THE PIG AS A MODEL FOR HUMAN WOUND HEALING

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Calcium Hydride‐Based Dressing to Promote Wound Healing

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Fibrin sealant improves graft adherence in a porcine full-thickness burn wound model

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Strategies Demonstrating Efficacy in Reducing Wound Contraction In Vivo

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Development of a Consistent and Reproducible Porcine Scald Burn Model

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Animal models of chronic wound care: the application of biofilms in clinical research

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International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig

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Scabies

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Second harmonic generation and multiphoton microscopic detection of collagen without the need for species specific antibodies

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Assessment of microcirculation dynamics during cutaneous wound healing phases in vivo using optical microangiography

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Laboratory Models for the Study of Normal and Pathologic Wound Healing

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Polyhexanide-Releasing Membranes for Antimicrobial Wound Dressings: A Critical Review

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Cold atmospheric plasma is bactericidal to wound-relevant pathogens and is compatible with burn wound healing

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Does Pressure Matter in Creating Burns in a Porcine Model?

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Age effects and the influence of varying proportions of terrestrial and marine dietary protein on the stable nitrogen-isotope compositions of pig bone collagen and soft tissues from a controlled feeding experiment

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Latent Oxidative Polymerization of Catecholamines as Potential Cross-linkers for Biocompatible and Multifunctional Biopolymer Scaffolds

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Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

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Mycolactone: More than Just a Cytotoxin

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Recipient wound bed characteristics affect scarring and skin graft contraction

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Validation of a porcine comb burn model

Singer, A. J., McClain, S. A., Taira, B. R., Romanov, A. B., Rooney, J., & Zimmerman, T. (2009) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2008.02.019 · Cited by 35

Use of a novel porcine collagen paste as a dermal substitute in full‐thickness wounds

Shevchenko, R. V., Sibbons, P. D., Sharpe, J. R., & James, S. E. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00360.x · Cited by 35

Reepithelialization of Mid-dermal Porcine Burns After Rapid Enzymatic Debridement With Debrase®

Singer, A. J., Taira, B. R., Anderson, R., McClain, S. A., & Rosenberg, L. A. (2011) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31822dc467 · Cited by 35

The use of collagen-based matrices in the treatment of full-thickness wounds

Petersen, W., Rahmanian‐Schwarz, A., Werner, J.-O., Schiefer, J. L., Rothenberger, J. M., Hübner, G., Schaller, H., & Held, M. (2016) · Burns · doi:10.1016/j.burns.2016.03.017 · Cited by 35

Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs

Bhatia, A., O’Brien, K., Chen, M., Wong, A. K., Garner, W. L., Woodley, D. T., & Li, W. (2016) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2016.41 · Cited by 35

Enhanced tissue adhesiveness of injectable gelatin hydrogels through dual catalytic activity of horseradish peroxidase

Thi, T. T. H., Lee, Y., Ryu, S. B., Nguyen, D. H., & Park, K. D. (2017) · Biopolymers · doi:10.1002/bip.23077 · Cited by 35

Histopathologic staining of low temperature cutaneous burns: Comparing biomarkers of epithelial and vascular injury reveals utility of HMGB 1 and hematoxylin phloxine saffron

Hirth, D. A., Singer, A. J., Clark, R. A. F., & McClain, S. A. (2012) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2012.00847.x · Cited by 34

Histological Assessment of a Combined Low-Level Laser/Light-Emitting Diode Therapy (685 nm/470 nm) for Sutured Skin Incisions in a Porcine Model: A Short Report

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Effectiveness of a monofilament wound debridement pad at removing biofilm and slough:ex vivoand clinical performance

Schultz, G. S., Woo, K. Y., Weir, D., & Yang, Q. (2018) · Journal of Wound Care · doi:10.12968/jowc.2018.27.2.80 · Cited by 35

Human peripheral blood mononuclear cells enriched in endothelial progenitor cells via quality and quantity controlled culture accelerate vascularization and wound healing in a porcine wound model

Kado, M., Tanaka, R., Arita, K., Okada, K., Ito‐Hirano, R., Fujimura, S., & Mizuno, H. (2018) · Cell Transplantation · doi:10.1177/0963689718780307 · Cited by 34

Preclinical evaluation of a novel silver gelling fiber dressing on Pseudomonas aeruginosa in a porcine wound infection model

Davis, S. C., Li, J., Gil, J., Head, C. R., Valdes, J., Glinos, G. D., Solis, M., Higa, A., & Pastar, I. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12718 · Cited by 34

Biofilm and Equine Limb Wounds

Jørgensen, E., Bjarnsholt, T., & Jacobsen, S. E. (2021) · Animals · doi:10.3390/ani11102825 · Cited by 34

Burn healing is dependent on burn site: A quantitative analysis from a porcine burn model

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Nanoemulsion is an Effective Antimicrobial for Methicillin-Resistant Staphylococcus Aureus in Infected Wounds

