Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 47 of the 50 references it cites were found in a registry or an index.

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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High density lipoprotein as a protective factor against coronary heart disease
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Self-citation
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Sustained Expression of Human Apolipoprotein A-I after Adenoviral Gene Transfer in C57BL/6 Mice: Role of Apolipoprotein A-I Promoter, Apolipoprotein A-I Introns, and Human Apolipoprotein E Enhancer
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“…Research Clinics Prevalence Mortality Follow-up Study, Coronary Prevention Trial, and Multiple Risk Factor Intervention Trial) demonstrated that a 1-mg/dl increment of HDL cholesterol was associated with a significant 2% cardiovascular risk reduction in men and 3% in women (Gordon et al ., 1989).”
Recent progress in synthesis of nano based liposomal drug delivery systems: A glance to their medicinal applications
Khafoor, A. A., Karim, A. S., & Sajadi, S. M. (2023) · Results in Surfaces and Interfaces · doi:10.1016/j.rsurfi.2023.100124 · Cited by 42
Reconstituted high-density lipoprotein infusion modulates fatty acid metabolism in patients with type 2 diabetes mellitus
Drew, B. G., Carey, A. L., Natoli, A. K., Formosa, M. F., Vizi, D., Reddy-Luthmoodoo, M., Weir, J. M., Barlow, C. K., van Hall, G., Meikle, P. J., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.p012518 · Cited by 42
Differential Effects of Cyproterone Acetate vs Spironolactone on Serum High-Density Lipoprotein and Prolactin Concentrations in the Hormonal Treatment of Transgender Women
Fung, R., Hellstern-Layefsky, M., Tastenhoye, C. A., Lega, I. C., & Steele, L. S. (2016) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2016.09.012 · Cited by 42
HDL metabolism and the role of HDL in the treatment of high-risk patients with cardiovascular disease
Brewer, H. B. (2007) · Current Cardiology Reports · doi:10.1007/bf02938393 · Cited by 42
“Over the past several decades, epidemiologic studies have identified low-density lipoprotein (LDL) cholesterol (LDL-C) and high-density lipoprotein (HDL) cholesterol (HDL-C) as independent risk factors that modulate cardiovascular disease (CVD) risk [1, 2 ].”
Background
Reverse cholesterol transport in man: promotion of fecal steroid excretion by infusion of reconstituted HDL
Angelin, B., Parini, P., & Eriksson, M. (2002) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(02)00047-8 · Cited by 42
Beneficial properties of olive oil
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Molecular Genetic Study of Finns With Hypoalphalipoproteinemia and Hyperalphalipoproteinemia
Miettinen, H. E., Gylling, H., Tenhunen, J., Virtamo, J. R. K., Jauhiainen, M., Huttunen, J. K., Kantola, I. M., Miettinen, T. A., & Kontula, K. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.4.591 · Cited by 42
A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease
Ikewaki, K., Matsunaga, A., Han, H., Watanabe, H., Endo, A., Tohyama, J., Kuno, M., Mogi, J., Sugimoto, K., Tada, N., et al. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.09.024 · Cited by 42
“Plasma concentrations of HDL-cholesterol (C) have strong inverse correlations with risk of atherosclerotic cardiovascular disease [1].”
Background
Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey
Yamakawa‐Kobayashi, K. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.2.331 · Cited by 41
“Data from family and twin studies suggest that genetic variation accounts for 40‐60% of the interindividual variation in serum HDL-C levels (16‐18), although environmental influences, including life style, are also of considerable importance ( 3 ,6,19).”
Background
Influence of apolipoprotein H polymorphism on levels of triglycerides
Cassader, M., Ruiu, G., Gambino, R., Guzzon, F., Pagano, A., Veglia, F., Pagni, R., & Pagano, G. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90066-3 · Cited by 41
Estimation of Multilocus Haplotype Effects Using Weighted Penalised Log‐Likelihood: Analysis of Five Sequence Variations at the Cholesteryl Ester Transfer Protein Gene Locus
Tanck, M. W. T., Klerkx, A. H. E. M., Jukema, J. W., de Knijff, P., Kastelein, J. J. P., & Zwinderman, A. H. (2003) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2003.00021.x · Cited by 41
“Thus, CETP may lower the concentration of atheroprotective HDL particles and is, therefore, often considered pro-atherogenic (Gordon & Rifkind, 1989; Föger et al. 1995).”
