Oxytocin, But Not Oxytocin Receptor, is Regulated by Oestrogen Receptor β in the Female Mouse Hypothalamus
Abstract
In the female rat, oestrogen receptor (ER) beta is colocalized with both oxytocin- and vasopressin-producing neurones in the paraventricular nucleus of the hypothalamus (PVN). In this study, we demonstrate that the same pattern of colocalization between ERbeta and oxytocin exists in the female mouse. Because this nucleus contains only a negligible quantity of ERalpha, it is likely that the oestrogen-dependent regulation of oxytocin and vasopressin synthesis in the PVN is mediated by ERbeta. Thus, we compared the effect of ovarian hormones on oxytocin and vasopressin mRNA expression in the PVN of wild-type (WT) and ERbeta knockout (betaERKO) mice. We also compared the effects of ovarian hormones on oxytocin receptor (OTR) expression in the medial amygdala (MeA) and ventromedial nucleus of the hypothalamus (VMN) in female WT and betaERKO mice. Ovariectomized mice underwent long-term treatment with oestradiol or oil. Progesterone was given concurrently on the final 7 days of treatment, and all mice were killed 48 h after the final progesterone injection. In the PVN, hormone treatment increased oxytocin mRNA expression in WT but not betaERKO females. These results suggest that ERbeta is necessary for the regulation of the expression of oxytocin in the PVN. Hormone treatment had no effect on vasopressin mRNA expression in the PVN, but significantly increased OTR binding in both the VMN and the MeA in both genotypes. Collectively, our data show region and peptide specific regulatio…
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Pathways coordinating social recognition are regulated by estrogen, with both ERα and ERβ knockout mice showing social impairments, and ERβ knockout females failing to generate OT or AVP mRNA expression in response to exogenous estrogen.
“Pathways coordinating social recognition are well known to be regulated by estrogen, with both ERα and ERβ knockout mice showing social impairments (130, 131), and ERβ knockout females failing to generate OT or AVP mRNA expression in response to exogenous estrogen administration (132, 133).”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [132]
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- Authors
- Patisaul, H. B., Scordalakes, E. M., Young, L. J., & Rissman, E. F.
- Affiliations
- Emory University (US)
- University of Virginia (US)
- Corresponding author
- Patisaul, H. B.
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2003-07
- Volume
- 15
- Issue
- 8
- Pages
- 787-793
- ISSN
- 0953-8194 (ISSN-L)
- 1365-2826
- OpenAlex
- W1955310396
- Cited by
- 160
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 11 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 13 · 2012: 8
- FWCI
- 12.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- University of Virginia
- National Institutes of Health
- National Institute of Mental Health (R01 MH 57759, K02 MH-01349, K02MH001349, R01MH057759)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- estrogen receptor beta, oxytocin, oxytocin receptor, vasopressin, paraventricular nucleus, hypothalamus, ovariectomy, estradiol, progesterone, ERβ knockout mice, medial amygdala, ventromedial hypothalamus, ovarian hormones, gene expression regulation
- MeSH terms
- Animals, Autoradiography, Estrogens, Female, Hypothalamus, Anterior, Immunohistochemistry, Mice, Inbred C57BL, Ovariectomy, Oxytocin, Paraventricular Hypothalamic Nucleus, Progesterone, Receptors, Estrogen, Vasopressins, Gene Expression, In Situ Hybridization, Receptors, Oxytocin, Mice, Knockout, Estrogen Receptor beta, Mice
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