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Cited by 224Physical Activity and HealthExercise and Physiological ResponsesAging and Gerontology Research

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

The associations between physical activity and inflammatory markers in high-functioning older persons: MacArthur Studies of Successful Aging

Reuben, David B., Judd‐Hamilton, Leslie, Harris, Tamara B., Seeman, Teresa E.·2003·Journal of the American Geriatrics Society
DOI 10.1046/j.1532-5415.2003.51380.x
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Abstract

OBJECTIVES: To determine the relationships between recreational activity, house/yard work activity, work activity, and total physical activity and high levels of two peripheral blood markers of inflammation: interleukin-6 (IL-6) and C-reactive protein (CRP). DESIGN: Cross-sectional study. SETTING: Three communities (Durham, NC; New Haven, CT; and East Boston, MA). PARTICIPANTS: Eight hundred seventy persons aged 70 to 79 who were in the top third of community-dwelling older persons with respect to physical and cognitive functioning. MEASUREMENTS: Blood levels of IL-6 and CRP and self-reported recreational activity, house/yard work activity, work activity, and total physical activity. RESULTS: The adjusted odds ratios (AORs) for individuals with high levels of recreational activity to have values in the top tertiles of IL-6 and CRP were 0.65 (95% confidence interval (CI) = 0.48-0.87) and 0.70 (95% CI = 0.51-0.95), respectively. The AORs for those with a high level of house/yard work activity to have values in the top tertile of IL-6 and CRP were 0.90 (95% CI = 0.67-1.20) and 0.70 (95% CI = 0.50-0.96), respectively. High levels of house/yard work and recreational activity were independently associated with lower risk of high CRP. CONCLUSION: The association between high levels of recreational activity and lower levels of the inflammatory markers IL-6 and CRP suggests a mechanism for its protective effect and supports interventions that increase physical activity in older persons. Such potential benefits of increased physical activity on inflammatory markers will need to be confirmed in clinical trials.

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Metadata

Authors
Reuben, D. B., Judd‐Hamilton, L., Harris, T. B., & Seeman, T. E.
Affiliations
  • University of California, Los Angeles (US)
  • National Institutes of Health (US)
Corresponding author
Reuben, David B.
ORCID
Venue
Journal of the American Geriatrics Society
Publisher
Wiley
Published
2003-07-31
Volume
51
Issue
8
Pages
1125-1130
ISSN
  • 0002-8614 (ISSN-L)
  • 1532-5415
DOI
10.1046/j.1532-5415.2003.51380.x
OpenAlex
W2024594664
Cited by
224
References
29
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 15 · 2021: 5 · 2020: 7 · 2019: 10 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 15 · 2014: 10 · 2013: 12 · 2012: 17
FWCI
6.71
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of the American Geriatrics Society (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
Keywords
physical activity, inflammation, interleukin-6, C-reactive protein, older adults, recreational activities, work activities, successful aging, community-dwelling older adults, cognitive function
MeSH terms
Aged, Aging, C-Reactive Protein, Cross-Sectional Studies, Female, Humans, Leisure Activities, Male, Physical Fitness, United States, Geriatric Assessment, Interleukin-6, Logistic Models, Statistics, Nonparametric

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