The DOI matches its Crossref record.
Rapid Measurement of B-Type Natriuretic Peptide in the Emergency Diagnosis of Heart Failure
Abstract
BACKGROUND: B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension. METHODS: We conducted a prospective study of 1586 patients who came to the emergency department with acute dyspnea and whose B-type natriuretic peptide was measured with a bedside assay. The clinical diagnosis of congestive heart failure was adjudicated by two independent cardiologists, who were blinded to the results of the B-type natriuretic peptide assay. RESULTS: The final diagnosis was dyspnea due to congestive heart failure in 744 patients (47 percent), dyspnea due to noncardiac causes in 72 patients with a history of left ventricular dysfunction (5 percent), and no finding of congestive heart failure in 770 patients (49 percent). B-type natriuretic peptide levels by themselves were more accurate than any historical or physical findings or laboratory values in identifying congestive heart failure as the cause of dyspnea. The diagnostic accuracy of B-type natriuretic peptide at a cutoff of 100 pg per milliliter was 83.4 percent. The negative predictive value of B-type natriuretic peptide at levels of less than 50 pg per milliliter was 96 percent. In multiple logistic-regression analysis, measurements of B-type natriuretic peptide added significant independent predictive power to other clinical variables in models predicting which patients had congestive heart failure. CONCLUSIONS: Used in conjunction with other clinical information, rapid measurement of B-type natriuretic peptide is useful in establishing or excluding the diagnosis of congestive heart failure in patients with acute dyspnea.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Circulation · doi:10.1161/cir.0000000000001063 · Cited by 4,922
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Colvin, M. M., Drazner, M. H., Filippatos, G. S., Fonarow, G. C., Givertz, M. M., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000509 · Cited by 3,109
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Heidenreich, P. A., Bozkurt, B., Aguilar, D., Allen, L. A., Byun, J. J., Colvin, M. M., Deswal, A., Drazner, M. H., Dunlay, S. M., Evers, L. R., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.12.012 · Cited by 2,862
Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872
State of the art: using natriuretic peptide levels in clinical practice
Maisel, A., Mueller, C., Adams, K., Anker, S. D., Aspromonte, N., Cleland, J. G. F., Cohen-Solal, A., Dahlstrom, U., DeMaria, A., Di Somma, S., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.07.014 · Cited by 839
Self-citationHeart Failure With Reduced Ejection Fraction: A Review
Murphy, S. P., Ibrahim, N. E., & Januzzi, J. L. (2020) · JAMA · doi:10.1001/jama.2020.10262 · Cited by 769
Ezekowitz, J. A., O'Meara, E., McDonald, M. A., Abrams, H., Chan, M., Ducharme, A., Giannetti, N., Grzeslo, A., Hamilton, P. G., Heckman, G. A., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.08.022 · Cited by 676
Obesity and suppressed B-type natriuretic peptide levels in heart failure
Mehra, M. R., Uber, P. A., Park, M. H., Scott, R. L., Ventura, H. O., Harris, B. C., & Frohlich, E. D. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.066 · Cited by 534
Mant, J., Doust, J., Roalfe, A., Barton, P., Cowie, M., Glasziou, P., Mant, D., McManus, R., Holder, R., Deeks, J., et al. (2009) · Health Technology Assessment · doi:10.3310/hta13320 · Cited by 498
Dokainish, H., Zoghbi, W. A., Lakkis, N. M., Al-Bakshy, F., Dhir, M., Quinones, M. A., & Nagueh, S. F. (2004) · Circulation · doi:10.1161/01.cir.0000127882.58426.7a · Cited by 465
Bergler-Klein, J., Klaar, U., Heger, M., Rosenhek, R., Mundigler, G., Gabriel, H., Binder, T., Pacher, R., Maurer, G., & Baumgartner, H. (2004) · Circulation · doi:10.1161/01.cir.0000126825.50903.18 · Cited by 465
Roberts, E., Ludman, A. J., Dworzynski, K., Al-Mohammad, A., Cowie, M. R., McMurray, J. J. V., Mant, J., & on behalf of the NICE Guideline Development Group for Acute Heart Failure (2015) · BMJ · doi:10.1136/bmj.h910 · Cited by 427
