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A randomized trial of protocol-based care for early septic shock.
Open accessAbstract
BACKGROUND: In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower among those who were treated according to a 6-hour protocol of early goal-directed therapy (EGDT), in which intravenous fluids, vasopressors, inotropes, and blood transfusions were adjusted to reach central hemodynamic targets, than among those receiving usual care. We conducted a trial to determine whether these findings were generalizable and whether all aspects of the protocol were necessary. METHODS: In 31 emergency departments in the United States, we randomly assigned patients with septic shock to one of three groups for 6 hours of resuscitation: protocol-based EGDT; protocol-based standard therapy that did not require the placement of a central venous catheter, administration of inotropes, or blood transfusions; or usual care. The primary end point was 60-day in-hospital mortality. We tested sequentially whether protocol-based care (EGDT and standard-therapy groups combined) was superior to usual care and whether protocol-based EGDT was superior to protocol-based standard therapy. Secondary outcomes included longer-term mortality and the need for organ support. RESULTS: We enrolled 1341 patients, of whom 439 were randomly assigned to protocol-based EGDT, 446 to protocol-based standard therapy, and 456 to usual care. Resuscitation strategies differed significantly with respect to the monitoring of central venous pressure and oxygen and the use of intravenous fluids, vasopressors, inotropes, and blood transfusions. By 60 days, there were 92 deaths in the protocol-based EGDT group (21.0%), 81 in the protocol-based standard-therapy group (18.2%), and 86 in the usual-care group (18.9%) (relative risk with protocol-based therapy vs. usual care, 1.04; 95% confidence interval [CI], 0.82 to 1.31; P=0.83; relative risk with protocol-based EGDT vs. protocol-based standard therapy, 1.15; 95% CI, 0.88 to 1.51; P=0.31). There were no significant differences in 90-day mortality, 1-year mortality, or the need for organ support. CONCLUSIONS: In a multicenter trial conducted in the tertiary care setting, protocol-based resuscitation of patients in whom septic shock was diagnosed in the emergency department did not improve outcomes. (Funded by the National Institute of General Medical Sciences; ProCESS ClinicalTrials.gov number, NCT00510835.).
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“Early detection and appropriate treatment of sepsis have been associated with a significant mortality benefit in hospitalized patients.1,2,3”
From External validation of a widely implemented proprietary sepsis prediction model in hospitalized patients (2021) · cites this paper as [2]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“In the PROCESS (64), ARISE (65) and PROMISE (66) trials, the average volume of fluid received pre-randomization was also in the range of 30 mL/kg, suggesting that this fluid volume has been adopted in routine clinical practice (67).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [64]
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“The observed reductions in ICU length of stay (1.8 days), mechanical ventilation duration (2.3 days), and 28-day mortality (5.7%) are clinically meaningful and compare favorably with other sepsis intervention studies22,23.”
From Machine learning predicts sepsis deterioration trajectories. (2026) · cites this paper as [23]
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In the citing paper
“Supplementary Table 8 benchmarks our model against prior studies, demonstrating a 2.1-fold longer lead time than Seymour et al16and a 38% greater mortality reduction than Yealy et al.23.”
