Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 47 of the 50 references it cites were found in a registry or an index.

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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High density lipoprotein as a protective factor against coronary heart disease
Gordon, T., Castelli, W. P., Hjortland, M. C., Kannel, W. B., & Dawber, T. R. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90874-9 · Cited by 5,059
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Self-citation
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“Four oligonucleotides were used to detect the 2 polymorphisms: (1) TGTATACCCACCCAGAG, (2) GTATACCCCCCCAGAGT, (3) TGTATACACACCCAGAG, and (4) TGTATACACCCCCAGAG (the polymorphic nucleotides are underlined and in bold).”
Method
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Result
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The Apolipoprotein L Gene Cluster Has Emerged Recently in Evolution and Is Expressed in Human Vascular Tissue
Monajemi, H., Fontijn, R. D., Pannekoek, H., & Horrevoets, A. J. G. (2002) · Genomics · doi:10.1006/geno.2002.6729 · Cited by 157
“Elevated plasma low-density lipoprotein (LDL)-cholesterol levels are associated with CHD [1], whereas there is a strong inverse relationship between high-density lipoprotein (HDL)-cholesterol levels and the incidence of CHD [2].”
Cause and Manner of Death Among Users of Anabolic Androgenic Steroids
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Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I
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Ability of reconstituted high density lipoproteins to inhibit cytokine-induced expression of vascular cell adhesion molecule-1 in human umbilical vein endothelial cells
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Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanistic studies in human Apo A-I transgenic and control mice.
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Torcetrapib Induces Aldosterone and Cortisol Production by an Intracellular Calcium-Mediated Mechanism Independently of Cholesteryl Ester Transfer Protein Inhibition
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“Epidemiologicaldatasupport thepotentialroleofelevatinghighdensity lipoprotein (HDL) cholesterol (C) levels in the treatment of atherosclerosis (1).”
Background
The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis.
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“A number of epidemiological studies have demonstrated an inverse association between plasma HDLlevels and the development of coronary artery disease (22, 23).”
Background
High-Density Lipoproteins Suppress Chemokines and Chemokine Receptors In Vitro and In Vivo
Bursill, C. A., Castro, M. L., Beattie, D. T., Nakhla, S., van der Vorst, E. P. C., Heather, A. K., Barter, P. J., & Rye, K.-A. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.211342 · Cited by 152
High-Density Lipoprotein Cholesterol and Risk of Ischemic Stroke Mortality
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Somatic Gene Transfer of Human ApoA-I Inhibits Atherosclerosis Progression in Mouse Models
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“ApoA-I–containing lipoproteins appear to exert their antiatherogenic effect by (1) facilitating reverse cholesterol transport, during which cholesterol excess is transported away from cells of extrahepatic tissues and carried back to the liver, where it can be eliminated or reused13,14; (2) inhibiting lipoprotein oxid…”
Background
Biased Ligands for Better Cardiovascular Drugs
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Testosterone up-regulates scavenger receptor BI and stimulates cholesterol efflux from macrophages
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High-Density Lipoproteins Protect Isolated Rat Hearts From Ischemia-Reperfusion Injury by Reducing Cardiac Tumor Necrosis Factor-α Content and Enhancing Prostaglandin Release
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“Further support to this concept comes from (1) the specific and saturable in vitro binding of HDLs to immobilized TNF- ; (2) the observation that TNF- is bound to HDLs”
Background
Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages
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“Supplementary key words ATP binding cassette transporters • lipopolysaccharide • cytokine • acute-phase response • reverse cholesterol transport • high density lipoprotein metabolism • liver X receptor • retinoid X receptor In epidemiological studies, plasma levels of HDL cholesterol are inversely correlated with the…”
Background
Obstructive sleep apnoea and its therapy influence high-density lipoprotein cholesterol serum levels
Börgel, J., Sanner, B. M., Bittlinsky, A., Keskin, F., Bartels, N. K., Buechner, N., Hüsing, A., Rump, L. C., & Mügge, A. (2005) · European Respiratory Journal · doi:10.1183/09031936.06.00131304 · Cited by 141
“Disorders in lipid metabolism may result in early occurrence of atherosclerotic alterations [1, 2]. In addition to the well characterised pro-atherosclerotic effect of high low-density lipoprotein cholesterol (LDL-C) [3] concentrations, there is an inverse correlation between the high-density lipoprotein cholesterol (…”
Background
Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria
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Modifying Apolipoprotein A-I by Malondialdehyde, but Not by an Array of Other Reactive Carbonyls, Blocks Cholesterol Efflux by the ABCA1 Pathway
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Lipoproteins and lipoprotein mimetics for imaging and drug delivery
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“[67] On the other hand, the levels of HDL-cholesterol are inversely correlated with the risk of cardiovascular disease.[68] Significant efforts have gone into the development of drugs that raise HDL-cholesterol levels, however such drugs have not shown a therapeutic benefit to date.”
The “best” of cholesterols, the “worst” of cholesterols: A tale of two receptors
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Tamoxifen elevates transforming growth factor–β and suppresses diet–induced formation of lipid lesions in mouse aorta
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Adipocyte Modulation of High-Density Lipoprotein Cholesterol
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“These data suggest that (1) SR-BI plays an important role in adipocyte cholesterol efflux to mature HDL particles (in contrast to findings in macrophages13) and (2) SR-BI does not mediate basal or LXR-induced adipocyte cholesterol efflux to apoA-I.”