Background
HDL as a contrast agent for medical imaging
Cormode, D. P., Frias, J. C., Ma, Y., Chen, W., Skajaa, T., Briley-Saebo, K. C., Barazza, A., Williams, K. J., Mulder, W. J. M., Fayad, Z. A., et al. (2009) · Clinical Lipidology · doi:10.2217/clp.09.38 · Cited by 42
Deficiency of choresteryl ester transfer protein and gene polymorphisms of lipoprotein lipase and hepatic lipase are not associated with longevity
Arai, Y., Hirose, N., Yamamura, K., Nakazawa, S., Shimizu, K.-I., Takayama, M., Ebihara, Y., Homma, S., Gondo, Y., Masui, Y., et al. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-002-0407-6 · Cited by 41
“Numerous epidemiological studies have confirmed that a low level of HDL-C is a strong risk factor for coronary artery disease (CAD) [1]; however, there is evidence that not quantity but underlying mechanisms of high HDL-C levels are important for preventing atherosclerosis [2, 3].”
Background
Evidence that hepatic lipase deficiency in humans is not associated with proatherogenic changes in HDL composition and metabolism
Ruel, I. L., Couture, P., Cohn, J. S., Bensadoun, A., Marcil, M., & Lamarche, B. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400090-jlr200 · Cited by 41
“against the development of atherosclerosis (36, 37), have also been reported to be at increased risk for premature CAD compared with subjects with normal HL activity (17–”
Fatty Acids and Atherosclerotic Risk
Thijssen, M. A. M. A., & Mensink, R. P. (2005) · Handbook of experimental pharmacology · doi:10.1007/3-540-27661-0_5 · Cited by 41
“Epidemiological studies now suggest that an increment of 0.1 mmol/l in LDL cholesterol results in an increase of 3.5%–4.0% in cardiovascular risk, while an increase of 0.1 mmol/l in HDL cholesterol lowers cardiovascular risk with 8%–12% ( Gordon and Rifkind 1989 ).”
BackgroundInfluential
The role of high‐density lipoprotein in the regulation of the immune response: implications for atherosclerosis and autoimmunity
das Neves, M. F., Batuca, J. R., & Alves, J. D. (2021) · Immunology · doi:10.1111/imm.13348 · Cited by 40
“[3] Highdensity lipoprotein (HDL) is the plasma lipoprotein responsible for reverse cholesterol transport (RCT), which is associated with a protective role in atherosclerosis through reducing the lipid burden of atherosclerotic plaques.[4,5] In addition to its role in cholesterol efflux, other properties are attribute…”
Background
Effect of oat supplementation interventions on cardiovascular disease risk markers: a systematic review and meta-analysis of randomized controlled trials
Llanaj, E., Dejanovic, G. M., Valido, E. M., Bano, A., Gamba, M., Kastrati, L., Minder, B., Stojic, S., Voortman, T., Marques-Vidal, P. M., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-021-02763-1 · Cited by 45
“In line with our work, a systematic review on oat intake and its association with CVD risk markers did not find convincing evidence of oat influence on insulin sensitivity and emphasized the importance of exploring additional CVD markers [4].”
BackgroundInfluential
Obesity Genotype Score and Cardiovascular Risk in Women With Type 2 Diabetes Mellitus
He, M., Cornelis, M. C., Franks, P. W., Zhang, C., Hu, F. B., & Qi, L. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.196196 · Cited by 40
Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention
Rader, D. J., & Maugeais, C. (2000) · Molecular Medicine Today · doi:10.1016/s1357-4310(00)01673-7 · Cited by 40
Apolipoprotein A-I-containing particles and reverse cholesterol transport: Evidence for connection between cholesterol efflux and atherosclerosis risk
Fruchart, J., Geteire, C. D., Delfly, B., & Castro, G. R. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)05374-r · Cited by 40
Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I
Jauhiainen, M., Huuskonen, J., Baumann, M., Metso, J., Oka, T., Egashira, T., Hattori, H., Olkkonen, V. M., & Ehnholm, C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32144-1 · Cited by 40
Lipoproteins Regulate C-Type Natriuretic Peptide Secretion From Cultured Vascular Endothelial Cells
Sugiyama, S., Kugiyama, K., Matsumura, T., Suga, S., Itoh, H., Nakao, K., & Yasue, H. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.11.1968 · Cited by 40
Diet modification alters plasma HDL cholesterol concentrations but not the transport of HDL cholesteryl esters to the liver in the hamster
Woollett, L. A., Kearney, D. M., & Spady, D. K. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34943-9 · Cited by 40
Endothelial Lipase Gene Polymorphism is Associated With Acute Myocardial Infarction, Independently of High-Density Lipoprotein-Cholesterol Levels
Shimizu, M., Kanazawa, K., Hirata, K., Ishida, T., Hiraoka, E., Matsuda, Y., Iwai, C., Miyamoto, Y., Hashimoto, M., Kajiya, T., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.842 · Cited by 39
