Cited by 1,547Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismParaoxonase enzyme and polymorphisms

The DOI matches its Crossref record; 47 of the 50 references it cites were found in a registry or an index.

High-Density Lipoprotein — The Clinical Implications of Recent Studies

Desforges, Jane F., Gordon, David J., Rifkind, Basil M.·1989·New England Journal of Medicine

DOI 10.1056/nejm198911093211907

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Abstract

DESPITE early observations suggesting an inverse relation between serum levels of high-density lipoprotein (HDL) cholesterol and coronary disease,1 2 3 the possible protective role of HDL in atherogenesis received little attention until its "rediscovery" by Miller and Miller4 in 1975 and the publication of confirmatory results from the Honolulu,5 Framingham,6 and Tromsø7 heart studies in 1976 and 1977. In the ensuing decade, research into the biochemistry, metabolism, epidemiology, and genetics of HDL has expanded rapidly, but many questions remain unanswered. The recent publication of the results of the Helsinki Heart Study8 , 9 — in which simultaneous 11 percent increases in HDL and reductions . . .

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High density lipoprotein as a protective factor against coronary heart disease
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Self-citation
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Background
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Background
Complex association of apolipoprotein E–containing HDL with coronary artery disease burden in cardiovascular disease
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Background
Atherosclerotic Plaque Regression: Fact or Fiction?
Shanmugam, N., Román-Rego, A., Ong, P., & Kaski, J. C. (2010) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-010-6241-0 · Cited by 19
“The benefits of raised HDL cholesterol have stimulated interest in the development of HDL targeted therapies [ 34 ].”
Background
Current evidence and biological plausibility linking periodontitis to atherosclerotic cardiovascular disease
Tabeta, K., Yoshie, H., & Yamazaki, K. (2014) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2014.03.001 · Cited by 20
“Therefore, the relationship between these two diseases has been carefully assessed considering the effect of these confounders, and periodontitis has been shown to be an independent risk factor for CHD.”
BackgroundInfluential
The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes
Ganesan, M., Bhaskar, S., Mani, R., Idris, M. M., Khaja, N., Gulla, S., Kumar, U., Moova, S., Vattam, K. K., Eppa, K., et al. (2010) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2010.10.001 · Cited by 20
“Several prospective epidemiological studies have shown that elevated levels of HDL-C constitute an independent negative risk factor for coronary heart disease (Gordon & Rifkind, 1989).”
Background
Serum Apo A-1 and Its Role as a Biomarker of Coronary Artery Disease
Rahim, S., Abdullah, H. M. A., Ali, Y., Khan, U. I., Ullah, W., Shahzad, M. A., & Waleed, M. (2016) · Cureus · doi:10.7759/cureus.941 · Cited by 20
“Introduction Plasma cholesterol levels are important predictors of coronary artery disease (CAD) [1-2].”
Background
High prevalence of cardiovascular disease in South Asians: Central role for brown adipose tissue?
Boon, M. R., Bakker, L. E. H., van der Linden, R. A. D., van Ouwerkerk, A. F., de Goeje, P. L., Counotte, J., Jazet, I. M., & Rensen, P. C. N. (2015) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.1003634 · Cited by 20
Effect of Plasma Lipoproteins on Natural Killer Cell Activity in the Elderly Population
Yasumasu, T., Takahara, K., Sadayasu, T., Date, H., Isozumi, K., Kouzuma, R., & Nakashima, Y. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.6.m561 · Cited by 20
