Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A. (1989) · Circulation · doi:10.1161/01.cir.79.1.8 · Cited by 3,162
Self-citation
PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
Miller, G. J., & Miller, N. E. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92376-4 · Cited by 2,621
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,512
Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Goodman, D. S. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380010040006 · Cited by 2,458
The plasma lecithin:cholesterol acyltransferase reaction
Glomset, J. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43114-1 · Cited by 2,396
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824
Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts
Blankenhorn, D. H. (1987) · JAMA · doi:10.1001/jama.1987.03390230069027 · Cited by 1,654
Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man.
Mattson, F. H., & Grundy, S. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34389-3 · Cited by 1,354

Show all 50 references

Research works printed but not linked: 10

Gofman, 1954, Plasma, 2, 413
Hulley, 1977, JAMA, 238, 2269, 10.1001/jama.1977.03280220037017 · DOI
Ernst, 1980, Circulation, 62, IV-41
Sacks, 1985, JAMA, 254, 1337, 10.1001/jama.1985.03360100087019 · DOI
Davis, 1980, Circulation, 62, IV-24
Enger, 1979, Artery, 5, 170
Levy, 1987, Circulation, 76, IV-167
Superko, 1986, JAMA, 256, 2714, 10.1001/jama.1986.03380190084030 · DOI
Hunninghake D, Gordon DJ, Tamir I, Rifkind BM. Management of hyperlipidemia. In: Pradhan SN, Maickel RP, Dutta SN, eds. Textbook of pharmacology. Bethesda, Md.: SP Press International, 1986:617–33.
Castelli, 1986, JAMA, 256, 2835, 10.1001/jama.1986.03380200073024 · DOI

