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Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer
Open accessAbstract
BACKGROUND: Accurate detection of lymph-node metastases in prostate cancer is an essential component of the approach to treatment. We investigated whether highly lymphotropic superparamagnetic nanoparticles, which gain access to lymph nodes by means of interstitial-lymphatic fluid transport, could be used in conjunction with high-resolution magnetic resonance imaging (MRI) to reveal small nodal metastases. METHODS: Eighty patients with presurgical clinical stage T1, T2, or T3 prostate cancer who underwent surgical lymph-node resection or biopsy were enrolled. All patients were examined by MRI before and 24 hours after the intravenous administration of lymphotropic superparamagnetic nanoparticles (2.6 mg of iron per kilogram of body weight). The imaging results were correlated with histopathological findings. RESULTS: Of the 334 lymph nodes that underwent resection or biopsy, 63 (18.9 percent) from 33 patients (41 percent) had histopathologically detected metastases. Of these 63 nodes, 45 (71.4 percent) did not fulfill the usual imaging criteria for malignancy. MRI with lymphotropic superparamagnetic nanoparticles correctly identified all patients with nodal metastases, and a node-by-node analysis had a significantly higher sensitivity than conventional MRI (90.5 percent vs. 35.4 percent, P<0.001) or nomograms. CONCLUSIONS: High-resolution MRI with magnetic nanoparticles allows the detection of small and otherwise undetectable lymph-node metastases in patients with prostate cancer.
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“Significantly higher sensitivity for lymph node characterization in patients with prostate cancer, in which metastases detection with positron emission tomography (PET) is problematic, could be achieved by using ferumoxtran compared to non-contrast-enhanced MR imaging [160, 161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [161]
In the citing paper
“Significantly higher sensitivity for lymph node characterization in patients with prostate cancer, in which metastases detection with positron emission tomography (PET) is problematic, could be achieved by using ferumoxtran compared to non-contrast-enhanced MR imaging [160, 161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [160]
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“By using USPIO and contrast-enhanced MRI, micro-metastatic lymph nodes can be distinguished much more efficiently from healthy and inflammatory nodes [161].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [161]
Citations
Cites
The Measurement of Observer Agreement for Categorical Data
Landis, J. R., & Koch, G. G. (1977) · Biometrics · doi:10.2307/2529310 · Cited by 81,148
Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis
(1991) · New England Journal of Medicine · doi:10.1056/nejm199108153250701 · Cited by 8,368
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506
Greenlee, R. T., Hill-Harmon, M. B., Murray, T., & Thun, M. J. (2001) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.51.1.15 · Cited by 3,281
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716
Self-citationROC Methodology in Radiologic Imaging
Metz, C. E. (1986) · Investigative Radiology · doi:10.1097/00004424-198609000-00009 · Cited by 1,628
Bolla, M., González, D., Warde, P. R., Dubois, J. B., Mirimanoff, R., Storme, G. A., Bernier, J., Kuten, A., Sternberg, C. N., Gil, T., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199707313370502 · Cited by 1,547
Messing, E. M., Manola, J. B., Sarosdy, M., Wilding, G., Crawford, E. D., & Trump, D. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912093412401 · Cited by 1,178
Magnetic relaxation switches capable of sensing molecular interactions
Pérez, J. M. S., Josephson, L., O'Loughlin, T., Högemann, D., & Weissleder, R. (2002) · Nature Biotechnology · doi:10.1038/nbt720 · Cited by 889
