Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 47 of the 50 references it cites were found in a registry or an index.

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

Open this paper in CoChat — free account

Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

Integrity signals

Registry

Crossref · 10.1056/nejm198911093211907

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia
Frick, M. H., Elo, O., Haapa, K., Heinonen, O. P., Heinsalmi, P., Helo, P., Huttunen, J. K., Kaitaniemi, P., Koskinen, P., Manninen, V., et al. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711123172001 · Cited by 3,881
High-density lipoprotein cholesterol and cardiovascular disease. Four prospective American studies.
Gordon, D. J., Probstfield, J. L., Garrison, R. J., Neaton, J. D., Castelli, W. P., Knoke, J. D., Jacobs, D. R., Bangdiwala, S., & Tyroler, H. A. (1989) · Circulation · doi:10.1161/01.cir.79.1.8 · Cited by 3,162
Self-citation
PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE
Miller, G. J., & Miller, N. E. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92376-4 · Cited by 2,621
Incidence of Coronary Heart Disease and Lipoprotein Cholesterol Levels
Castelli, W. P. (1986) · JAMA · doi:10.1001/jama.256.20.2835 · Cited by 2,512
Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Goodman, D. S. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380010040006 · Cited by 2,458
The plasma lecithin:cholesterol acyltransferase reaction
Glomset, J. A. (1968) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)43114-1 · Cited by 2,396
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
Canner, P. L., Berge, K. G., Wenger, N. K., Stamler, J., Friedman, L., Prineas, R. J., & Friedewald, W. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80293-5 · Cited by 1,824
Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts
Blankenhorn, D. H. (1987) · JAMA · doi:10.1001/jama.1987.03390230069027 · Cited by 1,654
Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man.
Mattson, F. H., & Grundy, S. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34389-3 · Cited by 1,354

Show all 50 references

Research works printed but not linked: 10

Gofman, 1954, Plasma, 2, 413
Hulley, 1977, JAMA, 238, 2269, 10.1001/jama.1977.03280220037017 · DOI
Ernst, 1980, Circulation, 62, IV-41
Sacks, 1985, JAMA, 254, 1337, 10.1001/jama.1985.03360100087019 · DOI
Davis, 1980, Circulation, 62, IV-24
Enger, 1979, Artery, 5, 170
Levy, 1987, Circulation, 76, IV-167
Superko, 1986, JAMA, 256, 2714, 10.1001/jama.1986.03380190084030 · DOI
Hunninghake D, Gordon DJ, Tamir I, Rifkind BM. Management of hyperlipidemia. In: Pradhan SN, Maickel RP, Dutta SN, eds. Textbook of pharmacology. Bethesda, Md.: SP Press International, 1986:617–33.
Castelli, 1986, JAMA, 256, 2835, 10.1001/jama.1986.03380200073024 · DOI

Sorted by citations

Items 301–400 of 1,000

High-density lipoprotein subfractions
Silverman, D. I., Ginsburg, G. S., & Pasternak, R. C. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90217-d · Cited by 88
The ABC transporters in lipid flux and atherosclerosis
Voloshyna, I., & Reiss, A. B. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.02.001 · Cited by 88
“Scheme is described in step-b atively correlated with risk for coronary artery disease [25].”
Background
Serendipitous Discovery and X-Ray Structure of a Human Phosphate Binding Apolipoprotein
Morales, R., Berna, A., Carpentier, P., Contreras‐Martel, C., Renault, F., Nicodeme, M., Chesne-Seck, M.-L., Bernier, F., Dupuy, J., Schaeffer‐Reiss, C., et al. (2006) · Structure · doi:10.1016/j.str.2005.12.012 · Cited by 88
Effects of Ramadan Fasting on Biochemical and Anthropometric Parameters in Physically Active Men
Trabelsi, K., Abed, K. E., Trepanowski, J. F., Stannard, S. R., Ghlissi, Z., Ghozzi, H., Masmoudi, L., Jammoussi, K., & Hakim, A. (2011) · Asian Journal of Sports Medicine · doi:10.5812/asjsm.34775 · Cited by 88
“Increases in HDL-C have been shown to reduce the likelihood of developing atherosclerosis and cardiovascular artery disease ([28]).”
