PSC-IBD: a unique form of inflammatory bowel disease associated with primary sclerosing cholangitis
Open accessAbstract
Background: Inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD) may have a high prevalence of rectal sparing, backwash ileitis, and colorectal neoplasia. Aims: To describe the clinical features and outcomes of PSC-IBD and compare these to a group of chronic ulcerative colitis (CUC) patients. Methods: The medical records of all patients with PSC-IBD evaluated at the Mayo Clinic Rochester between 1987 and 1992 were abstracted for information on endoscopic and histological features, colorectal neoplasia, surgery, and other clinical outcomes. Patients referred for colorectal neoplasia and those who did not undergo colonoscopy with biopsies were excluded. A control group of CUC patients matched for sex, duration of IBD at first clinic visit, and calendar year of first clinic visit was identified, and similar information was abstracted. Results: Seventy one PSC-IBD patients and 142 CUC patients without PSC were identified. Rectal sparing and backwash ileitis were more common in the PSC-IBD group (52% and 51%, respectively) than in controls (6% and 7%, respectively). Overall, colorectal neoplasia developed in 18 cases and 15 controls, including 11 cancers (seven cases and four controls). An increased risk of colorectal neoplasia or death was not detected in a matched analysis. Although the cumulative incidence of colorectal neoplasia was higher in cases (33%) than in controls (13%) at five years, this was of borderline statistical significance (p = 0.054, unmatched log rank test). Overall survival from first clinic visit was significantly worse among cases (79% v 97%) at five years (p<0.001, unmatched log rank test). Conclusion: PSC-IBD is frequently characterised by rectal sparing and backwash ileitis. Colorectal neoplasia develops in a substantial fraction and overall survival is worse. PSC-IBD may represent a distinct IBD phenotype.
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PSC-IBD generally runs a mild disease course.
“PSC-IBD generally runs a mild disease course.351,352,357”
From EASL Clinical Practice Guidelines on sclerosing cholangitis (2022) · cites this paper as [351]
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Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
Chapman, R. W., Arborgh, B., Rhodes, J. M., Summerfield, J. A., Dick, R., Scheuer, P. J., & Sherlock, S. (1980) · Gut · doi:10.1136/gut.21.10.870 · Cited by 732 · see citing works
Hepatic and extrahepatic malignancies in primary sclerosing cholangitis
Bergquist, A., Ekbom, A., Olsson, R., Kornfeldt, D., Lööf, L., Danielsson, Å., Hultcrantz, R., Lindgren, S., Prytz, H., Sandberg-Gertzén, H., et al. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(01)00288-4 · Cited by 717 · see citing works
Penna, C., Dozois, R. R., Tremaine, W. J., Sandborn, W. J., LaRusso, N. A., Schleck, C. D., & Ilstrup, D. M. (1996) · Gut · doi:10.1136/gut.38.2.234 · Cited by 559 · see citing works
Self-citationPardi, D. S., Loftus, E. V., Kremers, W. K., Keach, J. C., & Lindor, K. D. (2003) · Gastroenterology · doi:10.1053/gast.2003.50156 · Cited by 557 · see citing works
Self-citationClinicopathologic features of the syndrome of primary sclerosing cholangitis
Wiesner, R. H., & LaRusso, N. F. (1980) · Gastroenterology · doi:10.1016/0016-5085(80)90131-6 · Cited by 556 · see citing works
Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential
Broomé, U., Löfberg, R., VERESS, B., & Eriksson, L. S. (1995) · Hepatology · doi:10.1002/hep.1840220511 · Cited by 492 · see citing works
Tung, B. Y., Emond, M. J., Haggitt, R. C., Bronner, M. P., Kimmey, M. B., Kowdley, K. V., & Brentnall, T. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-2-200101160-00008 · Cited by 466 · see citing works
Cholangiocarcinoma Complicating Primary Sclerosing Cholangitis
Rosen, C. B. B., Nagorney, D. M., Wiesner, R. H., Coffey, R. J., & LaRusso, N. F. (1991) · Annals of Surgery · doi:10.1097/00000658-199101000-00004 · Cited by 389 · see citing works
Primary Sclerosing Cholangitis
LaRusso, N. F., Wiesner, R. H., Ludwig, J., & MacCarty, R. L. (1984) · New England Journal of Medicine · doi:10.1056/nejm198404053101407 · Cited by 355 · see citing works
Brentnall, T., Haggitt, R. C., Rabinovitch, P. S., Kimmey, M., Bronner, M., Ds, L., Kowdley, K. V., Stevens, A. C., Crispin, D. A., Emond, M. J., et al. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566577 · Cited by 335 · see citing works
Primary sclerosing cholangitis: findings on cholangiography and pancreatography.
