Cited by 204Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima

Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., Kovanen, P. T.·2000·Journal of Internal Medicine

Abstract

Abstract. Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki, Finland). Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima (Minisymposium). J Intern Med 2000; 247: 359–370. Atherosclerosis is characterized by chronic inflammation of an injured intima. The pathological processes are initiated by accumulation of morphologically distinct, modified forms of LDL, and followed by cellular infiltration and foam cell formation. Activated intimal cells secrete enzymes and agents capable of modifying LDL, and the modified lipids of LDL, in turn, are able to activate intimal cells and to trigger various inflammatory signals. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression. In this review, we focus on the LDL modifications relevant to the initial lipid accumulation and discuss their pro‐inflammatory effects.

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Crossref · 10.1046/j.1365-2796.2000.00655.x

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Authors
Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., & Kovanen, P. T.
Affiliations
Wihuri Research Institute (FI)
Corresponding author
Kovanen, P. T.
Venue
Journal of Internal Medicine
Publisher
Wiley
Published
2000-03
Volume
247
Issue
3
Pages
359-370
ISSN
  • 0954-6820 (ISSN-L)
  • 1365-2796
OpenAlex
W2021937355
Cited by
204
References
103
Citations by year
2026: 1 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 10
FWCI
1.01
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
modified LDL, atherosclerosis, arterial intima, inflammation, foam cell formation, lipid accumulation, pro-inflammatory effects, lesion progression
MeSH terms
Arteriosclerosis, Humans, Inflammation, Cholesterol, LDL, Tunica Intima

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