Cao, Z., Spilker, T., Fan, Y., Kalikin, L. M., Ciotti, S., LiPuma, J. J., Makidon, P. E., Wilkinson, J. E., Baker, J. R., & Wang, S. H. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0025 · Cited by 34

Electrical stimulation disrupts biofilms in a human wound model and reveals the potential for monitoring treatment response with volatile biomarkers

Ashrafi, M. H., Frazer, L. N., Morris, J., Baguneid, M. S., Rautemaa‐Richardson, R., & Bayat, A. (2018) · Wound Repair and Regeneration · doi:10.1111/wrr.12679 · Cited by 33

Effects of Dietary Selenium Deficiency or Excess on Selenoprotein Gene Expression in the Spleen Tissue of Pigs

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Adipose-Derived Stromal/Stem Cells from Large Animal Models: from Basic to Applied Science

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Skin regeneration is accelerated by a lower dose of multipotent mesenchymal stromal/stem cells—a paradigm change

Eylert, G., Dölp, R., Parousis, A., Cheng, R. Y., Auger, C., Holter, M., Lang, I., Reiner, V., Kamolz, L., & Jeschke, M. G. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02131-6 · Cited by 33

Multi-faceted enhancement of full-thickness skin wound healing by treatment with autologous micro skin tissue columns

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Evaluation of a new liquid occlusive dressing for excisional wounds

Singer, A. J., Nable, M., Cameau, P., Singer, D. D., & McClain, S. A. (2003) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.2003.11306.x · Cited by 33

Experimental pig model of clinically relevant wound healing delay by intrinsic factors

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A topical aqueous oxygen emulsion stimulates granulation tissue formation in a porcine second-degree burn wound

Li, J., Zhang, Y.-P., Zarei, M., Zhu, L., Sierra, J. O., Mertz, P. M., & Davis, S. C. (2014) · Burns · doi:10.1016/j.burns.2014.11.016 · Cited by 33

Development of a Novel Animal Burn Model Using Radiant Heat in Rats and Swine

Gurfinkel, R., Singer, A. J., Cagnano, E., & Rosenberg, L. A. (2010) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2010.00736.x · Cited by 33

Models to Study Ischemia in Chronic Wounds

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The Wound Reporting in Animal and Human Preclinical Studies (WRAHPS) Guidelines

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Pig dorsum model for examining impaired wound healing at the skin-implant interface of percutaneous devices

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The use of native chemical functional groups presented by wound beds for the covalent attachment of polymeric microcarriers of bioactive factors

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Mechanistic insight into the dermal delivery from nanoparticle-coated submicron O/W emulsions

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The role of secreted heat shock protein-90 (Hsp90) in wound healing - how could it shape future therapeutics?

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Acceleration of the healing process of full-thickness wounds using hydrophilic chitosan–silica hybrid sponge in a porcine model

Park, J., Jeong, S., Song, E.-H., Song, J., Kim, H., & Kim, S. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328217751246 · Cited by 32

Candida albicans Infections: a novel porcine wound model to evaluate treatment efficacy

Gil, J., Solis, M., Higa, A., & Davis, S. C. (2022) · BMC Microbiology · doi:10.1186/s12866-022-02460-x · Cited by 36

Drug-eluting microneedles for self-administered treatment of keloids

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β2-Adrenoceptor Activation Modulates Skin Wound Healing Processes to Reduce Scarring

Provost, G. S. L., & Pullar, C. E. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.312 · Cited by 33

Skingineering II: transplantation of large-scale laboratory-grown skin analogues in a new pig model

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Impact of Isolated Burns on Major Organs

Burmeister, D. M., McIntyre, M. K., Baker, B. A., Rizzo, J. A., Brown, A. W., Natesan, S., Chung, K. K., & Christy, R. J. (2016) · Shock · doi:10.1097/shk.0000000000000662 · Cited by 32

Buruli Ulcer

Röltgen, K., & Pluschke, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-11114-4 · Cited by 32

The p-rpS6-zone delineates wounding responses and the healing process

Ring, N. A. R., Dworak, H., Bachmann, B., Schädl, B., Valdivieso, K., Rozmaric, T., Heimel, P., Fischer, I., Klinaki, E., Gutasi, A., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.04.001 · Cited by 31

Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold

Harrison, S. L., Vavken, P., & Murray, M. M. (2011) · Journal of Orthopaedic Research® · doi:10.1002/jor.21321 · Cited by 31

The physical and physiological effects of vacuum massage on the different skin layers: a current status of the literature

Moortgat, P., Anthonissen, M., Meirte, J., Daele, U. V., & Maertens, K. (2016) · Burns & Trauma · doi:10.1186/s41038-016-0053-9 · Cited by 31

Treatment of limb wounds of horses with orf virus IL-10 and VEGF-E accelerates resolution of exuberant granulation tissue, but does not prevent its development

