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Cited by 1,106

The DOI matches its Crossref record.

The Syndromes of Insulin Resistance and Acanthosis Nigricans: Insulin-Receptor Disorders in Man

Kahn, C. Ronald, Flier, Jeffrey S., Bar, Robert S., Archer, Juanita A., Gorden, Phillip, Martin, Malcolm M., Roth, Jesse·1976·New England Journal of Medicine
DOI 10.1056/nejm197604012941401
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Abstract

In six patients with acanthosis nigricans variable degrees of glucose intolerance, hyperinsulinemia and marked resistance to exogenous insulin were found. Studies of insulin receptors on circulating monocytes suggest that the insulin resistance in these patients was due to a marked decrease in insulin binding to its membrane receptors. When these patients were fasted, there was a fall in plasma insulin but no increase in insulin binding, suggesting that the receptor defect was not secondary to the hyperinsulinemia. The clinical features shared by these cases and several similar ones previously reported may be divided into two unique clinical syndromes: Type A, a syndrome in younger females with signs of virilization or accelerated growth, in whom the receptor defect may be primary, and Type B, a syndrome in older females with signs of an immunologic disease, in whom circulating antibodies to the insulin receptor are found.

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Metadata

Authors
Kahn, C. R., Flier, J. S., Bar, R. S., Archer, J. A., Gorden, P., Martin, M. M., & Roth, J.
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1976-04
Volume
294
Issue
14
Pages
739-745
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm197604012941401
OpenAlex
W2340100375
Cited by
1,106
References
0
FWCI
67.88
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.