Background
DIET AND HEART DISEASE
Gaziano, J. M., & Manson, J. E. (1996) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70261-7 · Cited by 88
Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiency
KOIZUMI, J., Inazu, A., Yagi, K., Koizumi, I., Uno, Y., Kajinami, K., Miyamoto, S., Moulin, P., Tall, A. R., & Mabuchi, H. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90114-i · Cited by 88
HDL cholesterol and stroke risk: The Multi-Ethnic Study of Atherosclerosis
Reina, S. A., Llabre, M. M., Allison, M., Wilkins, J. T., Mendez, A. J., Arnan, M., Schneiderman, N., Sacco, R. L., Carnethon, M. R., & Delaney, J. A. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.09.031 · Cited by 87
“Although evidence shows that statin therapy can lower LDL and raise HDL cholesterol, one in seven statin-treated patients will still experience some CVD-related event within five years (Mora, Glynn, & Ridker, 2013).”
Influential
Association of Paraoxonase-1 Activity and Concentration With Angiographic Severity and Extent of Coronary Artery Disease
Granér, M., James, R. W., Kahri, J., Nieminen, M. S., Syvänne, M., & Taskinen, M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.01.074 · Cited by 87
Evidences of the cardioprotective potential of fruits: The case of cranberries
Ruel, G., & Couillard, C. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600286 · Cited by 86
Diet and survival of elderly Greeks: a link to the past
Trichopoulou, A., Kouris‐Blazos, A., Vassilakou, T., Gnardellis, C., Polychronopoulos, E., Venizelos, M., Λάγιου, Π., Ml, W., & Trichopoulos, D. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1346s · Cited by 87
Associations of obesity markers, insulin, and sex hormones with HDL-cholesterol levels in Turkish and German individuals
Hergenç, G., Schulte, H., Assmann, G., & von Eckardstein, A. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00027-1 · Cited by 87
Cholesterol Paradox in Patients with Paroxysmal Atrial Fibrillation
Annoura, M., Ogawa, M., Kumagai, K., Zhang, B., Saku, K., & Arakawa, K. (1999) · Cardiology · doi:10.1159/000006942 · Cited by 86
“An inverse relationship between plasma levels of high density lipoprotein cholesterol (HDL-C) and the risk for CHD has also been well established [”
Background
Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice
Arai, T., Rinninger, F., Varban, M. L., Fairchild-Huntress, V., Liang, C.-P., Chen, W., Seo, T., Deckelbaum, R. J., Huszar, D., & Tall, A. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12050 · Cited by 86
High-Density Lipoprotein Nanobiologics for Precision Medicine
Mulder, W. J. M., van Leent, M. M. T., Lameijer, M., Fisher, E. A. A., Fayad, Z. A., & Pérez‐Medina, C. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00339 · Cited by 86
Reverse Cholesterol Transport in Plasma of Patients With Different Forms of Familial HDL Deficiency
von Eckardstein, A., Huang, Y., Wu, S., Funke, H., Noseda, G., & Assmann, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.5.691 · Cited by 86
Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL on the endothelium
Norata, G. D., & Catapano, A. L. (2005) · Vascular Health and Risk Management · doi:10.2147/vhrm.1.2.119.64083 · Cited by 85
The role of adiponectin in cholesterol efflux and HDL biogenesis and metabolism
Hafiane, A., Gasbarrino, K., & Daskalopoulou, S. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153953 · Cited by 85
Obstructive sleep apnoea/hypopnea influences high-density lipoprotein cholesterol in the elderly
Roche, F., Sforza, E. A., Pichot, V., Maudoux, D., Garcin, A., Celle, S., Picard-Kossovsky, M., Gaspoz, J., & Barthélemy, J. (2009) · Sleep Medicine · doi:10.1016/j.sleep.2008.07.017 · Cited by 88
“The pro-atherosclerotic effects of elevated serum levels of lowdensity lipoprotein cholesterol (LDL-c) are well characterized, as is the inverse association between high-density lipoprotein cholesterol (HDL-c) levels and coronary artery disease [1].”
