The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis

GOTTESMANN, CLAUDE

doi:10.1046/j.1440-1819.2002.01022.x

Cited by 69Sleep and Wakefulness ResearchNeurotransmitter Receptor Influence on BehaviorNeuroscience of respiration and sleep

The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis

Open access

GOTTESMANN, CLAUDE·2002·Psychiatry and Clinical Neurosciences

DOI 10.1046/j.1440-1819.2002.01022.x

Open this paper in CoChat — free account Open PDF

Abstract

Abstract This paper describes a hypothesis related to the neurochemical background of sleep‐waking mental activity which, although associated with subcortical structures, is principally generated in the cerebral cortex. Acetylcholine, which mainly activates cortical neurons, is released at the maximal rate during waking and rapid eye movement (REM) sleep dreaming stage. Its importance in mental functioning is well‐known. However, brainstem‐generated monoamines, which mainly inhibit cortical neurons, are released during waking. Both kinds of influences contribute to the organized mentation of waking. During slow wave sleep, these two types of influence decrease in intensity but maintain a sufficiently high level to allow mental activity involving fairly abstract pseudo‐thoughts, a mode of activity modelled on the diurnal pattern of which it is a poor reply. During REM sleep, the monoaminergic neurons become silent except for the dopaminergic ones. This results in a large disinhibition and the maintained dopamine influence may be involved in the familiar psychotic‐like mental activity of dreaming. Indeed, in this original activation–disinhibition state, the increase of dopamine influence at the prefrontal cortex level could explain the almost total absence of negative symptoms of schizophrenia during dreaming, while an increase in the nucleus accumbens is possibly responsible for hallucinations and delusions, which are regular features of mentation during this sleep stage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1046/j.1440-1819.2002.01022.x

Cites

135 of 135 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Part of this paper’s reference list could not be split into single entries.

