Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 47 of the 50 references it cites were found in a registry or an index.

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
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Self-citation
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Background
Long-term physical exercise and quantitatively assessed human coronary collateral circulation
Senti, S., Fleisch, M., Billinger, M., Meier, B., & Seiler, C. A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00181-8 · Cited by 34
“The protective effect of sustained physical activity may be attributible to an array of adapations of the cardiocirculatory system, such as reduced activity of the sympathetic nervous system in fit compared with unfit people (5), less potential for platelet activation in active versus sedentary people (6), improved va…”
Background
Relationship between plasma phospholipid transfer protein activity and HDL subclasses among patients with low HDL and cardiovascular disease
Cheung, M. C., Wolfbauer, G., Brown, B. G., & Albers, J. J. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(98)00190-7 · Cited by 34
“A large number of epidemiological studies have demonstrated that the higher the HDL cholesterol concentration, the lower the cardiovascular disease (CVD) risk [1,2].”
Background
Lipoprotein composition in NIDDM: effects of dietary oleic acid on the composition, oxidisability and function of low and high density lipoproteins
Dimitriadis, E., Griffin, M., Collins, P. B., Johnson, A., Owens, D., & TOMKIN, G. (1996) · Diabetologia · doi:10.1007/bf00418538 · Cited by 34
“sclerosis [7] and it has b e e n suggested that the pro tec-”
Background
Association between idiopathic pulmonary fibrosis and coronary artery disease: a case-control study and cohort analysis.
Kim, W., Mok, Y., Kim, G. W., Baek, S.-J., Yun, Y. D., Jee, S. H., & Kim, D. S. (2015) · Sarcoidosis vasculitis and diffuse lung diseases · Cited by 33
Uncleaved ApoM Signal Peptide Is Required for Formation of Large ApoM/Sphingosine 1-Phosphate (S1P)-enriched HDL Particles
Liu, M., Allegood, J. C., Zhu, X., Seo, J., Gebre, A. K., Boudyguina, E. Y., Cheng, D., Chuang, C., Shelness, G. S., Spiegel, S., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.631101 · Cited by 34
“HDL cholesterol concentrations are inversely correlated with coronary heart disease (1, 2).”
Background
The dual PPARα/γ agonist tesaglitazar blocks progression of pre‐existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
van der Hoorn, J., Jukema, J. W., Havekes, L. M., Lundholm, E., Camejo, G., Rensen, P. C. N., & Princen, H. M. G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00109.x · Cited by 33
“It recently has been shown that PPARg activation may programme mononuclear precursor cells towards an M2 phenotype in vivo, leading to generation of a macrophage population with enhanced anti-inflammatory properties (Gordon and Rifkind, 1989; Bouhlel et al., 2007).”
Background
Effects of caloric restriction and gender on rat serum paraoxonase 1 activity
Thomàs‐Moyà, E., Gianotti, M., Lladó, I., & Proenza, A. M. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.07.004 · Cited by 33
“High-density lipoproteins (HDLs) have long been known to be antiatherogenic [1], and their protective role has been in part attributed to their associated enzymes [2].”
Background
Increased Phospholipid Transfer Protein Activity Associated with the Impaired Cellular Cholesterol Efflux in Type 2 Diabetic Subjects with Coronary Artery Disease
Attia, N., Nakbi, A., Smaoui, M., Châaba, R., Moulin, P., Hammami, S. O., Hamda, K. B., Chanussot, F., & Hammami, M. (2007) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.213.129 · Cited by 33
“The negative relationship between the HDL-C concentration and the risk of cardiovascular disease (Gordon and Rifkind 1989) is thought to be attributable, at least in part, to the key role of HDL in reverse cholesterol transport (RCT) from peripheral tissues to the liver for excretion (Fielding and Fielding 1995; Tall…”
Background
Biochemical and inflammatory changes in the exercising claudicant
Tisi, P. V., & Shearman, C. P. (1998) · Vascular Medicine · doi:10.1177/1358836x9800300303 · Cited by 33
Relation between insulinemia, body mass index, and lipoprotein composition in healthy, nondiabetic men and women.
Winocour, P. H., Kaluvya, S., Ramaiya, K. L., Brown, L., Millar, J. P., Farrer, M., Neil, H. A. W., Laker, M. F., & Alberti, K. G. M. M. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.3.393 · Cited by 33
Relation of laboratory and clinical variables to the grade of carotid atherosclerosis.
Szirmai, I. G., Kamondi, A., Magyar, H., & Juhász, C. (1993) · Stroke · doi:10.1161/01.str.24.12.1811 · Cited by 33
Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties
Zhu, X., Wu, G., Zeng, W., Xue, H., & Chen, B. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400401-jlr200 · Cited by 33
“Plasma levels of HDL and its apolipoprotein A-I (apoA-I) were demonstrated to be inversely correlated with the incidence of cardiovascular disease ( 1 ).”