Background
A Guideline-Driven Assessment of Need for Cardiovascular Disease Risk Intervention in Persons With Chronic Paraplegia
Nash, M. S., & Mendez, A. J. (2007) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2007.02.031 · Cited by 84
High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis
Vivekanandan‐Giri, A., Slocum, J. L., Byun, J., Tang, C., Sands, R. L., Gillespie, B. W., Heinecke, J. W., Saran, R., Kaplan, M. J., & Pennathur, S. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202033 · Cited by 84
Human Plasma High-density Lipoproteins are Stabilized by Kinetic Factors
Mehta, R., Gantz, D., & Gursky, O. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00155-4 · Cited by 83
Site-specific oxidation of apolipoprotein A-I impairs cholesterol export by ABCA1, a key cardioprotective function of HDL
Shao, B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.11.011 · Cited by 84
“This property has been attributed to several distinct pathways [6,25].”
Hematopoietic Stem/Progenitor Cell Proliferation and Differentiation Is Differentially Regulated by High-Density and Low-Density Lipoproteins in Mice
Feng, Y., Schouteden, S., Geenens, R., Duppen, V. V., Herijgers, P., Holvoet, P., Veldhoven, P. P. V., & Verfaillie, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047286 · Cited by 87
“In contrast, there is an inverse correlation between the incidence of CHD and plasma levels of HDL and its major apolipoprotein A-I (apoA-I) [15].”
Background
Organ Transplantation in Hereditary Apolipoprotein AI Amyloidosis
Gillmore, J. D., Stangou, A. J., Lachmann, H. J., Goodman, H. J. B., Wechalekar, A. D., Acheson, J. F., Tennent, G. A., Bybee, A., Gilbertson, J. A., Rowczenio, D. M., et al. (2006) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01507.x · Cited by 83
“ApoAI is secreted by the liver and intestine, catabolized in the liver and kidneys, and is the main protein in high-density lipoprotein (21).”
Background
Alterations in the main steps of reverse cholesterol transport in male patients with primary hypertriglyceridemia and low HDL-cholesterol levels
Brites, F. D., Bonavita, C. D., Geitere, C. D., Cloës, M., Delfly, B., Yael, M. J., Fruchart, J., Wikinski, R. L. W., & Castro, G. R. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00452-9 · Cited by 83
“Thus, while HDL-C stands as a manifest antiatherogenic factor [4], the direct intervention of triglycerides in the genesis of atherosclerosis still remains controversial.”
Background
Cell-Associated and Extracellular Phospholipid Transfer Protein in Human Coronary Atherosclerosis
O’Brien, K. D., Vuletic, S., McDonald, T. O., Wolfbauer, G., Lewis, K., Tu, A.-Y., Marcovina, S. M., Wight, T. N., Chait, A., & Albers, J. J. (2003) · Circulation · doi:10.1161/01.cir.0000079163.97653.cd · Cited by 84
Alterations in the concentration of an apolipoprotein E-containing subfraction of plasma high density lipoprotein in coronary heart disease
Wilson, H. M., Patel, J. C., Russell, D., & SKINNER, E. R. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90046-7 · Cited by 82
Bionanoparticles in cancer imaging, diagnosis, and treatment
Li, Y., Bao, Q., Yang, S., Yang, M., & Mao, C. (2022) · Open Research (University of Surrey) · doi:10.1002/viw.20200027 · Cited by 85
A prospective study of TaqIB polymorphism in the gene coding for cholesteryl ester transfer protein and risk of myocardial infarction in middle-aged men
Liu, S., Schmitz, C., Stampfer, M. J., Sacks, F. M., Hennekens, C. H., Lindpaintner, K., & Ridker, P. M. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(01)00673-6 · Cited by 82
“High-density lipoprotein (HDL) cholesterol is a powerful predictor for the development of atherosclerosis and myocardial infarction [1,2].”