Wise, L. M., Bodaan, C. J., Stuart, G. S., Real, N. C., Lateef, Z., Mercer, A. A., Riley, C. B., & Theoret, C. L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197223 · Cited by 31

Long-Term Accurate Continuous Glucose Biosensors via Extended Nitric Oxide Release

Malone‐Povolny, M. J., Merricks, E. P., Wimsey, L. E., Nichols, T. C., & Schoenfisch, M. H. (2019) · ACS Sensors · doi:10.1021/acssensors.9b01779 · Cited by 33

A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model

Yang, J., Huang, Y., Dai, J., Shi, X., & Zheng, Y. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab037 · Cited by 31

Nacre-driven water-soluble factors promote wound healing of the deep burn porcine skin by recovering angiogenesis and fibroblast function

Lee, K., Kim, H., Kim, J., Chung, Y. H., Lee, T. Y., Lim, H., Lim, J., Kim, T.-W., Bae, J. S., Woo, C.-H., et al. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1088-4 · Cited by 31

The effects of normal saline instillation in conjunction with negative pressure wound therapy on wound healing in a porcine model.

Leung, B. K., LaBarbera, L. A., Carroll, C. A., Allen, D., & McNulty, A. K. (2010) · PubMed · Cited by 31

Progress of clinical practice on the management of burn-associated pain: Lessons from animal models

McIntyre, M. K., Clifford, J. L., Maani, C. V., & Burmeister, D. M. (2016) · Burns · doi:10.1016/j.burns.2016.01.023 · Cited by 31

Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model

Kim, J., Park, S., Jeon, B.-S., Jang, W.-S., Lee, S., Son, Y., Rhim, K.-J., Lee, S.-I., & Lee, S. (2016) · Journal of Veterinary Science · doi:10.4142/jvs.2016.17.4.435 · Cited by 31

Organ-specific matrix self-assembled by mesenchymal cells improves the normal urothelial differentiation in vitro

Bouhout, S., Chabaud, S., & Bolduc, S. (2015) · World Journal of Urology · doi:10.1007/s00345-015-1596-2 · Cited by 31

Development and Characterisation of Human Skin Equivalents and Their Potential Application as a Burn Wound Model

Topping, G., Malda, J., Dawson, R., & Upton, Z. (2006) · Wound Practice & Research: Journal of the Australian Wound Management Association · Cited by 31

Characterization of acute and long-term sulfur mustard-induced skin injuries in hairless guinea-pigs using non-invasive methods

Dachir, S., Cohen, M., Fishbeine, E., Sahar, R., Brandies, R., Horwitz, V., & Kadar, T. (2009) · Skin Research and Technology · doi:10.1111/j.1600-0846.2009.00409.x · Cited by 30

Calotropis - A multi-potential plant to humankind: Special focus on its wound healing efficacy

Ali‐Seyed, M., & Ayesha, S. (2020) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2020.101725 · Cited by 30

Coming to Consensus: What Defines Deep Partial Thickness Burn Injuries in Porcine Models?

Gibson, A. L. F., Carney, B. C., Cuttle, L., Andrews, C. J., Kowalczewski, C. J., Liu, A., Powell, H. M., Stone, R., Supp, D. M., Singer, A. J., et al. (2020) · Journal of Burn Care & Research · doi:10.1093/jbcr/iraa132 · Cited by 30

The Discovery and Development of Natural-Based Biomaterials with Demonstrated Wound Healing Properties: A Reliable Approach in Clinical Trials

Fadilah, N. I. M., Maarof, M., Motta, A., Tabata, Y., & Fauzi, M. B. (2022) · Biomedicines · doi:10.3390/biomedicines10092226 · Cited by 31

An Overview of Methods for the In Vivo Evaluation of Tissue-Engineered Skin Constructs

Lammers, G., Verhaegen, P. D. H. M., Ulrich, M. M. W., Schalkwijk, J., Middelkoop, E., Weiland, D., Nillesen, S. T. M., Kuppevelt, T. H. V., & Daamen, W. F. (2010) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0473 · Cited by 32

Early versus Delayed Excision and Grafting of Full-Thickness Burns in a Porcine Model: A Randomized Study

Singer, A. J., Toussaint, J. D., Chung, W. T., McClain, S. A., Raut, V., & Rosenberg, L. A. (2016) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000002161 · Cited by 30

Noninvasive Techniques for the Determination of Burn Severity in Real Time

Burmeister, D. M., Cerna, C. Z., Becerra, S. C., Sloan, M. A., Wilmink, G. J., & Christy, R. J. (2016) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000338 · Cited by 30

Porcine Models of Biofilm Infections with Focus on Pathomorphology

Jensen, L. K., Johansen, A. S. B., & Jensen, H. E. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01961 · Cited by 30

Visions for Regenerative Medicine: Interface Between Scientific Fact and Science Fiction

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The efficacy of adipose-derived stem cells in burn injuries: a systematic review

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