Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima
Abstract
Abstract. Pentikäinen MO, Öörni K, Ala‐Korpela M, Kovanen PT (Wihuri Research Institute, Helsinki, Finland). Modified LDL – trigger of atherosclerosis and inflammation in the arterial intima (Minisymposium). J Intern Med 2000; 247: 359–370. Atherosclerosis is characterized by chronic inflammation of an injured intima. The pathological processes are initiated by accumulation of morphologically distinct, modified forms of LDL, and followed by cellular infiltration and foam cell formation. Activated intimal cells secrete enzymes and agents capable of modifying LDL, and the modified lipids of LDL, in turn, are able to activate intimal cells and to trigger various inflammatory signals. These processes can initiate and maintain a vicious circle in the intima and lead to lesion progression. In this review, we focus on the LDL modifications relevant to the initial lipid accumulation and discuss their pro‐inflammatory effects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Extracellular modification of infiltrated plasma lipoproteins initiates local innate and adaptive immune responses in the arterial intima.
“Extracellular modifications of the infiltrated plasma lipoproteins initiate the local innate and adaptive immune responses in the intima16.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [16]
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works
Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
The role of lipid peroxidation and antioxidants in oxidative modification of LDL
Esterbauer, H., Gebicki, J. M., Puhl, H., & Jürgens, G. (1992) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(92)90181-f · Cited by 2,307 · see citing works
LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in Atherosclerosis
Brown, M. S., & Goldstein, J. L. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.001255 · Cited by 2,300 · see citing works
Book ReviewAmbulatory Pediatric Care
Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,121 · see citing works
Saikku, P., Mattila, K. J., Nieminen, M. S., Huttunen, J. K., Leinonen, M., Ekman, M.-R., Mäkelä, P. H., & Valtonen, V. (1988) · The Lancet · doi:10.1016/s0140-6736(88)90741-6 · Cited by 1,961 · see citing works
Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877 · see citing works
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,643 · see citing works
Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626 · see citing works
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413 · see citing works
Anderson, T. J., Meredith, I. T., Yeung, A. C., Frei, B. B., Selwyn, A. P., & Ganz, P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502233320802 · Cited by 1,108 · see citing works
Napoli, C., D'Armiento, F. P., Mancini, F. P., Postiglione, A., Witztum, J. L., Palumbo, G., & Palinski, W. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119813 · Cited by 1,014 · see citing works
Regulation of Plasma Cholesterol by Lipoprotein Receptors
Brown, M. S., Kovanen, P. T., & Goldstein, J. L. (1981) · Science · doi:10.1126/science.6261329 · Cited by 947 · see citing works
Self-citationMinimally modified low density lipoprotein stimulates monocyte endothelial interactions.
Berliner, J. A., Territo, M., Sevanian, A., Ramin, S., Kim, J. A., Bamshad, B., Esterson, M., & Fogelman, A. M. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114562 · Cited by 924 · see citing works
The Yin and Yang of Oxidation in the Development of the Fatty Streak
Navab, M., Berliner, J. A., Watson, A. D., Hama, S. Y., Territo, M., Lusis, A. J., Shih, D. M., Lenten, B. J. V., Frank, J. S., Demer, L. L., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.7.831 · Cited by 699 · see citing works
Kovanen, P. T., Kaartinen, M., & Paavonen, T. (1995) · Circulation · doi:10.1161/01.cir.92.5.1084 · Cited by 615 · see citing works
Self-citationRoles of Infectious Agents in Atherosclerosis and Restenosis
Libby, P., Egan, D., & Skarlatos, S. I. (1997) · Circulation · doi:10.1161/01.cir.96.11.4095 · Cited by 559 · see citing works
Atherosclerosis and Coronary Artery Disease
(1996) · Nature Medicine · doi:10.1038/nm0796-822 · Cited by 441 · see citing works
Is atherosclerosis an immunologically mediated disease?
Wick, G., Schett, G. A., Amberger, A., Kleindienst, R., & Xu, Q. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80067-0 · Cited by 398 · see citing works
Presence of a modified low density lipoprotein in humans.
Avogaro, P., Bon, G. B., & Cazzolato, G. (1988) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.8.1.79 · Cited by 379 · see citing works
Vasile, E., Simionescu, M., & Simionescu, N. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.6.1677 · Cited by 364 · see citing works
The Relationship Between Plasma and Tissue Lipids in Human Atherosclerosis
Smith, E. B. (1974) · Advances in lipid research · doi:10.1016/b978-0-12-024912-1.50008-9 · Cited by 355 · see citing works
Schissel, S. L., Tweedie-Hardman, J., Rapp, J. H., Graham, G., Williams, K. J., & Tabas, I. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118934 · Cited by 342 · see citing works
Schissel, S. L., Jiang, X., Tweedie-Hardman, J., Jeong, T., Hurt‐Camejo, E., Najïb, J., Rapp, J. H., Williams, K. J., & Tabas, I. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2738 · Cited by 322 · see citing works
Borén, J., Olin, K., Lee, I., Chait, A., Wight, T. N., & Innerarity, T. L. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2265 · Cited by 320 · see citing works
Oxygen-mediated heterogeneity of apo-low-density lipoprotein.
