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Cited by 183Coffee research and impactsAlcohol Consumption and Health EffectsNutritional Studies and Diet

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Coffee consumption and the incidence of coronary heart disease.

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LaCroix, Andrea Z., Mead, Lucy A., Liang, Kung-Yee, Thomas, Caroline Bedell, Pearson, Thomas A.·1986·New England Journal of Medicine
DOI 10.1056/nejm198610163151601
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Abstract

We conducted a prospective investigation of the effect of coffee consumption on coronary heart disease in 1130 male medical students who were followed for 19 to 35 years. Changes in coffee consumption and cigarette smoking during follow-up were examined in relation to the incidence of clinically evident coronary disease in comparisons of three measures of coffee intake--base-line intake, average intake, and most recent intake reported before the manifestation of coronary disease. Clinical evidence of coronary disease included myocardial infarction, angina, and sudden cardiac death. In separate analyses for each measure of coffee intake, the relative risks for men drinking five or more cups of coffee per day, as compared with nondrinkers, were approximately 2.80 for all three measures in the univariate analyses (maximum width of 95 percent confidence intervals, 1.27 to 6.51). After adjustment for age, current smoking, hypertension status, and base-line level of serum cholesterol, the estimated relative risk for men drinking five or more cups of coffee per day (using the most recent coffee intake measure), as compared with those drinking none, was 2.49 (maximum width of 95 percent confidence interval, 1.08 to 5.77). The association between coffee and coronary disease was strongest when the time between the reports of coffee intake and the coronary event was shortest. These findings support an independent, dose-responsive association of coffee consumption with clinically evident coronary heart disease, which is consistent with a twofold to threefold elevation in risk among heavy coffee drinkers.

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Research works printed but not linked: 4

  1. 1972, Lancet, 2, 1278
  2. Heyden, 1978, Arch Intern Med, 138, 1472, 10.1001/archinte.1978.03630350010006 · DOI
  3. Thomas, 1951, Bull Johns Hopkins Hosp, 89, 419
  4. Peto, 1972, J R Stat Soc Ser (A), 135, 185

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Metadata

Authors
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1986-10-16
Volume
315
Issue
16
Pages
977-982
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm198610163151601
OpenAlex
W2054987034
Cited by
183
References
36
Citations by year
2025: 3 · 2022: 3 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
15.50
Type
journal article
Language
en
Open access
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institute on Aging (R01AG001760)
  • National Heart, Lung, and Blood Institute (5-T32 HL07024-10, T32HL007024)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
coffee consumption, coronary artery disease, myocardial infarction, angina pectoris, sudden cardiac death, dose-response relationship, cigarette smoking, serum cholesterol, hypertension, men, medical students
MeSH terms
Adult, Angina Pectoris, Coffee, Coronary Disease, Death, Sudden, Dose-Response Relationship, Drug, Humans, Hypertension, Male, Middle Aged, Myocardial Infarction, Prospective Studies, Risk, Smoking

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