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Items 101–200 of 1,000
Magnetic Nanoparticles and Their Applications in Medicine
Duguet, É., Vasseur, S., Mornet, S., & Devoisselle, J. (2006) · Nanomedicine · doi:10.2217/17435889.1.2.157 · Cited by 396
Surface engineering of inorganic nanoparticles for imaging and therapy
Nam, J., Won, N., Bang, J., Jin, H., Park, J., Jung, S., Jung, S., Park, Y., & Kim, S. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.08.015 · Cited by 392
Nanoparticle Architectures Templated by SiO2/Fe2O3 Nanocomposites
Yi, D. K., Lee, S. S., Papaefthymiou, G. C., & Ying, J. Y. (2006) · Chemistry of Materials · doi:10.1021/cm0512979 · Cited by 380
Oh, M. H., Lee, N., Kim, H., Park, S. P., Piao, Y., Lee, J., Jun, S. W., Moon, W. K., Choi, S. H., & Hyeon, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja200120k · Cited by 369
Multifunctional Yolk−Shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent
Gao, J., Liang, G., Cheung, J. S., Pan, Y., Kuang, Y., Zhao, F., Zhang, B., Zhang, X., Wu, E. X., & Xu, B. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803920b · Cited by 368
Kroon, B. K., Horenblas, S., Lont, A. P., Tanis, P. J., Gallee, M. P. W., & Nieweg, O. E. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000154565.37397.4d · Cited by 366
Molecular Imaging in the Clinical Arena
Jaffer, F. A. (2005) · JAMA · doi:10.1001/jama.293.7.855 · Cited by 366
Nanomaterials for Nanotheranostics: Tuning Their Properties According to Disease Needs
Wong, X. Y., Sena‐Torralba, A., Álvarez-Diduk, R., Muthoosamy, K., & Merkoçi, A. (2020) · ACS Nano · doi:10.1021/acsnano.9b08133 · Cited by 366
Advances in Radiation Therapy: Conventional to 3D, to IMRT, to 4D, and Beyond
Bucci, M. K., Bevan, A., & Roach, M. (2005) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.55.2.117 · Cited by 356
Yang, L. P. H., Mao, H. Z., Wang, Y. A., Cao, Z., Peng, X., Wang, X., Duan, H., Ni, C., Yuan, Q., Adams, G. P., et al. (2008) · Small · doi:10.1002/smll.200800714 · Cited by 360
Biocompatibility and Toxicity of Nanoparticles and Nanotubes
Li, X., Wang, L., Fan, Y., Feng, Q., & Cui, F. (2012) · Journal of Nanomaterials · doi:10.1155/2012/548389 · Cited by 353
Nanoparticles for Biomedical Imaging: Fundamentals of Clinical Translation
Choi, H. S., & Frangioni, J. V. (2010) · Molecular Imaging · doi:10.2310/7290.2010.00031 · Cited by 361
Multi-functional polymeric nanoparticles for tumour-targeted drug delivery
van Vlerken, L. E., & Amiji, M. M. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.2.205 · Cited by 358
Liu, Y., Ai, K., Liu, J., Yuan, Q., He, Y., & Lu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201106686 · Cited by 346
Recent progress in nanomedicine: therapeutic, diagnostic and theranostic applications
Rizzo, L. Y., Theek, B., Storm, G., Kiessling, F. M., & Lammers, T. (2013) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2013.02.020 · Cited by 348
Human-sized magnetic particle imaging for brain applications
Graeser, M., Thieben, F., Szwargulski, P., Werner, F., Gdaniec, N., Boberg, M., Griese, F., Möddel, M., Ludewig, P., van de Ven, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09704-x · Cited by 339
Rockall, A., Sohaib, S. A., Harisinghani, M. G., Babar, S. A., Singh, N., Jeyarajah, A., Oram, D. H., Jacobs, I. J., Shepherd, J. H., & Reznek, R. H. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.07.166 · Cited by 338
Self-citationMolecular imaging for cancer diagnosis and surgery
Hussain, T., & Nguyen, Q. T. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.007 · Cited by 347
Bourrinet, P., Bengele, H. H., Bonnemain, B., Dencausse, A., Idée, J., Jacobs, P. M., & Lewis, J. M. (2006) · Investigative Radiology · doi:10.1097/01.rli.0000197669.80475.dd · Cited by 335
Positron emission tomography for prostate, bladder, and renal cancer