MacCarty, R. L., LaRusso, N. F., Wiesner, R. H., & Ludwig, J. (1983) · Radiology · doi:10.1148/radiology.149.1.6412283 · Cited by 331 · see citing works
Marchesa, P., Lashner, B. A., Lavery, I. C., Milsom, J. W., Hull, T. L., Strong, S. A., Church, J. M., Navarro, G., & Fazio, V. W. (1997) · PubMed · Cited by 330 · see citing works
Relationship of Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
FAUSA, O., Schrumpf, E., & Elgjo, K. M. (1991) · Seminars in Liver Disease · doi:10.1055/s-2008-1040420 · Cited by 286 · see citing works
Primary Sclerosing Cholangitis: A Long-Term Follow-up Study
Aadland, E., Schrumpf, E., FAUSA, O., Elgjo, K. M., Heilo, A., Aakhus, T., & Gjone., E. (1987) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365528709011139 · Cited by 274 · see citing works
Kornfeld, D., Ekbom, A., & Ihre, T. (1997) · Gut · doi:10.1136/gut.41.4.522 · Cited by 253 · see citing works
The Risk for Cancer Or Dysplasia in Ulcerative Colitis Patients With Primary Sclerosing Cholangitis
Shetty, K., Rybicki, L. A., Brzezinski, A., Carey, W. D., & Lashner, B. A. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01156.x · Cited by 245 · see citing works
Broomé, U., Lindberg, G., & Löfberg, R. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90308-l · Cited by 193 · see citing works
Wee, A., Ludwig, J., Coffey, R. J., LaRusso, N. F., & Wiesner, R. H. (1985) · Human Pathology · doi:10.1016/s0046-8177(85)80158-1 · Cited by 190 · see citing works
Risk factors of colorectal cancer in inflammatory bowel disease.
Bansal, P., & Sonnenberg, A. (1996) · PubMed · Cited by 169 · see citing works
Lundqvist, K., & Broomé, U. (1997) · Diseases of the Colon & Rectum · doi:10.1007/bf02258391 · Cited by 159 · see citing works
Primary sclerosing cholangitis and ulcerative colitis: Evidence for increased neoplastic potential*1
Broomé, U. (1995) · Hepatology · doi:10.1016/0270-9139(95)90144-2 · Cited by 150 · see citing works
Risk of colorectal neoplasia in patients with primary sclerosing cholangitis
Loftus, E. V., Sandborn, W., Tremaine, W., Mahoney, D., Zinsmeister, A., Offord, K., & Melton, L. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566590 · Cited by 136 · see citing works
Self-citationLindberg, B. U., Broomé, U., & Persson, B. (2001) · Diseases of the Colon & Rectum · doi:10.1007/bf02234825 · Cited by 120 · see citing works
D’Haens, G., Lashner, B. A., & Hanauer, S. B. (1993) · PubMed · Cited by 108 · see citing works
Subclinical time span of inflammatory bowel disease in patients with primary sclerosing cholangitis
Broomé, U., Löfberg, R., Lundqvist, K., & VERESS, B. (1995) · Diseases of the Colon & Rectum · doi:10.1007/bf02049156 · Cited by 105 · see citing works
Current Concepts in Primary Sclerosing Cholangitis
Wiesner, R. H. (1994) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)61822-9 · Cited by 101 · see citing works
Jayaram, H., SATSANGI, J., & Chapman, R. W. (2001) · Gut · doi:10.1136/gut.48.3.430 · Cited by 100 · see citing works
Interactions Between Chronic Liver Disease and Inflammatory Bowel Disease
Loftus, E. V., Sandborn, W. J., Lindor, K. D., & LaRusso, N. F. (1997) · Inflammatory Bowel Diseases · doi:10.1002/ibd.3780030408 · Cited by 81 · see citing works
Self-citationKartheuser, A. H., Dozois, R. R., Larusso, N. F., Wiesner, R. H., Lstrup, D. M., & Schleck, C. D. (1996) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)64839-8 · Cited by 74 · see citing works
Colorectal neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis
Gürbüz, A. K., Giardiello, F. M., & Bayless, T. M. (1995) · Diseases of the Colon & Rectum · doi:10.1007/bf02053855 · Cited by 66 · see citing works
Interactions Between Chronic Liver Disease and Inflammatory Bowel Disease
Loftus, E. V., Sandborn, W. J., Lindor, K. D., et al. (1997) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199712000-00007 · Cited by 61 · see citing works
Self-citationLeidenius, M., Färkkilä, M. A., Kärkkäinen, P. A., Taskinen, E., Kellokumpu, I., & Höckerstedt, K. A. V. (1997) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529708996522 · Cited by 58 · see citing works