2. The Interpretation of Dreams
Freud, S., Crick, J., & Robertson, R. (1913) · MacMillan Co eBooks · doi:10.1037/10561-000 · Cited by 6,966 · see citing works
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307 · see citing works
Regularly Occurring Periods of Eye Motility, and Concomitant Phenomena, During Sleep
Aserinsky, E., & Kleitman, N. (1953) · Science · doi:10.1126/science.118.3062.273 · Cited by 2,488 · see citing works
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,019 · see citing works
Negative v Positive Schizophrenia
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070025006 · Cited by 2,008 · see citing works
Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle
Aston-Jones, G., & Bloom, F. (1981) · The Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00876.1981 · Cited by 1,960 · see citing works
Cyclic variations in EEG during sleep and their relation to eye movements, body motility, and dreaming
Dement, W., & Kleitman, N. (1957) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(57)90088-3 · Cited by 1,876 · see citing works
Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia
Grace, A. A. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90196-u · Cited by 1,831 · see citing works
The Interpretation of Dreams.
Wells, F. L., Freud, S., & Brill, A. A. (1913) · The Journal of Philosophy Psychology and Scientific Methods · doi:10.2307/2013727 · Cited by 1,341 · see citing works
Regional cerebral blood flow throughout the sleep-wake cycle. An H2(15)O PET study
Braun, A. (1997) · Brain · doi:10.1093/brain/120.7.1173 · Cited by 1,268 · see citing works
Sleep Cycle Oscillation: Reciprocal Discharge by Two Brainstem Neuronal Groups
Hobson, J. A., McCarley, R. W., & Wyzinski, P. (1975) · Science · doi:10.1126/science.1094539 · Cited by 1,238 · see citing works
Brainstem Control of Wakefulness and Sleep
Steriade, M., & McCarley, R. W. (1990) · doi:10.1007/978-1-4757-4669-3 · Cited by 1,188 · see citing works
Functional neuroanatomy of human rapid-eye-movement sleep and dreaming
Maquet, P., Péters, J.-M., Aerts, J., Delfiore, G., Degueldre, C., Luxen, A., & Franck, G. (1996) · Nature · doi:10.1038/383163a0 · Cited by 1,168 · see citing works
Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity
McCormick, D. A. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90012-4 · Cited by 1,117 · see citing works
The role of monoamines and acetylcholine-containing neurons in the regulation of the sleep-waking cycle
Jouvet, M. (1972) · Springer eBooks · doi:10.1007/3-540-05462-6_2 · Cited by 1,100 · see citing works
Nonrepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli
Aston-Jones, G., & Bloom, F. (1981) · Journal of Neuroscience · doi:10.1523/jneurosci.01-08-00887.1981 · Cited by 1,033 · see citing works
Dreaming and the brain: toward a cognitive neuroscience of conscious states
Hobson, J. A., Pace-Schott, E. F., & Stickgold, R. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00003976 · Cited by 985 · see citing works
Coherent 40-Hz oscillation characterizes dream state in humans.
Llinás, R., & Ribary, U. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2078 · Cited by 962 · see citing works
Histaminergic transmission in the mammalian brain
Schwartz, J., Arrang, J., Garbarg, M., Pollard, H., & Ruat, M. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.1 · Cited by 945 · see citing works
Dorsal raphe neurons: depression of firing during sleep in cats
McGinty, D., & Harper, R. M. (1976) · Brain Research · doi:10.1016/0006-8993(76)90480-7 · Cited by 900 · see citing works
Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system
Nicoll, R. A., Malenka, R. C., & Kauer, J. A. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.513 · Cited by 867 · see citing works
Acetylcholine in mind: a neurotransmitter correlate of consciousness?
Perry, E. K., Walker, M. P., Grace, J., & Perry, R. H. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01361-7 · Cited by 764 · see citing works
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET
Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., et al. (1997) · Nature · doi:10.1038/385634a0 · Cited by 710 · see citing works
Of dreaming and wakefulness
Llinás, R. R., & Paré, D. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90075-y · Cited by 641 · see citing works
5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex
Araneda, R. C., & Andrade, R. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90128-b · Cited by 621 · see citing works
Dreaming and REM sleep are controlled by different brain mechanisms
Solms, M. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00003988 · Cited by 595 · see citing works
Functional neuroimaging of normal human sleep by positron emission tomography
Maquet (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00214.x · Cited by 581 · see citing works
TEMPORAL PATTERNS OF DISCHARGE OF PYRAMIDAL TRACT NEURONS DURING SLEEP AND WAKING IN THE MONKEY
Evarts, E. V. (1964) · Journal of Neurophysiology · doi:10.1152/jn.1964.27.2.152 · Cited by 572 · see citing works
Dream reports from different stages of sleep
Foulkes, W. D. (1962) · The Journal of Abnormal and Social Psychology · doi:10.1037/h0040431 · Cited by 563 · see citing works
Magnetic field tomography of coherent thalamocortical 40-Hz oscillations in humans.
Ribary, U., Ioannides, A. A., Singh, K. D., Hasson, R., Bolton, J. P., Lado, F. A., Mogilner, A. Y., & Llinas, R. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11037 · Cited by 541 · see citing works
Gating of information flow within the limbic system and the pathophysiology of schizophrenia.