Elevated CETP Activity Improves Plasma Cholesterol Efflux Capacity From Human Macrophages in Women
Villard, E. F., Khoury, P. E., Duchêne, E., Bonnefont‐Rousselot, D., Clément, K., Bruckert, É., Bittar, R., Goff, W. L., & Guérin, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.252841 · Cited by 41
“2341 Elevated plasma high-density lipoprotein cholesterol (HDLC) level represents a protective factor against development of atherosclerosis.(1) Indeed, it is well established that HDL particles exhibit numerous potentially antiatherogenic activities, including reverse cholesterol transport (RCT), antioxidative, and a…”
Background
High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages
Inoue, M., Niki, M., Ozeki, Y., Nagi, S., Chadeka, E. A., Yamaguchi, T., Osada‐Oka, M., Ono, K., Oda, T., Mwende, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-24233-1 · Cited by 44
High-density lipoprotein nitration and chlorination catalyzed by myeloperoxidase impair its effect of promoting endothelial repair
Pan, B., Yu, B., Ren, H., Willard, B. B., Pan, L., Zu, L., Shen, X., Ma, Y., Li, X., Niu, C., et al. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.004 · Cited by 39
Serum lipids concentration in women with benign and malignant ovarian tumours
Gadomska, H., Grzechocińska, B., Janecki, J., Nowicka, G., Powolny, M., & MARIANOWSKI, L. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2004.02.045 · Cited by 39
Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolism
Zhou, H., Li, Z., Hojjati, M. R., Jang, D., Beyer, T. P., Cao, G., Tall, A. R., & Jiang, X. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600153-jlr200 · Cited by 39
“Lipid aP2-CETPTg (1-3) WT (1-3) aP2-CETPTg (1-9) WT (1-9)”
Influential
In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism
Ikewaki, K., Rader, D. J., Zech, L. A., & Brewer, H. B. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39776-5 · Cited by 39
Metabolism of HDL apolipoprotein A-I and A-II in Type 1 (insulin-dependent) diabetes mellitus
Taskinen, M., Kahri, J., Koivisto, V. A., Shepherd, J., & Packard, C. J. (1992) · Diabetologia · doi:10.1007/bf00401202 · Cited by 39
“A reduced H D L cholesterol level in plasma is a recognised risk factor for coronary heart disease [1].”
Background
Tibolone lowers high density lipoprotein cholesterol by increasing hepatic lipase activity but does not impair cholesterol efflux
von Eckardstein, A., Crook, D., Elbers, J. M. H., Ragoobir, J., Ezeh, B., Helmond, F. A., Miller, N. E., Dieplinger, H., Bennink, H. J. T. C., & Assmann, G. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01666.x · Cited by 39
“As epidemiological studies have shown an inverse association between both HDL-cholesterol and apoA-I and the risk of coronary artery disease (Gordon & Rifkind, 1989), which is consistent with the potentially antiatherogenic properties of this lipoprotein (von Eckardstein et al ., 2001a; Nofer et…”
Result
The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions
Liu, Y.-J., Ordovás, J. M., Gao, G., Province, M. A., Straka, R. J., Tsai, M. Y., Lai, C., Zhang, K., Borecki, I. B., Hixson, J. E., et al. (2008) · Journal of Human Genetics · doi:10.1007/s10038-008-0302-2 · Cited by 39
“High-density lipoprotein cholesterol (HDL-C) levels inversely correlated with CHD risk, suggesting HDL-C protects against atherosclerosis (Gordon and Rifkind 1989; Uiterwaal et al. 1994).”
Background
Induction of Bile Acid Synthesis by Cholesterol and Cholestyramine Feeding Is Unimpaired in Mice Deficient in Apolipoprotein Ai
Jolley, C. D., Dietschy, J. M., & Turley, S. D. (2000) · Hepatology · doi:10.1053/jhep.2000.19811 · Cited by 39
Heterozygosity for apolipoprotein A-I(R160L)Oslo is associated with low levels of high density lipoprotein cholesterol and HDL-subclass LpA-I/A-II but normal levels of HDL-subclass LpA-I.
Leren, T. P., Bakken, K. S., Daum, U., Ose, L., Berg, K., Assmann, G., & von Eckardstein, A. (1997) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37281-3 · Cited by 39
High-density lipoprotein metabolism: Molecular targets for new therapies for atherosclerosis
Kawashiri, M., Maugeais, C., & Rader, D. J. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0074-4 · Cited by 39
Transdermally administered oestradiol combined with oral medroxyprogesterone acetate: the effects on lipoprotein metabolism in postmenopausal women
Mattsson, L., Samsioe, G., von Schoultz, B., Uvebrant, M., & Wiklund, I. E. (1993) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1993.tb15270.x · Cited by 39
Progesterone inhibits apolipoprotein-mediated cellular lipid release: a putative mechanism for the decrease of high-density lipoprotein
Kojima, K. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(01)00124-x · Cited by 39

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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