Induction of tumor necrosis factor-? as a cause of bleomycin-related toxicity
Sleijfer, S., Vujašković, Ž., Limburg, P. C., Koops, H. S., & Mulder, N. H. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980301)82:5 · Cited by 37 · see citing works
Stockbrügger, R. W., Olsson, R., Jaup, B. H., & Jensen, J. (1988) · PubMed · Cited by 34 · see citing works
Relationship between colorectal neoplasia and primary sclerosing cholangitis in ulcerative colitis
Choi, P. M., Nugent, F. W., & Rossi, R. L. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91211-l · Cited by 32 · see citing works
Mattila, J. J., Aitola, P. T., & Matikainen, M. (2000) · International Journal of Colorectal Disease · doi:10.1007/s003840000223 · Cited by 19 · see citing works
Kartheuser, A. H., Dozois, R. R., LaRusso, N. F., et al. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.8.748 · Cited by 13 · see citing works
Controlled clinical trials: The controls are the key
Ahnen, D. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.agast960628 · Cited by 12 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Perdigoto R, Wiesner RH, LaRusso NF, et al. Inflammatory bowel disease assoicated with primary sclerosing cholangitis: incidence, severity and relationship to liver disease. Gastroenterology 1991;100:A238.
- Nuako KW, Ahlquist DA, Sandborn WJ, et al. Primary sclerosing cholangitis and colorectal carcinoma in patients with chronic ulcerative colitis: a case- control study. Cancer 1998;82:822-6.
- Cox DR. Regression models and life-tables (with discussion). J Royal Stat Soc 1972;34:187-220.
Cited by
Sorted by citations
EASL Clinical Practice Guidelines: management of cholestatic liver diseases
European Association for the Study of the Liver (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.009 · Cited by 1,729 · see citing works
The role of the gut microbiota in NAFLD
Leung, C., Rivera, L., Furness, J. B., & Angus, P. W. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.85 · Cited by 1,020 · see citing works
Primary sclerosing cholangitis – a comprehensive review
Karlsen, T. H., Folseraas, T., Thorburn, D., & Vesterhus, M. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.07.022 · Cited by 868 · see citing works
The International IBD Genetics Consortium (IIBDGC), Ellinghaus, D., International Genetics of Ankylosing Spondylitis Consortium (IGAS), International PSC Study Group (IPSCSG), Genetic Analysis of Psoriasis Consortium (GAPC), Psoriasis Association Genetics Extension (PAGE), Jostins, L., Spain, S. L., Cortes, A., Bethune, J., et al. (2016) · Nature Genetics · doi:10.1038/ng.3528 · Cited by 751 · see citing works
Psychological stress in IBD: new insights into pathogenic and therapeutic implications
Mawdsley, J. E., & Rampton, D. S. (2005) · Gut · doi:10.1136/gut.2005.064261 · Cited by 622 · see citing works
The bile acid TGR5 membrane receptor: from basic research to clinical application
Duboc, H., Taché, Y., & Hofmann, A. F. (2014) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.10.021 · Cited by 473 · see citing works
Kummen, M., Holm, K., Anmarkrud, J. A., Nygård, S., Vesterhus, M., Høivik, M. L., Trøseid, M., Marschall, H.-U., Schrumpf, E., Moum, B., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310500 · Cited by 426 · see citing works
Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0333-1 · Cited by 425 · see citing works
EASL Clinical Practice Guidelines on sclerosing cholangitis
Chazouilleres, O., Beuers, U., Bergquist, A., Karlsen, T. H., Levy, C., Samyn, M., Schramm, C., & Trauner, M. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.05.011 · Cited by 419 · see citing works
Alabraba, E., Nightingale, P., Gunson, B., Hubscher, S., Olliff, S., Mirza, D., & Neuberger, J. (2009) · Liver Transplantation · doi:10.1002/lt.21679 · Cited by 298 · see citing works
Chapman, M. H., Thorburn, D., Hirschfield, G. M., Webster, G. G. J., Rushbrook, S. M., Alexander, G., Collier, J., Dyson, J. K., Jones, D. E., Patanwala, I., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317993 · Cited by 284 · see citing works