BackgroundResult
Evidence that high-density lipoprotein cholesterol is an independent predictor of acute platelet-dependent thrombus formation
Naqvi, T. Z., Shah, P. K., Ivey, P. A., Molloy, M. D., Thomas, A. M., Panicker, S., Ahmed, A. E. E., Cercek, B., & Kaul, S. (1999) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)00489-0 · Cited by 134
Plasma triglycerides and three lipoprotein cholesterol fractions are independent predictors of the extent of coronary atherosclerosis.
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HDL3-Mediated Inhibition of Thrombin-Induced Platelet Aggregation and Fibrinogen Binding Occurs via Decreased Production of Phosphoinositide-Derived Second Messengers 1,2-Diacylglycerol and Inositol 1,4,5-tris-Phosphate
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Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice
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“In both mice (1, 2) and humans (3) there is a strong in-”
Background
Analysis of Glomerulosclerosis and Atherosclerosis in Lecithin Cholesterol Acyltransferase-deficient Mice
Lambert, G. C., Sakai, N., Vaisman, B. L., Neufeld, E. B., Marteyn, B., Chan, C., Paigen, B. J., Lupia, E., Thomas, A., Striker, L. J., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008466200 · Cited by 131
Dose-Dependent Acceleration of High-Density Lipoprotein Catabolism by Endothelial Lipase
Maugeais, C., Tietge, U. J. F., Broedl, U. C., Marchadier, D. H. L., Cain, W. J., McCoy, M. G., Lund‐Katz, S., Glick, J. M., & Rader, D. J. (2003) · Circulation · doi:10.1161/01.cir.0000092889.24713.dc · Cited by 132
Detection and treatment of atherosclerosis using nanoparticles
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Paradoxical enhancement of atherosclerosis by probucol treatment in apolipoprotein E-deficient mice.
Zhang, S. H., Reddick, R. L., Avdievich, E., Surles, L., Jones, R. G., Reynolds, J. B., Quarfordt, S. H., & Maeda, N. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119479 · Cited by 131
“Since the levels of plasma HDL cholesterol have been shown to be inversely associated with atherosclerosis in various studies (25), the adverse effect on the development of atherosclerosis seen with probucol treatment of apoE-deficient mice may be the result of the dramatic reduction of HDL cholesterol that accompanie…”
Background
High-Density Lipoprotein Cholesterol and Risk of Stroke in Japanese Men and Women: The Oyabe Study
Soyama, Y., Miura, K., Morikawa, Y., Nishijo, M., Nakanishi, Y., Naruse, Y., Kagamimori, S., & Nakagawa, H. (2003) · Stroke · doi:10.1161/01.str.0000060869.34009.38 · Cited by 128
Testosterone upregulates lipoprotein status to control sexual attractiveness in a colorful songbird
McGraw, K. J., Correa, S. M., & Adkins–Regan, E. (2005) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-005-0135-3 · Cited by 130
“In the case of carotenoid coloration, it is tempting to speculate about the fitness consequences of T-driven elevated cholesterol levels, given the body of work on the link between cholesterol and arteriosclerosis in humans (Gordon and Rifkind 1989; Campeau et al. 2005).”
Background
High Plasma Phospholipid Transfer Protein Levels as a Risk Factor for Coronary Artery Disease
Schlitt, A., Bickel, C., Thumma, P., Blankenberg, S., Rupprecht, H. J., Meyer, J., & Jiang, X. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000094433.98445.7f · Cited by 130
Combined Statin and Niacin Therapy Remodels the High-Density Lipoprotein Proteome
Green, P. S., Vaisar, T., Pennathur, S., Kulstad, J. J., Moore, A. B., Marcovina, S. M., Brunzell, J. D., Knopp, R. H., Zhao, X.-Q., & Heinecke, J. W. (2008) · Circulation · doi:10.1161/circulationaha.108.770669 · Cited by 131
Endothelial Lipase Modulates Susceptibility to Atherosclerosis in Apolipoprotein-E-deficient Mice
Ishida, T., Choi, S. Y., Kundu, R. K., Spin, J. M., Yamashita, T., Hirata, K., Kojima, Y., Yokoyama, M., Cooper, A. D., & Quertermous, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406360200 · Cited by 129
A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease
Hovingh, G. K., Brownlie, A., Bisoendial, R. J., Dubé, M., Levels, J. H. M., Petersen, W., Dullaart, R. P. F., Stroes, E. S. G., Zwinderman, A. H., de Groot, E., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.06.070 · Cited by 129
“f rospective epidemiologic studies have shown that highensity lipoprotein (HDL) cholesterol plasma levels are inersely related to coronary artery disease (CAD) risk (1).”
Background
Physiologic Testosterone Levels in Normal Men Suppress High-Density Lipoprotein Cholesterol Levels
Bagatell, C. J., Knopp, R. H., Vale, W., Rivier, J. E., & Bremner, W. J. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-12-967 · Cited by 129
Exercise and the Risk of Sudden Cardiac Death
Corrado, D., Migliore, F., Basso, C., & Thiene, G. (2006) · Herz · doi:10.1007/s00059-006-2885-8 · Cited by 131

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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