Cited by 5,850Lipoproteins and Cardiovascular HealthInflammatory Biomarkers in Disease PrognosisAdipokines, Inflammation, and Metabolic Diseases

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C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

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Ridker, Paul M., Hennekens, Charles H., Buring, Julie E., Rifai, Nader·2000·New England Journal of Medicine

DOI 10.1056/nejm200003233421202

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Abstract

BACKGROUND: Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events. METHODS: We conducted a prospective, nested case-control study among 28,263 apparently healthy postmenopausal women over a mean follow-up period of three years to assess the risk of cardiovascular events associated with base-line levels of markers of inflammation. The markers included high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, and soluble intercellular adhesion molecule type 1 (sICAM-1). We also studied homocysteine and a variety of lipid and lipoprotein measurements. Cardiovascular events were defined as death from coronary heart disease, nonfatal myocardial infarction or stroke, or the need for coronary-revascularization procedures. RESULTS: Of the 12 markers measured, hs-CRP was the strongest univariate predictor of the risk of cardiovascular events; the relative risk of events for women in the highest as compared with the lowest quartile for this marker was 4.4 (95 percent confidence interval, 2.2 to 8.9). Other markers significantly associated with the risk of cardiovascular events were serum amyloid A (relative risk for the highest as compared with the lowest quartile, 3.0), sICAM-1 (2.6), interleukin-6 (2.2), homocysteine (2.0), total cholesterol (2.4), LDL cholesterol (2.4), apolipoprotein B-100 (3.4), HDL cholesterol (0.3), and the ratio of total cholesterol to HDL cholesterol (3.4). Prediction models that incorporated markers of inflammation in addition to lipids were significantly better at predicting risk than models based on lipid levels alone (P<0.001). The levels of hs-CRP and serum amyloid A were significant predictors of risk even in the subgroup of women with LDL cholesterol levels below 130 mg per deciliter (3.4 mmol per liter), the target for primary prevention established by the National Cholesterol Education Program. In multivariate analyses, the only plasma markers that independently predicted risk were hs-CRP (relative risk for the highest as compared with the lowest quartile, 1.5; 95 percent confidence interval, 1.1 to 2.1) and the ratio of total cholesterol to HDL cholesterol (relative risk, 1.4; 95 percent confidence interval, 1.1 to 1.9). CONCLUSIONS: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.

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Summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
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Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., Macfarlane, P. W., McKillop, J. H., & Packard, C. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332001 · Cited by 7,449
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
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Hepherd, J. A. S., Obbe, S. T. M. C., Ord, I. A. F., Sles, C. H. G. I., Orimer, A. R. O. L., Acfarlane, P. E. W. M., Illop, J. A. H. M. C. K., Ackard, C. H. J. P., & Roup, S. T. G. (1995) · Cited by 3,453
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Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
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Production of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511

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Research works printed but not linked: 1