Schuh, J., Fairclough, G. F., & Haschemeyer, R. H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3173 · Cited by 271 · see citing works
Camejo, G. (1982) · Advances in lipid research · doi:10.1016/b978-0-12-024919-0.50007-2 · Cited by 231 · see citing works
PROTEOLYTIC ENZYMES OF MAST CELLS*
Lagunoff, D., & Benditt, E. P. (1963) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1963.tb53698.x · Cited by 201 · see citing works
Bhakdi, S., Dorweiler, B., Kirchmann, R., Torzewski, J., Weise, E., Tranum-Jensen, J., Walev, I., & Wieland, E. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1959 · Cited by 195 · see citing works
Frank, J. S., & Fogelman, A. M. (1989) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38299-7 · Cited by 194 · see citing works
Torzewski, M., Klouche, M., Hock, J., Meßner, M., Dorweiler, B., Torzewski, J., Gabbert, H. E., & Bhakdi, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.3.369 · Cited by 181 · see citing works
Nievelstein, P. F. E. M., Fogelman, A. M., Mottino, G. A., & Frank, J. S. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.6.1795 · Cited by 178 · see citing works
Localization of Nonpancreatic Secretory Phospholipase A 2 in Normal and Atherosclerotic Arteries
Hurt‐Camejo, E., Andersen, S. B., Standal, R., Rosengren, B. E., Sartipy, P., Stadberg, E., & Johansen, B. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.2.300 · Cited by 170 · see citing works
Arteriosclerosis: A Survey of the Problem.
(1933) · JAMA · doi:10.1001/jama.1933.02740380059033 · Cited by 155 · see citing works
Hoff, H. F., & O'Neil, J. C. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1209 · Cited by 154 · see citing works
Steinbrecher, U. P., & Lougheed, M. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.5.608 · Cited by 148 · see citing works
Complement C6 Deficiency Protects Against Diet-Induced Atherosclerosis in Rabbits
Schmiedt, W., Kinscherf, R., Deigner, H.-P., Kamencic, H., Nauen, O., Kilo, J., Oelert, H., Metz, J., & Bhakdi, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.11.1790 · Cited by 140 · see citing works
Öörni, K., Hakala, J. K., Annila, A., Ala‐Korpela, M., & Kovanen, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.29127 · Cited by 137 · see citing works
Self-citationSecretory group II phospholipase A2 in human atherosclerotic plaques
Menschikowski, M., Kasper, M. E., Lattke, P., Schiering, A., Schiefer, S., Stockinger, H., & Jaroß, W. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05604-1 · Cited by 130 · see citing works
Manual of Pathological Anatomy
Jones, C. H., & Sieveking, E. H. (1875) · The American Journal of the Medical Sciences · doi:10.1097/00000441-187510000-00028 · Cited by 129 · see citing works
Reichl, D., Simons, L. A., Myant, N. B., Pflug, J. J., & MILLS, G. L. (1973) · Clinical Science · doi:10.1042/cs0450313 · Cited by 126 · see citing works
Ultrastructure of Early Lipid Accumulation in ApoE-Deficient Mice
Tamminen, M., Mottino, G. A., Qiao, J. H., Breslow, J. L., & Frank, J. S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.847 · Cited by 122 · see citing works
Guyton, J. R., & Klemp, K. F. (1989) · Europe PMC (PubMed Central) · Cited by 117 · see citing works
Sniderman, A. D., Thomas, D. W., Marpole, D. G. F., & Teng, B. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109012 · Cited by 114 · see citing works
Is oxidized low‐density lipoprotein present in vivo?
