Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms
Abstract
Daily patterns of sleep and wakefulness are inextricably linked to the regulation of feeding and energy metabolism. Both are affected by homeostatic as well as circadian drives, and both are tightly linked to thermoregulation. In this chapter, we review the basic drain circuitry that regulates sleep and wakefulness, including the flip-flop switch relationship of the arousal system and the ventrolateral preoptic sleep-promoting neurons. We then examine the role of the orexin/hypocretin neurons, which stabilize the switch while driving both wakefulness and foraging for food. We also review the role of the subparaventricular nucleus and the dorsomedial nucleus of the hypothalamus in circadian integration and modulation of both feeding and wake-sleep patterns.
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Appetite and sleep patterns are significantly influenced by circadian phase.
“Since both appetite and sleep patterns are significantly influenced by circadian phase29”
From The impact of sleep deprivation on food desire in the human brain (2013) · cites this paper as [29]
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- Authors
- Saper, C. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Saper, Clifford B.
- ORCID
- Saper, Clifford B.
- Venue
- Progress in Brain Research
- Publisher
- Elsevier
- Published
- 2006
- Volume
- 153
- Pages
- 243-252
- ISSN
- 0079-6123 (ISSN-L)
- OpenAlex
- W1608253906
- Cited by
- 178
- References
- 58
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 5 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 22
- FWCI
- 28.68
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in brain research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- hypothalamus, sleep-wake regulation, food intake regulation, circadian rhythm, energy metabolism, thermoregulation, arousal system, ventrolateral preoptic nucleus, dorsomedial hypothalamus, foraging behavior
- MeSH terms
- Animals, Circadian Rhythm, Eating, Feeding Behavior, Humans, Hypothalamus, Neural Pathways, Neurons, Sleep
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