Schöder, H. M., & Larson, S. M. (2004) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2004.06.004 · Cited by 334
ANATOMICAL EXTENT OF LYMPH NODE DISSECTION: IMPACT ON MEN WITH CLINICALLY LOCALIZED PROSTATE CANCER
Allaf, M. E., Palapattu, G. S., Trock, B. J., Carter, H. B., & Walsh, P. C. (2004) · The Journal of Urology · doi:10.1097/01.ju.0000140912.45821.1d · Cited by 330
Koh, I., & Josephson, L. (2009) · Sensors · doi:10.3390/s91008130 · Cited by 336
Towards clinically translatable in vivo nanodiagnostics
Park, S.-M., Aalipour, A., Vermesh, O., Yu, J. H., & Gambhir, S. S. (2017) · Nature Reviews Materials · doi:10.1038/natrevmats.2017.14 · Cited by 330
Lee, H., Yu, M. K., Park, S.-J., Moon, S., Min, J. J., Jeong, Y. Y., Kang, H.-W., & Jon, S. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072210i · Cited by 335
Ji, X., Shao, R., Elliott, A. M., Stafford, R. J., Esparza‐Coss, E., Bankson, J. A., Liang, G., Luo, Z.-P., Park, K., Markert, J. T., et al. (2007) · The Journal of Physical Chemistry C · doi:10.1021/jp0702245 · Cited by 326
Imaging Angiogenesis: Applications and Potential for Drug Development
Miller, J. C., Pien, H. H., Sahani, D. V., Sorensen, A. G., & Thrall, J. H. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji023 · Cited by 326
Brain cancer diagnosis and therapy with nanoplatforms☆
KOO, Y., REDDY, G., Bhojani, M. S., Schneider, R., PHILBERT, M., Rehemtulla, A., Ross, B. D., & Kopelman, R. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.012 · Cited by 324
Lee, G. Y., Qian, W. P., Wang, L., Wang, Y. A., Staley, C. A., Satpathy, M., Nie, S., Mao, H. Z., & Yang, L. P. H. (2013) · ACS Nano · doi:10.1021/nn3043463 · Cited by 323
Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma
Keu, K. V., Witney, T. H., Yaghoubi, S. S., Rosenberg, J., Kurien, A., Magnusson, R., Williams, J. H. H., Habte, F. G., Wagner, J. R., Forman, S. J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aag2196 · Cited by 322
Anatomical Extent of Pelvic Lymphadenectomy in Patients Undergoing Radical Prostatectomy
Heidenreich, A., Ohlmann, C., & Polyakov, S. (2007) · European Urology · doi:10.1016/j.eururo.2007.04.020 · Cited by 318
Multifunctional magnetic nanoparticles for medical imaging applications
Fang, C., & Zhang, M. (2009) · Journal of Materials Chemistry · doi:10.1039/b902182e · Cited by 318
The pinpoint promise of nanoparticle-based drug delivery and molecular diagnosis
Emerich, D. F., & Thanos, C. G. (2006) · Biomolecular Engineering · doi:10.1016/j.bioeng.2006.05.026 · Cited by 315
Wang, A. Z., Bagalkot, V., Vassiliou, C. C., Gu, F., Alexis, F., Zhang, L., Shaikh, M. R., Yuet, K. P., Cima, M. J., Langer, R., et al. (2008) · ChemMedChem · doi:10.1002/cmdc.200800091 · Cited by 317
Heesakkers, R. A., Hövels, A. M., Jager, G. J., van den Bosch, H. C., Witjes, J. A., Raat, H. P., Severens, J. L., Adang, E. M., van der Kaa, C. H., Fütterer, J. J., et al. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70203-1 · Cited by 307
Self-citationStrategic role of selected noble metal nanoparticles in medicine
Rai, M., Ingle, A. P., Birla, S. S., Yadav, A., & dos Santos, C. A. (2015) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2015.1018131 · Cited by 301
Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages
Ovais, M., Guo, M., & Chen, C. (2019) · Advanced Materials · doi:10.1002/adma.201808303 · Cited by 304
Modo, M., Hoehn, M., & Bulte, J. W. M. (2005) · Molecular Imaging · doi:10.1162/15353500200505145 · Cited by 298
Herlemann, A., Wenter, V., Kretschmer, A., Thierfelder, K. M., Bartenstein, P., Faber, C., Gildehaus, F., Stief, C. G., Gratzke, C., & Fendler, W. P. (2016) · European Urology · doi:10.1016/j.eururo.2015.12.051 · Cited by 293
Lee, N., Choi, Y., Lee, Y., Park, M., Moon, W. K., Choi, S. H., & Hyeon, T. (2012) · Nano Letters · doi:10.1021/nl3010308 · Cited by 299
Functionalized Magnetite Nanoparticles—Synthesis, Properties, and Bio-Applications