Background
New insights into the role of the adenosine triphosphate–binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport
Brewer, H. B., & Santamarina-Fojo, S. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)03382-9 · Cited by 82
Apolipoprotein C-III(Lys58----Glu). Identification of an apolipoprotein C-III variant in a family with hyperalphalipoproteinemia.
von Eckardstein, A., Holz, H., Sandkamp, M., Weng, W., Funke, H., & Assmann, G. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115190 · Cited by 81
Different postprandial metabolism of olive oil and soybean oil: a possible mechanism of the high-density lipoprotein conserving effect of olive oil
de Bruin, T. W. A., Brouwer, C., Trip, M. V. L.-S., Jansen, H., & Erkelens, D. W. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/58.4.477 · Cited by 81
Evaluation of apoA-I kinetics in humans using simultaneous endogenous stable isotope and exogenous radiotracer methods.
Ikewaki, K., Rader, D., Schaefer, J., Fairwell, T., Zech, L. A., & Brewer, H. B. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35361-x · Cited by 81
Influence of glycemic load on HDL cholesterol in youth1–3
Slyper, A. H., Jurva, J. W., Pleuss, J. A., Hoffmann, R. G., & Gutterman, D. D. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn.81.2.376 · Cited by 80
Interactions Between Glucose and FFA Metabolism in Man
Saloranta, C., & Groop, L. (1996) · Diabetes/Metabolism Reviews · doi:10.1002/(sici)1099-0895(199603)12:1 · Cited by 37
Apolipoprotein B and A-I in relation to serum cholesterol and triglycerides in 43 000 Swedish males and females
Jungner, I., Walldius, G., Holme, I., Kolar, W., & Steiner, E. (1992) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02591655 · Cited by 80
“The atherogenic property of high blood cholesterol is mainly due to cholesterol in low-density lipoproteins (LDL), whereas high cholesterol in high-density lipoprotein (HDL) is in fact considered to be anti-atherogenic [ 11 , 12, 21].”
Background
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
Tsai, M. Y., Johnson, C. W., Kao, W. H. L., Sharrett, A. R., Arends, V. L., Kronmal, R. A., Jenny, N. S., Jacobs, D. R., Arnett, D. K., O’Leary, D. H., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.12.038 · Cited by 79
HDL Cholesterol: Physiology, Pathophysiology, and Management
Link, J. J., Rohatgi, A. K., & de Lemos, J. A. (2007) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2007.01.004 · Cited by 81
A Novel Protein Glycan–Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality
McGarrah, R. W., Kelly, J. P., Craig, D. M., Haynes, C. S., Jessee, R. C., Huffman, K. M., Kraus, W. E., & Shah, S. H. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.261636 · Cited by 80
“Large human studies have shown a consistent relationship between overall HDL-C concentrations and cardiovascular risk (25).”
Background
Pathophysiology of plaque rupture and the concept of plaque stabilization
Shah, P. K. (2003) · Cardiology Clinics · doi:10.1016/s0733-8651(03)00058-4 · Cited by 79
Is Exercise Beneficial -- or Hazardous -- to Your Heart?
Curfman, G. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312023292310 · Cited by 79
Resveratrol in Cholesterol Metabolism and Atherosclerosis
Voloshyna, I., Hussaini, S. M. A., & Reiss, A. B. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0025 · Cited by 79
“43 In humans, lack of ABCA1 caused by mutations in the ABCA1 gene on chromosome 9q31 results in Tangi-er’s disease, a rare autosomal codominant disease associated with marked reductions in HDL plasma levels and increased risk of cardiovascular disease.”
