Cited by 363T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune Responses

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Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., SANSONI, P.·1996·Immunology

DOI 10.1046/j.1365-2567.1996.d01-689.x

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Abstract

Ageing is associated with complex remodelling in the phenotypic and functional profiles of T lymphocytes. We investigated whether expression of CD28 antigen on T cells is conserved throughout adulthood and ageing in humans. For this purpose we analysed T cells obtained from peripheral blood of 102 healthy people of ages ranging from 20 to 105 years. We found an age‐related increase of CD28 − T cells in percentage and absolute number, predominantly among CD8 + T cells. CD28 − T cells from aged donors analysed by flow cytometry appeared as resting cells (not expressing CD25, CD38, CD69, CD71, DR), bearing markers of cytotoxic activity (CD11b and CD57) and with a phenotype compatible with ‘memory’ cells (up‐regulated CD2 and CD11a; CD62L absent). At the functional level, freshly isolated purified CD28 − CD8 + T cells showed high anti‐CD3 redirected cytotoxic activity against Fc‐bearing P815 cells. The same activity tested on freshly isolated bulk T lymphocytes was significantly augmented with age. We found a positive correlation between age, number of CD8 + CD28 − T cells and anti‐CD3 redirected cytotoxicity by freshly isolated T cells. These data suggest that an activation of unknown nature within the cytotoxic arm of the immune system occurs with age. We speculate that these cytotoxic T lymphocytes (CTL) in vivo may constitute armed effector cells for immediate killing of targets bearing peptides from pathogens of intracellular origin.

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Self-citation
Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing
Teteloshvili, N., Kluiver, J. L., van der Geest, K. S. M., van der Lei, R. J., Jellema, P. G., Pawelec, G., Brouwer, E., Kroesen, B., Boots, A. M. H., & van den Berg, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137556 · Cited by 25

Authors: FAGNONI, F. F., VESCOVINI, R., MAZZOLA, M., BOLOGNA, G., NIGRO, E., LAVAGETTO, G., FRANCESCHI, C., PASSERI, M., & SANSONI, P.
Affiliations: University of Parma (IT)
University of Modena and Reggio Emilia (IT)
Corresponding author: SANSONI, P.
ORCID: FRANCESCHI, C.
Venue: Immunology
Publisher: Wiley
Published: 1996-08
Volume: 88
Issue: 4
Pages: 501-507
ISSN: 0019-2805 (ISSN-L)
1365-2567
DOI: 10.1046/j.1365-2567.1996.d01-689.x
OpenAlex: W2030414136
Cited by: 362
References: 36
Citations by year: 2026: 6 · 2025: 8 · 2024: 13 · 2023: 12 · 2022: 15 · 2021: 13 · 2020: 14 · 2019: 13 · 2018: 15 · 2017: 23 · 2016: 12 · 2015: 8 · 2014: 13 · 2013: 9 · 2012: 5
FWCI: 4.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2646 d)
Locations: Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: CD28-negative T cells, CD8+ T cells, cytotoxic T lymphocytes, aging, centenarians, T cell activation, cytotoxicity, T cell memory phenotype, CD11b, CD57, age-related immune changes
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Cell Separation, Cytotoxicity, Immunologic, Flow Cytometry, Humans, Middle Aged, CD3 Complex, CD28 Antigens, CD8-Positive T-Lymphocytes, Lymphocyte Count

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Expansion of cytotoxic CD8 + CD28 − T cells in healthy ageing people, including centenarians

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