The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
C-Reactive Protein and Other Markers of Inflammation in the Prediction of Cardiovascular Disease in Women
Open accessAbstract
BACKGROUND: Since inflammation is believed to have a role in the pathogenesis of cardiovascular events, measurement of markers of inflammation has been proposed as a method to improve the prediction of the risk of these events. METHODS: We conducted a prospective, nested case-control study among 28,263 apparently healthy postmenopausal women over a mean follow-up period of three years to assess the risk of cardiovascular events associated with base-line levels of markers of inflammation. The markers included high-sensitivity C-reactive protein (hs-CRP), serum amyloid A, interleukin-6, and soluble intercellular adhesion molecule type 1 (sICAM-1). We also studied homocysteine and a variety of lipid and lipoprotein measurements. Cardiovascular events were defined as death from coronary heart disease, nonfatal myocardial infarction or stroke, or the need for coronary-revascularization procedures. RESULTS: Of the 12 markers measured, hs-CRP was the strongest univariate predictor of the risk of cardiovascular events; the relative risk of events for women in the highest as compared with the lowest quartile for this marker was 4.4 (95 percent confidence interval, 2.2 to 8.9). Other markers significantly associated with the risk of cardiovascular events were serum amyloid A (relative risk for the highest as compared with the lowest quartile, 3.0), sICAM-1 (2.6), interleukin-6 (2.2), homocysteine (2.0), total cholesterol (2.4), LDL cholesterol (2.4), apolipoprotein B-100 (3.4), HDL cholesterol (0.3), and the ratio of total cholesterol to HDL cholesterol (3.4). Prediction models that incorporated markers of inflammation in addition to lipids were significantly better at predicting risk than models based on lipid levels alone (P<0.001). The levels of hs-CRP and serum amyloid A were significant predictors of risk even in the subgroup of women with LDL cholesterol levels below 130 mg per deciliter (3.4 mmol per liter), the target for primary prevention established by the National Cholesterol Education Program. In multivariate analyses, the only plasma markers that independently predicted risk were hs-CRP (relative risk for the highest as compared with the lowest quartile, 1.5; 95 percent confidence interval, 1.1 to 2.1) and the ratio of total cholesterol to HDL cholesterol (relative risk, 1.4; 95 percent confidence interval, 1.1 to 1.9). CONCLUSIONS: The addition of the measurement of C-reactive protein to screening based on lipid levels may provide an improved method of identifying persons at risk for cardiovascular events.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“longitudinal studies demonstrate that high blood levels of pro-inflammatory markers, including high-sensitivity CRP assay and IL-6, predict the risk of cardiovascular disease in both middle-aged and older adults, independent of other CVD risk factors”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [158]
Experimental — accuracy not yet measuredIn the citing paper
“Fluvastatin, pravastatin, pitavastatin, and rosuvastatin are metabolized through different CYP enzymes than the others and have less potential for interaction [507].”
From 2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk (2019) · cites this paper as [507]
In the citing paper
“IL-6 and IL-1 contribute to atherosclerosis and should be considered to be therapeutic targets”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [158]
In the citing paper
“Elevated CRP has been significantly associated with inflammation and is a high risk factor of CVD.”
