Effect of long-term intranasal oxytocin on sexual dysfunction in premenopausal and postmenopausal women: a randomized trial
Open accessAbstract
Objective To assess the effect of on-demand intranasal oxytocin administration on female sexual function and activity. Design Randomized, prospective, double-blind, placebo-controlled, crossover trial with duration of 22 weeks. Setting Academic medical center. Patient(s) Thirty pre-and postmenopausal women with sexual dysfunction. Intervention(s) Over 8 weeks, intranasal oxytocin (32 IU) or placebo self-administered by women within 50 minutes before sexual intercourse; after a washout period of 2 weeks, crossover with patients switched to the alternate group for another 8 weeks. Main outcome measure(s) Primary outcome parameter: Female Sexual Function Index (FSFI); secondary outcome parameters: Female Sexual Distress Scale (FSDS), Sexual Quality of Life-Female (SQOL-F), Sexual Interest and Desire Inventory-Female (SIDI-F), and Hamilton depression scale (HDS). Result(s) After oxytocin and placebo, the FSFI score increased by 26% and 31%, SQOL-F score by 144% and 125%, and SIDI-F score by 29% and 23%, respectively (repeated measures analysis of variance between groups). After oxytocin and placebo, the FSDS score decreased by 36% and 45%, respectively (repeated measures analysis of variance between groups). There was no statistically significant treatment, sequence (placebo first/second), or interaction effect. Conclusion(s) Long-term intranasal oxytocin and placebo administration both improved sexual function and symptoms of depression in women over time with no treatment, sequence (placebo first/second), or interaction effect. Clinical trial registration number NCT02229721.
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- Authors
- Muin, D. A., Wolzt, M., Marculescu, R., Sheikh Rezaei, S., Salama, M., Fuchs, C., Luger, A., Bragagna, E., Litschauer, B., & Bayerle-Eder, M.
- Affiliations
- Medical University of Vienna (AT)
- Otto Wagner Hospital (AT)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 104
- Issue
- 3
- Pages
- 715-723.e4
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2120743651
- Cited by
- 48
- References
- 46
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 8 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 3 · 2015: 1
- FWCI
- 4.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- intranasal oxytocin, female sexual dysfunction, menopause, premenopausal women, postmenopausal women, sexual desire, sexual distress, sexual quality of life
- MeSH terms
- Administration, Intranasal, Adult, Aged, Austria, Depression, Double-Blind Method, Drug Administration Schedule
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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