Ylä‐Herttuala, S. (1998) · Current Opinion in Lipidology · doi:10.1097/00041433-199808000-00009 · Cited by 111 · see citing works
Öörni, K., Pentikäinen, M. O., Annila, A., & Kovanen, P. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21303 · Cited by 101 · see citing works
Self-citationGuyton, J. R., & Klemp, K. F. (1993) · PubMed · Cited by 99 · see citing works
Li, F., & Hui, D. Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28666 · Cited by 97 · see citing works
Olsson, U., Bondjers, G., & Camejo, G. (1999) · Diabetes · doi:10.2337/diabetes.48.3.616 · Cited by 97 · see citing works
Aggregation and fusion of modified low density lipoprotein
Pentikäinen, M. O., Lehtonen-Smeds, E. M. P., & Kovanen, P. T. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37467-8 · Cited by 96 · see citing works
Self-citationFree Cholesterol-Induced Cytotoxicity
Tabas, I. A. (1997) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00086-8 · Cited by 94 · see citing works
Smith, E. B. (1990) · European Heart Journal · doi:10.1093/eurheartj/11.suppl_e.72 · Cited by 90 · see citing works
Kruth, H. S. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90045-0 · Cited by 86 · see citing works
Binding of Human Phospholipase A2 Type II to Proteoglycans
Sartipy, P., Johansen, B., Camejo, G., Rosengren, B. E., Bondjers, G., & Hurt‐Camejo, E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26307 · Cited by 86 · see citing works
Atherogenic Properties of Enzymatically Degraded LDL
Klouche, M., Gottschling, S., Gerl, V. B., Hell, W., Husmann, M., Dorweiler, B., Meßner, M., & Bhakdi, S. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.9.1376 · Cited by 84 · see citing works
An Animal Model to Study Local Oxidation of LDL and Its Biological Effects in the Arterial Wall
Calara, F. B., Dimayuga, P. C., Niemann, A., Thyberg, J., Diczfalusy, U., Witztum, J. L., Palinski, W., Shah, P. K., Cercek, B., Nilsson, J., et al. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.6.884 · Cited by 84 · see citing works
Kokkonen, J. O., & Kovanen, P. T. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)81685-4 · Cited by 83 · see citing works
Self-citationRomano, M., Romano, E. L., Björkerud, S., & Hurt‐Camejo, E. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.4.519 · Cited by 83 · see citing works
Aortic cholesterol esterase: Characteristics of normal rat and rabbit enzyme
Kothari, H. V., Miller, B. F., & Kritchevsky, D. (1973) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(73)90102-1 · Cited by 83 · see citing works
Klouche, M., May, A. E., Hemmes, M., Meßner, M., Kanse, S. M., Preissner, K. T., & Bhakdi, S. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.3.784 · Cited by 79 · see citing works
The Proteoglycan Decorin Links Low Density Lipoproteins with Collagen Type I
Pentikäinen, M. O., Öörni, K., Lassila, R., & Kovanen, P. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7633 · Cited by 78 · see citing works
Self-citationChlamydia pneumoniae and coronary heart disease
Gupta, S., & Camm, A. J. (1997) · BMJ · doi:10.1136/bmj.314.7097.1778 · Cited by 78 · see citing works
Chao, F. F., Blanchette‐Mackie, E. J., Chen, Y. J., Dickens, B. F., Berlin, E., Amende, L. M., Skarlatos, S. I., Gamble, W., Resau, J. H., & Mergner, W. T. (1990) · PubMed Central · Cited by 75 · see citing works
Shamir, R., Johnson, W. J., Morlock-Fitzpatrick, K. R., Zolfaghari, R., Li, L., Mas, E., Lombardo, D., Morel, D. W., & Fisher, E. A. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118596 · Cited by 75 · see citing works
Guyton, J. R., Bocan, T. M. A., & Schifani, T. A. (1985) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.5.6.644 · Cited by 74 · see citing works
Piha, M., Lindstedt, L., & Kovanen, P. T. (1995) · Biochemistry · doi:10.1021/bi00032a004 · Cited by 71 · see citing works
Self-citationJuul, K., Nielsen, L. B., Munkholm, K., Stender, S., & Nordestgaard, B. G. (1996) · Circulation · doi:10.1161/01.cir.94.7.1698 · Cited by 70 · see citing works
Kol, A., & Libby, P. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(98)00010-3 · Cited by 69 · see citing works
Potential involvement of type II phospholipase A2 in atherosclerosis
Hurt‐Camejo, E., & Camejo, G. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00085-3 · Cited by 67 · see citing works
Early extracellular and cellular lipid deposits in aorta of cholesterol-fed rabbits.
Guyton, J. R., & Klemp, K. F. (1992) · PubMed · Cited by 66 · see citing works
Paananen, K., & Kovanen, P. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42130-2 · Cited by 64 · see citing works
Self-citationCholesterol ester hydrolase in homogenates and lysosomal fractions of human aorta
Kothari, H. V., Bonner, M. J., & Miller, B. F. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90194-3 · Cited by 63 · see citing works
Synthesis and secretion of the pancreatic-type carboxyl ester lipase by human endothelial cells
Li, F., & HUI, Y. D. (1998) · Biochemical Journal · doi:10.1042/bj3290675 · Cited by 59 · see citing works
Kokkonen, J. O., & Kovanen, P. T. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38637-4 · Cited by 56 · see citing works
Self-citationRole of Mast Cells in Atherosclerosis
Kovanen, P. T. (2015) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000424598 · Cited by 56 · see citing works
Self-citationTertov, V. V., Bittolo-Bon, G., Sobenin, I. A., Cazzolato, G., Orekhov, A. N., & Avogaro, P. (1995) · Experimental and Molecular Pathology · doi:10.1006/exmp.1995.1018 · Cited by 54 · see citing works
Mast cells in human fatty streaks and atheromas: implications for intimal lipid accumulation
Kovanen, P. T. (1996) · Current Opinion in Lipidology · doi:10.1097/00041433-199610000-00004 · Cited by 53 · see citing works
Self-citationHydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome.