Pathogenesis of cholestatic liver disease and therapeutic approaches
Hirschfield, G. M., Heathcote, E. J., & Gershwin, M. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.004 · Cited by 287 · see citing works
Kaplan, G. G., Laupland, K. B., Butzner, D., Urbanski, S. J., & Lee, S. S. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01103.x · Cited by 273 · see citing works
Aabakken, L., Karlsen, T., Albert, J., Arvanitakis, M., Chazouilleres, O., Dumonceau, J.-M., Färkkilä, M., Fickert, P., Hirschfield, G., Laghi, A., et al. (2017) · Endoscopy · doi:10.1055/s-0043-107029 · Cited by 255 · see citing works
Distinctive inflammatory bowel disease phenotype in primary sclerosing cholangitis
Vries, A. B. D. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i6.1956 · Cited by 253 · see citing works
Autoimmune liver disease, autoimmunity and liver transplantation
Carbone, M., & Neuberger, J. M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.020 · Cited by 250 · see citing works
Lunder, A. K., Hov, J. R., Borthne, A., Gleditsch, J., Johannesen, G., Tveit, K., Viktil, E., Henriksen, M., Hovde, Ø., Huppertz-Hauss, G., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.06.021 · Cited by 212 · see citing works
Autoantibodies in primary sclerosing cholangitis
Hov, J. R., Boberg, K. M., & Karlsen, T. H. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3781 · Cited by 187 · see citing works
Bergquist, A., Montgomery, S. M., Bahmanyar, S., Olsson, R., Danielsson, Å., Lindgren, S., Prytz, H., Hultcrantz, R., Lööf, L., Sandberg–Gertzén, H., et al. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.03.016 · Cited by 188 · see citing works
Risk factors for recurrent primary sclerosing cholangitis after liver transplantation
Ravikumar, R., Tsochatzis, E., Jose, S., Allison, M., Athale, A., Creamer, F., Gunson, B., Iyer, V., Madanur, M., Manas, D., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.005 · Cited by 173 · see citing works
Genetics of primary sclerosing cholangitis and pathophysiological implications
Jiang, X., & Karlsen, T. H. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.154 · Cited by 155 · see citing works
Zheng, H.-H., & Jiang, X.-L. (2016) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000576 · Cited by 159 · see citing works
Jrgensen, K. K., Grzyb, K., Lundin, K. E. A., Clausen, O. P. F., Aamodt, G., Schrumpf, E., Vatn, M. H., & Boberg, K. M. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21699 · Cited by 149 · see citing works
The features of mucosa‐associated microbiota in primary sclerosing cholangitis
Torres, J., Bao, X., Goel, A., Colombel, J. ‐., Pekow, J., Jabri, B., Williams, K. M., Castillo, A., Odin, J. A., Meckel, K., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13552 · Cited by 149 · see citing works
Tedesco, D., Thapa, M., Chin, C. Y., Ge, Y., Gong, M., Li, J., Gumber, S., Speck, P., Elrod, E. J., Burd, E. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.02.019 · Cited by 137 · see citing works
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Singh, S., & Talwalkar, J. A. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.016 · Cited by 119 · see citing works
Shah, S. C., ten Hove, J. R., Castaneda, D., Palmela, C., Mooiweer, E., Colombel, J.-F., Harpaz, N., Ullman, T. A., van Bodegraven, A. A., Jansen, J. M., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.01.023 · Cited by 109 · see citing works
Aabakken, L., Karlsen, T. H., Albert, J., Arvanitakis, M., Chazouilleres, O., Dumonceau, J.-M., Färkkilä, M., Fickert, P., Hirschfield, G. M., Laghi, A., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.02.013 · Cited by 107 · see citing works
Lynch, K. D., Chapman, R. W., Keshav, S., Montano-Loza, A. J., Mason, A. L., Kremer, A. E., Vetter, M., de Krijger, M., Ponsioen, C. Y., Trivedi, P., et al. (2020) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2019.05.013 · Cited by 105 · see citing works