Fenofibric Acid, an Active Form of Fenofibrate, Increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by Enhancing Transcription of ATP-Binding Cassette Transporter A1 Gene in a Liver X Receptor–Dependent Manner
Arakawa, R., Tamehiro, N., Nishimaki‐Mogami, T., Ueda, K., & Yokoyama, S. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163844.07815.c4 · Cited by 79
Effects of Gemfibrozil and Other Fibric Acid Derivatives on Blood Lipids and Lipoproteins
ZIMETBAUM, P. J., Frishman, W. H., & Kahn, S. (1991) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1991.tb01883.x · Cited by 78
Trans monounsaturated fatty acids in nutrition and their impact on serum lipoprotein levels in man
Mensink, R. P., & Katan, M. (1993) · Progress in Lipid Research · doi:10.1016/0163-7827(93)90007-j · Cited by 78
Arg123-Tyr166 Domain of Human ApoA-I Is Critical for HDL-Mediated Inhibition of Macrophage Homing and Early Atherosclerosis in Mice
Holvoet, P., Peeters, K., Lund‐Katz, S., Mertens, A. C., Verhamme, P. B., Quarck, R. A., Stengel, D., Lox, M., Deridder, E., Bernar, H., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq1201.100221 · Cited by 78
Bias in relative odds estimation owing to imprecise measurement of correlated exposures
Phillips, A. N., & Smith, G. D. (1992) · Statistics in Medicine · doi:10.1002/sim.4780110712 · Cited by 108
Leukocyte telomere length is associated with HDL cholesterol levels: The Bogalusa heart study
Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., Berenson, G. S., & Aviv, A. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.021 · Cited by 78
“Diminished levels of high-density lipoprotein cholesterol (HDL) are associated with an increased risk for atherosclerosis [1–4], a isease that is marked by chronic, low grade, inflammation and ncreased burden of oxidative stress [5,6].”
Background
Human ApoA-I Transfer Attenuates Transplant Arteriosclerosis via Enhanced Incorporation of Bone marrow–derived Endothelial Progenitor Cells
Feng, Y., Jacobs, F., Craeyveld, E. V., Brunaud, C., Snoeys, J., Tjwa, M., Linthout, S. V., & Geest, B. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.158741 · Cited by 77
“Discussion The main findings of the present study are that (1) increased HDL cholesterol after human apoA-I gene transfer increases the number of endothelial progenitor cells (EPCs) in the circulation and in bone marrow in apoE / mice; (2) HDL improves EPC function in vitro; (3) human apoA-I transfer stimulates incorp…”
Result
Amyloidosis
Pinney, J. H., & Hawkins, P. N. (2012) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011225 · Cited by 78
Quantum Dot and Cy5.5 Labeled Nanoparticles to Investigate Lipoprotein Biointeractions via Förster Resonance Energy Transfer
Skajaa, T., Zhao, Y., van den Heuvel, D. J., Gerritsen, H. C., Cormode, D. P., Koole, R., van Schooneveld, M. M., Post, J. A., Fisher, E. A., Fayad, Z. A., et al. (2010) · Nano Letters · doi:10.1021/nl1037903 · Cited by 76
Role of the spleen in lipid metabolism
Fatouros, M., Bourantas, K. L., Bairaktari, E. T., Elisaf, M., Tsolas, O., & Cassioumis, D. (1995) · British journal of surgery · doi:10.1002/bjs.1800821230 · Cited by 74
Expression of Human Scavenger Receptor B1 on and in Human Platelets
Imachi, H., Murao, K., Cao, W.-M., Tada, S., Taminato, T., Wong, N. C. W., Takahara, J., & Ishida, T. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000067429.46333.7b · Cited by 76
Influence of caveolin-1 on cellular cholesterol efflux mediated by high-density lipoproteins
Frank, P. G., Galbiati, F., Volonté, D., Razani, B., Cohen, D. E., Marcel, Y. L., & Lisanti, M. P. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.5.c1204 · Cited by 76
“The importance of HDL in cholesterol elimination has been suggested by several epidemiological studies that show an inverse correlation between the development of coronary artery disease and HDL cholesterol levels (9, 31, 32, 46, 79).”
Background
Plasma lipids and lipoproteins and the prevalence of risk for coronary heart disease in Canadian adults. Canadian Heart Health Surveys Research Group.
