The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Coffee consumption and the incidence of coronary heart disease.
Open accessAbstract
We conducted a prospective investigation of the effect of coffee consumption on coronary heart disease in 1130 male medical students who were followed for 19 to 35 years. Changes in coffee consumption and cigarette smoking during follow-up were examined in relation to the incidence of clinically evident coronary disease in comparisons of three measures of coffee intake--base-line intake, average intake, and most recent intake reported before the manifestation of coronary disease. Clinical evidence of coronary disease included myocardial infarction, angina, and sudden cardiac death. In separate analyses for each measure of coffee intake, the relative risks for men drinking five or more cups of coffee per day, as compared with nondrinkers, were approximately 2.80 for all three measures in the univariate analyses (maximum width of 95 percent confidence intervals, 1.27 to 6.51). After adjustment for age, current smoking, hypertension status, and base-line level of serum cholesterol, the estimated relative risk for men drinking five or more cups of coffee per day (using the most recent coffee intake measure), as compared with those drinking none, was 2.49 (maximum width of 95 percent confidence interval, 1.08 to 5.77). The association between coffee and coronary disease was strongest when the time between the reports of coffee intake and the coronary event was shortest. These findings support an independent, dose-responsive association of coffee consumption with clinically evident coronary heart disease, which is consistent with a twofold to threefold elevation in risk among heavy coffee drinkers.
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“Among the possible explanations for this dis- crepancy is that some earlier hospital based case-control studies included patients among the controls who may have reduced their intake of coffee after a diagnosis of chronic illness-for example, digestive diseases.'035”
From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]
In the citing paper
“Thus case-control studies that included control patients admitted for chronic conditions may have overestimated the association between coffee consumption and risk of heart disease.'035”
From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]
In the citing paper
“In cohort studies with repeated measurements of exposure assess- ment, the association between heart disease and coffee intake was strongest when the exposure measurement used was nearest to the outcome.'042”
From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]
In the citing paper
“In the study by LaCroix et al the relative risk for five or more cups/day compared with none increased from 1-8 (95% CI 0-8 to 4 0) when intake was assessed 10 or more years previously, to 2-5 (95% CI 1-1 to 5 8) when the intake within the past five years was used.'0”
From Does coffee drinking increase the risk of coronary heart disease? Results from a meta‐analysis (1994) · cites this paper as [10]
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Citations
Cites
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Haynes, S., Levine, S., Scotch, N. A., Feinleib, M., & Kannel, W. B. (1978) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112556 · Cited by 800
Coffee, Alcohol and Risk of Coronary Heart Disease among Japanese Men Living in Hawaii
Yano, K., Rhoads, G. G., & Kagan, A. (1977) · New England Journal of Medicine · doi:10.1056/nejm197708252970801 · Cited by 524
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Cited by
Sorted by citations
Insomnia in Young Men and Subsequent Depression: The Johns Hopkins Precursors Study
Chang, P. P., Ford, D. E., Mead, L. A., Cooper, L. A., & Klag, M. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009241 · Cited by 674
Self-citationScientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613
Serum Cholesterol in Young Men and Subsequent Cardiovascular Disease
Klag, M. J., Ford, D. E., Mead, L. A., He, J., Whelton, P. K., Liang, K., & Levine, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302043280504 · Cited by 518
Self-citationCoffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490
Clinical Pharmacology Of Caffeine
Benowitz, N. L. (1990) · Annual Review of Medicine · doi:10.1146/annurev.me.41.020190.001425 · Cited by 441
Metadata
- Authors
- LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1986-10-16
- Volume
- 315
- Issue
- 16
- Pages
- 977-982
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2054987034
- Cited by
- 183
- References
- 36
- Citations by year
- 2025: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- green
- escholarship.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG001760)
- National Heart, Lung, and Blood Institute (5-T32 HL07024-10, T32HL007024)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- coffee consumption, coronary artery disease, myocardial infarction, angina pectoris, sudden cardiac death, dose-response relationship, cigarette smoking, serum cholesterol, hypertension, men, medical students
- MeSH terms
- Adult, Angina Pectoris, Coffee, Coronary Disease, Death, Sudden, Dose-Response Relationship, Drug, Humans, Hypertension, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk, Smoking
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