Grace, A. (2000) · Brain research. Brain research reviews · doi:10.1016/s0165-0173(99)00049-1 · Cited by 532 · see citing works
A review of mentation in REM and NREM sleep: ‘covert’ REM sleep as a possible reconciliation of two opposing models
Nielsen, T. A. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x0000399x · Cited by 521 · see citing works
Functional Neuroanatomy of Human Slow Wave Sleep
Maquet, P., Degueldre, C., Delfiore, G., Aerts, J. J., Peters, J., Luxen, A., & Franck, G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02807.1997 · Cited by 514 · see citing works
Functional neuroimaging of normal human sleep by positron emission tomography
Aquet, P. I. M. (2000) · Cited by 496 · see citing works
5‐HT2A and D2 receptor blockade increases cortical DA release via 5‐HT1A receptor activation: a possible mechanism of atypical antipsychotic‐induced cortical dopamine release
Ichikawa, J., Ishii, H., Bonaccorso, S., Fowler, W. L., O'Laughlin, I. A., & Meltzer, H. Y. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00154.x · Cited by 495 · see citing works
Microdialysis measurement of cortical and hippocampal acetylcholine release during sleep-wake cycle in freely moving cats
Marrosu, F., Portas, C., Mascia, M. S., Casu, M. A., Fà, M., Giagheddu, M., Imperato, A., & Gessa, G. L. (1995) · Brain Research · doi:10.1016/0006-8993(94)01399-3 · Cited by 480 · see citing works
Dissociated pattern of activity in visual cortices and their projections during human rapid eye movement sleep
Braun, A. R., Balkin, T. J., Wesensten, N. J., Gwadry, F., Carson, R. E., Varga, M., Baldwin, P., Belenky, G., & Herscovitch, P. (1998) · Science · doi:10.1126/science.279.5347.91 · Cited by 474 · see citing works
Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex
Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458 · see citing works
The occurence of low voltage, fast, electroencephalogram patterns during behavioral sleep in the cat
Dement, W. C. (1958) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(58)90037-3 · Cited by 445 · see citing works
Cortical cholinergic inputs mediating arousal, attentional processing and dreaming: differential afferent regulation of the basal forebrain by telencephalic and brainstem afferents.
Sarter, M., & Bruno, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00487-x · Cited by 440 · see citing works
Acetylcholine released from cerebral cortex in relation to state of activation
Celesia, G. G., & Jasper, H. H. (1966) · Neurology · doi:10.1212/wnl.16.11.1053 · Cited by 429 · see citing works
Acetylcholine Liberation from Cerebral Cortex during Paradoxical (REM) Sleep
Jasper, H. H., & Tessier, J. (1971) · Science · doi:10.1126/science.172.3983.601 · Cited by 427 · see citing works
Positive and Negative Symptoms in Schizophrenia: A Critical Reappraisal
Andreasen, N. C. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810190015002 · Cited by 410 · see citing works
Increased Brain Dopamine and Dopamine Receptors in Schizophrenia
Mackay, A. V. P. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290090001001 · Cited by 399 · see citing works
Regional Cerebral Blood Flow Changes as a Function of Delta and Spindle Activity during Slow Wave Sleep in Humans
Hofle, N., Paus, T., Reutens, D. C., Fiset, P., Gotman, J., Evans, A. C., & Jones, B. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-12-04800.1997 · Cited by 360 · see citing works
Increased dopamine synthesis rate in medial prefrontal cortex and striatum in schizophrenia indicated by L-(beta-11C) DOPA and PET.
Lindström, L., Gefvert, O., Hagberg, G., Lundberg, T., Bergström, M., Hartvig, P., & Långström, B. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00109-2 · Cited by 332 · see citing works
The neuropsychology of REM sleep dreaming
Hobson, J. A., Stickgold, R., & Pace-Schott, E. F. (1998) · Neuroreport · doi:10.1097/00001756-199802160-00033 · Cited by 319 · see citing works
Mechanisms of action of atypical antipsychotic drugs: a critical analysis
Kinon, B. J., & Lieberman, J. A. (1996) · Psychopharmacology · doi:10.1007/bf02245602 · Cited by 317 · see citing works
Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R- ACPD
Wang, Z., & McCormick, D. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02199.1993 · Cited by 307 · see citing works
Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment
Pothos, E., Rada, P., Mark, G. P., & Hoebel, B. G. (1991) · Brain Research · doi:10.1016/0006-8993(91)91724-f · Cited by 288 · see citing works
ACTIONS OF CERTAIN AMINES ON CEREBRAL CORTICAL NEURONES
Krnjević, K., & Phillis, J. W. (1963) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1963.tb01484.x · Cited by 283 · see citing works
Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and waking in the rat
Miller, J. D., Farber, J., Gatz, P., Roffwarg, H. P., & German, D. C. (1983) · Brain Research · doi:10.1016/0006-8993(83)91101-0 · Cited by 269 · see citing works
Paradoxical Sleep — A Study of its Nature and Mechanisms
Jouvet, M. (1965) · Progress in brain research · doi:10.1016/s0079-6123(08)63582-7 · Cited by 268 · see citing works
Origin of noradrenergic afferents to the shell subregion of the nucleus accumbens: anterograde and retrograde tract-tracing studies in the rat
Delfs, J. M., Zhu, Y., Druhan, J. P., & Aston‐Jones, G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00672-6 · Cited by 267 · see citing works
Pharmacologic Dissociation of Behavior and EEG "Sleep Patterns" in Dogs: Morphine, N-Allylnormorphine, and Atropine
Wikler, A. (1952) · Experimental Biology and Medicine · doi:10.3181/00379727-79-19345 · Cited by 258 · see citing works
