A role for CO2 and bicarbonate transporters in metabolic exchanges in the brain
Open accessAbstract
Acid‐base transporters are linked to the energy metabolism via the end product of oxidative metabolism, carbon dioxide, together with carbonic anhydrase activity. In a tissue such as the brain, where some cells (neurones) are high‐energy consumers when active, and other cells (astroglial cells) are destined for homeostatic and trophic tasks, transport systems may complement each other and cooperate in order to maintain physiological functions. Here, some aspects of the coupling of metabolite shuttling and acid/base‐dependent transport in neurones and glial cells are discussed.
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Carbonic anhydrases are expressed in glial cells and are involved in modulating CO2 and other metabolic end products to levels that may enable buffering/secretion of lactate.
“Carbonic anhydrases are expressed in glial cells and are involved in modulating CO2 and other metabolic end products to levels that may enable buffering/secretion of lactate (37, 39).”
From Evolution of increased glia–neuron ratios in the human frontal cortex (2006) · cites this paper as [39]
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- Authors
- Deitmer, J. W.
- Affiliations
- University of Kaiserslautern (DE)
- Corresponding author
- Deitmer, Joachim W.
- ORCID
- Deitmer, Joachim W.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2002-03
- Volume
- 80
- Issue
- 5
- Pages
- 721-726
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2053680791
- Cited by
- 36
- References
- 58
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 530)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- bicarbonate transporters, acid-base transporters, carbonic anhydrase, brain energy metabolism, neuronal metabolism, astrocytes, glial cells, oxidative metabolism, pH homeostasis
- MeSH terms
- Animals, Bicarbonates, Brain, Carbon Dioxide, Citric Acid Cycle, Energy Metabolism, Humans, Neuroglia, Neurons, Ion Transport, Monocarboxylic Acid Transporters, Sodium-Bicarbonate Symporters
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