Chao, F. F., Blanchette‐Mackie, E. J., Tertov, V. V., Skarlatos, S. I., Chen, Y. J., & Kruth, H. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42929-8 · Cited by 52 · see citing works
Hoff, H. F., O'Neil, J. C., Pepin, J. M., & Cole, T. B. (1990) · European Heart Journal · doi:10.1093/eurheartj/11.suppl_e.105 · Cited by 52 · see citing works
Hakala, J. K., Öörni, K., Ala‐Korpela, M., & Kovanen, P. T. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.5.1276 · Cited by 51 · see citing works
Self-citationDobrian, A. D., Mora, R. C., Simionescu, M., & Simionescu, N. (1993) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(93)90076-l · Cited by 51 · see citing works
Camejo, G., Rosengren, B. E., Olson, U., Lopez, F., Olofson, S.-O., Westerlund, C., & Bondjers, G. (1990) · European Heart Journal · doi:10.1093/eurheartj/11.suppl_e.164 · Cited by 50 · see citing works
Kao, C. H., Chen, J. K., Kuo, J. S., & Yang, V. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05519-3 · Cited by 47 · see citing works
Öörni, K., Saarinen, J., Annila, A., & Kovanen, P. T. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.20.12257 · Cited by 46 · see citing works
Self-citationComplement and atherogenesis: The unknown connection
Bhakdi, S. (1998) · Annals of Medicine · doi:10.3109/07853899809002596 · Cited by 46 · see citing works
Observations on the Passage of Apoproteins from Plasma Lipoproteins into Peripheral Lymph in Two Men
Reichl, D., Postiglione, A., Myant, N. B., Pflug, J. J., & Press, M. (1975) · Clinical Science · doi:10.1042/cs0490419 · Cited by 44 · see citing works
Kaartinen, M., Penttilä, A., & Kovanen, P. T. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.2047 · Cited by 43 · see citing works
Self-citationThe possible role of the arterial microcirculation in the pathogenesis of atherosclerosis
Groszek, E., & Grundy, S. M. (1980) · Journal of Chronic Diseases · doi:10.1016/0021-9681(80)90054-5 · Cited by 42 · see citing works
Gorshkova, I. N., Menschikowski, M., & Jaroß, W. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00237-5 · Cited by 39 · see citing works
Engström, A., & FINEAN, J. B. (1958) · Elsevier eBooks · doi:10.1016/b978-1-4832-3141-9.50008-1 · Cited by 39 · see citing works
Pentikäinen, M. O., Lehtonen-Smeds, E. M. P., Öörni, K., Lusa, S., Somerharju, P. J., Jauhiainen, M., & Kovanen, P. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.40.25283 · Cited by 38 · see citing works
Self-citationCompartmentation and characterization of different proteoglycans in bovine arterial wall.
Völker, W., Schmidt, A., & Buddecke, E. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.10.2427568 · Cited by 38 · see citing works
Amanuma, K., Kanaseki, T., Ikeuchi, Y., Ohkuma, S., & Takano, T. (1987) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00710829 · Cited by 37 · see citing works
Modification of low density lipoproteins by secretory granules of rat serosal mast cells
Kovanen, P. T., & Kokkonen, J. O. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64340-x · Cited by 36 · see citing works
Self-citationSTRUCTURE OF HUMAN SERUM LIPOPROTEINS
Scanu, A. M. (1972) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1972.tb54819.x · Cited by 29 · see citing works
Ala‐Korpela, M., Pentikäinen, M. O., Korhonen, A., Hevonoja, T., Lounila, J., & Kovanen, P. T. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32201-x · Cited by 27 · see citing works
Self-citationElectron microscopy of lipid deposits in human atherosclerosis.
Pasquinelli, G., PREDA, P., Vici, M., Gargiulo, M., Stella, A., D'Addato, M., & Laschi, R. (1989) · PubMed · Cited by 25 · see citing works
Role of Mast Cells in Atherosclerosis (Part 1 of 2)
Kovanen, P. T. (1995) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000319300 · Cited by 17 · see citing works
Self-citationUltrastructure and permeability of endothelial cells in branched regions of rat arteries
Kao, C. H., Chen, J. K., & Yang, V. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90012-4 · Cited by 15 · see citing works
Ayad, S., Boot-Handford, R., Humphries, M. J., Kadler, K. E., & Shuttleworth, A. (1998) · Elsevier eBooks · doi:10.1016/b978-012068911-8.50106-8 · Cited by 11 · see citing works
Pentikäinen, M. O., Öörni, K., & Kovanen, P. T. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)89160-5 · Cited by 3 · see citing works
Self-citationRole of Mast Cells in Atherosclerosis (Part 2 of 2)
Kovanen, P. T. (1995) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000319301 · Cited by 1 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities
Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works
Self-citationThe immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982 · see citing works
Roberts, W. L., Moulton, L., Law, T. C., Farrow, G., Cooper-Anderson, M., Savory, J., & Rifai, N. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.418 · Cited by 652 · see citing works
Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics
Li, Z.-M., Xu, S., & Liu, P. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.193 · Cited by 567 · see citing works