Joshi, D., Bjarnason, I., Belgaumkar, A., O'Grady, J., Suddle, A., Heneghan, M. A., Aluvihare, V., Rela, M., Heaton, N., & Agarwal, K. (2013) · Liver International · doi:10.1111/j.1478-3231.2011.02677.x · Cited by 99 · see citing works
The IBD and PSC phenotypes of PSC-IBD
Ricciuto, A., Kamath, B. M., & Griffiths, A. M. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0620-2 · Cited by 94 · see citing works
Ponsioen, C. Y., Assis, D. N., Boberg, K. M., Bowlus, C. L., Deneau, M., Thorburn, D., Aabakken, L., Färkkilä, M., Petersen, B., Rupp, C., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.07.046 · Cited by 95 · see citing works
Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis
Tabibian, J. H., Talwalkar, J. A., & Lindor, K. D. (2013) · BioMed Research International · doi:10.1155/2013/389537 · Cited by 91 · see citing works
Krugliak Cleveland, N., Rubin, D. T., Hart, J., Weber, C. R., Meckel, K., Tran, A. L., Aelvoet, A. S., Pan, I., Gonsalves, A., Gaetano, J. N., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2017.07.023 · Cited by 85 · see citing works
Jendrek, S. T., Gotthardt, D., Nitzsche, T., Widmann, L., Korf, T., Michaels, M. A., Weiss, K.-H., Liaskou, E., Vesterhus, M., Karlsen, T. H., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-311739 · Cited by 83 · see citing works
Fevery, J., Van Steenbergen, W., Van Pelt, J., Laleman, W., Hoffman, I., Geboes, K., Vermeire, S., & Nevens, F. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13516 · Cited by 61 · see citing works
Ricciuto, A., Fish, J., Carman, N., Walters, T. D., Church, P. C., Hansen, B. E., Crowley, E., Siddiqui, I., Nguyen, G. C., Kamath, B. M., et al. (2018) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.01.020 · Cited by 47 · see citing works
Peverelle, M., Paleri, S., Hughes, J., De Cruz, P., & Gow, P. J. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz325 · Cited by 47 · see citing works
Barnes, E. L., Holubar, S. D., & Herfarth, H. H. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjab025 · Cited by 42 · see citing works
Epigenetics in the primary biliary cholangitis and primary sclerosing cholangitis
Cheung, A., LaRusso, N., Gores, G., & Lazaridis, K. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1603324 · Cited by 37 · see citing works
Kumagai, J., Taida, T., Ogasawara, S., Nakagawa, T., Iino, Y., Shingyoji, A., Ishikawa, K., Akizue, N., Yamato, M., Takahashi, K., et al. (2018) · PLOS ONE · doi:10.1371/journal.pone.0209352 · Cited by 29 · see citing works
Wang, M.-H., Mousa, O. Y., Friton, J. J., Raffals, L. E., Leighton, J. A., Pasha, S. F., Picco, M. F., Cushing, K. C., Monroe, K., Nix, B. D., et al. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz209 · Cited by 27 · see citing works
Yang, J., Hirai, Y., Imamura, S., Tsuchiya, T., Tabata, O., & Kamei, K.-I. (2022) · doi:10.1101/2022.01.31.478467 · Cited by 21 · see citing works
- Authors
- Loftus, E. V., Harewood, G. C., Loftus, C. G., Tremaine, W. J., Harmsen, W. S., Zinsmeister, A. R., Jewell, D. A., & Sandborn, W. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Loftus, E V
- Loftus, C G
- ORCID
- Loftus, E V
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2004-12-10
- Volume
- 54
- Issue
- 1
- Pages
- 91-96
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1774346
- OpenAlex
- W1992431640
- Cited by
- 777
- References
- 40
- Citations by year
- 2026: 17 · 2025: 31 · 2024: 34 · 2023: 39 · 2022: 33 · 2021: 33 · 2020: 68 · 2019: 45 · 2018: 41 · 2017: 44 · 2016: 50 · 2015: 44 · 2014: 41 · 2013: 53 · 2012: 42
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- inflammatory bowel disease, primary sclerosing cholangitis, rectal sparing, backwash ileitis, colorectal neoplasia, colorectal cancer, ulcerative colitis, overall survival, IBD phenotypes, clinical outcomes
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Colitis, Ulcerative, Female, Humans, Ileitis, Male, Middle Aged, Prognosis, Colorectal Neoplasms, Cholangitis, Sclerosing, Inflammatory Bowel Diseases, Survival Analysis, Case-Control Studies, Disease-Free Survival
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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