081/851 · Cited by 77 · see citing works
A three-year longitudinal study on the effects of a diet containing genetically modified Bt176 maize on the health status and performance of sheep
Trabalza‐Marinucci, M., Brandi, G., Rondini, C., Avellini, L., Giammarini, C., Costarelli, S., Acuti, G., Orlandi, C., Filippini, G., Chiaradia, E., et al. (2007) · Livestock Science · doi:10.1016/j.livsci.2007.03.009 · Cited by 74 · see citing works
A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development
Brake, D. G., & Evenson, D. P. (2003) · Food and Chemical Toxicology · doi:10.1016/j.fct.2003.08.003 · Cited by 71 · see citing works
Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean
Malatesta, M., Caporaloni, C., Rossi, L., Battistelli, S., Rocchi, M. B. L., Tonucci, F., & Gazzanelli, G. (2002) · Journal of Anatomy · doi:10.1046/j.0021-8782.2002.00103.x · Cited by 68 · see citing works
Effects of Feeding Bt Maize to Sows during Gestation and Lactation on Maternal and Offspring Immunity and Fate of Transgenic Material
Buzoianu, S. G., Walsh, M. C., Rea, M. C., O’Donovan, Ó., Gelencsér, É., Ujhelyi, G., Szabó, E., Nagy, A., Ross, R. P., Gardiner, G. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047851 · Cited by 50 · see citing works
Value of eight-amino-acid matches in predicting the allergenicity status of proteins: an empirical bioinformatic investigation
Herman, R. A., Song, P., & ThirumalaiswamySekhar, A. (2009) · Clinical and Molecular Allergy · doi:10.1186/1476-7961-7-9 · Cited by 48 · see citing works
Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean.
Malatesta, M., Tiberi, C., Baldelli, B., Battistelli, S., Manuali, E., & Biggiogera, M. (2005) · PubMed · doi:10.4081/950 · Cited by 45 · see citing works
Effects of Feeding Bt MON810 Maize to Pigs for 110 Days on Peripheral Immune Response and Digestive Fate of the cry1Ab Gene and Truncated Bt Toxin
Walsh, M. C., Buzoianu, S. G., Rea, M. C., O’Donovan, Ó., Gelencsér, É., Ujhelyi, G., Ross, R. P., Gardiner, G. E., & Lawlor, P. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036141 · Cited by 44 · see citing works
Multigeneration Reproductive and Developmental Toxicity Study of bar Gene Inserted into Genetically Modified Potato on Rats
Rhee, G. S., Cho, D. H., Won, Y.-H., Seok, J. H., Kim, S. S., Kwack, S. J., Lee, R. D., Chae, S. Y., Kim, J. W., Lee, B. M., et al. (2005) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390500182446 · Cited by 41 · see citing works
A long term trial with Atlantic salmon (Salmo salar L.) fed genetically modified soy; focusing general health and performance before, during and after the parr–smolt transformation
Sissener, N. H., Sanden, M., Bakke, A. M., Krogdahl, Å., & HEMRE, G.-I. (2009) · Aquaculture · doi:10.1016/j.aquaculture.2009.05.002 · Cited by 41 · see citing works
The Effect of Feeding Bt MON810 Maize to Pigs for 110 Days on Intestinal Microbiota
Buzoianu, S. G., Walsh, M. C., Rea, M. C., O’Sullivan, Ó., Crispie, F., Cotter, P. D., Ross, R. P., Gardiner, G. E., & Lawlor, P. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033668 · Cited by 40 · see citing works
ORIGINAL ARTICLE: Effects of long-term feeding of genetically modified corn (event MON810) on the performance of lactating dairy cows: Long-term feeding of genetically modified corn in dairy cows
Steinke, K., Guertler, P., Paul, V., Wiedemann, S., Ettle, T., Albrecht, C., Meyer, H. H. D., Spiekers, H., & Schwarz, F. J. (2010) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.2010.01003.x · Cited by 38 · see citing works
New EU legislation for risk assessment of GM food: No scientific justification for mandatory animal feeding trials
Kuiper, H. A., Kok, E. J., & Davies, H. V. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12091 · Cited by 38 · see citing works
Effect of feeding genetically modified Bt MON810 maize to ∼40-day-old pigs for 110 days on growth and health indicators
Buzoianu, S. G., Walsh, M. C., Rea, M. C., Cassidy, J. P., Ross, R. P., Gardiner, G. E., & Lawlor, P. G. (2012) · animal · doi:10.1017/s1751731112000249 · Cited by 34 · see citing works
Evaluation of Bt (Bacillus thuringiensis) Corn on Mouse Testicular Development by Dual Parameter Flow Cytometry
Brake, D. G., Thaler, R. C., & Evenson, D. P. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0347362 · Cited by 32 · see citing works
Transgenerational effects of feeding genetically modified maize to nulliparous sows and offspring on offspring growth and health1
Buzoianu, S. G., Walsh, M. C., Rea, M. C., Cassidy, J. P., Ryan, T., Ross, R. P., Gardiner, G. E., & Lawlor, P. G. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5360 · Cited by 30 · see citing works
A 104-Week Feeding Study of Genetically Modified Soybeans in F344 Rats
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The effect of multigenerational diet containing genetically modified triticale on immune system in mice.