Majewski, P. J., & Thierry, B. (2007) · Critical reviews in solid state and materials sciences/CRC critical reviews in solid state and materials sciences · doi:10.1080/10408430701776680 · Cited by 292
Recent Developments in Magnetic Diagnostic Systems
Lee, H., Shin, T.-H., Cheon, J., & Weissleder, R. (2015) · Chemical Reviews · doi:10.1021/cr500698d · Cited by 296
Self-citationTracking Neural Stem Cells in Patients with Brain Trauma
Zhu, J., Zhou, L., & XingWu, F. (2006) · New England Journal of Medicine · doi:10.1056/nejmc055304 · Cited by 291
Magnetic nanoparticles: a novel platform for cancer theranostics
Singh, A., & Sahoo, S. K. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.10.005 · Cited by 289
Evaluation of [18F]-choline PET/CT for staging and restaging of prostate cancer
Husarik, D. B., Miralbell, R., Dubs, M., John, H. A., Giger, O., Gelet, A., Cservenyák, T., & Hany, T. F. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0552-9 · Cited by 288
Magnetic Functionalized Nanoparticles for Biomedical, Drug Delivery and Imaging Applications
Anderson, S. D., Gwenin, V., & Gwenin, C. D. (2019) · Nanoscale Research Letters · doi:10.1186/s11671-019-3019-6 · Cited by 291
Cancer nanotechnology: current status and perspectives
Kemp, J. A., & Kwon, Y. J. (2021) · Nano Convergence · doi:10.1186/s40580-021-00282-7 · Cited by 290
Biodegradable and Renal Clearable Inorganic Nanoparticles
Ehlerding, E. B., Chen, F., & Cai, W. (2015) · Advanced Science · doi:10.1002/advs.201500223 · Cited by 281
Evangelista, L., Guttilla, A., Zattoni, F., Muzzio, P. C., & Zattoni, F. (2012) · European Urology · doi:10.1016/j.eururo.2012.09.039 · Cited by 274
Sun, C., Du, K. N., Fang, C., Bhattarai, N., Omid Veiseh, A., Kievit, F. M., Stephen, Z. R., Lee, D., Ellenbogen, R. G., Ratner, B. D., et al. (2010) · ACS Nano · doi:10.1021/nn100190v · Cited by 272
A targeted approach to cancer imaging and therapy
Li, C. (2014) · Nature Materials · doi:10.1038/nmat3877 · Cited by 271
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions
Perez, J. M., Josephson, L., & Weissleder, R. (2004) · ChemBioChem · doi:10.1002/cbic.200300730 · Cited by 268
Self-citationZhu, L., Zhou, Z., Mao, H. Z., & Yang, L. P. H. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0316 · Cited by 268
Jain, K. K. (2008) · Springer eBooks · doi:10.1007/978-1-4939-6966-1 · Cited by 269
Beheshti, M., Imamovic, L., Broinger, G., Vali, R., Waldenberger, P., Stoiber, F., Nader, M., Gruy, B., Janetschek, G., & Langsteger, W. (2010) · Radiology · doi:10.1148/radiol.09090413 · Cited by 264
Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis
Will, O., Purkayastha, S., Chan, C., Athanasiou, T., Darzi, A. W., Gedroyc, W. M. W., & Tekkis, P. P. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70537-4 · Cited by 260
van Leeuwen, P. J., Stricker, P. D., Hruby, G., Kneebone, A. B., Ting, F., Thompson, B. T., Nguyen, Q. A., Ho, B., & Emmett, L. (2015) · British Journal of Urology · doi:10.1111/bju.13397 · Cited by 258
Managing nano-bio-info-cogno innovations
Bainbridge, W. S., & Roco, M. C. (2006) · Springer eBooks · doi:10.1007/1-4020-4107-1 · Cited by 261
Nanoparticle–aptamer bioconjugates for cancer targeting
Farokhzad, O. C., Karp, J. M., & Langer, R. (2006) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.3.3.311 · Cited by 259
Targeted Delivery of Multifunctional Magnetic Nanoparticles
McCarthy, J. R., Kelly, K. A., Sun, E. Y., & Weissleder, R. (2007) · Nanomedicine · doi:10.2217/17435889.2.2.153 · Cited by 254
Self-citationSelf-luminescing BRET-FRET near-infrared dots for in vivo lymph-node mapping and tumour imaging
Xiong, L., Shuhendler, A. J., & Rao, J. (2012) · Nature Communications · doi:10.1038/ncomms2197 · Cited by 253
Applications of nanomaterials inside cells
Gao, J., & Xu, B. (2008) · Nano Today · doi:10.1016/j.nantod.2008.10.009 · Cited by 251
Sajja, H. K., East, M. P., Mao, H. Z., Wang, Y., Nie, S., & Yang, L. P. H. (2009) · Current Drug Discovery Technologies · doi:10.2174/157016309787581066 · Cited by 250