Buring JE, 1992, J Myocard Ischemia, 4, 27

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Adamstein, N. H., MacFadyen, J. G., Rose, L. M., Glynn, R. J., Dey, A. K., Libby, P., Tabas, I. A., Mehta, N. N., & Ridker, P. M. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa1034 · Cited by 369
Self-citation
Rationale and design of the Cardiovascular Inflammation Reduction Trial: A test of the inflammatory hypothesis of atherothrombosis
Everett, B. M., Pradhan, A. D., Solomon, D. H., Paynter, N., MacFadyen, J., Zaharris, E., Gupta, M., Clearfield, M., Libby, P., Hasan, A. A. K., et al. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.03.018 · Cited by 368
Self-citation
C-Reactive Protein and the 10-Year Incidence of Coronary Heart Disease in Older Men and Women: The Cardiovascular Health Study
Cushman, M., Arnold, A. M., Psaty, B. M., Manolio, T. A., Kuller, L. H., Burke, G. L., Polak, J. F., & Tracy, R. P. (2005) · Circulation · doi:10.1161/circulationaha.104.504159 · Cited by 368
Integrated safety in tocilizumab clinical trials
Schiff, M. H., Kremer, J. M., Jahreis, A., Vernon, E., Isaacs, J. D., & van Vollenhoven, R. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3455 · Cited by 366
Inflammatory biomarkers in coronary artery disease
Zakynthinos, E. G., & Pappa, N. (2009) · Journal of Cardiology · doi:10.1016/j.jjcc.2008.12.007 · Cited by 363
Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease
Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 363
Summary of Updated Recommendations for Primary Prevention of Cardiovascular Disease in Women
Cho, L., Davis, M. B., Elgendy, I. Y., Epps, K., Lindley, K. J., Mehta, P. K., Michos, E. D., Minissian, M., Pepine, C. J., Vaccarino, V., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.03.060 · Cited by 363
Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment
Ceriello, A., Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Esposito, K., & Giugliano, D. (2004) · Diabetes · doi:10.2337/diabetes.53.3.701 · Cited by 362
Small-Intestinal Histopathology and Mortality Risk in Celiac Disease
Ludvigsson, J. F. (2009) · JAMA · doi:10.1001/jama.2009.1320 · Cited by 362
Arsenic and Cardiovascular Disease
States, J. C., Srivastava, S., Chen, Y., & Barchowsky, A. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn236 · Cited by 359
Our Reviewers
Gelenberg, A. J. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0101 · Cited by 355
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Acute mental stress elicits delayed increases in circulating inflammatory cytokine levels
STEPTOE, A., WILLEMSEN, G., OWEN, N., FLOWER, L., & MOHAMED-ALI, V. (2001) · Clinical Science · doi:10.1042/cs1010185 · Cited by 354
Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications
Yang, R., Lee, M., Hu, H., Pollin, T. I., Ryan, A. S., Nicklas, B. J., Snitker, S., Horenstein, R. B., Hull, K., Goldberg, N. H., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030287 · Cited by 354
New Risk Factors for Atherosclerosis and Patient Risk Assessment
Fruchart, J., Nierman, M. C., Stroes, E. S. G., Kastelein, J. J. P., & Duriez, P. (2004) · Circulation · doi:10.1161/01.cir.0000131513.33892.5b · Cited by 354
Simvastatin Lowers C-Reactive Protein Within 14 Days
Plenge, J. K., Hernandez, T. L., Weil, K. M., Poirier, P., Grunwald, G. K., Marcovina, S. M., & Eckel, R. H. (2002) · Circulation · doi:10.1161/01.cir.0000029743.68247.31 · Cited by 354
Overexpression of Functionally Coupled Cyclooxygenase-2 and Prostaglandin E Synthase in Symptomatic Atherosclerotic Plaques as a Basis of Prostaglandin E 2 -Dependent Plaque Instability
Cipollone, F., Prontera, C., Pini, B., Marini, M., Fazia, M. L., Cesare, D. D., Iezzi, A., Ucchino, S., Boccoli, G., Saba, V., et al. (2001) · Circulation · doi:10.1161/hc3401.093152 · Cited by 351
Tumour necrosis factor antagonist use and associated risk reduction of cardiovascular events among patients with rheumatoid arthritis
Greenberg, J. D., Kremer, J. M., Curtis, J. R., Hochberg, M. C., Reed, G., Tsao, P., Farkouh, M. E., Nasir, A., Setoguchi, S., & Solomon, D. H. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.129916 · Cited by 350
Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study
Ma, Y., Hébert, J. R., Li, W., Bertone‐Johnson, E. R., Olendzki, B. C., Pagoto, S., Tinker, L. F., Rosal, M. C., Ockene, I. S., Ockene, J. K., et al. (2008) · Nutrition · doi:10.1016/j.nut.2008.04.005 · Cited by 350
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Ruan, X. Z., Varghese, Z., & Moorhead, J. F. (2009) · Nature Reviews Nephrology · doi:10.1038/nrneph.2009.184 · Cited by 349
Inflammation markers predicting frailty and mortality in the elderly
Martinis, M. D., Franceschi, C., Monti, D., & Ginaldi, L. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.11.004 · Cited by 349
Humoral Innate Immunity and Acute-Phase Proteins
Mantovani, A., & Garlanda, C. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2206346 · Cited by 349
Endothelial Function Predicts Future Development of Coronary Artery Disease
Bugiardini, R., Manfrini, O., Pizzi, C., Fontana, F., & Morgagni, G. (2004) · Circulation · doi:10.1161/01.cir.0000128208.22378.e3 · Cited by 347
Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study
Dumurgier, J., Elbaz, A., Ducimetiere, P., Tavernier, B., Alperovitch, A., & Tzourio, C. (2009) · BMJ · doi:10.1136/bmj.b4460 · Cited by 344
Association Between Depression and Elevated C-Reactive Protein
Danner, M., Kasl, S. V., Abramson, J. L., & Vaccarino, V. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000041542.29808.01 · Cited by 341
Circulating Levels of Inflammatory Markers Predict Change in Bone Mineral Density and Resorption in Older Adults: A Longitudinal Study
Ding, C., Parameswaran, V., Ray, U., Burgess, J. R., & Jones, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2325 · Cited by 341
Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study
Ridker, P. M., Paré, G., Parker, A. N., Zee, R. Y. L., Danik, J. S., Buring, J. E., Kwiatkowski, D. J., Cook, N. R., Miletich, J. P., & Chasman, D. I. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.03.015 · Cited by 341
Self-citation
Association of C-Reactive Protein and HIV Infection With Acute Myocardial Infarction
Triant, V. A., Meigs, J. B., & Grinspoon, S. K. (2009) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e3181a9992c · Cited by 341
The association between burnout, depression, anxiety, and inflammation biomarkers: C-reactive protein and fibrinogen in men and women
Toker, S., Shirom, A., Shapira, I., Berliner, S., & Melamed, S. (2005) · Journal of Occupational Health Psychology · doi:10.1037/1076-8998.10.4.344 · Cited by 340
Use of Framingham risk score and new biomarkers to predict cardiovascular mortality in older people: population based observational cohort study
de Ruijter, W., Westendorp, R. G. J., Assendelft, W. J. J., den Elzen, W. P. J., de Craen, A. J. M., le Cessie, S., & Gussekloo, J. (2009) · BMJ · doi:10.1136/bmj.a3083 · Cited by 339
Blood Pressure, C-Reactive Protein, and Risk of Future Cardiovascular Events
Blake, G. J., Rifai, N., Buring, J. E., & Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000104566.10178.af · Cited by 338
Self-citation
Platelet Expression Profiling and Clinical Validation of Myeloid-Related Protein-14 as a Novel Determinant of Cardiovascular Events
Healy, A. M., Pickard, M. D., Pradhan, A. D., Wang, Y., Chen, Z., Croce, K., Sakuma, M., Shi, C., Zago, A. C., Garasic, J. M., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.607333 · Cited by 336
Self-citation
Alcohol Consumption and Plasma Concentration of C-Reactive Protein
Albert, M. A., Glynn, R. J., & Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000045669.16499.ec · Cited by 333
Self-citation
FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
Martinelli, N., Girelli, D., Malerba, G., Guarini, P., Illig, T., Trabetti, E., Sandri, M. F., Friso, S., Pizzolo, F., Schaeffer, L., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.941 · Cited by 332