Fast fronto-parietal rhythms during combined focused attentive behaviour and immobility in cat: cortical and thalamic localizations
Bouyer, J. J., Montaron, M., & Rougeul, A. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90138-3 · Cited by 256 · see citing works
Positive and negative symptoms in schizophrenia
Rosen, W. G., Mohs, R. C., Johns, C. A., Small, N. S., Kendler, K. S., Horvath, T., & Davis, K. L. (1984) · Psychiatry Research · doi:10.1016/0165-1781(84)90075-1 · Cited by 238 · see citing works
Modulatory role for biogenic amines in the cerebral cortex. Microiontophoretic studies
Reader, T. A., Ferron, A., Descarries, L., & Jasper, H. H. (1979) · Brain Research · doi:10.1016/0006-8993(79)90420-7 · Cited by 236 · see citing works
Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brainin vivo
Chergui, K., Suaud‐Chagny, M., & Gonon, F. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90465-0 · Cited by 229 · see citing works
Mesencephalic Reticular Activating System and Cortical Acetylcholine Output
Kanai, T., & Szerb, J. C. (1965) · Nature · doi:10.1038/205080b0 · Cited by 228 · see citing works
Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats
Kurosawa, M., Sato, A., & Sato, Y. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90371-6 · Cited by 212 · see citing works
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release
Gobert, A., Rivet, J., Audinot, V., Newman‐Tancredi, A., Cistarelli, L., & Millan, M. J. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00565-4 · Cited by 203 · see citing works
Two distinct effects of 5-hydroxytryptamine on single cortical neurons
Davies, M. F., Deisz, R. A., Prince, D. A., & Peroutka, S. J. (1987) · Brain Research · doi:10.1016/0006-8993(87)90861-4 · Cited by 195 · see citing works
Correlation of high-frequency oscillations with the sleep-wake cycle and cognitive activity in humans.
Gross, D. W., & Gotman, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00343-7 · Cited by 184 · see citing works
Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides.
Bourson, A., Borroni, E., Austin, R. H., Monsma, F. J., & Sleight, A. J. (1995) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10539-9 · Cited by 181 · see citing works
Slow wave sleep dreaming
Cavallero, C., Cicogna, P., Natale, V., Occhionero, M., & Zito, A. (1992) · Sleep · doi:10.1093/sleep/15.6.562 · Cited by 173 · see citing works
16. A Note Upon the "Mystic Writing-Pad"
Freud, S. (1951) · Columbia University Press eBooks · doi:10.7312/rapa92214-019 · Cited by 165 · see citing works
Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2 -activated interneuron
Sheldon, P. W., & Aghajanian, G. K. (1990) · Brain Research · doi:10.1016/0006-8993(90)91199-q · Cited by 164 · see citing works
Human Regional Cerebral Blood Flow during Rapid-Eye-Movement Sleep
Madsen, P. L., Holm, S., Vorstrup, S., Friberg, L., Lassen, N. A., & Wildschiødtz, G. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.94 · Cited by 162 · see citing works
Dopamine-containing ventral tegmental area neurons in freely moving cats: Activity during the sleep-waking cycle and effects of stress
Trulson, M. E., & Preussler, D. W. (1984) · Experimental Neurology · doi:10.1016/s0014-4886(84)90105-5 · Cited by 162 · see citing works
ACTIVITY OF NEURONS IN VISUAL CORTEX OF THE CAT DURING SLEEP WITH LOW VOLTAGE FAST EEG ACTIVITY
Evarts, E. V. (1962) · Journal of Neurophysiology · doi:10.1152/jn.1962.25.6.812 · Cited by 161 · see citing works
Localization of pontine PGO wave generation sites and their anatomical projections in the rat
Datta, S., Siwek, D. F., Patterson, E. H., & Cipolloni, P. B. (1998) · Synapse · doi:10.1002/(sici)1098-2396(199812)30:4 · Cited by 156 · see citing works
Tonus of Extrinsic Laryngeal Muscles during Sleep and Dreaming
Berger, R. J. (1961) · Science · doi:10.1126/science.134.3482.840 · Cited by 154 · see citing works
Pontogeniculooccipital waves: spontaneous visual system activity during rapid eye movement sleep
Callaway, C. W., Lydic, R., Baghdoyan, H. A., & Hobson, J. A. (1987) · Cellular and Molecular Neurobiology · doi:10.1007/bf00711551 · Cited by 153 · see citing works
Postsynaptic 5‐hydroxytryptamine1A receptor activation increases in vivo dopamine release in rat prefrontal cortex
Sakaue, M., Somboonthum, P., Nishihara, B., Kōyama, Y., Hashimoto, H., Baba, A., & Matsuda, T. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703139 · Cited by 143 · see citing works
Dopamine D4Receptor-Deficient Mice Display Cortical Hyperexcitability
Rubinstein, M., Cepeda, C., Hurst, R. S., Flores‐Hernández, J., Ariano, M. A., Falzone, T. L., Kozell, L. B., Meshul, C. K., Bunzow, J. R., Low, M. J., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03756.2001 · Cited by 138 · see citing works
[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
Vanni-Mercier, G., Sakai, K., & Jouvet, M. (1984) · PubMed · Cited by 135 · see citing works
In vivo effects of the 5‐HT6 antagonist SB‐271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5‐HT, glutamate and aspartate
Dawson, L. A., Nguyen, H. Q., & Li, P. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703288 · Cited by 133 · see citing works
M100,907, a selective 5-HT2A antagonist, attenuates dopamine release in the rat medial prefrontal cortex
Pehek, E. A., McFarlane, H. G., Maguschak, K. A., Price, B., & Pluto, C. P. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03004-3 · Cited by 131 · see citing works
The Transition from Slow-wave Sleep to Paradoxical Sleep: Evolving Facts and Concepts of the Neurophysiological Processes Underlying the Intermediate Stage of Sleep
Gottesmann, C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00055-0 · Cited by 131 · see citing works