“HDL is considered to facilitate cholesterol transport back to the liver (14) and to be a negative risk factor for coronary artery disease (15).”
Background
Apolipoprotein E gene polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease risk
Sheehan, D., Bennett, T., & Cashman, K. D. (2000) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf03170486 · Cited by 20
The plasma concentration of Lpa-I:A-II particles as a predictor of the inflammatory response in patients with ST-elevation myocardial infarction
Gomaraschi, M., Sinagra, G., Serdoz, L. V., Pitzorno, C., Fonda, M., Cattin, L., Calabresi, L., & Franceschini, G. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.004 · Cited by 20
Atherogenesis
Stoltzfus, L. J., & Rubin, E. M. (1993) · Trends in Cardiovascular Medicine · doi:10.1016/1050-1738(93)90013-v · Cited by 20
The predictive power of low-density lipoprotein cholesterol for coronary calcification
Allison, M. (2003) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00571-5 · Cited by 20
The Establishment of Telomerase-immortalized Tangier Disease Cell Lines Indicates the Existence of an Apolipoprotein A-I-inducible but ABCA1-independent Cholesterol Efflux Pathway
Walter, M., Forsyth, N. R., Wright, W. E., Shay, J. W., & Roth, M. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401714200 · Cited by 19
Molecular Basis of Fish-Eye Disease in a Patient From Spain
Blanco‐Vaca, F., Qu, S., Fiol, C., Fan, H.-Z., Pao, Q., Marzal-Casacuberta, À., Albers, J. J., Hurtado, I., Gracia, V., Pintó, X., et al. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.7.1382 · Cited by 20
The Expression of Intact and Mutant Human apoAI/CIII/AIV/AV Gene Cluster in Transgenic Mice
Gao, J., Wei, Y., Huang, Y., Liu, D., Liu, G., Wu, M., Wu, L., Zhang, Q.-J., Zhang, Z., Zhang, R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409883200 · Cited by 20
Clinical Evaluation of Probucol in Hypercholesterolemia: Individual Lipoprotein Responses and Inhibitory Effect on Carotid Atherosclerosis Progression
Baldassarre, D., Franceschini, G., Peruzzotti, G., Brusoni, B., & Sirtori, C. R. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199712000-00013 · Cited by 20
A polymorphic site in the 3′ untranslated region of the cholesteryl ester transfer protein (CETP) gene is associated with low CETP activity
Tamminen, M., Kakko, S., Kesäniemi, Y. A., & Savolainen, M. J. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05833-9 · Cited by 20
Relationship between LDL, HDL, blood pressure and atheroma progression in the coronaries
Nicholls, S. J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832ec396 · Cited by 19
Postprandial Studies Uncover Differing Effects on HDL Particles of Overt and Subclinical Hypothyroidism
McGowan, A., Widdowson, W. M., O’Regan, A., Young, I. S., Boran, G. P., McEneny, J., & Gibney, J. (2016) · Thyroid · doi:10.1089/thy.2015.0443 · Cited by 19
“An inverse relationship exists between plasma HDL concentration and coronary artery disease (38).”
Inducing apolipoprotein A-I synthesis to reduce cardiovascular risk: from ASSERT to SUSTAIN and beyond
Bartolo, B. A. D., Scherer, D. J., & Nicholls, S. J. (2016) · Archives of Medical Science · doi:10.5114/aoms.2016.62906 · Cited by 20
Diabetic Conditions Differentially Affect the Endothelial Function, Arterial Stiffness and Carotid Atherosclerosis
Kinouchi, M., Aihara, K., Fujinaka, Y., Yoshida, S., Oguro, Y., Kurahashi, K., Kondo, T., Aki, N., Kuroda, A., Endo, I., et al. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.20834 · Cited by 19
Screening for naturally occurring apolipoprotein A-I variants: apo A-I(?K107) is associated with low HDL-cholesterol levels in men but not in women
Nofer, J., von Eckardstein, A., Wiebusch, H., Weng, W., Funke, H., Schulte, H., K�hler, E., & Assmann, G. (1995) · Human Genetics · doi:10.1007/bf00207375 · Cited by 19
