The DOI matches its Crossref record; 120 of the 121 references it cites were found in a registry or an index.
The Intestinal Microenvironment and Functional Gastrointestinal Disorders
Open accessAbstract
For decades, interactions between the enteric neuromuscular apparatus and the central nervous system have served as the primary focus of pathophysiological research in the functional gastrointestinal disorders. The accumulation of patient reports, as well as clinical observations, has belatedly led to an interest in the role of various luminal factors and their interactions with each other and the host in functional gastrointestinal disorders. Most prominent among these factors has been the role of food. As a consequence, while not always evidence-based, dietary interventions are enjoying a renaissance in irritable bowel syndrome management. Not surprisingly, given its exploration in many disease states, the gut microbiota has also been studied in functional gastrointestinal disorders; data remain inconclusive. Likewise, there is also a considerable body of experimental and some clinical data to link functional gastrointestinal disorders pathogenesis to disturbances in epithelial barrier integrity, abnormal entero-endocrine signaling and immune activation. These data provide growing evidence supporting the existence of micro-organic changes, particularly in subgroups of patients with functional dyspepsia and IBS. However, their exact role in the complex pathophysiology and symptom generation of functional gastrointestinal disorders needs to be further studied and elucidated particularly with longitudinal and interventional studies.
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“Yet, gastrointestinal flora disorder, mild mucosal inflammation, chronic immune activation, changes in intestinal permeability, and psychosocial factors are implicated in IBS [4,15,16,17].”
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“An increase in mucosal immune cells including mast cells, macrophages or monocytes, T-cells, and eosinophils has been reported in both pediatric and adult FGID populations79, 113, 114.”
From The gut Microbiome in adult and pediatric functional gastrointestinal disorders (2019) · cites this paper as [114]
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Human gut microbiome viewed across age and geography
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Intestinal mucosal barrier function in health and disease
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The role of the gut microbiota in nutrition and health
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Intestinal permeability – a new target for disease prevention and therapy
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Self-citationThe Oslo definitions for coeliac disease and related terms
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Self-citationClaudins and the Modulation of Tight Junction Permeability
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Rome IV—Functional GI Disorders: Disorders of Gut-Brain Interaction
Drossman, D. A., & Hasler, W. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.03.035 · Cited by 1,928
ACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893
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Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
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Metadata
- Authors
- Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M.
- Affiliations
- University of Bologna (IT)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Vall d'Hebron Institut de Recerca (ES)
- Queen's University (CA)
- Université Toulouse III - Paul Sabatier (FR)
- Wageningen University & Research (NL)
- Houston Methodist (US)
- Corresponding author
- Barbara, Giovanni
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 150
- Issue
- 6
- Pages
- 1305-1318.e8
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2344284541
- Cited by
- 335
- References
- 121
- Citations by year
- 2026: 26 · 2025: 21 · 2024: 25 · 2023: 32 · 2022: 50 · 2021: 38 · 2020: 31 · 2019: 32 · 2018: 31 · 2017: 38 · 2016: 11
- FWCI
- 40.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Socio-Environmental Systems Modeling (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- intestinal microenvironment, functional gastrointestinal disorders, irritable bowel syndrome, functional dyspepsia, gut microbiota, dietary intervention, epithelial barrier integrity, immune activation, enteric nervous system, pathogenesis
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