Self-citation
Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats
Rasmussen, K., Heym, J. H., & Jacobs, B. L. (1984) · Experimental Neurology · doi:10.1016/s0014-4886(84)90100-6 · Cited by 127 · see citing works
Drug-Induced Nightmares
Thompson, D. F., & Pierce, D. R. (1999) · Annals of Pharmacotherapy · doi:10.1345/aph.18150 · Cited by 127 · see citing works
Central actions of histamine: Microelectrophoretic studies
Haas, H. L., & Wolf, P. S. (1977) · Brain Research · doi:10.1016/0006-8993(77)90294-3 · Cited by 126 · see citing works
Macromolecular Specificity and Biological Memory
MCCRUM, W. R. (1963) · American Journal of Psychiatry · doi:10.1176/ajp.119.10.1016-b · Cited by 118 · see citing works
Human cerebral potentials associated with REM sleep rapid eye movements: links to PGO waves and waking potentials
McCarley, R. W., Winkelman, J. W., & Duffy, F. H. (1983) · Brain Research · doi:10.1016/0006-8993(83)90719-9 · Cited by 117 · see citing works
Dorsal raphe stimulation differentially modulates dopaminergic neurons in the ventral tegmental area and substantia nigra
Gervais, J., & Rouillard, C. (2000) · Synapse · doi:10.1002/(sici)1098-2396(20000315)35:4 · Cited by 109 · see citing works
Sleep in schizophrenia: A polysomnographic study on drug-naive patients
Lauer, C. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00159-5 · Cited by 107 · see citing works
Effects of noradrenaline on frequency tuning of auditory cortex neurons during wakefulness and slow‐wave sleep
Manunta, Y., & Edeline, J. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00633.x · Cited by 104 · see citing works
Biologie de la conscience
Edelman, G. M. (1992) · Medical Entomology and Zoology · Cited by 99 · see citing works
Involvement of Serotonin and Dopamine in the Mechanism of Action of Novel Antidepressant Drugs
Bonhomme, N., & Esposito, E. (1998) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199812000-00005 · Cited by 96 · see citing works
The action of noradrenaline on cortical neurons: effects of pH
Frederickson, R. C. A., Jordan, L. M., & Phillis, J. W. (1971) · Brain Research · doi:10.1016/0006-8993(71)90500-2 · Cited by 93 · see citing works
Altered Serotonin and Dopamine Metabolism in the CNS of Serotonin 5‐HT1A or 5‐HT1B Receptor Knockout Mice
Ase, A. R., Reader, T. A., Hen, R., Riad, M., & Descarries, L. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752415.x · Cited by 93 · see citing works
Nicotinic receptor-mediated regulation of dopamine transporter activity in rat prefrontal cortex
Drew, A. E., Derbez, A. E., & Werling, L. L. (2000) · Synapse · doi:10.1002/1098-2396(200010)38:1 · Cited by 89 · see citing works
Neurophysiological support of consciousness during waking and sleep
Gottesmann, C. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00014-3 · Cited by 85 · see citing works
Self-citation
Models of positive and negative symptoms in schizophrenia: An empirical evaluation of latent structures.
Lenzenweger, M. F., Dworkin, R. H., & Wethington, E. (1989) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.98.1.62 · Cited by 82 · see citing works
Phasic activation of lateral geniculate and perigeniculate thalamic neurons during sleep with ponto-geniculo-occipital waves
Steriade, M., Pare, D., Bouhassira, D., Deschênes, M., & Oakson, G. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-07-02215.1989 · Cited by 81 · see citing works
Bimodal distribution of REM sleep latencies in depression.
Schulz, H., Lund, R., Cording, C., & Dirlich, G. (1979) · PubMed · Cited by 75 · see citing works
Macromolecular specificity and biological memory
Schmitt, F. O. (1962) · Medical Entomology and Zoology · Cited by 72 · see citing works
Paradoxical Sleep is Characterized by Uncoupled Gamma Activity Between Frontal and Perceptual Cortical Regions
Pérez‐Garci, E., del Río‐Portilla, Y., Guevara, M. Á., Arce, C., & Corsi‐Cabrera, M. (2001) · SLEEP · doi:10.1093/sleep/24.1.118 · Cited by 71 · see citing works
Comparison of Effects of Haloperidol Administration on Amphetamine-Stimulated Dopamine Release in the Rat Medial Prefrontal Cortex and Dorsal Striatum
Pehek, E. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38101-7 · Cited by 70 · see citing works
Cytochemical and pharmacological studies on polysensory neurons in the primate frontal cortex
Nelson, C. N., Hoffer, B. J., Chu, N.-S., & Bloom, F. E. (1973) · Brain Research · doi:10.1016/0006-8993(73)90623-9 · Cited by 66 · see citing works
PYRAMIDAL ACTIVITY DURING SLEEP AND WAKEFULNESS.
ARDUINI, A., Berlucchi, G., & Strata, P. (1963) · PubMed · Cited by 65 · see citing works
The noradrenaline–dopamine interaction in the rat medial prefrontal cortex studied by multi-probe microdialysis
Kawahara, H., Kawahara, Y., & Westerink, B. H. C. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00863-9 · Cited by 63 · see citing works
Characterization of endogenous serotonin-mediated regulation of dopamine release in the rat prefrontal cortex
Matsumoto, M., Togashi, H., Mori, K., Ueno, K., Miyamoto, A., & Yoshioka, M. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00636-6 · Cited by 62 · see citing works
Region‐Specific Enhancement of Basal Extracellular and Cocaine‐Evoked Dopamine Levels Following Constitutive Deletion if tge Seritibub1B Receptor
Shippenberg, T. S., Hen, R., & He, M. L. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750258.x · Cited by 61 · see citing works
Chronic Psychotic Illness From Methamphetamine
Buffenstein, A., HEASTER, J., & KO, P. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.662 · Cited by 59 · see citing works