Background
Physicochemical binding properties of the proteoglycan receptor for serum lipoproteins
Siegel, G. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00042-8 · Cited by 33
Postmenopausal hormone replacement therapy — clinical implications
Ravn, S., Rosenberg, J., & Bostofte, E. (1994) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(94)90213-5 · Cited by 34
Recent Developments in the Toxicology of Anabolic Steroids
Graham, S., & Kennedy, M. (1990) · Drug Safety · doi:10.2165/00002018-199005060-00007 · Cited by 33
Age‐Dependent Impairment in Endothelial Function and Arterial Stiffness in Former High Class Male Athletes Is No Different to That in Men With No History of Physical Training
Majerczak, J., Grandys, M., Frołow, M., Szkutnik, Z., Zakrzewska, A., Niżankowski, R., Duda, K., Chłopicki, S., & Zoladz, J. A. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.012670 · Cited by 32
“Moreover, a clear tendency toward higher HDLcholesterol and lower insulin resistance assessed by HOMA-IR in young and former endurance-trained athletes when comparedwith age-matched controls was found (Figure 3C and 3F), which might suggest that endurance training performed at a young age is indeed more preferable for…”
Using Tandem Mass Spectrometry to Quantify Site‐Specific Chlorination and Nitration of Proteins: Model System Studies with High‐Density Lipoprotein Oxidized by Myeloperoxidase
Shao, B., & Heinecke, J. W. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00803-8 · Cited by 32
Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice
Brodeur, M. R., Luangrath, V., Bourret, G., Falstrault, L., & Brissette, L. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400165-jlr200 · Cited by 32
“rectly related to plasma concentrations of LDL cholesterol (1) and inversely associated with plasma levels of HDL (2).”
Background
The association between high-density lipoprotein cholesterol level and cholesteryl ester transfer protein TaqIB gene polymorphism is influenced by alcohol drinking in a population-based sample
Tsujita, Y., Nakamura, Y., Zhang, Q., Tamaki, S., Nozaki, A., Amamoto, K., Kadowaki, T., Kita, Y., Okamura, T., Horie, M., et al. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.028 · Cited by 32
Risk Factors for Coronary Artery Disease in Patients With Elevated High-Density Lipoprotein Cholesterol
Yeh, D. D., Freeman, M. W., Meigs, J. B., & Grant, R. W. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.07.053 · Cited by 32
HDL3 reduces the association and modulates the metabolism of oxidized LDL by osteoblastic cells: A protection against cell death
Brodeur, M. R., Brissette, L., Falstrault, L., & Moreau, R. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21938 · Cited by 32
“Given that it was demonstrated that HDL exert a beneficial effect on cardiovascular system [Gordon and Rifkind, 1998] and bone tissue [Yamaguchi et al., 2002; Solomon et al., 2005; Dennison et al., 2007], we evaluated if HDL have the capacity to inhibit the deleterious effects of OxLDL on…”
BackgroundInfluential
Mechanisms of HDL deficiency in mice overexpressing human apoA-II
Julve, J., Escolá‐Gil, J. C., Ribas, V., González‐Sastre, F., Ordóñez‐Llanos, J., Sánchez‐Quesada, J. L., & Blanco‐Vaca, F. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200081-jlr200 · Cited by 32
“HDLs have received considerable attention owing to their protective role against premature atherosclerosis ( 1 , 2). Significant progress has been made in identifying important factors involved in HDL metabolism.”
Background
Locus on Chromosome 6p Linked to Elevated HDL Cholesterol Serum Levels and to Protection Against Premature Atherosclerosis in a Kindred With Familial Hypercholesterolemia
Canizales‐Quinteros, S., Aguilar-Salinas, C. A., Reyes-Rodríguez, E., Riba, L., Rodríguez-Torres, M., Ramı́rez-Jiménez, S., Huertas‐Vázquez, A., Fragoso‐Ontiveros, V., Zentella‐Dehesa, A., Ventura-Gallegos, J. L., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000064174.69165.66 · Cited by 32
Effect of Probucol in Lecithin-Cholesterol Acyltransferase–Deficient Mice
TOMIMOTO, S., Tsujita, M., Okazaki, M., Usui, S., Tada, T., Fukutomi, T., Ito, S., Itoh, M., & Yokoyama, S. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.3.394 · Cited by 32
“At least 2 distinct mechanisms are identified for this reaction: (1) spontaneous cholesterol efflux by diffusion through the aqueous phase in which lecithin-cholesterol acyltransferase (LCAT)-mediated extracellular cholesterol esterification is a driving force for the net efflux and (2) apolipoprotein-cell interaction…”
BackgroundMethodInfluential
Sex-specific effects of the glutamine/histidine polymorphism in apo A-IV on HDL metabolism.
von Eckardstein, A., Funke, H., Chirazi, A., Chen-Haudenschild, C., Schulte, H., Schönfeld, R., Köhler, E., Schwarz, S., Steinmetz, A., & Assmann, G. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.7.1114 · Cited by 32
Clinical characteristics of double heterozygotes with familial hypercholesterolemia and cholesteryl ester transfer protein deficiency
Haraki, T. (1997) · Atherosclerosis · doi:10.1016/s0021-9150(97)00093-2 · Cited by 32
“Most prospective epidemiological studies indicate that HDL-C levels negatively correlate with the incidence of CHD [22].”
