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Cited by 152Natural Antidiabetic Agents StudiesDiet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Cinnamon extract prevents the insulin resistance induced by a high-fructose diet

Bolin Qin, Masaru Nagasaki, M.  Ren, Gustavo Bajotto, Y. Oshida, Youichi Sato·2004·Hormone and Metabolic Research
DOI 10.1055/s-2004-814223
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Abstract

The aim of this study was to determine whether cinnamon extract (CE) would improve the glucose utilization in normal male Wistar rats fed a high-fructose diet (HFD) for three weeks with or without CE added to the drinking water (300 mg/kg/day). In vivo glucose utilization was measured by the euglycemic clamp technique. Further analyses on the possible changes in insulin signaling occurring in skeletal muscle were performed afterwards by Western blotting. At 3 mU/kg/min insulin infusions, the decreased glucose infusion rate (GIR) in HFD-fed rats (60 % of controls, p < 0.01) was improved by CE administration to the same level of controls (normal chow diet) and the improving effect of CE on the GIR of HFD-fed rats was blocked by approximately 50 % by N-monometyl-L-arginine. The same tendency was found during the 30 mU/kg/min insulin infusions. There were no differences in skeletal muscle insulin receptor (IR)-beta, IR substrate (IRS)-1, or phosphatidylinositol (PI) 3-kinase protein content in any groups. However, the muscular insulin-stimulated IR-beta and IRS-1 tyrosine phosphorylation levels and IRS-1 associated with PI 3-kinase in HFD-fed rats were only 70 +/- 9 %, 76 +/- 5 %, and 72 +/- 6 % of controls (p < 0.05), respectively, and these decreases were significantly improved by CE treatment. These results suggest that early CE administration to HFD-fed rats would prevent the development of insulin resistance at least in part by enhancing insulin signaling and possibly via the NO pathway in skeletal muscle.

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  • In rats on a high-fructose diet, cinnamon has been found to prevent insulin resistance by improving insulin signaling, perhaps through skeletal muscle nitric oxide pathways.

    “It has been shown that cinnamon prevents the development of insulin resistance in rats fed a high-fructose diet by enhancing the insulin signaling, possibly via the nitric oxide pathway in skeletal muscle (10).”

    From Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects (2007) · cites this paper as [10]

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Authors
Qin, B., Nagasaki, M., Ren, M., Bajotto, G., Oshida, Y., & Sato, Y.
Affiliations
  • Nagoya University (JP)
  • Research Center of Health, Physical Fitness and Sports, Nagoya University (JP)
ORCID
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2004-02
Volume
36
Issue
2
Pages
119-125
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2004-814223
OpenAlex
W199222752
Cited by
152
References
0
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 8
FWCI
4.55
Type
journal article
Language
en
Open access
closed
Locations
  • Hormone and Metabolic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
cinnamon extract, insulin resistance, high-fructose diet, glucose utilization, skeletal muscle, insulin signaling, IRS-1 tyrosine phosphorylation, PI3-kinase, nitric oxide pathway, L-NMMA, insulin receptor beta
MeSH terms
Animals, Blood Glucose, Body Weight, Cinnamomum zeylanicum, Diet, Dose-Response Relationship, Drug, Eating, Fatty Acids, Nonesterified, Fructose, Glucose, Insulin, Insulin Resistance, Male, Phosphoproteins, Phosphorylation, Plant Extracts, Receptor, Insulin, Tyrosine, Glucose Clamp Technique, Rats, Wistar, Rats, Insulin Receptor Substrate Proteins

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