The effect of n-3 fatty acids on C-reactive protein levels in patients with chronic renal failure
Abstract
Background Cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic renal failure (CRF). C-reactive protein (CRP), a strong independent risk marker of CVD, is elevated in a large proportion of patients with CRF. The long-chain n-3 polyunsaturated fatty acids (PUFA) have cardioprotective effects, which may be partly attributed to their anti-inflammatory properties.Objective The study objective was to investigate the effect of n-3 PUFA on serum levels of CRP in patients with CRF.Design We performed a randomized, double-blind, placebo-controlled study.Setting The study took place at an outpatients clinic at the Department of Nephrology, Aalborg Hospital, Denmark.Patients The study comprised 46 patients (30 men and 16 women; mean age 59 +/- 11 years) with a serum creatinine level in the range of 150 to 400 micromol/L.Intervention The patients were randomly assigned to daily supplementation with 2.4 g n-3 PUFA or identical capsules containing 2.4 g of olive oil (control) for 8 weeks.Main outcome measure CRP was measured with a high-sensitivity C-reactive protein (hs-CRP) assay and the content of n-3 PUFA in granulocyte membranes before and after supplementation.Results The n-3 PUFA concentration increased in granulocytes after the n-3 PUFA supplements but was unaltered by the control oil. A nonsignificant reduction in hs-CRP was observed in the n-3 PUFA group after supplementation (2.46 vs. 1.47 mg/L; P = .06), and hs-CRP was unaltered by the control oil (3.27 vs. 3.14 mg/L; P = .12). There was no difference in median hs-CRP change in the two groups.Conclusion A trend was seen toward a reduction in hs-CRP in the n-3 PUFA group, but there was no significant difference in hs-CRP levels when both groups were compared.
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In 974 subjects aged 42-87 years, dietary GI is positively associated with CRP concentration.
“In another study in 974 subjects aged 42-87 years, dietary GI was positively associated with CRP concentration (673) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [673]
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- Authors
- Madsen, T., Schmidt, E. B., & Christensen, J. H.
- Affiliations
- Aalborg University Hospital (DK)
- Corresponding author
- Madsen, Trine
- Venue
- Journal of Renal Nutrition
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 17
- Issue
- 4
- Pages
- 258-263
- ISSN
- 1051-2276 (ISSN-L)
- OpenAlex
- W2077479591
- Cited by
- 52
- References
- 30
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 7 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Renal Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- omega-3 fatty acids, C-reactive protein, chronic kidney disease, omega-3 supplementation, cardiovascular risk, inflammation, olive oil placebo, high-sensitivity C-reactive protein
- MeSH terms
- Olive Oil, Adult, Aged, C-Reactive Protein, Cardiovascular Diseases, Cell Membrane, Creatinine, Dietary Fats, Unsaturated, Double-Blind Method, Female, Granulocytes, Humans, Kidney Failure, Chronic, Male, Middle Aged, Plant Oils, Risk Factors, Fatty Acids, Omega-3, Treatment Outcome, Dietary Supplements
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