Background
Strain/strain rate imaging of impaired left atrial function in patients with metabolic syndrome
Fang, N., Sui, D., Yu, J., Gong, H., Zhong, M., Zhang, Y., & Zhang, W. (2015) · Hypertension Research · doi:10.1038/hr.2015.76 · Cited by 31
Exogenous Expression of Human apoA-I Enhances Cardiac Differentiation of Pluripotent Stem Cells
Ng, K., Lee, Y.-K., Lai, W., Chan, Y.-C., Fung, M., Tse, H., & Siu, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019787 · Cited by 30
“With each 1 mg/dL increment of HDL-C, there is a 2 to 3% reduction in risk of coronary artery disease [6,7].”
Background
Impact of pitavastatin on high-sensitivity C-reactive protein and adiponectin in hypercholesterolemic patients with the metabolic syndrome: The PREMIUM Study
Matsubara, T., Naruse, K., Arakawa, T., Nakao, M., Yokoi, K., Oguri, M., Marui, N., Amano, T., Ichimiya, S., Ohashi, T., et al. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.07.012 · Cited by 31
Macrophage-Independent Regulation of Reverse Cholesterol Transport by Liver X Receptors
Breevoort, S. R., Angdisen, J. J., & Schulman, I. G. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303383 · Cited by 31
“These studies that define particle function may open the door to new therapeutic approaches for targeting HDL.”
BackgroundInfluential
Hepatic Overexpression of Endothelial Lipase Lowers High-Density Lipoprotein but Maintains Reverse Cholesterol Transport in Mice: Role of Scavenger Receptor Class B Type I/ATP-Binding Cassette Transporter A1-Dependent Pathways
Takiguchi, S., Ayaori, M., Yakushiji, E., Nishida, T., Nakaya, K., Sasaki, M., Iizuka, M., Uto-Kondo, H., Terao, Y., Yogo, M., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.118.311056 · Cited by 25
“1454 Low plasma levels of HDL-C (high-density lipoproteincholesterol) have been consistently associated with increased risk of atherosclerotic cardiovascular diseases, and it is therefore considered to be an antiatherogenic lipoprotein.(1) The development of novel therapies to enhance the atheroprotective properties o…”
Background
Mulberry Fruit Extract Promotes Serum HDL-Cholesterol Levels and Suppresses Hepatic microRNA-33 Expression in Rats Fed High Cholesterol/Cholic Acid Diet
Lee, S., Lee, M.-S., Chang, E., Lee, Y., Lee, J., Kim, J., Kim, C., Kim, I.-H., & Kim, Y. (2020) · Nutrients · doi:10.3390/nu12051499 · Cited by 33
“Given a negative correlation between HDL-C levels and the risk of CVD, HDL-C has been demonstrated as a strong predictor of CVD [4,5].”
Background
Association between cardiometabolic risk factors and COVID-19 susceptibility, severity and mortality: a review
Sharifi, Y., Payab, M., Mohammadi‐Vajari, E., Aghili, S. M. M., Sharifi, F., Mehrdad, N., Kashani, E., Shadman, Z., Larijani, B. A., & Ebrahimpur, M. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00822-2 · Cited by 32
Effects of high dietary fat and cholesterol on expression of PPARα, LXRα, and their responsive genes in the liver of apoE and LDLR double deficient mice
Zou, Y., Du, H., Yin, M., Zhang, L., Mao, L., Xiao, N., Ren, G., Zhang, C., & Pan, J. (2008) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-008-9982-3 · Cited by 31
“There were evidences supporting that the level of plasma HDL was inversely correlated with the morbidity of coronary heart disease [15].”
Background
2,5,6-Trisubstituted imidazo[2,1-b][1,3,4]thiadiazoles: Search for antihyperlipidemic agents
Patel, H., Noolvi, M. N., Goyal, A., & Thippeswamy, B. S. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.04.020 · Cited by 31
Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells
Shang, W., Yu, X., Wang, H., CHEN, T., Fang, Y., Yang, X., Zhou, P., Nie, F., ZHOU, Q., & Zhou, J.-Z. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2731 · Cited by 32
“The inverse correlation between plasma HDL levels and the risk of atherosclerosis has been extensively investigated (25,26).”
Particle size analysis of high density lipoproteins in patients with genetic cholesteryl ester transfer protein deficiency
Arai, T., Tsukada, T., Murase, T., & Matsumoto, K. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00328-4 · Cited by 31
Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells
Yan, N., Ding, T., Dong, J., Li, Y., & Wu, M.-P. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-46 · Cited by 31
“Lee CY, Lesimple A, Denis M, Vincent J, Larsen A, Mamer O, Krimbou L, Genest J, Marcil M: Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B.”
BackgroundInfluential

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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