“Moreover, HDL as well as apo A-I containing proteoliposomes promote cholesterol effiux from peripheral cells thus providing substrate for the LCAT reaction (Johnson et al. 1991).This reverse cholesterol transport model is frequently used to explain the inverse association of HDL-cholesterol levels with the risk of ath…”
Background
Biosensing of arteriosclerotic nanoplaque formation and interaction with an HMG‐CoA reductase inhibitor
Abletshauser, C., Klüßendorf, D., Schmidt, A., Winkler, K. E., März, W., Buddecke, E., Malmsten, M., & Siegel, G. (2002) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2002.01020.x · Cited by 19
FACTORS AFFECTING HIGH-DENSITY LIPOPROTEINS
Gordon, D. J. (1998) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70034-7 · Cited by 19
Self-citation
Red grape leaf extract improves endurance capacity by facilitating fatty acid utilization in skeletal muscle in mice
Minegishi, Y., Haramizu, S., Hase, T., & Murase, T. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1826-2 · Cited by 21
“HDLcholesterol mediates reverse cholesterol transportation, transferring cholesterol from non-hepatic cells to the liver and suppressing the accumulation of excessive cholesterol, and low levels of HDL-cholesterol are an important risk factor for cardiovascular disease ( Gordon and Rifkind 1989 ).”
Background
The Apolipoprotein E Phenotype Has a Strong Influence on Tracking of Serum Cholesterol and Lipoprotein Levels in Children: A Follow-Up Study from Birth to the Age of 11 Years
KALLIO, M. J. T., Salmenperä, L., Siimes, M. A., Perheentupa, J., Gylling, H., & Miettinen, T. A. (1998) · Pediatric Research · doi:10.1203/00006450-199803000-00012 · Cited by 19
Genetic Polymorphisms in Emerging Cardiovascular Risk Factors and Response to Statin Therapy
Dornbrook-Lavender, K. A., & Pieper, J. A. (2003) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1024212026578 · Cited by 19
“Elevated concentrations of CETP have been associated with reduced concentrations of HDL-C [26], a strong and independent risk factor for the development of CHD [27].”
Background
HDL heterogeneity and coronary heart disease
Fiévet, C., & Fruchart, J. (1991) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610070304 · Cited by 19
Lower High-Density Lipoprotein Cholesterol is a Significant and Independent Risk for Coronary Artery Disease in Japanese Men
Satoh, H., Tomita, K., Fujii, S., Kishi, R., & Tsutsui, H. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1644 · Cited by 18
Pharmacologic Management of Isolated Low High-Density Lipoprotein Syndrome
Bermúdez, V., Cano, R., Cano, C., Bermúdez, F., Arráiz, N., Acosta, L., Finol, F., Pabón, M. R., Amell, A., Reyna, N., et al. (2008) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e318169bc0b · Cited by 17
Association of the LIPG 584C > T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations
Liu, W., Yin, R., Zhang, L., Cao, X., Miao, L., Wu, D., Aung, L. H. H., Hu, X.-J., Lin, W., & Yang, D.-Z. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-110 · Cited by 18
“In the present study, we also showed that the levels of TC and ApoAI in Bai Ku Yao and the levels of TC and TG in Han were different between the CC and CT/TT genotypes.”
BackgroundInfluential
Clinical trials with cholesteryl ester transfer protein inhibitors
Bartolo, B. A. D., Duong, M., & Nicholls, S. J. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000352 · Cited by 18
High-density lipoprotein cholesterol associated with change in coronary plaque lipid burden assessed by near infrared spectroscopy
Honda, S., Sidharta, S. L., Shishikura, D., Takata, K., Giovanni, G. D., Nguyen, T., Janssan, A., Kim, S. W., Andrews, J., Psaltis, P. J., et al. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.016 · Cited by 18
Clusterin, paraoxonase 1, and myeloperoxidase alterations induce high‐density lipoproteins dysfunction and contribute to peripheral artery disease; aggravation by type 2 diabetes mellitus