From Berries: emerging impact on cardiovascular health (2010) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia
Shepherd, J., Cobbe, S. M., Ford, I., Isles, C. G., Lorimer, A. R., Macfarlane, P. W., McKillop, J. H., & Packard, C. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511163332001 · Cited by 7,449
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Self-citationDowns, J. R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D. R., Beere, P. A., Langendorfer, A., Stein, E. A., Kruyer, W., Gotto, Jr., et al. (1998) · JAMA · doi:10.1001/jama.279.20.1615 · Cited by 5,236
PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA
Hepherd, J. A. S., Obbe, S. T. M. C., Ord, I. A. F., Sles, C. H. G. I., Orimer, A. R. O. L., Acfarlane, P. E. W. M., Illop, J. A. H. M. C. K., Ackard, C. H. J. P., & Roup, S. T. G. (1995) · Cited by 3,453
The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina
Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952
Ridker, P. M., Buring, J. E., Shih, J., Matias, M., & Hennekens, C. H. (1998) · Circulation · doi:10.1161/01.cir.98.8.731 · Cited by 1,642
Self-citationProduction of C-reactive protein and risk of coronary events in stable and unstable angina
Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511
Research works printed but not linked: 1
- Buring JE, 1992, J Myocard Ischemia, 4, 27
Cited by
Sorted by citations
Items 301–400 of 1,069
Interleukin-18 and the Risk of Coronary Heart Disease in European Men
Blankenberg, S., Luc, G., Ducimetière, P., Arveiler, D., Ferrières, J., Amouyel, P., Evans, A., Cambien, F., & Tiret, L. (2003) · Circulation · doi:10.1161/01.cir.0000099509.76044.a2 · Cited by 332
Boulman, N., Levy, Y., Leiba, R., Shachar, S. S., Linn, R., Zinder, O., & Blumenfeld, Z. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031096 · Cited by 332
Heilbronn, L. K., Noakes, M., & Clifton, P. M. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.21.6.968 · Cited by 331
Turesson, C., O’Fallon, W. M., Crowson, C. S., Gabriel, S. E., & Matteson, E. L. (2002) · PubMed · Cited by 331
Jones, M. L., Martoni, C., Parent, M., & Prakash, S. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004703 · Cited by 331
Anti-Inflammatory Treatments for Chronic Diseases: A Review
Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V. G. M., Talla, V., Verma, V., Kaur, N., & Nagpal, R. (2013) · Inflammation & Allergy - Drug Targets · doi:10.2174/18715281113129990053 · Cited by 330
Mustapha, I. Z., Debrey, S. M., Oladubu, M., & Ugarte, R. M. (2007) · Journal of Periodontology · doi:10.1902/jop.2007.070140 · Cited by 328
The Hordaland Homocysteine Studies
Ueland, P. M., Nygard, O. K., Vollset, S. E., & Refsum, H. (2001) · Lipids · doi:10.1007/s11745-001-0679-7 · Cited by 328
Cohen, H. J., Harris, T., & Pieper, C. F. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01484-5 · Cited by 327
C-Reactive Protein and Cerebral Small-Vessel Disease
van Dijk, E. J., Prins, N. D., Vermeer, S. E., Vrooman, H. A., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2005) · Circulation · doi:10.1161/circulationaha.104.506337 · Cited by 327
Boersma, E. H., Mercado, N. F., Poldermans, D., Gardien, M., Vos, J., & Simoons, M. L. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12712-2 · Cited by 327
Lewis, T. T., Aiello, A. E., Leurgans, S. E., Kelly, J., & Barnes, L. L. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.11.011 · Cited by 327
C-Reactive Protein, Carotid Intima-Media Thickness, and Incidence of Ischemic Stroke in the Elderly
Cao, J. J., Thach, C. T., Manolio, T. A., Psaty, B. M., Kuller, L. H., Chaves, P. H. M., Polak, J. F., Sutton-Tyrrell, K., Herrington, D. M., Price, T. R., et al. (2003) · Circulation · doi:10.1161/01.cir.0000079160.07364.6a · Cited by 327
Carlson, C. S., Aldred, S. F., Lee, P. K., Tracy, R. P., Schwartz, S. M., Rieder, M. J., Liu, K., Williams, O. D., Iribarren, C., Lewis, E. C., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/431366 · Cited by 326
Ray, W. A., Stein, C., Hall, K., Daugherty, J. R., & Griffin, M. R. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07370-1 · Cited by 326
The Evidence for Dietary Prevention and Treatment of Cardiovascular Disease
Horn, L. V., McCoin, M., Kris‐Etherton, P. M., Burke, F., Carson, J. A. S., Champagne, C. M., Karmally, W., & Sikand, G. (2008) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.10.050 · Cited by 325
Peripheral Inflammatory Biomarkers and Risk of Parkinson's Disease
