THE PIG AS A MODEL FOR HUMAN WOUND HEALING

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Photobiomodulation Therapy in Burn Wound Healing: Systematic Review and Meta-Analysis of Preclinical Studies

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A Peptide/MicroRNA-31 nanomedicine within an electrospun biomaterial designed to regenerate wounds in vivo

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Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates

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CCN2 is transiently expressed by keratinocytes during re-epithelialization and regulates keratinocyte migration in vitro by the ras-MEK-ERK signaling pathway

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β-irradiation (166Ho patch)-induced skin injury in mini-pigs: effects on NF-κB and COX-2 expression in the skin

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Biodegradable lysine-derived polyurethane scaffolds promote healing in a porcine full-thickness excisional wound model

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A mini pig model for visualization of perforator flap by using angiography and MIMICS

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Dermatotoxicology: Safety Evaluation of Topical Products in Minipigs: Study Designs and Practical Considerations

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Navigating the complexities of diabetic foot ulcers: From pathophysiology to advanced treatment strategies

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Thermally damaged porcine skin is not a surrogate mechanical model of human skin

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Incorporating temperature-dependent properties into the modeling of photo-thermo-mechanical interactions in cancer tissues

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A Standardized Porcine Model for Partial-Thickness Wound Healing Studies: Design, Characterization, Model Validation, and Histological Insights

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Infected animal models for tissue engineering

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An immune-competent rat split thickness skin graft model: useful tools to develop new therapies to improve skin graft survival.

Zhai, Q., Zhou, F., Ibrahim, M. M., Zhao, J., Liu, X., Wu, J., Chen, L., & Qi, S. (2018) · Europe PMC (PubMed Central) · Cited by 18

Advantages and Disadvantages of Using Small and Large Animals in Burn Research: Proceedings of the 2021 Research Special Interest Group

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Establishing a Reproducible Hypertrophic Scar following Thermal Injury

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Acticoat™ stimulates inflammation, but does not delay healing, in acute full‐thickness excisional wounds

Hartmann, C., Rode, H., & Kramer, B. (2015) · International Wound Journal · doi:10.1111/iwj.12525 · Cited by 17

Biomechanical Testing and Histologic Examination of Intradermal Skin Closure in Dogs Using Barbed Suture Device and Non‐Barbed Monofilament Suture

Law, A. Y., Butler, J. R., Patnaik, S. S., Cooley, J. A., & Elder, S. H. (2016) · Veterinary Surgery · doi:10.1111/vsu.12576 · Cited by 17

Hypoperfusion in response to epinephrine in local anaesthetics: Investigation of dependence on epinephrine concentration, spread of hypoperfusion and time to maximal cutaneous vasoconstriction

Sheikh, R., Memarzadeh, K., Torbrand, C., Blohmé, J., & Malmsjö, M. (2016) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2016.10.017 · Cited by 17

Full‐thickness skin columns: A method to reduce healing time and donor site morbidity in deep partial‐thickness burns

Keenan, C. S., Cooper, L. E., Nuutila, K., Chapa, J., Christy, S., Chan, R. K., & Carlsson, A. H. (2023) · Wound Repair and Regeneration · doi:10.1111/wrr.13114 · Cited by 16

Catheter securement systems: comparison of two investigational devices to a sutureless securement device, a securement dressing, and sutures in a pig model

Rutledge, L. F., DeCabooter, D. P., Walters, S.-A., & Bernatchez, S. F. (2015) · Intensive Care Medicine Experimental · doi:10.1186/s40635-015-0060-3 · Cited by 16

Clinical effect of ablative fractional laser-assisted topical anesthesia on human skin: A randomized pilot study

Tian, T., Luo, Y.-J., Jiang, T.-L., Dong, Y., Yu, A., Chen, H., Gao, X., & Li, Y.-H. (2016) · Journal of Cosmetic and Laser Therapy · doi:10.1080/14764172.2016.1197404 · Cited by 16

Experimental In-Vivo Models Used in Fat Grafting Research for Volume Augmentation in Soft Tissue Reconstruction

Lujan-Hernandez, J., Appasani, R. K., Sullivan, K., Siegel‐Reamer, L., & Lalikos, J. F. (2017) · Archives of Plastic Surgery · doi:10.5999/aps.2017.44.5.361 · Cited by 16

Probing Skin Barrier Recovery on Molecular Level Following Acute Wounds: An In Vivo/Ex Vivo Study on Pigs

Mojumdar, E. H., Madsen, L. B., Hansson, H., Taavoniku, I., Kristensen, K., Persson, C., Morén, A. K., Mokso, R., Schmidtchen, A., Ruzgas, T. A., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9040360 · Cited by 16