Sanda, G. M., Toma, L., Barbălată, T., Moraru, O. E., Niculescu, L. S., Sima, A. V., & Stancu, C. S. (2021) · BioFactors · doi:10.1002/biof.1800 · Cited by 18
Association of Human Cholesteryl Ester Transfer Protein-TaqI Polymorphisms with Serum HDL Cholesterol Levels in a Normolipemic Japanese Rural Population.
Chen, J., Yokoyama, T., Saito, K., Yoshiike, N., Date, C., & Tanaka, H. (2002) · Journal of Epidemiology · doi:10.2188/jea.12.77 · Cited by 18
Preservation of micronutrients during rapeseed oil refining: A tool to optimize the health value of edible vegetable oils? Rationale and design of the Optim'Oils randomized clinical trial
Gladine, C., Meunier, N., Blot, A., Bruchet, L., Pagès, X., Gaud, M., Flöter, E., Metin, Z., Rossignol‐Castera, A., Cano, N., et al. (2010) · Contemporary Clinical Trials · doi:10.1016/j.cct.2010.11.003 · Cited by 18
NALTREXONE EXERTS A FAVOURABLE EFFECT ON PLASMA LIPIDS IN ABSTINENT PATIENTS WITH ALCOHOL DEPENDENCE
Budzyński, J. (2000) · Alcohol and Alcoholism · doi:10.1093/alcalc/35.1.91 · Cited by 18
“The latter is recognized as a main antiatherogenic factor responsible for the lipidmediated protective effect of moderate alcohol consumption (Casleli et al., 1983; Gordon and Rifkind, 1989; Kervinen et al., 1991; Camps et al., 1994; Freedman et al., 1994; Goldberg et al., 1995).”
Background
CETP activity variation in mice does not affect two major HDL antiatherogenic properties: Macrophage-specific reverse cholesterol transport and LDL antioxidant protection
Rotllán, N., Calpe‐Berdiel, L., Guillaumet-Adkins, A., Süren‐Castillo, S., Blanco‐Vaca, F., & Escolá‐Gil, J. C. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2007.05.007 · Cited by 18
“Plasma levels of high-density lipoprotein cholesterol HDLc) are inversely correlated with the incidence of therosclerotic cardiovascular disease [1].”
Background
Protective roles of HDL, apoA-I and mimetic peptide on endothelial function: Through endothelial cells and endothelial progenitor cells
Zhang, Q., Liu, L., & Zheng, X. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.034 · Cited by 18
“Lots of clinical and epidemiological studies have demonstrated the inverse association between high-density lipoprotein (HDL) levels and the risk of coronary heart disease (CHD) events [1,2].”
Background
Effect of Two Common Polymorphisms in the ATP Binding Cassette Transporter A1 Gene on HDL-Cholesterol Concentration
Woll, P. S., Hanson, N. Q., Arends, V. L., & Tsai, M. Y. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2004.047126 · Cited by 18
Lack of inhibitory effect of HDL on TNFα-induced adhesion molecule expression in human aortic endothelial cells
Zhang, W.-J., Stocker, R., McCall, M. R., Forte, T. M., & Frei, B. B. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00247-2 · Cited by 18

Authors: Desforges, J. F., Gordon, D. J., & Rifkind, B. M.
Affiliations: National Heart, Lung, and Blood Institute (US)
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 1989-11-09
Volume: 321
Issue: 19
Pages: 1311-1316
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm198911093211907
OpenAlex: W2339616051
Cited by: 1,547
References: 50
Citations by year: 2026: 9 · 2025: 6 · 2024: 15 · 2023: 19 · 2022: 13 · 2021: 22 · 2020: 22 · 2019: 30 · 2018: 21 · 2017: 24 · 2016: 36 · 2015: 47 · 2014: 42 · 2013: 42 · 2012: 38
FWCI: 9.17
Type: journal article
Language: en
Open access: closed
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: high-density lipoprotein, HDL cholesterol, coronary artery disease, atherogenesis, cardioprotection, HDL metabolism, Helsinki Heart Study
MeSH terms: Coronary Disease, Humans, Lipoproteins, HDL, Cholesterol, HDL

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High-Density Lipoprotein — The Clinical Implications of Recent Studies

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