Authors: Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N.
Affiliations: Brigham and Women's Hospital (US)
Boston Children's Hospital (US)
ORCID: Ridker, Paul M.
Hennekens, Charles H.
Buring, Julie E.
Rifai, Nader
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2000-03-23
Volume: 342
Issue: 12
Pages: 836-843
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejm200003233421202
OpenAlex: W2058610272
Cited by: 5,850
References: 30
Citations by year: 2026: 97 · 2025: 120 · 2024: 113 · 2023: 125 · 2022: 148 · 2021: 143 · 2020: 165 · 2019: 140 · 2018: 167 · 2017: 131 · 2016: 169 · 2015: 199 · 2014: 223 · 2013: 234 · 2012: 258
FWCI: 286.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
University Libraries (University of Maryland) (submittedVersion)
Digital Repository at the University of Maryland (University of Maryland College Park)
Funders: National Institutes of Health (5r01hl043851-10)
National Heart, Lung, and Blood Institute (R01HL058755, HL43851, HL-58755)
National Cancer Institute (CA-47988, R01CA047988)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: C-reactive protein, inflammatory markers, cardiovascular risk prediction, postmenopausal women, serum amyloid A, interleukin-6, sICAM-1, homocysteine, apolipoprotein B-100, LDL cholesterol, coronary artery disease, myocardial infarction, stroke, coronary revascularization, risk prediction model
MeSH terms: Serum Amyloid A Protein, Analysis of Variance, Apolipoproteins, C-Reactive Protein, Cardiovascular Diseases, Female, Homocysteine, Humans, Lipids, Middle Aged, Prospective Studies, Protein Precursors, Risk, Biomarkers, Interleukin-6, Case-Control Studies, Intercellular Adhesion Molecule-1

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C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women

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