Combination of Nitric Oxide Release and Surface Texture for Mitigating the Foreign Body Response

Malone‐Povolny, M. J., Bradshaw, T. M., Merricks, E. P., Long, C. T., Nichols, T. C., & Schoenfisch, M. H. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00022 · Cited by 16

Dissolved oxygen technologies as a novel strategy for non‐healing wounds: A critical review

Ntentakis, D. P., Ntentaki, A. M., Delavogia, E., Kalomoiris, L., Venieri, D., Arkadopoulos, N. F., & Kalogerakis, N. E. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12972 · Cited by 16

Characterization of the mucilages extracted from hibiscus rosa-sinensis linn and hibiscus mutabilis linn and their skin moisturizing effect

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Healing of Mid-Dermal Burns in a Diabetic Porcine Model

Singer, A. J., Taira, B. R., McClain, S. A., Rooney, J., Steinhauff, N., Zimmerman, T., & Clark, R. A. F. (2009) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181b48a6b · Cited by 16

Transcriptomic analysis of Rongchang pig brains and livers

Gan, L., Xie, L., Zuo, F., Xiang, Z., & He, N. (2015) · Gene · doi:10.1016/j.gene.2015.01.051 · Cited by 16

Genome-wide expression analysis of wounded skin reveals novel genes involved in angiogenesis

Brönneke, S., Brückner, B., Söhle, J., Siegner, R., Smuda, C., Stäb, F., Wenck, H., Kolbe, L., Grönniger, E., & Winnefeld, M. (2015) · Angiogenesis · doi:10.1007/s10456-015-9472-7 · Cited by 16

Effects of burn location and investigator on burn depth in a porcine model

Singer, A. J., Toussaint, J. D., Chung, W. T., Thode, H. C., McClain, S. A., & Raut, V. (2015) · Burns · doi:10.1016/j.burns.2015.09.016 · Cited by 16

The Effects of Negative Pressure by External Tissue Expansion Device on Epithelial Cell Proliferation, Neo-Vascularization and Hair Growth in a Porcine Model

Hsiao, H., Liu, J., Brey, E. M., & Cheng, M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154328 · Cited by 18

Development of a guinea pig cutaneous radiation injury model using low penetrating X-rays

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A Randomized Controlled Trial of Silver Sulfadiazine, Biafine, and Saline-soaked Gauze in the Treatment of Superficial Partial-thickness Burn Wounds in Pigs

Glesinger, R., Cohen, A. D., Bogdanov‐Berezovsky, A., Krieger, Y., & Rosenberg, L. A. (2004) · Academic Emergency Medicine · doi:10.1197/j.aem.2003.11.015 · Cited by 16

The effect of supplementing glycine and serine to a low crude protein diet on growth and skin collagen abundance of nursery pigs1

Silva, K. E., Mansilla, W. D., Shoveller, A. K. K., Htoo, J. K. K., Cant, J. P., de Lange, C. F. M., & Huber, L. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa023 · Cited by 15

Laser–tissue interaction simulation considering skin-specific data to predict photothermal damage lesions during laser irradiation

Kim, H.-J., Um, S., Kang, Y. G., Shin, M., Jeon, H., Kim, B., Lee, D., & Yoon, K. (2023) · Journal of Computational Design and Engineering · doi:10.1093/jcde/qwad033 · Cited by 15

In Situ Identification of Both IL-4 and IL-10 Cytokine–Receptor Interactions during Tissue Regeneration

Nikovics, K., Favier, A., Rocher, M., Mayinga, C., Gómez, J., Dufour‐Gaume, F., & Riccobono, D. (2023) · Cells · doi:10.3390/cells12111522 · Cited by 15

Swine Model of Biofilm Infection and Invisible Wounds

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An intra‐individual quantitative assessment of acute laser injury patterns in facial versus abdominal skin

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Experimental study on the hemostatic effect of cyanoacrylate intended for catheter securement

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Buruli Ulcer in Animals and Experimental Infection Models

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Thyroxine restores severely impaired cutaneous re-epithelialisation and angiogenesis in a novel preclinical assay for studying human skin wound healing under “pathological” conditions ex vivo

Post, H., Hundt, J. E., Zhang, G., Depping, R., Rosé, C., Langan, E. A., & Paus, R. (2020) · Archives of Dermatological Research · doi:10.1007/s00403-020-02092-z · Cited by 15

A Pilot Study of Negative Pressure Therapy with Autologous Skin Cell Suspensions in a Porcine Model

Carney, B. C., Moffatt, L. T., Travis, T. E., Nisar, S., Keyloun, J. W., Prindeze, N. J., Oliver, M. A., Kirkpatrick, L. D., & Shupp, J. W. (2021) · Journal of Surgical Research · doi:10.1016/j.jss.2021.05.010 · Cited by 15