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Siegel, G., Malmsten, M., Pietzsch, J., Schmidt, A., Buddecke, E., Michel, F., Ploch, M., & Schneider, W. (2004) · Phytomedicine · doi:10.1078/0944-7113-00377 · Cited by 27
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Ordovás, J. M. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.139 · Cited by 27
Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase
Wroblewski, J. M., Jahangiri, A., Ji, A., de Beer, F. C., van der Westhuyzen, D. R., & Webb, N. R. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m017681 · Cited by 28
Alterations in the lipid profile and liver enzymes of rats treated with monosodium glutamate
Okediran, B. S., Olurotimi, A., Rahman, S., Michael, O., & Olukunle, J. (2015) · Sokoto Journal of Veterinary Sciences · doi:10.4314/sokjvs.v12i3.8 · Cited by 27
“HDL and LDL are two of the four main groups of plasma lipoproteins that are involved in lipid metabolism and the exchange of cholesterol, cholesterol ester and triglycerides between tissue (Gordon & Rifkind 1989; McNamara 1999).”
Background
2-Arylbenzoxazoles as CETP inhibitors: Substitution and modification of the α-alkoxyamide moiety
Hunt, J. A., González, S., Kallashi, F., Hammond, M. L., Pivnichny, J. V., Tong, X., Xu, S. S., Anderson, M. S., Chen, Y., Eveland, S. S., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.12.046 · Cited by 27
Reverse cholesterol transport in familial hypercholesterolemia
Guérin, M. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328353ef07 · Cited by 28
Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein
He, Y., Song, H. D., Anantharamaiah, G. M., Palgunachari, M. N., Bornfeldt, K. E., Segrest, J. P., & Heinecke, J. W. (2019) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000878 · Cited by 29
HDL and electronegative LDL exchange anti- and pro-inflammatory properties
Bancells, C., Sánchez‐Quesada, J. L., Birkelund, R., Ordóñez‐Llanos, J., & Benı́tez, S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m005777 · Cited by 27
Targeted Proteomics Identifies Paraoxonase/Arylesterase 1 (PON1) and Apolipoprotein Cs as Potential Risk Factors for Hypoalphalipoproteinemia in Diabetic Subjects Treated with Fenofibrate and Rosiglitazone
Ronsein, G. E., Reyes‐Soffer, G., He, Y., Oda, M. N., Ginsberg, H. N., & Heinecke, J. W. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.054528 · Cited by 27
“HDL-C are an independent risk factor for CVD (8).”
BackgroundInfluential
Hypercholesterolaemia in briards in the United Kingdom
Watson, P., Simpson, K. W., & Bedford, P. G. C. (1993) · Research in Veterinary Science · doi:10.1016/0034-5288(93)90015-8 · Cited by 27
Associations between serum high-density lipoprotein cholesterol or apolipoprotein AI levels and common genetic variants of the ABCA1 gene in Japanese school-aged children
Yamakawa‐Kobayashi, K., Yanagi, H., Yu, Y., Endo, K., Arinami, T., & Hamaguchi, H. (2004) · Metabolism · doi:10.1016/j.metabol.2003.08.009 · Cited by 28
Inhibition of cholesteryl ester transfer protein activity: A new therapeutic approach to raising high-density lipoprotein
Rader, D. J. (2004) · Current Atherosclerosis Reports · doi:10.1007/s11883-004-0052-3 · Cited by 27
“HDL cholesterol is well known to be strongly inversely associated with cardiovascular risk [ 2 ].”
Background
Analysis of particle size and lipid composition as determinants of the metabolic clearance of human high density lipoproteins in a rabbit model
Lamarche, B., Uffelman, K. D., Steiner, G. A., Barrett, P. H. R., & Lewis, G. F. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32540-2 · Cited by 27
Transcriptional Induction of Rat Liver Apolipoprotein A‐I Gene Expression by Glucocorticoids Requires the Glucocorticoid Receptor and a Labile Cell‐Specific Protein
Saladin, R., Vu‐Dac, N., Fruchart, J., Auwerx, J. H., & Staels, B. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0451u.x · Cited by 27
Development of congenic strains of mice carrying amyloidogenic apolipoprotein A‐II (Apoa2c)
Higuchi, K., Kitado, H., Kitagawa, K., Kogishi, K., Naiki, H., & Takeda, T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81277-7 · Cited by 27
Distribution of subclasses of HDL containing apoA-I without apoA-II (LpA-I) in normolipidemic men and women.
Duverger, N., Rader, D. J., & Brewer, H. B. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.10.1594 · Cited by 27
Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I
Gruen, M. L., Plummer, M. R., Zhang, W., Posey, K. A., Linton, M. F., Fazio, S., & Hasty, A. H. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500181-jlr200 · Cited by 27
“It is well established that HDL and apoA-I levels are inversely correlated with the risk of cardiovascular disease (23, 24).”
Background
The novel compound NO-1886 elevates plasma high-density lipoprotein cholesterol levels in hamsters and rabbits by increasing lipoprotein lipase without any effect on cholesteryl ester transfer protein activity
Tsutsumi, K., Inoue, Y., Hagi, A., & Murase, T. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90250-x · Cited by 27
Regulated expression of endothelial lipase in atherosclerosis
Wu, X., Huang, H., Tang, F., Le, K., Xu, S., & Liu, P. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.003 · Cited by 26
High-Density Lipoprotein Cholesterol Level Is Associated With Fibrous Cap Thickness in Acute Coronary Syndrome
Ozaki, Y., Tanaka, A., Komukai, K., Ishibashi, K., Tanimoto, T., Kitabata, H., Ino, Y., Kubo, T., Imanishi, T., & Akasaka, T. (2013) · Circulation Journal · doi:10.1253/circj.cj-13-0512 · Cited by 26
Cardioprotective Properties of HDL: Structural and Functional Considerations
Pappa, E. T., Elisaf, M., Kostara, C. E., Bairaktari, E. T., & Tsimihodimos, V. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190201142321 · Cited by 28
Nutritional Values and Potential Health Benefits of Millets- A Review
Mishra, A., Pattnaik, B., Dutta, T., & Baitharu, I. (2022) · Journal of Nutrients · doi:10.18488/87.v8i1.3176 · Cited by 27
“That means, every 1 mg/dL increase in LDL enhances the risk of CVDs by 2%; whereas, every 1 mg/dL increase in HDL declines the risk of CVDs by 2-3% [62].”
Background
Chapter 7 Cell Protective Functions of Secretory Clusterin (sCLU)
Klock, G., Baiersdörfer, M., & Koch-Brandt, C. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)04007-x · Cited by 27