cT3N0 Rectal Cancer: Potential Overtreatment With Preoperative Chemoradiotherapy Is Warranted
Guillem, J. G., Díaz-González, J. A., Minsky, B. D., Valentini, V., Jeong, S., Rodrı́guez-Bigas, M. A., Coco, C., Leon, R., Hernández-Lizoáin, J. L., Aristu, J., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.5434 · Cited by 249
Perturbational profiling of nanomaterial biologic activity
Shaw, S. Y., Westly, E. C., Pittet, M. J., Subramanian, A., Schreiber, S. L., & Weissleder, R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802878105 · Cited by 248
Self-citationWáng, Y. X. J., & Idée, J.-M. (2017) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims.2017.02.09 · Cited by 247
Scattoni, V., Picchio, M., Suardi, N. R., Messa, C., Freschi, M., Roscigno, M., Pozzo, L. D., Bocciardi, A. M., Rigatti, P., & Fazio, F. (2007) · European Urology · doi:10.1016/j.eururo.2007.03.032 · Cited by 247
Quantum dots and nanocomposites
Mansur, H. S. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.78 · Cited by 245
Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications
Mosayebi, J., Kiyasatfar, M., & Laurent, S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700306 · Cited by 250
18 F Labeled Nanoparticles for in Vivo PET-CT Imaging
Devaraj, N. K., Keliher, E. J., Thurber, G. M., Nahrendorf, M., & Weissleder, R. (2009) · Bioconjugate Chemistry · doi:10.1021/bc8004649 · Cited by 243
Self-citationWang, L., Hricak, H., Kattan, M. W., Chen, H.-N., Scardino, P. T., & Kuroiwa, K. (2006) · Radiology · doi:10.1148/radiol.2382041905 · Cited by 241
Hu, G., Guo, M., Xu, J., Wu, F., Fan, J., Huang, Q., Yang, G., Lv, Z., Wang, X., & Jin, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01998 · Cited by 241
Nguyen, P. L., D'Amico, A. V., Lee, A. K., & Suh, W. W. (2007) · Cancer · doi:10.1002/cncr.22941 · Cited by 238
Thoeny, H. C., Triantafyllou, M., Birkhaeuser, F. D., Froehlich, J. M., Vogel, D. W. T., Binser, T., Fleischmann, A., Vermathen, P., & Studer, U. E. (2009) · European Urology · doi:10.1016/j.eururo.2008.12.034 · Cited by 238
Interactions of nanoparticles with pulmonary structures and cellular responses
Mühlfeld, C., Rothen‐Rutishauser, B., Blank, F., Vanhecke, D., Ochs, M., & Gehr, P. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00442.2007 · Cited by 237
Lee, N., Cho, H. R., Oh, M. H., Lee, S. H., Kim, K. M., Kim, B. H., Shin, K., Ahn, T.-Y., Choi, J. W., Kim, Y., et al. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3016582 · Cited by 238
Nanotechnology for Cancer Therapy
Narayan, M., & Pathak, V. (2006) · CRC Press eBooks · doi:10.1201/9781420006636 · Cited by 236
Biomedical nanomaterials for imaging-guided cancer therapy
Huang, Y., He, S., Cao, W., Cai, K., & Liang, X. (2012) · Nanoscale · doi:10.1039/c2nr31715j · Cited by 236
Fate and Toxicity of Metallic and Metal‐Containing Nanoparticles for Biomedical Applications
Li, Y., & Chen, C. (2011) · Small · doi:10.1002/smll.201101059 · Cited by 237
Rauscher, I., Maurer, T., Beer, A. J., Graner, F.-P., Haller, B., Weirich, G., Doherty, A. P., Gschwend, J. E., Schwaiger, M., & Eiber, M. J. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.173492 · Cited by 233
Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging
Wáng, Y. X. J. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i47.13400 · Cited by 233
Tietze, R., Lyer, S., Dürr, S., Struffert, T., Engelhorn, T., Schwarz, M., Eckert, E., Göen, T., Vasylyev, S., Peukert, W., et al. (2013) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2013.05.001 · Cited by 232
LaConte, L. E. W., Nitin, N., & Bao, G. (2005) · Materials Today · doi:10.1016/s1369-7021(05)00893-x · Cited by 232
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications
Sosnovik, D. E., Nahrendorf, M., & Weissleder, R. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0710-7 · Cited by 229
Self-citationNanoparticles for Imaging: top or Flop?