From Machine learning predicts sepsis deterioration trajectories. (2026) · cites this paper as Yealy et al.23
Experimental — accuracy not yet measuredIn the citing paper
“The four largest clinical trials in sepsis resuscitation used moderate to large amounts of fluids in the first 72 h.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [64]
In the citing paper
“ProCESS[64], ARISE [65] and ProMISe [66] administered approximately 7–8 L in the usual care groups with a reported low mortality rate.”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [64]
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Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742
Bone, R. C., BALK, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · CHEST Journal · doi:10.1378/chest.101.6.1644 · Cited by 13,317
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Dellinger, R. P., Levy, M. M., Carlet, J. M., Bion, J., Parker, M. M., Jaeschke, R., Reinhart, K., Angus, D. C., Brun‐Buisson, C., Beale, R. J., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0934-2 · Cited by 6,789
A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
Hébert, P. C., Wells, G., Blajchman, M. A., Marshall, J., Martin, C., Pagliarello, G., Tweeddale, M., Schweitzer, I., & Yetisir, E. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400601 · Cited by 5,187
Severe Sepsis and Septic Shock
Angus, D. C., & van der Poll, T. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1208623 · Cited by 4,119
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
Dellinger, R. P., Carlet, J. M., Masur, H., Gerlach, H., Calandra, T., Cohen, J., Gea‐Banacloche, J., Keh, D., Marshall, J. C., Parker, M. M., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2210-z · Cited by 3,309
Research works printed but not linked: 3
- 10.1111/j.1553-2712.2007.tb02391.x · DOI
- Pike F, 2013, Crit Care Resusc, 15, 301
- Rivers EP, 2012, Minerva Anestesiol, 78, 712
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Wallgren, U. M., Antonsson, V. E., Castrén, M. K., & Kurland, L. (2016) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-015-0193-0 · Cited by 112
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Xu, Y., Wang, H., Luan, C., Liu, Y., Chen, B., & Zhao, Y. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.09.032 · Cited by 109
Nishida, O., Ogura, H., Egi, M., Fujishima, S., Hayashi, Y., Iba, T., Imaizumi, H., Inoue, S., Kakihana, Y., Kotani, J., et al. (2018) · Journal of Intensive Care · doi:10.1186/s40560-017-0270-8 · Cited by 107
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Russell, J. A., Vincent, J.-L., Kjølbye, A. L., Olsson, H., Blemings, A., Spapen, H., Carl, P., Laterre, P.-F., & Grundemar, L. (2017) · Critical Care · doi:10.1186/s13054-017-1798-7 · Cited by 103
Zangrillo, A., Putzu, A., Monaco, F., Oriani, A., Frau, G., Luca, M. D., Tomasso, N. N. D., Bignami, E. G., Ломиворотов, В. В., Likhvantsev, V. V., et al. (2015) · Journal of Critical Care · doi:10.1016/j.jcrc.2015.05.017 · Cited by 106
de Groot, B., Ansems, A., Gerling, D. H., Rijpsma, D., van Amstel, P., Linzel, D. S., Kostense, P. J., Jonker, M. A., & de Jonge, E. (2015) · Critical Care · doi:10.1186/s13054-015-0936-3 · Cited by 107
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Jones, S. L., Ashton, C. M., Kiehne, L., Gigliotti, E., Bell-Gordon, C., Disbot, M., Masud, F. N., Shirkey, B. A., & Wray, N. P. (2015) · The Joint Commission Journal on Quality and Patient Safety · doi:10.1016/s1553-7250(15)41063-3 · Cited by 117
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Kamel, K. S., Oh, M. S., & Halperin, M. L. (2019) · Kidney International · doi:10.1016/j.kint.2019.08.023 · Cited by 128
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Ryoo, S. M., Han, K. S., Ahn, S., Shin, T. G., Hwang, S. Y., Chung, S. P., Hwang, Y. J., Park, Y. S., Jo, Y. H., Chang, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-42972-7 · Cited by 105
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Richard, J., Bayle, F., Bourdin, G., Leray, V., Debord, S., Delannoy, B., Stoian, A. C., Wallet, F., Yonis, H., & Guérin, C. (2015) · Critical Care · doi:10.1186/s13054-014-0734-3 · Cited by 99