Connelly, P. W., MacLean, D. R., Horlick, L., O'Connor, B., Petrasovits, A., & Little, J. A. (1992) · Europe PMC (PubMed Central) · Cited by 76
ABCA1 Overexpression in the Liver of LDLr-KO Mice Leads to Accumulation of Pro-atherogenic Lipoproteins and Enhanced Atherosclerosis
Joyce, C. W., Wagner, E. M., Basso, F., Amar, M. J., Freeman, L. A., Shamburek, R. D., Knapper, C. L., Syed, J., Wu, J., Vaisman, B. L., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604526200 · Cited by 80
Scavenger Receptor Class B Type I Protein as an Independent Predictor of High-Density Lipoprotein Cholesterol Levels in Subjects with Hyperalphalipoproteinemia
West, M., Greason, E., Kolmakova, A., Jahangiri, A., Asztalos, B. F., Pollin, T. I., & Rodríguez, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1223 · Cited by 75
Rapid reversal of endothelial dysfunction in hypercholesterolemic apolipoprotein E-null mice by recombinant apolipoprotein A-IMilano-phospholipid complex
Kaul, S., Coin, B. D., Hedayiti, A., Yano, J., Cercek, B., Chyu, K., & Shah, P. K. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.028 · Cited by 75
Low High-Density Lipoprotein Cholesterol
Hersberger, M., & von Eckardstein, A. (2003) · Drugs · doi:10.2165/00003495-200363180-00003 · Cited by 74
“In patients ence of cofactors such as hepatic lipase, which with angiographically assessed CHD, this associa- © Adis Data Information BV 2003.”
BackgroundInfluential
Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells
Desrumaux, C. M., Mak, P. A., Boisvert, W. A., Masson, D., Stupack, D., Jauhiainen, M., Ehnholm, C., & Curtiss, L. K. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200281-jlr200 · Cited by 75
Pig plasma phospholipid transfer protein facilitates HDL interconversion.
Pussinen, P. J., Jauhianinen, M., Metso, J., Tyynelä, J., & Ehnholm, C. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39855-2 · Cited by 77
ABCA1 and Biogenesis of HDL
Yokoyama, S. (2006) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.13.1 · Cited by 76
Differences in dyslipidemia between American and Italian women with polycystic ovary syndrome
Essah, P. A., Nestler, J. E., & Carmina, E. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03345564 · Cited by 74
Antihyperlipidaemic activity of swertiamarin, a secoiridoid glycoside in poloxamer-407-induced hyperlipidaemic rats
Vaidya, H. B., Rajani, M., Sudarsanam, V., Padh, H., & Goyal, R. K. (2009) · Journal of Natural Medicines · doi:10.1007/s11418-009-0350-8 · Cited by 74
Perspectives on Dyslipidemia and Coronary Heart Disease in Women
Bittner, V. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.05.089 · Cited by 73
Diabetes Impairs Cellular Cholesterol Efflux From ABCA1 to Small HDL Particles
He, Y., Ronsein, G. E., Tang, C., Jarvik, G. P., Davidson, W. S., Kothari, V. M., Song, H. D., Segrest, J. P., Bornfeldt, K., & Heinecke, J. W. (2020) · Circulation Research · doi:10.1161/circresaha.120.317178 · Cited by 74
Does sports activity enhance the risk of sudden cardiac death?
Corrado, D., Basso, C., Schiavon, M., & Thiene, G. (2006) · Journal of Cardiovascular Medicine · doi:10.2459/01.jcm.0000219313.89633.45 · Cited by 73
Poloxamer 407-mediated alterations in the activities of enzymes regulating lipid metabolism in rats.
Wasan, K. M., Subramanian, R., Kwong, M., Goldberg, I. J., Wright, T., & Johnston, T. P. (2003) · PubMed · Cited by 73
Interrelationships among Lipoprotein Levels, Sex Hormones, Anthropometric Parameters, and Age in Hypogonadal Men Treated for 1 Year with a Permeation-Enhanced Testosterone Transdermal System1
Dobs, A. S., Bachorik, P. S., Arver, S., Meikle, A. W., Sanders, S. W., Caramelli, K. E., & Mazer, N. A. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7285 · Cited by 73
HDL-subpopulation patterns in response to reductions in dietary total and saturated fat intakes in healthy subjects
Berglund, L., Oliver, E. H., Fontanez, N., Holleran, S., Matthews, K. A., Roheim, P. S., Ginsberg, H. N., Ramakrishnan, R., & LeFevre, M. L. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.992 · Cited by 71
Association Between Serum High‐Density Lipoprotein Cholesterol Levels and Progression of Chronic Kidney Disease: Results From the KNOW‐CKD
Nam, K., Chang, T., Joo, Y. S., Kim, J., Lee, S.-M., Lee, C., Yun, H., Park, J., Yoo, T., Sung, S.-A., et al. (2019) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.118.011162 · Cited by 59
“Low HDL-C is a traditional risk factor for future cardiovascular events.(7) In line with this, several epidemiologic studies have suggested an association between low HDL-C and poor renal function in the general population.”