Inflammation in atherosclerosis: pathophysiology and mechanisms
Ajoolabady, A., Praticò, D., Lin, L., Mantzoros, C. S., Bahijri, S., Tuomilehto, J. O., & Ren, J. T. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07166-8 · Cited by 510 · see citing works
Hevonoja, T., Pentikäinen, M. O., Hyvönen, M., Kovanen, P. T., & Ala‐Korpela, M. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00123-2 · Cited by 439 · see citing works
Self-citationAviram, M., & Rosenblat, M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.030 · Cited by 434 · see citing works
Inhibition of Atherosclerosis in ApoE-Null Mice by Immunization with ApoB-100 Peptide Sequences
Fredrikson, G. N., Söderberg, I., Lindholm, M., Dimayuga, P. C., Chyu, K., Shah, P. K., & Nilsson, J. Å. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000067937.93716.db · Cited by 261 · see citing works
Covey, S. D., Krieger, M., Wang, W., Penman, M., & Trigatti, B. L. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000083343.19940.a0 · Cited by 221 · see citing works
Phospholipase A2in Vascular Disease
Hurt‐Camejo, E., Camejo, G., Peilot, H., Öörni, K., & Kovanen, P. T. (2001) · Circulation Research · doi:10.1161/hh1601.095598 · Cited by 219 · see citing works
Self-citationHalcox, J., & Deanfield, J. E. (2004) · Circulation · doi:10.1161/01.cir.0000129500.29229.92 · Cited by 200 · see citing works
Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration
Curcio, C. A., Johnson, M., Huang, J.-D., & Rudolf, M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r002238 · Cited by 201 · see citing works
Biochemical properties and regulation of cathepsin K activity
Lecaille, F., Brömme, D., & Lalmanach, G. (2007) · Biochimie · doi:10.1016/j.biochi.2007.08.011 · Cited by 183 · see citing works
The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis
Summerhill, V. I., Grechko, A. V., Yet, S., Sobenin, I. A., & Orekhov, A. N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143561 · Cited by 167 · see citing works
Evaluation of Methods for the Measurement of Low-Density Lipoprotein Cholesterol
Bairaktari, E. T., Seferiadis, K. I., & Elisaf, M. (2005) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424840501000106 · Cited by 142 · see citing works
Clinical implications for statin pleiotropy
Liao, J. K. (2005) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000191913.16321.60 · Cited by 139 · see citing works
Mast cells: multipotent local effector cells in atherothrombosis
Kovanen, P. T. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00515.x · Cited by 131 · see citing works
Self-citationSystems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers
Wang, I., Zhang, B., Yang, X., Zhu, J., Stepaniants, S., Zhang, C., Meng, Q., Peters, M. A., He, Y. D., Ni, C., et al. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.24 · Cited by 130 · see citing works
Apoptosis in atherosclerosis: focus on oxidized lipids and inflammation
Martinet, W., & Kockx, M. M. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200110000-00009 · Cited by 129 · see citing works
Signaling Pathways and Key Genes Involved in Regulation of foam Cell Formation in Atherosclerosis
Poznyak, A. V., Wu, W., Melnichenko, A. А., Wetzker, R., Sukhorukov, V. N., Markin, A. M., Khotina, V. A., & Orekhov, A. N. (2020) · Cells · doi:10.3390/cells9030584 · Cited by 110 · see citing works
Development of a point-of-care assay system for high-sensitivity C-reactive protein in whole blood
Ahn, J. S., Choi, S., Jang, S. H., Chang, H., Kim, J., Nahm, K. B., Oh, S. W., & Choi, E. Y. (2003) · Clinica Chimica Acta · doi:10.1016/s0009-8981(03)00113-x · Cited by 110 · see citing works
Lipoprotein Lipase in the Arterial Wall
Pentikäinen, M. O., Oksjoki, R. K., Öörni, K., & Kovanen, P. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.101551 · Cited by 108 · see citing works
Self-citationFredrikson, G. N., Andersson, L. I. M., Söderberg, I., Dimayuga, P. C., Chyu, K., Shah, P. K., & Nilsson, J. Å. (2005) · Autoimmunity · doi:10.1080/08916930500050525 · Cited by 102 · see citing works
Orekhov, A. N., Bobryshev, Y. V., Sobenin, I. A., Melnichenko, A. А., & Chistiakov, D. A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150712807 · Cited by 100 · see citing works
Fu, T., & Borensztajn, J. (2002) · Biochemical Journal · doi:10.1042/bj20020045 · Cited by 97 · see citing works
Tesoriere, L., D’Arpa, D., Butera, D., Allegra, M., Renda, D., Maggio, A., Bongiorno, A., & Livrea, M. A. (2001) · Free Radical Research · doi:10.1080/10715760100300461 · Cited by 93 · see citing works
Kumar, V., Butcher, S. J., Öörni, K., Engelhardt, P., Heikkonen, J., Kaski, K. K., Ala‐Korpela, M., & Kovanen, P. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018841 · Cited by 90 · see citing works
Self-citationKhuseyinova, N., Imhof, A., Rothenbacher, D., Trischler, G., Kuelb, S., Scharnagl, H., Maerz, W., Brenner, H., & Köenig, W. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.10.046 · Cited by 89 · see citing works