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Huygh, J., Peeters, Y., Bernards, J. A., & Malbrain, M. L. N. G. (2016) · F1000Research · doi:10.12688/f1000research.8991.1 · Cited by 99
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Roullet, S., Freyburger, G., Cruc, M., Quinart, A., Stecken, L., Audy, M., Chiche, L., & Sztark, F. (2014) · Liver Transplantation · doi:10.1002/lt.24030 · Cited by 98
Seymour, C., Cooke, C., Heckbert, S., Spertus, J., Callaway, C., Martin-Gill, C., Yealy, D., Rea, T., & Angus, D. (2014) · Critical Care · doi:10.1186/s13054-014-0533-x · Cited by 91
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Aïssaoui, N., Boissier, F., Chew, M. S., Singer, M., & Vignon, P. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf340 · Cited by 112
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Gao, X., Yin, Y., Wu, H., Hao, Z., Li, J., Wang, S., & Liu, Y. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03981 · Cited by 94
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Chebl, R. B., Jamali, S., Sabra, M., Safa, R., Berbari, I., Shami, A., Makki, M. H., Tamim, H., & Dagher, G. A. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.550182 · Cited by 98
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Leisman, D. E., Wie, B., Doerfler, M. E., Bianculli, A. R., Ward, M. F., Akerman, M. B., D’Angelo, J. K., & D’Amore, J. A. (2016) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2016.02.044 · Cited by 96
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László, I., Trásy, D., Molnár, Z., & Fazakas, J. (2015) · Journal of Immunology Research · doi:10.1155/2015/510436 · Cited by 92
Yadav, H., Nolan, M. E., Bohman, J. K., Cartin‐Ceba, R., Peters, S. G., Hogan, W. J., Gajic, O., & Kor, D. J. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000001617 · Cited by 82
Barker, G., Leeuwenburgh, C., Brusko, T. M., Moldawer, L. L., Reddy, S. T., & Guirgis, F. W. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081693 · Cited by 83
on behalf of JAAM FORECAST group, Abe, T., Kushimoto, S., Tokuda, Y., Phillips, G. S., Rhodes, A., Sugiyama, T., Komori, A., Iriyama, H., Ogura, H., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2644-x · Cited by 73
The initial resuscitation of septic shock
Cinel, I., Kasapoglu, U. S., Gul, F., & Dellinger, R. P. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.02.004 · Cited by 69
Burdick, H., Pino, E., Gabel-Comeau, D., McCoy, A., Gu, C., Roberts, J., Le, S., Slote, J., Pellegrini, E., Green-Saxena, A., et al. (2020) · BMJ Health & Care Informatics · doi:10.1136/bmjhci-2019-100109 · Cited by 80
Chen, H., Zhu, Z., Zhao, C., Guo, Y., Chen, D., Wei, Y., & Jin, J. (2020) · Critical Care · doi:10.1186/s13054-020-03109-9 · Cited by 82
Managing sepsis: Electronic recognition, rapid response teams, and standardized care save lives
Guirgis, F. W., Jones, L., Esma, R., Weiss, A., McCurdy, K., Ferreira, J., Cannon, C., McLauchlin, L., Smotherman, C. R., Kraemer, D. F., et al. (2017) · Journal of Critical Care · doi:10.1016/j.jcrc.2017.04.005 · Cited by 80
The recognition and management of sepsis and septic shock: a guide for non-intensivists
Keeley, A. J., Hine, P., & Nsutebu, E. F. (2017) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2016-134519 · Cited by 85
Fluid and electrolyte overload in critically ill patients: An overview
Besen, B. A. M. P. (2015) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v4.i2.116 · Cited by 85
Urosepsis: Overview of the Diagnostic and Treatment Challenges
Wagenlehner, F. R. A., Pilatz, A. M. E., Weidner, W., & Naber, K. G. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.uti-0003-2012 · Cited by 80
Pepper, D. J., Jaswal, D. S., Sun, J., Welsh, J. A., Natanson, C., & Eichacker, P. Q. (2018) · Annals of Internal Medicine · doi:10.7326/m17-2947 · Cited by 80
Surviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician
Oczkowski, S. J. W., Alshamsi, F. E., Belley‐Côté, E. P., Centofanti, J., Møller, M. H., Nunnally, M., & Alhazzani, W. A. (2022) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.16290 · Cited by 85
van Paridon, B. M., Sheppard, C., Garcia Guerra, G., Joffe, A. R., & for the Alberta Sepsis Network (2015) · Critical Care · doi:10.1186/s13054-015-1010-x · Cited by 79