Chen, H., O'Reilly, E. J., Schwarzschild, M. A., & Ascherio, A. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm260 · Cited by 325
Pathophysiology of oxidative stress in diabetes mellitus
Lipinski, B. (2001) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00143-x · Cited by 324
Personalized protein corona on nanoparticles and its clinical implications
Corbo, C., Molinaro, R., Tabatabaei, M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Biomaterials Science · doi:10.1039/c6bm00921b · Cited by 324
Ridker, P. M., MacFadyen, J. G., Glynn, R. J., Köenig, W., Libby, P., Everett, B. M., Lefkowitz, M. P., Thuren, T. Y., & Cornel, J. H. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.490 · Cited by 324
Self-citationGender and C-reactive protein: Data from the Multiethnic Study of Atherosclerosis (MESA) cohort
Gilchrist, S. C., Cushman, M., Criqui, M. H., Rundek, T., Blumenthal, R. S., D'Agostino, R. B., & Herrington, D. M. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.02.015 · Cited by 323
Roberts, C. K., Barnard, R. J., Sindhu, R. K., Jurczak, M., Ehdaie, A., & Vaziri, N. D. (2006) · Metabolism · doi:10.1016/j.metabol.2006.02.022 · Cited by 322
Brain morphology links systemic inflammation to cognitive function in midlife adults
Marsland, A. L., Gianaros, P. J., Kuan, D. C.-H., Sheu, L. K., Krajina, K., & Manuck, S. B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.015 · Cited by 321
Gargalovic, P. S., Imura, M., Zhang, B., Gharavi, N. M., Clark, M. J., Pagnon, J. C., Yang, W.-P., He, A., Truong, A. B., Patel, S. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605457103 · Cited by 321
Targeting Interleukin-1 in Heart Disease
Tassell, B. W. V., Toldo, S. A., Mezzaroma, E., & Abbate, A. (2013) · Circulation · doi:10.1161/circulationaha.113.003199 · Cited by 321
Prostaglandins, Leukotrienes and Essential Fatty Acids
Kaur, G., Sinclair, A. J., Cameron‐Smith, D., Barr, D. P., Molero, J. C., & Konstantopoulos, N. (2009) · Cited by 321
Bellamy, M., Pellikka, P. A., Klarich, K. W., Tajik, A. J., & Enriquez-Sarano, M. L. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02496-8 · Cited by 320
Nonalcoholic fatty liver disease is associated with coronary artery calcification
Kim, D., Choi, S., Park, E. H., Lee, W., Kang, J. H., Kim, W. K., Kim, Y. J., Yoon, J., Jeong, S., Lee, D. H., et al. (2012) · Hepatology · doi:10.1002/hep.25593 · Cited by 318
Schwingshackl, L., & HOFFMANN, G. E. (2012) · Nutrients · doi:10.3390/nu4121989 · Cited by 317
Utilizing Human Blood Plasma for Proteomic Biomarker Discovery
Jacobs, J., Adkins, J., Qian, W., Liu, T., Shen, Y., Camp, D., & Smith, R. D. (2005) · Journal of Proteome Research · doi:10.1021/pr0500657 · Cited by 317
What is metabolic syndrome, and why are children getting it?
Weiss, R., Bremer, A. A., & Lustig, R. H. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12030 · Cited by 314
Strawberry As a Functional Food: An Evidence-Based Review
Basu, A., Nguyen, A., Betts, N. M., & Lyons, T. J. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.608174 · Cited by 312
Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis
Cramer, H., Lauche, R., Haller, H., Steckhan, N., Michalsen, A., & Dobos, G. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.02.017 · Cited by 310
Liao, J. K. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.009 · Cited by 310
Leukocyte Count as an Independent Predictor of Recurrent Ischemic Events
Grau, A., Boddy, A. W., Dukovic, D., Buggle, F., Lichy, C., Brandt, T., & Hacke, W. (2004) · Stroke · doi:10.1161/01.str.0000124122.71702.64 · Cited by 309
Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer’s disease
Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02970-x · Cited by 307
Premature Mortality From General Medical Illnesses Among Persons With Bipolar Disorder: A Review
Roshanaei-Moghaddam, B., & Katon, W. (2009) · Psychiatric Services · doi:10.1176/ps.2009.60.2.147 · Cited by 305
Effects of Exercise Training on Chronic Inflammation in Obesity
You, T., Arsenis, N. C., DiSanzo, B., & LaMonte, M. J. (2013) · Sports Medicine · doi:10.1007/s40279-013-0023-3 · Cited by 303
Reduction in C-reactive protein through cardiac rehabilitation and exercise training
Milani, R. V., Lavie, C. J., & Mehra, M. R. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.041 · Cited by 302
Stress and Inflammation in Coronary Artery Disease: A Review Psychoneuroendocrineimmunology-Based