Kiessling, F., Mertens, M. E., Grimm, J., & Lammers, T. (2014) · Radiology · doi:10.1148/radiol.14131520 · Cited by 228
Nanomaterials in combating cancer: Therapeutic applications and developments
Nazir, S., Hussain, T., Ayub, A., Rashid, U., & MacRobert, A. J. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.07.001 · Cited by 236
In Vivo Targeting of Underglycosylated MUC-1 Tumor Antigen Using a Multimodal Imaging Probe
Moore, A. V., Medarova, Z. O., Potthast, A., & Dai, G. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3230 · Cited by 227
Near-infrared fluorescent nanoprobes for cancer molecular imaging: status and challenges
He, X., Gao, J., Gambhir, S. S., & Cheng, Z. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.08.006 · Cited by 229
Emerging concepts in molecular MRI
Sosnovik, D. E., & Weissleder, R. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.11.001 · Cited by 225
Self-citationTargeted nanoparticle-based drug delivery and diagnosis
Emerich, D. F., & Thanos, C. G. (2007) · Journal of drug targeting · doi:10.1080/10611860701231810 · Cited by 226
Mease, R. C., Dusich, C. L., Foss, C. A., Ravert, H. T., Dannals, R. F., Seidel, J., Prideaux, A. R., Fox, J. J., Sgouros, G., Kozikowski, A. P., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1517 · Cited by 222
A high-throughput label-free nanoparticle analyser
Fraikin, J.-L., Teesalu, T., McKenney, C. M., Ruoslahti, E. I., & Cleland, A. N. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.24 · Cited by 221
Nanobiosensors: Concepts and Variations
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Wang, M. D., Shin, D. M., Simons, J. W., & Nie, S. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.6.833 · Cited by 217
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Murat, F. J., Poissonnier, L., Rabilloud, M., Belot, A., Bouvier, R., Rouvière, O., Chapelon, J., & Gelet, A. (2008) · European Urology · doi:10.1016/j.eururo.2008.04.091 · Cited by 215
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Metadata
- Authors
- Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., & Weissleder, R.
- Affiliations
- Harvard University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-06-19
- Volume
- 348
- Issue
- 25
- Pages
- 2491-2499
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2116810900
- Cited by
- 1,971
- References
- 42
- Citations by year
- 2026: 13 · 2025: 15 · 2024: 34 · 2023: 42 · 2022: 54 · 2021: 49 · 2020: 59 · 2019: 50 · 2018: 66 · 2017: 82 · 2016: 83 · 2015: 94 · 2014: 95 · 2013: 120 · 2012: 129
- FWCI
- 81.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institutes of Health (5r01ca059649-07)
- National Cancer Institute (R01-CA59649)
- Topics
- Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › MRI in cancer diagnosis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- prostate cancer, lymph node metastasis, superparamagnetic iron oxide nanoparticles, magnetic resonance imaging, non-invasive detection, lymphatic drainage, diagnostic sensitivity
- MeSH terms
- Aged, Biopsy, Contrast Media, Ferric Compounds, Humans, Image Processing, Computer-Assisted, Lymph Nodes, Lymphatic Metastasis, Magnetic Resonance Imaging, Magnetics, Male, Middle Aged, Neoplasm Staging, Particle Size, Prospective Studies, Prostatic Neoplasms, Sensitivity and Specificity, Nanotechnology
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