Result
Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats
Kim, H., Jeong, D. M., Jung, H. J., Jung, Y. J., Yokozawa, T., & Choi, J. S. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.73 · Cited by 72
Apolipoprotein A-II Modulates the Binding and Selective Lipid Uptake of Reconstituted High Density Lipoprotein by Scavenger Receptor BI
de Beer, M. C., Durbin, D. M., Cai, L., Mirocha, N., Jonas, A., Webb, N. R., de Beer, F. C., & van der Westhuyzen, D. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100228200 · Cited by 72
Lipoprotein abnormalities related to women’s health
Bittner, V. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02637-1 · Cited by 72
Expression of the human apolipoprotein A-I gene in transgenic mice alters high density lipoprotein (HDL) particle size distribution and diminishes selective uptake of HDL cholesteryl esters.
Chajek‐Shaul, T., Hayek, T., Walsh, A., & Breslow, J. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.15.6731 · Cited by 72
Cholesterol Efflux, Cholesterol Esterification, and Cholesteryl Ester Transfer by LpA-I and LpA-I/A-II in Native Plasma
Huang, Y., von Eckardstein, A., Wu, S., & Assmann, G. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.9.1412 · Cited by 72
Triglyceride-rich lipoproteins and atherosclerosis
Patsch, J. R. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)05372-p · Cited by 72
Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects
Dullaart, R. P. F., de Vries, R., Roozendaal, C., Kobold, A. C. M., & Sluiter, W. J. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02943.x · Cited by 71
The Effect of Cholesteryl Ester Transfer Protein −629C→A Promoter Polymorphism on High-Density Lipoprotein Cholesterol Is Dependent on Serum Triglycerides
Borggreve, S. E., Hillege, H. L., Wolffenbuttel, B. H. R., de Jong, P. E., Bakker, S. J. L., van der Steege, G., van Tol, A., & Dullaart, R. P. F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0182 · Cited by 71
Apolipoprotein A-II Production Rate Is a Major Factor Regulating the Distribution of Apolipoprotein A-I Among HDL Subclasses LpA-I and LpA-I:A-II in Normolipidemic Humans
Ikewaki, K., Zech, L. A., Kindt, M. R., Brewer, H. B., & Rader, D. J. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.3.306 · Cited by 71
Cloning and Characterization of HB2, a Candidate High Density Lipoprotein Receptor
Matsumoto, A., Mitchell, A., Kurata, H., Pyle, L. E., Kondo, K. N., Itakura, H., & Fidge, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.16778 · Cited by 70
Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI
Crauwels, H. M. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00353-5 · Cited by 70
Antiinflammatory Actions of HDL
Rye, K., & Barter, P. J. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.173575 · Cited by 70
The complexity of HDL
Francis, G. A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.08.009 · Cited by 69
Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease
Yamazaki, K., Honda, T., Domon, H., Okui, T., Kajita, K., Amanuma, R., Kudoh, C., Takashiba, S., Kokeguchi, S., Nishimura, F., et al. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03450.x · Cited by 69
A role for the scavenger receptor, class B type I in high density lipoprotein dependent activation of cellular signaling pathways
Al‐Jarallah, A., & Trigatti, B. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.08.006 · Cited by 69
Influence of the HDL receptor SR-BI on atherosclerosis
Krieger, M., & Kozarsky, K. (1999) · Current Opinion in Lipidology · doi:10.1097/00041433-199912000-00003 · Cited by 70
Expression of serum amyloid A protein in the absence of the acute phase response does not reduce HDL cholesterol or apoA-I levels in human apoA-I transgenic mice
Hosoai, H., Webb, N. R., Glick, J. M., Tietge, U. J. F., Purdom, M. S., de Beer, F. C., & Rader, D. J. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32143-x · Cited by 69