N-Methyl-D-aspartate (NMDA) receptor-based treatment approaches in schizophrenia: the first decade
Heresco‐Levy, U. (2000) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145700001978 · Cited by 59 · see citing works
Le sommeil et les rêves
Maury, A., & Cie, D. (1865) · Cited by 59 · see citing works
EEG sleep in primary depression
Coble, P. A., Kupfer, D. J., Spiker, D. G., et al. (1979) · Journal of Affective Disorders · doi:10.1016/0165-0327(79)90032-6 · Cited by 57 · see citing works
β-Adrenergic Antagonism Alters the Behavioral and Neurochemical Responses to Cocaine
Harris, G. C. M. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00089-v · Cited by 55 · see citing works
Cortical Unit Activity in Desynchronized Sleep
McCarley, R. W., & Hobson, J. A. (1970) · Science · doi:10.1126/science.167.3919.901 · Cited by 54 · see citing works
The intermediate stage of sleep in mice
Glin, L., Arnaud, C., Berracochea, D., Galey, D., Jaffard, R., & Gottesmann, C. (1991) · Physiology & Behavior · doi:10.1016/0031-9384(91)90420-s · Cited by 53 · see citing works
Self-citation
Depression of rat cerebral cortical neurones by H1 and H2 histamine receptor agonists
Sastry, B. S. R., & Phillis, J. W. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90329-0 · Cited by 52 · see citing works
Sleep: a physiological "cerveau isolé" stage?
Gottesmann, C., User, P., & Gioanni, H. (1980) · PubMed · Cited by 52 · see citing works
Self-citation
Intrinsic dreams are not produced without REM sleep mechanisms: evidence through elicitation of sleep onset REM periods
Takeuchi, T., Miyasita, A., Inugami, M., & Yamamoto, Y. (2001) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2001.00237.x · Cited by 51 · see citing works
Calcium mediation of the inhibitory effects of biogenic amines on cerebral cortical neurones
Phillis, J. W., Lake, N., & Yarbrough, G. G. (1973) · Brain Research · doi:10.1016/0006-8993(73)90235-7 · Cited by 45 · see citing works
Mind and consciousness during sleep
Bosinelli, M. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00003-c · Cited by 45 · see citing works
Biological predictors of 1-year outcome in schizophrenia in males and females
Goldman, M., Tandon, R., DeQuardo, J. R., Taylor, S. F., Goodson, J. A., & McGrath, M. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(96)00021-7 · Cited by 42 · see citing works
Electrophysiological evidence for dreaming: human cerebral potentials associated with rapid eye movement during REM sleep
Miyauchi, S., Takino, R., Fukuda, H., & Torii, S. (1987) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(87)90207-0 · Cited by 41 · see citing works
Transmission processes in the ventrobasal complex of rat during the sleep-waking cycle
Gandolfo, G., Arnaud, C., & Gottesmann, C. (1980) · Brain Research Bulletin · doi:10.1016/0361-9230(80)90262-2 · Cited by 38 · see citing works
Self-citation
Intermediate stage of sleep in the cat.
Gottesmann, C., Gandolfo, G., & Zernicki, B. (1984) · PubMed · Cited by 37 · see citing works
Self-citation
Covert REM sleep effects on REM mentation: Further methodological considerations and supporting evidence
Nielsen, T. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00974028 · Cited by 36 · see citing works
Diffuse regulation of visual thalamo-cortical responsiveness during sleep and wakefulness
Demetrescu, M., Demetrescu, M., & Iosif, G. (1966) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(66)90102-7 · Cited by 35 · see citing works
Activation of corticostriatal pathway leads to similar morphological changes observed following haloperidol treatment
Meshul, C. K., Buckman, J. F., Allen, C., Riggan, J. P., & Feller, D. J. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199604)22:4 · Cited by 30 · see citing works
Reports of Mental Activity from Sleep Stages 2 and 4
Tracy, R. L., & Tracy, L. N. (1974) · Perceptual and Motor Skills · doi:10.2466/pms.1974.38.2.647 · Cited by 25 · see citing works
Nightmares and Psychotic Decompensation: A Case Study
Levin, R., & Daly, R. S. (1998) · Psychiatry · doi:10.1080/00332747.1998.11024833 · Cited by 22 · see citing works
Histamine does not play an essential role in electrocortical activation during waking behavior
Servos, P., Barke, K. E., Hough, L. B., et al. (1994) · Brain Research · doi:10.1016/0006-8993(94)90180-5 · Cited by 20 · see citing works
Neuromodulation of the prefrontal cortex during sleep
Hilaire, Z. D. S., Orosco, M., Rouch, C., Python, A., & Nicolaı̈dis, S. (2000) · Neuroreport · doi:10.1097/00001756-200006050-00005 · Cited by 19 · see citing works
[Psychophysiology of sleep].
Gottesmann, C. (1971) · PubMed · Cited by 18 · see citing works
Self-citation
Direct cortical response and PGO spike during paradoxical sleep of the cat
Satoh, T. (1971) · Brain Research · doi:10.1016/0006-8993(71)90070-9 · Cited by 14 · see citing works
ELECTROMYOGRAM SUPPRESSION DURING SLEEP, DREAM RECALL, AND ORIENTATION TIME
Larson, J. D., & Foulkes, D. (1969) · Psychophysiology · doi:10.1111/j.1469-8986.1969.tb02857.x · Cited by 13 · see citing works
Psychophysiologie du sommeil
Gottesmann, C. (1971) · L’Année psychologique · doi:10.3406/psy.1971.27755 · Cited by 13 · see citing works
Self-citation
Each distinct type of mental state is supported by specific brain functions
Gottesmann, C. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00434023 · Cited by 8 · see citing works
Self-citation
La psychophysiologie du sommeil
Gottesmann, C. (1971) · Bulletin de psychologie · doi:10.3406/bupsy.1971.1166 · Cited by 7 · see citing works
Self-citation
[Deficit schizophrenia: from pharmacology to clinical practice].
Tassin, J. (1996) · PubMed · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 14