Carracedo, M., Artiach, G., Arnardottir, H. H., & Bäck, M. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00767-y · Cited by 92 · see citing works
Metabolism of oxidized LDL by macrophages
Jessup, W., & Kritharides, L. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200010000-00005 · Cited by 86 · see citing works
Cyclodextrins: Potential therapeutics against atherosclerosis
Mahjoubin‐Tehran, M., Kovanen, P. T., Xu, S., Jamialahmadi, T., & Sahebkar, A. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107620 · Cited by 77 · see citing works
Self-citationModified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 80 · see citing works
Self-citationImmune Mechanisms in Cardiovascular Diseases Associated With Viral Infection
Gopal, R., Marinelli, M. A., & Alcorn, J. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570681 · Cited by 74 · see citing works
Role of extracellular retention of low density lipoproteins in atherosclerosis
Borén, J., Gustafsson, M. V., Skålén, K., Flood, C., & Innerarity, T. L. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200010000-00002 · Cited by 75 · see citing works
Kurosawa, S., Nakamura, M., Park, J.-W., Aizawa, H., Yamada, K., & Hirata, M. (2004) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.05.016 · Cited by 73 · see citing works
MiR-223-3p in Cardiovascular Diseases: A Biomarker and Potential Therapeutic Target
Zhang, M., Shen, Y., Shi, J., & Yu, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.610561 · Cited by 74 · see citing works
Mast Cells as Potential Accelerators of Human Atherosclerosis—From Early to Late Lesions
Kovanen, P. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184479 · Cited by 72 · see citing works
Self-citationVarghese, J. F., Patel, R. P., & Yadav, U. C. S. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.10.020 · Cited by 67 · see citing works
MicroRNAs as Therapeutic Targets and Clinical Biomarkers in Atherosclerosis
Solly, E., Dimasi, C., Bursill, C., Psaltis, P., & Tan, J. T. M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122199 · Cited by 61 · see citing works
Taskinen, S., Kovanen, P. T., Jarva, H., Meri, S., & Pentikäinen, M. O. (2002) · Biochemical Journal · doi:10.1042/bj20020492 · Cited by 65 · see citing works
Self-citationRafieian‐Kopaei, M., Asgary, S., Adelnia, A., Setorki, M., Khazaei, M., Kazemi, S., & Shamsi, F. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9001202 · Cited by 64 · see citing works
Evaluation of fluorescence hs-CRP immunoassay for point-of-care testing
Oh, S. W., Moon, J. D., Park, S. Y., Jang, H. J., Kim, J. H., Nahm, K. B., & Choi, E. Y. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.01.026 · Cited by 64 · see citing works
Cedó, L., Metso, J., Santos, D., García‐León, A., Plana, N., Sabaté‐Soler, S., Rotllán, N., Rivas-Urbina, A., Méndez‐Lara, K. A., Tondo, M., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316424 · Cited by 62 · see citing works
Self-citationNew insights into immunological aspects of atherosclerosis
Jawień, J. (2008) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.332 · Cited by 62 · see citing works
Mann, N. J., O’Connell, S. L., Baldwin, K. M., Singh, I., & Meyer, B. J. (2010) · Lipids · doi:10.1007/s11745-010-3450-z · Cited by 60 · see citing works
Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View
Lee‐Rueckert, M., Lappalainen, J., Kovanen, P. T., & Escolá‐Gil, J. C. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.777822 · Cited by 59 · see citing works
Self-citationCardiovascular benefits of phlebotomy: relationship to changes in hemorheological variables
Holsworth, R., Cho, Y. I., Weidman, J. J., Sloop, G. D., & Cyr, J. A. S. (2013) · Perfusion · doi:10.1177/0267659113505637 · Cited by 57 · see citing works
Future of Anticathepsin K Drugs: Dual Therapy for Skeletal Disease and Atherosclerosis?
Podgorski, I. (2009) · Future Medicinal Chemistry · doi:10.4155/fmc.09.4 · Cited by 54 · see citing works
Apostolov, E. O., Basnakian, A. G., Yin, X., Ok, E., & Shah, S. V. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01079.2006 · Cited by 52 · see citing works
Sánchez‐Quesada, J. L., Villegas, S., & Ordóñez‐Llanos, J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328357c933 · Cited by 51 · see citing works
Quantification of Atherosclerosis in Mice
Centa, M., Ketelhuth, D. F. J., Malin, S., & Gisterå, A. (2019) · Journal of Visualized Experiments · doi:10.3791/59828 · Cited by 55 · see citing works
Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves
Lehti, S., Käkelä, R., Hörkkö, S., Kummu, O., Suihko, S., Kupari, M. M., Werkkala, K., Kovanen, P. T., & Öörni, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065810 · Cited by 48 · see citing works
Self-citationBengtsson, T., Karlsson, H., Gunnarsson, P., Skoglund, C., Elison, C., Leanderson, P., & Lindahl, M. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01917.x · Cited by 49 · see citing works
Jaarsveld, H. V., & Pool, G. F. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00638-4 · Cited by 48 · see citing works