The Role of Lipoprotein A-I and Lipoprotein A-I/A-II in Predicting Coronary Artery Disease
O’Brien, T., Nguyen, T. T., Hallaway, B. J., Hodge, D. O., Bailey, K. R., Holmes, D. R., & Kottke, B. A. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.2.228 · Cited by 69
High-density lipoprotein and homocysteine levels correlate inversely in preeclamptic women in northern Nigeria
VanderJagt, D. J., Patel, R. J., El-Nafaty, A. U., Melah, G. S., Crossey, M., & Glew, R. H. (2004) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2004.00513.x · Cited by 68
Effects of Hepatic Expression of the High-Density Lipoprotein Receptor SR-BI on Lipoprotein Metabolism and Female Fertility
Yesilaltay, A., Morales, M. G., Amigo, L., Zanlungo, S., Rigotti, A., Karackattu, S. L., Donahee, M. H., Kozarsky, K., & Krieger, M. (2006) · Endocrinology · doi:10.1210/en.2005-1286 · Cited by 68
Anthocyanin supplementation at different doses improves cholesterol efflux capacity in subjects with dyslipidemia—a randomized controlled trial
Xu, Z., Xie, J., Zhang, H., Pang, J., Li, Q., Wang, X., Xu, H., Sun, X., Zhao, H. W., Yang, Y., et al. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-0609-4 · Cited by 69
Effects of Diet on High-Density Lipoprotein Cholesterol
Siri‐Tarino, P. W. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0207-y · Cited by 70
Cellular and physiological roles of SR-BI, a lipoprotein receptor which mediates selective lipid uptake
Trigatti, B. L. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00154-2 · Cited by 66
The expression of scavenger receptor class B, type I (SR-BI) and caveolin-1 in parenchymal and nonparenchymal liver cells
Malerød, L., Juvet, L. K., Gjøen, T., & Berg, T. (2001) · Cell and Tissue Research · doi:10.1007/s00441-001-0476-9 · Cited by 67
“Many epidemiological studies have established that elevated plasma LDL cholesterol levels are related to the development of cardiovascular disease, whereas this risk is inversely proportional to plasma HDL cholesterol levels ( Gordon and Rifkind 1989 ).”
Background
Cholesterol efflux by acute-phase high density lipoprotein: role of lecithin:cholesterol acyltransferase
Khovidhunkit, W., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grünfeld, C. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31621-7 · Cited by 67
PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION
Shah, P. K. (1996) · Cardiology Clinics · doi:10.1016/s0733-8651(05)70258-7 · Cited by 68
Proteomics Investigations of HDL: Challenges and Promise
Vaisar, T. (2012) · Current Vascular Pharmacology · doi:10.2174/157016112800812755 · Cited by 69
“It is well established by many clinical, epidemiological and genetic studies that while increased levels of high density lipoprotein (HDL) cholesterol are associated with decreased the risk of cardiovascular disease (CVD) low levels of HDL are associated with increased risk.[1, 2] These data strongly suggest that HDL…”
Background
Plasma Cholesterol–Induced Lesion Networks Activated before Regression of Early, Mature, and Advanced Atherosclerosis
Björkegren, J., Hägg, S., Talukdar, H. A., Asl, H. F., Jain, R. K., Cedergren, C., Shang, M.-M., Rossignoli, A., TAKOLANDER, R., Melander, O., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004201 · Cited by 67
“This strategy is motivated by the fact that plasma levels of HDL-cholesterol and ApoA1 in humans correlate inversely and independently with coronary heart disease [37,38].”
Background
Pharmaceutical Cost Savings of Treating Obesity with Weight Loss Medications
Greenway, F. L., Ryan, D. H., Bray, G. A., Rood, J. C., Tucker, E. W., & Smith, S. R. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00709.x · Cited by 66

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks