Naïve and memory CD8 T cell pool homeostasis in advanced aging: impact of age and of antigen-specific responses to cytomegalovirus
Open accessAbstract
Alterations in the circulating CD8+ T cell pool, with a loss of naïve and accumulation of effector/effector memory cells, are pronounced in older adults. However, homeostatic forces that dictate such changes remain incompletely understood. This observational cross-sectional study explored the basis for variability of CD8+ T cell number and composition of its main subsets: naïve, central memory and effector memory T cells, in 131 cytomegalovirus (CMV) seropositive subjects aged over 60 years. We found great heterogeneity of CD8+ T cell numbers, which was mainly due to variability of the CD8 + CD28- T cell subset regardless of age. Analysis, by multiple regression, of distinct factors revealed that age was a predictor for the loss in absolute number of naïve T cells, but was not associated with changes in central or effector memory CD8+ T cell subsets. By contrast, the size of CD8+ T cells specific to pp65 and IE-1 antigens of CMV, predicted CD28 - CD8+ T cell, antigen-experienced CD8+ T cell, and even total CD8+ T cell numbers, but not naïve CD8+ T cell loss. These results indicate a clear dichotomy between the homeostasis of naïve and antigen-experienced subsets of CD8+ T cells which are independently affected, in human later life, by age and antigen-specific responses to CMV, respectively.
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Naïve T cells decline with age even in individuals not infected with CMV.
“considering the age-associated decline of these cells even in those not infected with CMV (Vescovini et al. 2013; Wertheimer et al. 2014).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Vescovini et al. 2013
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Memory T cell aging and rejuvenation
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- Authors
- Vescovini, R., Fagnoni, F. F., Telera, A. R., Bucci, L., Pedrazzoni, M., Magalini, F., Stella, A., Pasin, F., Medici, M. C., Calderaro, A., Volpi, R., Monti, D., Franceschi, C., Nikolich-Žugich, J., & Sansoni, P.
- Affiliations
- University of Parma (IT)
- Ospedale di Parma (IT)
- University of Bologna (IT)
- University of Florence (IT)
- Corresponding author
- Vescovini, Rosanna
- ORCID
- Venue
- AGE
- Published
- 2013-12-08
- Volume
- 36
- Issue
- 2
- Pages
- 625-640
- ISSN
- 0161-9152 (ISSN-L)
- 1574-4647
- PMC
- PMC4039262
- OpenAlex
- W1978279708
- Cited by
- 48
- References
- 52
- Citations by year
- 2026: 3 · 2025: 3 · 2022: 4 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 5 · 2015: 4 · 2014: 2
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- AGE (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Funders
- Fondazione Cariparma
- National Institute on Aging (R01AG035309, R01AG020719)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- CD8+ T cells, T cell homeostasis, aging, naive T cells, memory T cells, central memory T cells, effector memory T cells, cytomegalovirus, pp65 antigen, CD28-negative T cells, antigen-experienced T cells, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Antibodies, Viral, Antigens, Viral, Cross-Sectional Studies, Cytomegalovirus Infections, Cytomegalovirus, Female, Flow Cytometry, Follow-Up Studies, Homeostasis, Humans, Immunologic Memory, Lymphocyte Activation, Male, Middle Aged, Phenotype, CD8-Positive T-Lymphocytes
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