Alteration of biomechanical properties of burned skin

Held, M., Rahmanian‐Schwarz, A., Rothenberger, J. M., Schiefer, J. L., Esfahani, B. J., Schaller, H.-E., & Jaminet, P. (2014) · Burns · doi:10.1016/j.burns.2014.09.021 · Cited by 15

A closer examination of atraumatic dressings for optimal healing

Davis, S. C., Li, J., Gil, J., Valdes, J., Solis, M., Treu, R., & Kirnser, R. S. (2013) · International Wound Journal · doi:10.1111/iwj.12144 · Cited by 15

Targeting Microtubules for Wound Repair

Charafeddine, R. A., Nosanchuk, J. D., & Sharp, D. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2015.0658 · Cited by 15

Blockade of IgM-Mediated Inflammation Alters Wound Progression in a Swine Model of Partial-Thickness Burn

Sadeghipour, H., Torabi, R., Gottschall, J. D., Lujan-Hernandez, J., Sachs, D. H., Moore, F. D., & Cetrulo, C. L. (2016) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000459 · Cited by 15

Improving skin integration around long‐term percutaneous devices using fibrous scaffolds in a reconstructed human skin equivalent model

Bolle, E. C. L., Bartnikowski, N., Haridas, P., Parker, T. J., Fraser, J. F., Gregory, S. D., & Dargaville, T. R. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34428 · Cited by 15

Donor Site Healing Dynamics

Mauskar, N. A., Sood, S., Travis, T. E., Matt, S. E., Mino, M. J., Burnett, M.-S., Moffatt, L. T., Fidler, P. E., Epstein, S. E., Jordan, M. H., et al. (2013) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3182839aca · Cited by 15

The Effects of a High-potency Topical Steroid on Cutaneous Healing of Burns in Pigs

Singer, A. J., & McClain, S. A. (2002) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.2002.tb02128.x · Cited by 15

Combination product of dermal matrix, preconditioned human mesenchymal stem cells and timolol promotes wound healing in the porcine wound model

Yang, H., Fierro, F. A., Yoon, D. J., Gallegos, A., Osborn, S. L., Nguyen, A. V., Peavy, T. R., Ferrier, W. T., Talken, L., Ma, B. W., et al. (2022) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35022 · Cited by 14

A New Technique of Ex Vivo Gene Delivery of VEGF to Wounds Using Genetically Modified Skin Particles Promotes Wound Angiogenesis

Koyama, T., Hackl, F., Aflaki, P., Bergmann, J., Zuhaili, B., Waisbren, E. C., Govindarajulu, U. S., Yao, F., & Eriksson, E. K. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.10.017 · Cited by 14

Greater Surgical Precision of a Flexible Carbon Dioxide Laser Fiber Compared to Monopolar Electrosurgery in Porcine Myometrium

Bailey, A. P., Lancerotto, L., Gridley, C. M., Orgill, D. P., Nguyen, H. T., Pescarini, E., Lago, G., & Gargiulo, A. (2014) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2014.05.004 · Cited by 14

Applications of bioresorbable polymers in skin and eardrum

Danti, S., D’Alessandro, D., Mota, C., Bruschini, L., & Berrettini, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100262-9.00018-5 · Cited by 14

Permeation of skin with (C60) fullerene dispersions

Martins, M., Azóia, N. G., Melle‐Franco, M., Ribeiro, A., & Cavaco-Paulo, A. M. (2017) · Engineering in Life Sciences · doi:10.1002/elsc.201600244 · Cited by 14

Dermis, acellular dermal matrix, and fibroblasts from different layers of pig skin exhibit different profibrotic characteristics: evidence fromin vivostudy

Zuo, Y., & Lu, S. (2017) · Oncotarget · doi:10.18632/oncotarget.15389 · Cited by 14

The effects of topical nitric oxide on healing of partial thickness porcine burns

Singer, A. J., Choi, Y., Rashel, M., Toussaint, J. D., & McClain, S. A. (2017) · Burns · doi:10.1016/j.burns.2017.07.017 · Cited by 14

The effect of tadalafil on reepithelialization and scarring of partial thickness porcine burns

Goldsmith, K., Goradia, E., McClain, S. A., Sandoval, S., & Singer, A. J. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12770 · Cited by 14

Comparison of comparable scald and contact burns in a porcine model: A preliminary report

Singer, A. J., Zhou, J. W., Osman, O. B., Harris, Z. B., Khani, M. E., Baer, E., Zhang, N., McClain, S. A., & Arbab, M. H. (2020) · Wound Repair and Regeneration · doi:10.1111/wrr.12848 · Cited by 14

The Impact of Composites with Silicate-Based Glasses and Gold Nanoparticles on Skin Wound Regeneration

Mârza, S. M., Magyari, K., BOGDAN, S. A., Moldovan, M., Peștean, C. P., Nagy, A. L., Adrian Florin, G. A. L., Tăbăran, F., Purdoiu, R. C., Licărete, E., et al. (2021) · Molecules · doi:10.3390/molecules26030620 · Cited by 14

Mechanical characterisation of commercial artificial skin models

Kho, A. S. K., Béguin, S., O’Cearbhaill, E. D., & Annaidh, A. N. (2023) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2023.106090 · Cited by 14

Does Systemic Isotretinoin Inhibit Healing in a Porcine Wound Model?

Larson, D. L., Flugstad, N. A., O'Connor, E., Kluesner, K. A., & Plaza, J. A. (2012) · Aesthetic Surgery Journal · doi:10.1177/1090820x12462383 · Cited by 14

The aetiology of deep tissue injury: a literature review

Peart, J. (2016) · British Journal of Nursing · doi:10.12968/bjon.2016.25.15.840 · Cited by 14

Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin

Carvajal-Vidal, P., Mallandrich, M., García, M. L., & Calpena, A. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112475 · Cited by 14

Vital, Porcine, Gal-Knockout Skin Transplants Provide Efficacious Temporary Closure of Full-Thickness Wounds: Good Laboratory Practice-Compliant Studies in Nonhuman Primates

Holzer, P. W., Adkins, J., Moulton, K., Zhu, L., Monroy, R. L., & Cetrulo, C. L. (2020) · Journal of Burn Care & Research · doi:10.1093/jbcr/irz124 · Cited by 14

The influence of a PHI-5-loaded silicone membrane, on cutaneous wound healing in vivo

van Rossum, M. M., Vooijs, D. P. P., Walboomers, X. F., Hoekstra, M. J., Spauwen, P. H. M., & Jansen, J. A. (2007) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-006-0112-z · Cited by 14

Donor Site Healing Dynamics

Nuutila, K., Kankuri, E. M., & Vuola, J. (2014) · Journal of Burn Care & Research · doi:10.1097/bcr.0000000000000090 · Cited by 14

Wound Repair and Experimental Wound Models

Baktır, G. (2020) · Experimed · doi:10.26650/experimed.2019.19023 · Cited by 13

Novel Cyclic Lipopeptides Fusaricidin Analogs for Treating Wound Infections

Gil, J., Pastar, I., Houghten, R. A., Padhee, S., Higa, A., Solis, M., Valdez, J., Head, C. R., Michaels, H. A., Lenhart, B. J., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.708904 · Cited by 13

Effects of Placenta-Derived Human Amniotic Epithelial Cells on the Wound Healing Process and TGF-β Induced Scar Formation in Murine Ischemic-Reperfusion Injury Model

Biniazan, F., Rajaei, F., Darabi, S., Babajani, A., Mashayekhi, M., Vousooghi, N., Abdollahifar, M., Salimi, M., & Niknejad, H. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10355-7 · Cited by 13

Simultaneous Extraction of Oil and Protein from Silkworm (Bombyx mori L.) Pupae (Lueng Parroj var.) and Their In Vitro Skin Moisturization

Susirirut, P., Thitipramote, N., & Chaiwut, P. (2023) · Molecules · doi:10.3390/molecules28207032 · Cited by 13

Autonomous Multi-modality Burn Wound Characterization using Artificial Intelligence

Jacobson, M. J., Masry, M. S. E., Chanci, D., Tricas, M. R., Gnyawali, S. C., Zhang, X., Gordillo, G. M., Xue, Y., Sen, C. K., & Wachs, J. P. (2023) · Military Medicine · doi:10.1093/milmed/usad301 · Cited by 13

Short‐wave infrared light imaging measures tissue moisture and distinguishes superficial from deep burns

Mironov, S. V., Hwang, C. D., Nemzek, J. A., Li, J., Ranganathan, K., Butts, J. T., Cholok, D. J., Dolgachev, V. A., Wang, S. C., Hemmila, M. R., et al. (2019) · Wound Repair and Regeneration · doi:10.1111/wrr.12779 · Cited by 13

The curative effects of the traditional Chinese herbal medicine “Jinchuang ointment” on excisional wounds

Ho, T., Chen, J.-K., Li, T. S., Lin, J.-H., Hsu, Y., Wu, J., Tsai, W.-T., & Chen, H. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00324-y · Cited by 13

Wound Healing Driver Gene and Therapeutic Development: Political and Scientific Hurdles

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