The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer
Open accessAbstract
Observational studies have suggested that lifestyle risk factors such as tobacco, alcohol, high-fat diet, radiation, and infections can cause cancer and that a diet consisting of fruits and vegetables can prevent cancer. Evidence from our laboratory and others suggests that agents either causing or preventing cancer are linked through the regulation of inflammatory pathways. Genes regulated by the transcription factor NF- kappaB have been shown to mediate inflammation, cellular transformation, tumor cell survival, proliferation, invasion, angiogenesis, and metastasis. Whereas various lifestyle risk factors have been found to activate NF- kappaB and NF- kappaB-regulated gene products, flavonoids derived from fruits and vegetables have been found to suppress this pathway. The present review describes various flavones, flavanones, flavonols, isoflavones, anthocyanins, and chalcones derived from fruits, vegetables, legumes, spices, and nuts that can suppress the proinflammatory cell signaling pathways and thus can prevent and even treat the cancer.
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Cited by
Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids
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The STAT3 pathway as a therapeutic target in head and neck cancer: barriers and innovations
Geiger, J. L., Grandis, J. R., & Bauman, J. E. (2016) · Oral Oncology · doi:10.1016/j.oraloncology.2015.11.022 · Cited by 193
Buonocore, D., Nobile, Cestone, Santin, Bottone, Marzatico, Lazzeretti, & Tocabens (2012) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s36102 · Cited by 57
Metadata
- Authors
- Prasad, S., Phromnoi, K., Yadav, V., Chaturvedi, M., & Aggarwal, B.
- Venue
- Planta Medica
- Publisher
- Georg Thieme Verlag KG
- Published
- 2010-07-15
- Volume
- 76
- Issue
- 11
- Pages
- 1044-1063
- ISSN
- 0032-0943 (ISSN-L)
- 1439-0221
- OpenAlex
- W2006049488
- Cited by
- 229
- References
- 14
- FWCI
- 14.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Prasad, S., Phromnoi, K., Yadav, V., Chaturvedi, M., & Aggarwal, B. (2010). Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer. Planta Medica. https://doi.org/10.1055/s-0030-1250111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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