Möckel, M. M., Müller, R., Vollert, J. O., Müller, C., Danne, O., Gareis, R., Störk, T. V., Dietz, R., & Köenig, W. (2007) · Clinical Research in Cardiology · doi:10.1007/s00392-007-0540-x · Cited by 48 · see citing works
Novel Biomarkers of Atherosclerotic Vascular Disease—Latest Insights in the Research Field
Adam, C. A., Șalaru, D. L., Prisacariu, C., Marcu, D. T. M., Sascău, R. A., & Stătescu, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094998 · Cited by 49 · see citing works
Kijani, S., Vázquez, A. M., Levin, M. C., Borén, J., & Fogelstrand, P. (2017) · Physiological Reports · doi:10.14814/phy2.13334 · Cited by 44 · see citing works
Nagayama, D., Watanabe, Y., Saiki, A., Shirai, K., & Tatsuno, I. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.42291 · Cited by 45 · see citing works
The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs
DiMarco, D. M., & Fernández, M. (2015) · Biology · doi:10.3390/biology4030494 · Cited by 33 · see citing works
Yang, B., Hang, S., Xu, S., Gao, Y., Yu, W., Zang, G., Zhang, L., & Wang, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32073 · Cited by 45 · see citing works
Vliegen, I., Duijvestijn, A. M., Stassen, F. R. M., & Bruggeman, C. A. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.05.020 · Cited by 40 · see citing works
Pro-inflammatory action of LDL(−) on mononuclear cells is counteracted by increased IL10 production
Benı́tez, S., Bancells, C., Ordóñez‐Llanos, J., & Sánchez‐Quesada, J. L. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.03.001 · Cited by 40 · see citing works
Williams, K. J. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320065 · Cited by 41 · see citing works
Molecular and cellular mechanisms of macrophage survival in atherosclerosis
Martinet, W., Schrijvers, D. M., & Meyer, G. R. Y. D. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0297-x · Cited by 37 · see citing works
The impact of mast cells on cardiovascular diseases
Kritikou, E., Kuiper, J., Kovanen, P. T., & Bot, I. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.04.050 · Cited by 37 · see citing works
Self-citationThe Role of Protein SUMOylation in the Pathogenesis of Atherosclerosis
Dehnavi, S., Sadeghi, M., Penson, P. E., Banach, M., Jamialahmadi, T., & Sahebkar, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111856 · Cited by 37 · see citing works
Park, J., Kurosawa, S., Takai, M., & Ishihara, K. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.032 · Cited by 35 · see citing works
Mast cell tryptase – Marker and maker of cardiovascular diseases
Mohajeri, M., Kovanen, P. T., Bianconi, V., Pirro, M., Cicero, A. F. G., & Sahebkar, A. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.008 · Cited by 35 · see citing works
Self-citationLDL electronegativity index: a potential novel index for predicting cardiovascular disease
Bobryshev, Ivanova, E. A., & Orekhov, A. N. (2015) · Vascular Health and Risk Management · doi:10.2147/vhrm.s74697 · Cited by 34 · see citing works
Will autoantibodies help to determine severity and progression of atherosclerosis?
Nilsson, J. Å., & Kovanen, P. T. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200410000-00002 · Cited by 33 · see citing works
Self-citationChi, L., Peng, L., Hu, X., PAN, N., & Zhang, Y. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1748 · Cited by 33 · see citing works
HDL and Atherothrombotic Vascular Disease
Annema, W., von Eckardstein, A., & Kovanen, P. T. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_11 · Cited by 32 · see citing works
Self-citationPlant Stanol Esters Reduce LDL (Low-Density Lipoprotein) Aggregation by Altering LDL Surface Lipids
Ruuth, M. K., Äikäs, L., Tigistu‐Sahle, F., Käkelä, R., Lindholm, H. J., Simonen, P. P., Kovanen, P. T., Gylling, H., & Öörni, K. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314329 · Cited by 32 · see citing works
Self-citationŻak, I., Balcerzyk, A., Sarecka, B., Niemiec, P., Ciemniewski, Z., & Dyląg, S. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.06.011 · Cited by 32 · see citing works
Effect of nonsurgical periodontal therapy on crevicular fluid levels of Cathepsin K in periodontitis
Garg, G., Pradeep, A. R., & Thorat, M. S. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.08.007 · Cited by 32 · see citing works
Margiana, R., Alsaikhan, F., Al‐Awsi, G. R. L., Patra, I., Sivaraman, R., Fadhil, A. A., Al-Baghdady, H. F. A., Qasim, M. T., Hameed, N. M., Mustafa, Y. F., et al. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110471 · Cited by 31 · see citing works
Mackiewicz, M. R., Hodges, H. L., & Reed, S. M. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp911617q · Cited by 31 · see citing works
Ding, X., Ma, X., Meng, P., Yue, J., Li, L., & Xu, L. (2024) · Clinical Interventions in Aging · doi:10.2147/cia.s447514 · Cited by 33 · see citing works
Howard, J. C., Florentinus-Mefailoski, A., Bowden, P., Trimble, W. S., Grinstein, S., & Marshall, J. G. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.07.021 · Cited by 30 · see citing works