Fioranelli, M., Bottaccioli, A. G., Bottaccioli, F., Bianchi, M., Rovesti, M., & Roccia, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02031 · Cited by 302
Risk factors for coronary heart disease: implications of gender
van Lennep, J. R. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00388-1 · Cited by 302
Ajani, U. A., Ford, E. S., & Mokdad, A. H. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.5.1181 · Cited by 301
Sarcopenic-obesity and cardiovascular disease risk in the elderly
Stephen, W. C., & Janssen, I. (2009) · The Journal of nutrition, health and aging · doi:10.1007/s12603-009-0084-z · Cited by 301
Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301
Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Tracy, R. P., Rubin, S. M., Harris, T. B., & Pahor, M. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00718-5 · Cited by 301
O’Brien, K. A., Ling, S., Abbas, E., Dai, A., Zhang, J., Wang, W. C., Bensoussan, A., Luo, R., Guo, Z., & Komesaroff, P. A. (2008) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/ecam/nen060 · Cited by 301
Lehrke, M., Becker, A., Greif, M., Stark, R. G., Laubender, R. P., von Ziegler, F., Lebherz, C., Tittus, J., Reiser, M. F., Becker, C. R., et al. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0380 · Cited by 301
Sudden Cardiac Death: Exploring the Limits of Our Knowledge
Myerburg, R. J. (2001) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2001.00369.x · Cited by 300
C-Reactive Protein and Reclassification of Cardiovascular Risk in the Framingham Heart Study
Wilson, P. W. F., Pencina, M., Jacques, P., Selhub, J., D'Agostino, R., & O'Donnell, C. J. (2008) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.108.831198 · Cited by 299
Periodontal disease and cardiovascular disease
Genco, R. J., Offenbacher, S., & Beck, J. D. (2002) · The Journal of the American Dental Association · doi:10.14219/jada.archive.2002.0375 · Cited by 299
How much is too much? Interleukin-6 and its signalling in atherosclerosis
Schuett, H., Luchtefeld, M., Grothusen, C., Grote, K., & Schieffer, B. (2009) · Thrombosis and Haemostasis · doi:10.1160/th09-05-0297 · Cited by 299
Assessing the Role of Circulating, Genetic, and Imaging Biomarkers in Cardiovascular Risk Prediction
Wang, T. J. (2011) · Circulation · doi:10.1161/circulationaha.109.912568 · Cited by 299
Is C-reactive protein an independent risk factor for essential hypertension?
Bautista, L. E., López-Jaramillo, P. A., Vera, L. M., Casas, J. P., Otero, A. P., & Guaracao, A. I. (2001) · Journal of Hypertension · doi:10.1097/00004872-200105000-00004 · Cited by 299
Graham, I. D., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000277984.31558.c4 · Cited by 299
Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing
Tauman, R., Ivanenko, A., O'Brien, L. M., & Gozal, D. (2004) · PEDIATRICS · doi:10.1542/peds.113.6.e564 · Cited by 297
Human C-reactive protein and the metabolic syndrome
Devaraj, S., Singh, U. S., & Jialal, I. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32832ac03e · Cited by 295
Yoneda, M., Mawatari, H., Fujita, K., Iida, H., Yonemitsu, K., Kato, S., Takahashi, H., Kirikoshi, H., Inamori, M., Nozaki, Y., et al. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-007-2060-x · Cited by 294
Public health and components of particulate matter: The changing assessment of black carbon
Grahame, T. J., Klemm, R., & Schlesinger, R. B. (2014) · Journal of the Air & Waste Management Association · doi:10.1080/10962247.2014.912692 · Cited by 294
Systemic Oxidative Stress is Associated With Visceral Fat Accumulation and the Metabolic Syndrome
Fujita, K., Nishizawa, H., Funahashi, T., Shimomura, I., & Shimabukuro, M. (2006) · Circulation Journal · doi:10.1253/circj.70.1437 · Cited by 291
Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes
Micha, R., & Mozaffarian, D. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.79 · Cited by 290
Ridker, P. M. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.04.028 · Cited by 290
Self-citationKempf, T., Horn-Wichmann, R., Brabant, G. E., Peter, T., Allhoff, T., Klein, G. G., Drexler, H., Johnston, N., Wallentin, L. C., & Wollert, K. C. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2006.076828 · Cited by 290
Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke
Napoli, M. D., Schwaninger, M., Cappelli, R., Ceccarelli, E., Gianfilippo, G. D., Donati, C., Emsley, H. C. A., Forconi, S., Hopkins, S. J., Masotti, L., et al. (2005) · Stroke · doi:10.1161/01.str.0000165929.78756.ed · Cited by 290
