Cited by 114Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

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White Adipose Tissue: Getting Nervous

Fliers, E., Kreier, F., Voshol, P. J., Havekes, L. M., Sauerwein, H. P., Kalsbeek, A., Buijs, R. M., Romijn, J. A.·2003·Journal of Neuroendocrinology

DOI 10.1046/j.1365-2826.2003.01096.x

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Abstract

Neuroendocrine research has altered the traditional perspective of white adipose tissue (WAT) as a passive store of triglycerides. In addition to fatty acids, WAT produces many hormones and can therefore be designated as a traditional endocrine gland actively participating in the integrative physiology of fuel and energy metabolism, eating behaviour and the regulation of hormone secretion and sensitivity. WAT is controlled by humoral factors, para‐ and intracrine factors and by neural regulation. Sympathetic nerve fibres innervate WAT and stimulate lipolysis, leading to the release of glycerol and free fatty acids. In addition, recent research in rats has clearly shown a functional parasympathetic innervation of WAT. There appears to be a distinct somatotopy within the parasympathetic nuclei: separate sets of autonomic neurones in the brain stem innervate either the visceral or the subcutaneous fat compartment. We therefore propose that the central nervous system (CNS) plays a major role in the hitherto unexplained regulation of body fat distribution. Parasympathectomy induces insulin resistance with respect to glucose and fatty acid uptake in the innervated fat depot and has selective effects on local hormone synthesis. Thus, the CNS is involved not only in the regulation of hormone production by WAT, but also in its hormone sensitivity. The developments in this research area are likely to increase our insights in the pathogenesis of metabolic disorders such as hypertriglyceridemia, diabetes mellitus type 2 and lipodystrophy syndromes.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
Role of leptin in the neuroendocrine response to fasting
Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
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A transgenic model of visceral obesity and the metabolic syndrome
Masuzaki, H., Paterson, J., Shinyama, H., Morton, N. M., Mullins, J. J., Seckl, J. R., & Flier, J. S. (2001) · Science · doi:10.1126/science.1066285 · Cited by 1,766
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What's in a Name? In Search of Leptin's Physiologic Role
Flier, J. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.5.4779 · Cited by 576

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Lévesque, K., Bureau, S., Moskowitz, D. S., Tardif, J., Lavoie, J., Dupuis, G., & D’Antono, B. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.12.003 · Cited by 10
Neuromuscular complications in HIV: effects of aging
Robinson‐Papp, J., Tan, I. L., & Simpson, D. M. (2011) · Journal of NeuroVirology · doi:10.1007/s13365-011-0074-x · Cited by 10
Tail skin temperatures reflect coping styles in rats
Ågren, G., Lund, I., Thiblin, I., & Lundeberg, T. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.11.003 · Cited by 10
Obesity paradigm: an introduction to the emerging discipline of adipobiology
Johnson, P. J., Ganjam, S. K., Messer, N. T., Turk, J. R., Keisler, D. H., Buff, P. R., & Wiedmeyer, C. E. (2006) · Cited by 8
Dietary Polyphenols in Obesity Management: Critical Insights on Health Benefits and Mechanisms of Action
Fu, J., Ping‐Ping, W., Fu, X., Chin‐Ping, T., Chen, C., & Yun‐Ping, P. (2025) · Journal of Food Science · doi:10.1111/1750-3841.70267 · Cited by 10
Effect of d -β-hydroxybutyrate-( R )-1,3 butanediol on plasma levels of asprosin and leptin: results from a randomised controlled trial
Charles, S., Liu, Y., Kimita, W., Ko, J., Bharmal, S. H., & Petrov, M. S. (2022) · Food & Function · doi:10.1039/d2fo02405e · Cited by 7
Hostile personality as a risk factor for hyperglycemia and obesity in adult populations: a systematic review
Vassou, C., D'Cunha, N. M., Naumovski, N., & Panagiotakos, D. B. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00551-y · Cited by 6
A pilot study on lipolytic effect of subcutaneous botulinum toxin injection in rabbits.
Bagheri, M., Jahromi, B. M., Bagheri, M., Borhani‐Haghighi, A., Noorafshan, A., Kumar, P. V., & Omrani, G. R. (2010) · PubMed · Cited by 5
Association of female sex and heart rate with increased arterial stiffness in patients with type 2 diabetes mellitus
Kang, M.-K. (2017) · The Anatolian Journal of Cardiology · doi:10.14744/anatoljcardiol.2017.7773 · Cited by 5
Role of Inflammatory Processes in the Brain-Body Relationship Underlying Hypertension
Carnevale, D. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01268-y · Cited by 5
Metabolic Syndrome: Early Development and Aging
Veronica, G., & Esther, R.-R. M. (2012) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s2-002 · Cited by 4
Genetic independence of fat depots in cattle.
Egarr, A. R. (2012) · Adelaide Research & Scholarship (AR&S) (University of Adelaide) · Cited by 3
Neurohormonal mechanisms in insulin resistance and type 2 diabetes
Lindmark, S. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 3
[The effect of cholinergic stimulation on autonomic balance and immune response in patients with chronic heart failure].
Biel, B., Jankowska, E. A., Banasiak, W., & Ponikowski, P. P. (2007) · PubMed · Cited by 2
Role of Inflammation in the Pathogenesis of Insulin Resistance in Obesity: Specific Role of Reactive Oxygen and Reactive Nitrogen Species
Issa, N. G. (2016) · Cited by 2
Fat and Wound Healing
Turek, J. J. (2006) · CRC series in modern nutrition science · doi:10.1201/9780203500231.ch3 · Cited by 1
Raman spectroscopy of blood and blood components and chemometrics
Aziz, S., Bano, A., Tahira, M., Yaseen, S., Rashid, N., & Nawaz, H. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21834-7.00015-3 · Cited by 1
Thyroid hormone, metabolism and the brain
Klieverik, L. P. (2009) · Data Archiving and Networked Services (DANS) · Cited by 1
Melanocortins and the control of body weight
Tolle, V., & Low, M. J. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541643.008 · Cited by 1
Molecular Mechanism and Effects of Furan Fatty Acid Metabolite CMPF on Adipocytes
Kim, J. H. (2017) · TSpace (University of Toronto) · Cited by 1

Authors: Fliers, E., Kreier, F., Voshol, P. J., Havekes, L. M., Sauerwein, H. P., Kalsbeek, A., Buijs, R. M., & Romijn, J. A.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
Leiden University Medical Center (NL)
Netherlands Organisation for Applied Scientific Research (NL)
Corresponding author: Fliers, E.
ORCID: Fliers, E.
Voshol, P. J.
Kalsbeek, A.
Buijs, R. M.
Romijn, J. A.
Venue: Journal of Neuroendocrinology
Publisher: Wiley
Published: 2003-10-21
Volume: 15
Issue: 11
Pages: 1005-1010
ISSN: 0953-8194 (ISSN-L)
1365-2826
DOI: 10.1046/j.1365-2826.2003.01096.x
OpenAlex: W2151336952
Cited by: 114
References: 31
Citations by year: 2025: 4 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 10
FWCI: 4.94
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Neuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: white adipose tissue, adipose tissue endocrine function, sympathetic innervation, parasympathetic innervation, lipolysis, body fat distribution, insulin resistance, visceral fat, subcutaneous adipose tissue, hypertriglyceridemia, type 2 diabetes, lipodystrophy
MeSH terms: Adaptation, Physiological, Adipose Tissue, Animals, Endocrine System, Humans, Parasympathetic Nervous System, Sympathetic Nervous System, Leptin

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White Adipose Tissue: Getting Nervous

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