Cámara, M., Fernández‐Ruiz, V., Sánchez‐Mata, M. D. C., Díaz, L. D., Kardinaal, A. F. M., & Lieshout, M. V. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1577215 · Cited by 30 · see citing works
Determinants of glycated LDL levels in nondiabetic and diabetic hyperlipidaemic patients in Kuwait
Akanji, A. O., Abdella, N., & Mojiminiyi, O. A. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(01)00792-6 · Cited by 28 · see citing works
Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins
Linke, M., Gordon, R. E., Brillard‐Bourdet, M., Lecaille, F., Lalmanach, G., & Brömme, D. (2006) · Biological Chemistry · doi:10.1515/bc.2006.160 · Cited by 28 · see citing works
Xu, Y., Yuan, Q., Cao, S., Cui, S., Li, X., Song, X., Li, Z., Xu, R., Yuan, Q., & Li, R. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.06.075 · Cited by 25 · see citing works
Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis
Yeo, K. P., Lim, H. Y., & Angeli, V. (2021) · Cells · doi:10.3390/cells10061344 · Cited by 23 · see citing works
Exploring the regulatory roles of circular RNAs in the pathogenesis of atherosclerosis
Sun, X., Deng, K., Zang, Y., Zhang, Z., Zhao, B., Fan, J., & Huang, L. (2021) · Vascular Pharmacology · doi:10.1016/j.vph.2021.106898 · Cited by 23 · see citing works
Lopez, L. R., Buckner, T. R., HURLEY, B. L., Kobayashi, K., & Matsuura, E. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1398.036 · Cited by 23 · see citing works
Diabetic Dyslipidaemia in Kuwait
Akanji, A. (2002) · Medical Principles and Practice · doi:10.1159/000066409 · Cited by 29 · see citing works
Pancreatic Enzymes and Microvascular Cell Activation in Multiorgan Failure
Schmid‐Schönbein, G. W., Hugli, T. E., Kistler, E. B., Sofianos, A., & Mitsuoka, H. (2001) · Microcirculation · doi:10.1111/j.1549-8719.2001.tb00153.x · Cited by 21 · see citing works
Electronegative LDL: An Active Player in Atherogenesis or a By- Product of Atherosclerosis?
Rivas-Urbina, A., Rull, A., Ordóñez‐Llanos, J., & Sánchez‐Quesada, J. L. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180330093953 · Cited by 20 · see citing works
Zhen, H., Yan, Q., Liu, Y., Li, Y., Yang, S., & Jiang, Z. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.03.027 · Cited by 20 · see citing works
Two decades of vaccine development against atherosclerosis
Moreno‐Gonzalez, M. A., Ortega-Rivera, O. A., & Steinmetz, N. F. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101822 · Cited by 21 · see citing works
Bı́ró, A., Ling, W. L., & Arlaud, G. J. (2010) · Biochemistry · doi:10.1021/bi9021022 · Cited by 20 · see citing works
Ala‐Korpela, M., Sipola, P., & Kaski, K. K. (2006) · Annals of Medicine · doi:10.1080/07853890600862418 · Cited by 19 · see citing works
Self-citationEquisetin protects from atherosclerosis in vivo by binding to STAT3 and inhibiting its activity
Yang, Y., Wang, J., Tian, Y., Li, M., Xu, S.-H., Zhang, L., Luo, X., Tan, Y., Liang, H., & Chen, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107289 · Cited by 18 · see citing works
[Role of inflammation in atherogenesis].
Rodríguez, G., Mago, N., & Rosa, F. (2009) · PubMed · Cited by 26 · see citing works
Wang, Y., Butler, L. M., Hansson, G. K., Yan, Z.-Q., Söderberg-Nauclér, C., Assinger, A., & Ketelhuth, D. F. J. (2014) · Thrombosis and Haemostasis · doi:10.1160/th13-12-1026 · Cited by 18 · see citing works
Electronegative LDL: a useful biomarker of cardiovascular risk?
Sánchez‐Quesada, J. L., Estruch, M., Benı́tez, S., & Ordóñez‐Llanos, J. (2012) · Clinical Lipidology · doi:10.2217/clp.12.26 · Cited by 18 · see citing works
Acidity increases the uptake of native LDL by human monocyte-derived macrophages
Plihtari, R., Kovanen, P. T., & Öörni, K. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.04.013 · Cited by 17 · see citing works
Self-citationHakala, J. K., Lindstedt, K. A., Kovanen, P. T., & Pentikäinen, M. O. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000245796.97133.ad · Cited by 16 · see citing works
Self-citationModified lipoproteins as biomarkers of cardiovascular risk in diabetes mellitus
Sánchez‐Quesada, J. L., & Pérez, A. (2013) · Endocrinología y Nutrición (English Edition) · doi:10.1016/j.endoen.2013.11.007 · Cited by 16 · see citing works
- Authors
- Pentikäinen, M. O., Öörni, K., Ala‐Korpela, M., & Kovanen, P. T.
- Affiliations
- Wihuri Research Institute (FI)
- Corresponding author
- Kovanen, P. T.
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2000-03
- Volume
- 247
- Issue
- 3
- Pages
- 359-370
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2021937355
- Cited by
- 204
- References
- 103
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 10 · 2023: 8 · 2022: 8 · 2021: 9 · 2020: 11 · 2019: 17 · 2018: 7 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 10
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- modified LDL, atherosclerosis, arterial intima, inflammation, foam cell formation, lipid accumulation, pro-inflammatory effects, lesion progression
- MeSH terms
- Arteriosclerosis, Humans, Inflammation, Cholesterol, LDL, Tunica Intima
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review