Atherothrombosis, inflammation, and diabetes
Biondi‐Zoccai, G., Abbate, A., Liuzzo, G., & Biasucci, L. M. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00088-3 · Cited by 290
Goodson, N. J., Symmons, D. P. M., Scott, D. G. I., Bunn, D. K., Lunt, M., & Silman, A. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21204 · Cited by 289
Potential Role of Endotoxin as a Proinflammatory Mediator of Atherosclerosis
Stoll, L. L., Denning, G. M., & Weintraub, N. L. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000147534.69062.dc · Cited by 288
The metabolic consequences of childhood obesity
Weiss, R., & Caprio, S. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.04.009 · Cited by 288
Satoh, N., Ogawa, Y., Usui, T., Tagami, T., Kono, S., Uesugi, H., Sugiyama, H., Sugawara, A., Yamada, K., Shimatsu, A., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.9.2493 · Cited by 287
Schram, M. T., Chaturvedi, N., Schalkwijk, C., Fuller, J., Stehouwer, C. D. A., & EURODIAB Prospective Complications Study Group (2005) · Diabetologia · doi:10.1007/s00125-004-1628-8 · Cited by 285
Inflammation, C‐Reactive Protein, and Atherothrombosis
Ridker, P. M., & Silvertown, J. D. (2008) · Journal of Periodontology · doi:10.1902/jop.2008.080249 · Cited by 285
Self-citationEndothelial dysfunction in young patients with rheumatoid arthritis and low disease activity
Vaudo, G., Marchesi, S., Gerli, R., Allegrucci, R., Giordano, A., Siepi, D., Pirro, M., Shoenfeld, Y., Schillaci, G., & Mannarino, E. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.007740 · Cited by 284
Increased Thrombosis After Arterial Injury in Human C-Reactive Protein–Transgenic Mice
Danenberg, H. D., Szalai, A. J., Swaminathan, R. V., Peng, L., Chen, Z., Seifert, P. A., Fay, W. P., Simon, D. I., & Edelman, E. R. (2003) · Circulation · doi:10.1161/01.cir.0000085568.13915.1e · Cited by 284
Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults
Hsue, P. Y., Deeks, S. G., & Hunt, P. W. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis200 · Cited by 281
Barregård, L., Sällsten, G., Gustafson, P., Andersson, L., Johansson, L., Basu, S., & Stigendal, L. (2006) · Inhalation Toxicology · doi:10.1080/08958370600685798 · Cited by 280
Inflammatory pathways in atherosclerosis and acute coronary syndromes
Plutzky, J. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01924-5 · Cited by 279
Novel biomarkers for cardiovascular risk prediction.
Wang, J., Tan, G.-J., Han, L.-N., Bai, Y., He, M., & Liu, H. (2017) · Europe PMC (PubMed Central) · doi:10.11909/j.issn.1671-5411.2017.02.008 · Cited by 277
Bruce, I. N. (2005) · Rheumatology · doi:10.1093/rheumatology/kei142 · Cited by 276
Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science
McSweeney, J. C., Rosenfeld, A. G., Abel, W. M., Braun, L. T., Burke, L. E., Daugherty, S. L., Fletcher, G. F., Gulati, M., Mehta, L. S., Bricker, C., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000381 · Cited by 276
Chocolate and Prevention of Cardiovascular Disease: A Systematic Review
Ding, E. L., Hutfless, S. M., Ding, X., & Girotra, S. R. (2006) · Nutrition & Metabolism · doi:10.1186/1743-7075-3-2 · Cited by 275
C‐Reactive Protein (CRP)‐Lowering Agents
Prasad, K. (2006) · Cardiovascular Drug Reviews · doi:10.1111/j.1527-3466.2006.00033.x · Cited by 274
Salivary markers of inflammation in response to acute stress
Slavish, D. C., Graham‐Engeland, J. E., Smyth, J. M., & Engeland, C. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.008 · Cited by 274
Reis, J. F., Monteiro, V. S., Gomes, R. D. S., do Carmo, M. M., da Costa, G. V., Ribera, P. C., & Monteiro, M. C. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1076-5 · Cited by 274
Jonnalagadda, S. S., Harnack, L., Liu, R. H., McKeown, N. M., Seal, C. J., Liu, S., & Fahey, G. C., Jr. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132944 · Cited by 272
Rajendran, A., Minhas, A., Kazzi, B. E., Varma, B., Choi, E., Thakkar, A., & Michos, E. D. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117269 · Cited by 272
MacNeill, B. D., Jang, I., Bouma, B. E., Iftimia, N. V., Takano, M., Yabushita, H., Shishkov, M. S., Kauffman, C. R., Houser, S. L., Aretz, H. T., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.05.066 · Cited by 271
Protein Biomarkers of Cardiovascular Disease and Mortality in the Community