Braun AR, Balkin TJ, Wesensten NJ et al. Regional cerebral blood flow throughout the sleep-wake cycle. Brain 1997; 120: 1173-1197.
Rubinstein M, Cepeda C, Hurst RS et al. Dopamine D4 receptor-deficient mice display cortical hyper- excitability. J. Neurosci. 2001; 21: 3756-3763.
Sastry BSR, Phillis JW. Depression of rat cerebral cortical neurons by H 1 and H 2 histamine receptor agonists. Eur. J. Pharmacol. 1976; 38: 269-273.
Haas HL. Histamine actions in the mammalian central nervous system. In: Ganelin CR, Schwartz JC (eds). Frontiers in Histamine Research. Pergamon, Oxford, 1985; 215-234.
Vanni-Mercier G, Sakai K, Jouvet M. Neurones spéci- fiques de l'éveil dans l'hypothalamus postérieur du Chat. C. R. Acad. Sci. 1984; 298: 195-200.
Hobson JA, Pace-Schott E, Stickgold R. Toward a cog- nitive neuroscience of conscious states. Behav. Brain Sci. 2000; 23: 793-842.
Jouvet M, Michel F. Corrélations électromyo- graphiques du sommeil chez le Chat décortiqué et mésencéphalique chronique. C. R. Soc. Biol. 1959; 153: 422-425.
Jouvet M, Michel F, Courjon J. Sur un stade d'activité électrique rapide au cours du sommeil physiologique. C. R. Soc. Biol. 1959; 153: 1024-1028.
Mikiten T, Niebyl P, Hendley C. EEG desynchroniza- tion during behavioral sleep associated with spike dis- charges from the thalamus of the cat. Fed. Proc. 1961; 20: 327.
Michel F, Jeannerod M, Rechschaffen A, Jouvet M. Sur les mécanismes de l'activité de pointe au niveau du système visuel au cours de la phase paradoxale du sommeil. C. R. Soc. Biol. 1964; 158: 103-106.
Hobson JA. L'activité électrique phasique du cortex et du thalamus au cours du sommeil désynchronisé chez le Chat. C. R. Soc. Biol. 1964; 158: 2131-2135.
Gottesmann C. Données sur l'activité corticale au cours du sommeil profond chez le Rat. C.R. Soc. Biol. 1964; 158: 1829-1834.
Gottesmann C, User P, Gioanni H. Sleep: a creveau isolé stage? Waking Sleep 1980; 4: 111-117.
Bremer F. Cerveau isolé et Physiologie du sommeil. C.R. Soc. Biol. 1935; 118: 1235-1241.