Krzyżowska, M., Wincenciak, M., Winnicka, A., Baranowski, A., Jaszczak, K., Zimny, J., & Niemiałtowski, M. (2010) · PubMed · Cited by 22 · see citing works
The Impact of Dietary Organic and Transgenic Soy on the Reproductive System of Female Adult Rat
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Effects of feeding Bt MON810 maize to sows during first gestation and lactation on maternal and offspring health indicators
Walsh, M. C., Buzoianu, S. G., Gardiner, G. E., Rea, M. C., O’Donovan, Ó., Ross, R. P., & Lawlor, P. G. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002607 · Cited by 19 · see citing works
A 52-Week Feeding Study of Genetically Modified Soybeans in F344 Rats
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A Meta-Analysis of the Impacts of Genetically Modified Crops
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“Numerous independent science academies and regulatory bodies have reviewed the evidence about risks, concluding that commercialized GM crops are safe for human consumption and the environment [5–7].”
Background
Prevalence and impacts of genetically engineered feedstuffs on livestock populations1
Van Eenennaam, A. L., & Young, A. E. (2014) · Journal of Animal Science · doi:10.2527/jas.2014-8124 · Cited by 154 · see citing works
Viewpoint: The uptake of new crop science: Explaining success, and failure
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Plants rendered herbicide-susceptible by cauliflower mosaic virus–elicited suppression of a 35S promoter-regulated transgene
Al‐Kaff, N. S., Kreike, M. M., Covey, S. N., Pitcher, R., Page, A. M., & Dale, P. J. (2000) · Nature Biotechnology · doi:10.1038/79501 · Cited by 72 · see citing works
Chapter 31. Genetically modified crops as a source for pharmaceuticals
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Transgenic Plants in Modern Agriculture
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Safety Assessment of Foods Obtained from Crops Developed Using Biotechnology
Delaney, B. (2009) · General, Applied and Systems Toxicology · doi:10.1002/9780470744307.gat139 · Cited by 2 · see citing works
A perspective on genetically modified food crops
Ekıcı, K., & Sancak, Y. C. (2011) · Van Yüzüncü Yıl University Academic Data Management System · doi:10.5897/ajar.9000009 · Cited by 16 · see citing works

Authors: DeFrancesco, L.
Corresponding author: DeFrancesco, Laura
Venue: Nature Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2013-09
Volume: 31
Issue: 9
Pages: 794-802
ISSN: 0733-222X (ISSN-L)
1087-0156
1546-1696
DOI: 10.1038/nbt.2686
OpenAlex: W1967446674
Semantic Scholar: 57ec579fa00c713d26211f1025bfa6be1833bc12
Cited by: 86
References: 42
Citations by year: 2026: 2 · 2025: 4 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 3 · 2015: 10 · 2014: 14 · 2013: 2 · 2012: 1
FWCI: 11.67
Type: journal article
Language: en
Update notices: erratum (2013-12-01)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
Social Sciences › Sociology and Political Science › Risk Perception and Management
Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
Keywords: transgenic foods, food safety assessment, genetically modified crops, public perception, risk assessment, food safety regulation
MeSH terms: Animals, Biotechnology, Humans, Swine, Plants, Genetically Modified, Food, Genetically Modified, Biomedical Research, Mice, Rats, Food Safety

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