Transfusion Threshold of 7 g per Deciliter — The New Normal
Hébert, P. C., & Carson, J. L. (2014) · New England Journal of Medicine · doi:10.1056/nejme1408976 · Cited by 81
Evidence and triggers for the transfusion of blood and blood products
Shah, A., Stanworth, S. J., & McKechnie, S. (2014) · Anaesthesia · doi:10.1111/anae.12893 · Cited by 78
Holder, A. L., Gupta, N., Lulaj, E., Furgiuele, M., Hidalgo, I., Jones, M. P., Jolly, T., Gennis, P., & Birnbaum, A. J. (2016) · International Journal of Emergency Medicine · doi:10.1186/s12245-016-0106-7 · Cited by 82
Sepsis Diagnosis and Management
Gotur, D. B. (2017) · Journal of Medical Sciences and Health · doi:10.46347/jmsh.2017.v03i03.001 · Cited by 80
The intensive care medicine research agenda on septic shock
Perner, A., Gordon, A. C., Angus, D. C., Lamontagne, F., Machado, F. R., Russell, J. A., Timsit, J., Marshall, J. C., Myburgh, J., Shankar‐Hari, M., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4821-1 · Cited by 78
Nishida, O., Ogura, H., Egi, M., Fujishima, S., Hayashi, Y., Iba, T., Imaizumi, H., Inoue, S., Kakihana, Y., Kotani, J., et al. (2018) · Acute Medicine & Surgery · doi:10.1002/ams2.322 · Cited by 78
Huang, X., Zhang, Z., Chen, L., Lin, Y., Zeng, R., Xu, J., Chen, S., Zhang, J., Cai, H., Zhou, H., et al. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114414 · Cited by 76
Severe Sepsis and Septic Shock Trials (ProCESS, ARISE, ProMISe)
Osborn, T. M. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2016.12.004 · Cited by 77
Biochemical markers for clinical monitoring of tissue perfusion
Janotka, M., & Ošťádal, P. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-020-04019-8 · Cited by 78
He, H., Long, Y., Liu, D., Wang, X., & Zhou, X. Q. (2015) · Critical Care · doi:10.1186/s13054-015-1057-8 · Cited by 75
Sepsis in pregnancy and the puerperium
Burlinson, C. E. G., Sirounis, D., Walley, K. R., & Chau, A. M. T. (2018) · International Journal of Obstetric Anesthesia · doi:10.1016/j.ijoa.2018.04.010 · Cited by 98
Renal failure in critically ill patients, beware of applying (central venous) pressure on the kidney
Chen, X., Wang, X., Honoré, P. M., Spapen, H. D., & Liu, D. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0439-x · Cited by 75
Evaluation of sepsis prediction models before onset of treatment
Kamran, F., Tjandra, D., Heiler, A., Virzi, J., Singh, K., King, J. E., Valley, T. S., & Wiens, J. (2024) · NEJM AI · doi:10.1056/aioa2300032 · Cited by 74
Park, J. H., Byeon, H. J., Lee, K. H., Lee, J. W., Kronbichler, A., Eisenhut, M., & Shin, J. I. (2017) · Inflammation Research · doi:10.1007/s00011-017-1066-y · Cited by 74
Metadata
- Authors
- The ProCESS Investigators
- Affiliations
- University of Pittsburgh Medical Center (US)
- Corresponding author
- The ProCESS Investigators
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-05
- Volume
- 370
- Issue
- 18
- Pages
- 1683-1693
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4101700
- OpenAlex
- W2104415072
- Cited by
- 2,414
- References
- 23
- Citations by year
- 2026: 81 · 2025: 90 · 2024: 101 · 2023: 129 · 2022: 124 · 2021: 179 · 2020: 193 · 2019: 183 · 2018: 213 · 2017: 292 · 2016: 329 · 2015: 332 · 2014: 158
- FWCI
- 280.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000005)
- National Institute of General Medical Sciences (P50GM076659)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Health Sciences › Medicine › Surgery › Abdominal Surgery and Complications
- Keywords
- septic shock, early goal-directed therapy, protocol-based care, sepsis resuscitation, in-hospital mortality, vasopressors, inotropic agents, blood transfusion, central venous pressure monitoring, emergency department, organ support, usual care comparison, 60-day mortality, 90-day mortality
- MeSH terms
- Adult, Aged, Anti-Bacterial Agents, Blood Transfusion, Cardiotonic Agents, Clinical Protocols, Combined Modality Therapy, Emergency Service, Hospital, Female, Fluid Therapy, Humans, Male, Middle Aged, Resuscitation, Shock, Septic, Vasoconstrictor Agents, Hospital Mortality, Outcome Assessment, Health Care
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