Sorted by citations

Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep–wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats
Léna, I., Parrot, S., Deschaux, O., Muffat‐Joly, S., Sauvinet, V., Renaud, B., Suaud‐Chagny, M. ‐., & Gottesmann, C. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20602 · Cited by 322 · see citing works
Self-citation
Sleep and psychiatry
Abad, V. C., & Guilleminault, C. (2005) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2005.7.4/vabad · Cited by 102 · see citing works
Apical drive-A cellular mechanism of dreaming?
Aru, J., Siclari, F., Phillips, W. A., & Storm, J. F. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.018 · Cited by 74 · see citing works
EEG oscillations during sleep and dream recall: state- or trait-like individual differences?
Scarpelli, S., Dâ€™Atri, A., Gorgoni, M., Ferrara, M., & Gennaro, L. D. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.00605 · Cited by 41 · see citing works
The dreaming brain/mind, consciousness and psychosis
Limosani, I., D’Agostino, A., Manzone, M. L., & Scarone, S. (2011) · Consciousness and Cognition · doi:10.1016/j.concog.2010.11.014 · Cited by 28 · see citing works

Authors: GOTTESMANN, C.
Affiliations: Université Nice Sophia Antipolis (FR)
Corresponding author: GOTTESMANN, CLAUDE
Venue: Psychiatry and Clinical Neurosciences
Publisher: Wiley
Published: 2002-08
Volume: 56
Issue: 4
Pages: 345-354
ISSN: 1323-1316 (ISSN-L)
1440-1819
DOI: 10.1046/j.1440-1819.2002.01022.x
OpenAlex: W2041869040
Cited by: 69
References: 135
Citations by year: 2025: 1 · 2024: 3 · 2023: 1 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 3
FWCI: 0.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 2195 d)
Locations: Psychiatry and Clinical Neurosciences (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords: sleep-wake cycle, REM sleep, slow-wave sleep, acetylcholine, monoamines, dopamine, disinhibition, cortical inhibition, dreams, negative symptoms of schizophrenia, hallucinations, delusions, prefrontal cortex, nucleus accumbens, monoaminergic neurons
MeSH terms: Acetylcholine, Cerebral Cortex, Dopamine, Dreams, Hallucinations, Humans, Neurons, Norepinephrine, Schizophrenia, Serotonin, Sleep, REM

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The neurochemistry of waking and sleeping mental activity: the disinhibition-dopamine hypothesis

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks