The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging
Abstract
OBJECTIVES: To determine the relationships between recreational activity, house/yard work activity, work activity, and total physical activity and high levels of two peripheral blood markers of inflammation: interleukin-6 (IL-6) and C-reactive protein (CRP). DESIGN: Cross-sectional study. SETTING: Three communities (Durham, NC; New Haven, CT; and East Boston, MA). PARTICIPANTS: Eight hundred seventy persons aged 70 to 79 who were in the top third of community-dwelling older persons with respect to physical and cognitive functioning. MEASUREMENTS: Blood levels of IL-6 and CRP and self-reported recreational activity, house/yard work activity, work activity, and total physical activity. RESULTS: The adjusted odds ratios (AORs) for individuals with high levels of recreational activity to have values in the top tertiles of IL-6 and CRP were 0.65 (95% confidence interval (CI) = 0.48-0.87) and 0.70 (95% CI = 0.51-0.95), respectively. The AORs for those with a high level of house/yard work activity to have values in the top tertile of IL-6 and CRP were 0.90 (95% CI = 0.67-1.20) and 0.70 (95% CI = 0.50-0.96), respectively. High levels of house/yard work and recreational activity were independently associated with lower risk of high CRP. CONCLUSION: The association between high levels of recreational activity and lower levels of the inflammatory markers IL-6 and CRP suggests a mechanism for its protective effect and supports interventions that increase physical activity in older persons. Such potential benefits of increased physical activity on inflammatory markers will need to be confirmed in clinical trials.
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“The exaggerated postprandial inflammatory response of the obese is reversible upon reduction of body weight (155,164) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [164]
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“¼ CRP, IL-6, sTNFR1, sTNFR2, PAI-1”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [164]
Citations
Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Pfeiffer, E. A. (1975) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1975.tb00927.x · Cited by 5,320
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., & Wallace, R. B. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503023320902 · Cited by 4,083
Interleukin-6 and the acute phase response
Heinrich, P. C., Castell, J. V., & Andus, T. (1990) · Biochemical Journal · doi:10.1042/bj2650621 · Cited by 2,734
Katz, S. (1963) · JAMA · doi:10.1001/jama.1963.03060120024016 · Cited by 2,421
Danesh, J., Collins, R., Appleby, P. N., & Peto, R. (1998) · JAMA · doi:10.1001/jama.279.18.1477 · Cited by 2,027
PHYSICAL ACTIVITY AS AN INDEX OF HEART ATTACK RISK IN COLLEGE ALUMNI1
PAFFENBARGER, R. S., WING, A. L., & HYDE, R. T. (1978) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112608 · Cited by 1,980
Endres, S., Ghorbani, R., Kelley, V. E., Georgilis, K., Lonnemann, G., van der Meer, J. W. M., Cannon, J. G., Rogers, T. S., Klempner, M. S., Weber, P. C., et al. (1989) · New England Journal of Medicine · doi:10.1056/nejm198902023200501 · Cited by 1,911
Stuck, A. E., Walthert, J. M., Nikolaus, T., Büla, C., Hohmann, C., & Beck, J. C. (1999) · Social Science & Medicine · doi:10.1016/s0277-9536(98)00370-0 · Cited by 1,887
A questionnaire for the assessment of leisure time physical activities
Taylor, H. L., Jacobs, D. R., Schucker, B., Knudsen, J., Leon, A. S., & Debacker, G. (1978) · Journal of Chronic Diseases · doi:10.1016/0021-9681(78)90058-9 · Cited by 1,848
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Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Proinflammatory Cytokines, Aging, and Age-Related Diseases
Michaud, M., Balardy, L., Moulis, G., Gaudin, C., Peyrot, C., Vellas, B., Cesari, M., & Nourhashemi, F. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.009 · Cited by 1,094
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Metadata
- Authors
- Reuben, D. B., Judd‐Hamilton, L., Harris, T. B., & Seeman, T. E.
- Affiliations
- University of California, Los Angeles (US)
- National Institutes of Health (US)
- Corresponding author
- Reuben, David B.
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2003-07-31
- Volume
- 51
- Issue
- 8
- Pages
- 1125-1130
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2024594664
- Cited by
- 224
- References
- 29
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 15 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 15 · 2014: 10 · 2013: 12 · 2012: 17
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Keywords
- physical activity, inflammation, interleukin-6, C-reactive protein, older adults, recreational activities, work activities, successful aging, community-dwelling older adults, cognitive function
- MeSH terms
- Aged, Aging, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Leisure Activities, Male, Physical Fitness, United States, Geriatric Assessment, Interleukin-6, Logistic Models, Statistics, Nonparametric
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