“There is a broad agreement today concerning the risk of a high concentration of low-density lipoprotein (LDL) and LDL cholesterol to developing atherosclerotic diseases, while high-density lipoprotein (HDL) and HDL cholesterol are considered to be protective (Gordon and Rifkind, 1989).”
Background
LDL Apheresis and Inflammation – Implications for Atherosclerosis
Hovland, A., Lappegård, K. T., & Mollnes, T. E. (2012) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2012.02734.x · Cited by 26
Mechanistic studies of blood pressure in rats treated with a series of cholesteryl ester transfer protein inhibitors
Depasquale, M. J., Cadelina, G. W., Knight, D. R., Loging, W., Winter, S. J., Blasi, E., Perry, D., & Keiser, J. A. (2009) · Drug Development Research · doi:10.1002/ddr.20282 · Cited by 26
High Density Lipoprotein: Assembly, Structure, Cargo, and Functions
Murphy, A. J. (2013) · ISRN Physiology · doi:10.1155/2013/186365 · Cited by 26
“LCAT interacts with unesterified cholesterol in discoidal or pre-β HDL to generate cholesterol esters (CE), which move to the core of HDL causing it to undergo a conformational change from a discoidal shape to a sphere [50, 51].”
Background
Gene-environment interactions of CETP gene variation in a high cardiovascular risk Mediterranean population
Corella, D., Carrasco, P., Fitó, M., Martínez‐González, M. Á., Salas‐Salvadó, J., Arós, F., Lapetra, J., Guillén, M., Ortega‐Azorín, C., Wärnberǵ, J., et al. (2010) · Journal of Lipid Research · doi:10.1194/jlr.p005199 · Cited by 26
ApoA-IMALLORCA impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia
Martín-Campos, J. M., Julve, J., Escolá‐Gil, J. C., Ordóñez‐Llanos, J., Gómez, J., Binimelis, J., González‐Sastre, F., & Blanco‐Vaca, F. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30194-2 · Cited by 26
Could high-density lipoprotein cholesterol predict increased cardiovascular risk?
Chang, T. I., Streja, E., & Moradi, H. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000318 · Cited by 27
CETP‐Inhibition and HDL‐Cholesterol: A Story of CV Risk or CV Benefit, or Both
Nicholls, S. J. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1118 · Cited by 25
Protective Effect of Policosanol on Atherosclerotic Plaque on Aortas in Monkeys
Noa, M., & Más, R. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.03.039 · Cited by 27
HDL Therapy for the Treatment of Cardiovascular Diseases
Parolini, C., Marchesi, M., & Chiesa, G. (2009) · Current Vascular Pharmacology · doi:10.2174/157016109789043856 · Cited by 26
“Several epidemiological studies have shown that there is an independent and inverse relationship between circulating HDL cholesterol (HDL-C) levels and coronary heart disease; it has been estimated that there is a 2-3% decrease in cardiovascular risk for every 1 mg increase in HDL cholesterol [3].”
Background
Remodeling of HDL remnants generated by scavenger receptor class B type I
Webb, N. R., de Beer, M. C., Asztalos, B. F., Whitaker, N. L., van der Westhuyzen, D. R., & de Beer, F. C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400026-jlr200 · Cited by 26
“Numerous population studies have established an inverse correlation between the risk for atherosclerosis and plasma HDL levels ( 1 ).”
Background
Association of Coronary Heart Disease with Pre-β-HDL Concentrations in Japanese Men
Hattori, H., Kujiraoka, T., Egashira, T., Saito, E., FUJIOKA, T., Takahashi, S., Ito, M., Cooper, J. A., Stepanova, I. P., Nanjee, M. N., et al. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.029207 · Cited by 26
“The risk of coronary heart disease (CHD)6 is inversely related to plasma HDL-cholesterol ( 1 ). Studies in transgenic animals have shown that HDLs have antiatherogenic activity (2, 3) , but the mechanism for this activity is not known.”
Background
Traditional Greek Diet and Coronary Heart Disease
Trichopoulou, A., Λάγιου, Π., & Trichopoulos, D. (1994) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/174182679400100103 · Cited by 26
Recombinant apolipoprotein A-I[Formula: See Text]: a novel agent for the induction of regression of atherosclerotic plaques
Chiesa, G., & Sirtori, C. R. (2003) · Annals of Medicine · doi:10.1080/07853890310005281 · Cited by 26
Low density lipoproteins develop resistance to oxidative modification due to inhibition of cholesteryl ester transfer protein by a monoclonal antibody
Sugano, M., Sawada, S., Tsuchida, K., Makino, N., & Kamada, M. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32082-4 · Cited by 26
Hepatic lipase activity during oral and parenteral 17β-estradiol replacement therapy: high-density lipoprotein increase may not be antiatherogenic
Basdevant, A., Lignieres, B. D., Simon, P., Blache, D., Ponsin, G., & Guy-grand, B. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54361-1 · Cited by 26
Long-term incidence and prognostic factors of the progression of new coronary lesions in Japanese coronary artery disease patients after percutaneous coronary intervention
Kaneko, H., Yajima, J., Oikawa, Y., Tanaka, S., Fukamachi, D., Suzuki, S. S., Sagara, K., Otsuka, T., Matsuno, S., Kano, H., et al. (2013) · Heart and Vessels · doi:10.1007/s00380-013-0382-6 · Cited by 26
“There is a well-known inverse relationship between the level of HDL and the presence and the development of coronary artery disease [14].”
Background
Biochemical and Functional Characterization of Charge-Defined Subfractions of High-Density Lipoprotein From Normal Adults
Hsieh, J.-Y., Chang, C., Huang, M. T.-H., Chang, C., Chen, C.-Y., Shen, M.-Y., Liao, H.-Y., Wang, G., Chen, C., Chen, C., et al. (2013) · Analytical Chemistry · doi:10.1021/ac402516u · Cited by 25
Serum Bilirubin and Coronary Artery Disease: Intricate Relationship, Pathophysiology, and Recent Evidence
Jain, V., Ghosh, R. K., Bandyopadhyay, D., Kondapaneni, M. D., Mondal, S., Hajra, A., Aronow, W. S., & Lavie, C. J. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.06.003 · Cited by 25
History of cardiovascular disease and cardiovascular biomarkers are associated with 30-day mortality in patients with hip fracture
Norring-Agerskov, D., Madsen, C. M., Bathum, L., Pedersen, O. B., Lauritzen, J. B., Jørgensen, N. R., & Jørgensen, H. L. (2019) · Osteoporosis International · doi:10.1007/s00198-019-05056-w · Cited by 25

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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