Ho, J. E., Lyass, A., Courchesne, P. L., Chen, G., Liu, C., Yin, X., Hwang, S., Massaro, J. M., Larson, M. G., & Levy, D. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008108 · Cited by 271
Vehkavaara, S., Silveira, A. M. V., Hakala‐Ala‐Pietilä, T., Virkamäki, A., Hovatta, O., Hamsten, A., Taskinen, M., & Yki‐Järvinen, H. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615643 · Cited by 271
Persistent Insomnia is Associated with Mortality Risk
Parthasarathy, S., Vasquez, M. M., Halonen, M. J., Bootzin, R. R., Quan, S. F., Martínez, F. D., & Guerra, S. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.10.015 · Cited by 270
Insulin resistance, inflammation, and the prediabetic state
Haffner, S. M. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00612-x · Cited by 270
Ridker, P. M. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03404.x · Cited by 269
Self-citationPalomeras, E., & Ruiz, V. C. (2010) · Current Cardiology Reviews · doi:10.2174/157340310791658785 · Cited by 269
Effects of Etanercept in Patients With the Metabolic Syndrome
Bernstein, L. E., Berry, J., Kim, S. S. Y., Hron, B. M., & Grinspoon, S. K. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.8.902 · Cited by 268
Vaccarino, V., Johnson, B. D., Sheps, D. S., Reís, S. E., Kelsey, S. F., Bittner, V., Rutledge, T., Shaw, L. J., Sopko, G. S., & Merz, C. N. B. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.07.069 · Cited by 267
Improvement of Cardiovascular Risk Markers by Pioglitazone Is Independent From Glycemic Control
Pfützner, A., Marx, N., Lübben, G., Langenfeld, M. R. W., Walcher, D., Konrad, T., & Forst, T. M. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.03.041 · Cited by 267
C-reactive Protein, Obstructive Sleep Apnea, and Cognitive Dysfunction in School-aged Children
Gozal, D., Crabtree, V. M., Capdevila, Ó. S., Witcher, L. A., & Gozal, D. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200610-1519oc · Cited by 267
Albert, M. A., Glynn, R. J., & Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000080289.72166.cf · Cited by 267
Self-citationKumagai, K. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.018 · Cited by 267
Bahçeci, M., Gökalp, D., Bahçeci, S., Tuzcu, A. K., Atmaca, S., & Arikan, S. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03347427 · Cited by 266
Suleiman, M., Khatib, R., Agmon, Y., Mahamid, R., Boulos, M., Kapeliovich, M., Levy, Y., Beyar, R., Markiewicz, W., Hammerman, H., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.10.055 · Cited by 264
Relationship of total and abdominal adiposity with CRP and IL-6 in women
Rexrode, K. M., Pradhan, A. D., Manson, J. E., Buring, J. E., & Ridker, P. M. (2003) · Annals of Epidemiology · doi:10.1016/s1047-2797(03)00053-x · Cited by 264
Self-citation
Metadata
- Authors
- Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N.
- Affiliations
- Brigham and Women's Hospital (US)
- Boston Children's Hospital (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2000-03-23
- Volume
- 342
- Issue
- 12
- Pages
- 836-843
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2058610272
- Cited by
- 5,850
- References
- 30
- Citations by year
- 2026: 97 · 2025: 120 · 2024: 113 · 2023: 125 · 2022: 148 · 2021: 143 · 2020: 165 · 2019: 140 · 2018: 167 · 2017: 131 · 2016: 169 · 2015: 199 · 2014: 223 · 2013: 234 · 2012: 258
- FWCI
- 286.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- University Libraries (University of Maryland) (submittedVersion)
- Digital Repository at the University of Maryland (University of Maryland College Park)
- Funders
- National Institutes of Health (5r01hl043851-10)
- National Heart, Lung, and Blood Institute (R01HL058755, HL43851, HL-58755)
- National Cancer Institute (CA-47988, R01CA047988)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- C-reactive protein, inflammatory markers, cardiovascular risk prediction, postmenopausal women, serum amyloid A, interleukin-6, sICAM-1, homocysteine, apolipoprotein B-100, LDL cholesterol, coronary artery disease, myocardial infarction, stroke, coronary revascularization, risk prediction model
- MeSH terms
- Serum Amyloid A Protein, Analysis of Variance, Apolipoproteins, C-Reactive Protein, Cardiovascular Diseases, Female, Homocysteine, Humans, Lipids, Middle Aged, Prospective Studies, Protein Precursors, Risk, Biomarkers, Interleukin-6, Case-Control Studies, Intercellular Adhesion Molecule-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