Cardiac Lipid Accumulation Associated with Diastolic Dysfunction in Obese Mice
Christoffersen, C., Bollano, E., Lindegaard, M. L. S., Bartels, E. D., Goetze, J. P., Andersen, C. B., & Nielsen, L. B. (2003) · Endocrinology · doi:10.1210/en.2003-0242 · Cited by 375
Madamanchi, C., Alhosaini, H., Sumida, A., & Runge, M. S. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.08.007 · Cited by 357
Münzel, T., Feil, R., Mülsch, A., Lohmann, S. M., Hofmann, F., & Walter, U. (2003) · Circulation · doi:10.1161/01.cir.0000094403.78467.c3 · Cited by 316
La Gerche, A., Connelly, K. A., Mooney, D. J., MacIsaac, A. I., & Prior, D. L. (2008) · Heart · doi:10.1136/hrt.2006.101063 · Cited by 258
McKelvie, R. S., Moe, G. W., Ezekowitz, J. A., Heckman, G. A., Costigan, J., Ducharme, A., Estrella-Holder, E., Giannetti, N., Grzeslo, A., Harkness, K., et al. (2013) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2012.10.007 · Cited by 208
Adedinsewo, D., Carter, R. E., Attia, Z., Johnson, P., Kashou, A. H., Dugan, J. L., Albus, M., Sheele, J. M., Bellolio, F., Friedman, P. A., et al. (2020) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.120.008437 · Cited by 169
Household Air Pollution from Solid Fuel Use: Evidence for Links to CVD
McCracken, J. P., Wellenius, G. A., Bloomfield, G. S., Brook, R. D., Tolunay, H. E., Dockery, D. W., Rabadan-Diehl, C., Checkley, W., & Rajagopalan, S. (2012) · Global Heart · doi:10.1016/j.gheart.2012.06.010 · Cited by 76
Association of sST2 and hs-CRP levels with new-onset atrial fibrillation in coronary artery disease
Nortamo, S., Ukkola, O., Lepojärvi, S., Kenttä, T., Kiviniemi, A., Junttila, J., Huikuri, H., & Perkiömäki, J. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.07.022 · Cited by 65
Jarolim, P., White, W. B., Cannon, C. P., Gao, Q., & Morrow, D. A. (2018) · Diabetes Care · doi:10.2337/dc18-0109 · Cited by 56
Six-Year Changes in Physical Activity and the Risk of Incident Heart Failure: ARIC Study
Florido, R., Kwak, L., Lazo, M., Nambi, V., Ahmed, H. M., Hegde, S. M., Gerstenblith, G., Blumenthal, R. S., Ballantyne, C. M., Selvin, E., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.030226 · Cited by 56
Scallan, J. P., Davis, M. J., & Huxley, V. H. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.260042 · Cited by 49
Screening for Asymptomatic Left Ventricular Dysfunction Using B‐Type Natriuretic Peptide
McDonagh, T. A., McDonald, K., & Maisel, A. S. (2008) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2008.tb00002.x · Cited by 35
Self-citationGastric Bypass Surgery Elevates NT-ProBNP Levels
Abrahamsson, N., Engström, B. E., Sundbom, M., & Karlsson, F. A. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0889-z · Cited by 33
Costantino, G., Solbiati, M., Casazza, G., Bonzi, M., Vago, T., Montano, N., McDermott, D., Quinn, J., & Furlan, R. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.08.044 · Cited by 21
Çetin, İ., Tokel, K., Varan, B., Örün, U. A., Gökdemir, M., Cındık, N., Eyüboğlu, F., Ulubay, G., & Aşlamacı, S. (2008) · Journal of Cardiac Surgery · doi:10.1111/j.1540-8191.2008.00634.x · Cited by 17
Abdulle, A. M., Nagelkerke, N. J. D., Adem, A., Abouchacra, S., Pathan, J. Y., Al-Rukhaimi, M., Suleiman, M. N., Mathew, M. C., Nicholls, M. G., & Obineche, E. N. (2007) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002210 · Cited by 11
Czech Society of Cardiology Guidelines for the Diagnosis and Treatment of Chronic Heart Failure 2011
Špinar, J., Vítovec, J., Hradec, J., Málek, I., Meluzín, J., Špinarová, L., Hošková, L., Hegarová, M., Ludka, O., & Táborský, M. (2012) · Cor et Vasa · doi:10.1016/j.crvasa.2012.03.002 · Cited by 10
Metadata
- Authors
- Maisel, A. S., Krishnaswamy, P., Nowak, R. M., McCord, J., Hollander, J. E., Duc, P., Omland, T., Storrow, A. B., Abraham, W. T., Wu, A. H. B., Clopton, P., Steg, P. G., Westheim, A., Knudsen, C. W., Perez, A., Kazanegra, R., Herrmann, H. C., & McCullough, P. A.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2002-07-18
- Volume
- 347
- Issue
- 3
- Pages
- 161-167
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1988816170
- Cited by
- 3,362
- References
- 0
- FWCI
- 112.10
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
