The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts
Open accessAbstract
BACKGROUND: Observational cohort studies and a secondary prevention trial have shown inverse associations between adherence to the Mediterranean diet and cardiovascular risk. METHODS: In a multicenter trial in Spain, we assigned 7447 participants (55 to 80 years of age, 57% women) who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Participants received quarterly educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. The primary end point was a major cardiovascular event (myocardial infarction, stroke, or death from cardiovascular causes). After a median follow-up of 4.8 years, the trial was stopped on the basis of a prespecified interim analysis. In 2013, we reported the results for the primary end point in the Journal. We subsequently identified protocol deviations, including enrollment of household members without randomization, assignment to a study group without randomization of some participants at 1 of 11 study sites, and apparent inconsistent use of randomization tables at another site. We have withdrawn our previously published report and now report revised effect estimates based on analyses that do not rely exclusively on the assumption that all the participants were randomly assigned. RESULTS: A primary end-point event occurred in 288 participants; there were 96 events in the group assigned to a Mediterranean diet with extra-virgin olive oil (3.8%), 83 in the group assigned to a Mediterranean diet with nuts (3.4%), and 109 in the control group (4.4%). In the intention-to-treat analysis including all the participants and adjusting for baseline characteristics and propensity scores, the hazard ratio was 0.69 (95% confidence interval [CI], 0.53 to 0.91) for a Mediterranean diet with extra-virgin olive oil and 0.72 (95% CI, 0.54 to 0.95) for a Mediterranean diet with nuts, as compared with the control diet. Results were similar after the omission of 1588 participants whose study-group assignments were known or suspected to have departed from the protocol. CONCLUSIONS: In this study involving persons at high cardiovascular risk, the incidence of major cardiovascular events was lower among those assigned to a Mediterranean diet supplemented with extra-virgin olive oil or nuts than among those assigned to a reduced-fat diet. (Funded by Instituto de Salud Carlos III, Spanish Ministry of Health, and others; Current Controlled Trials number, ISRCTN35739639 .).
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Diets emphasizing whole, minimally processed foods—such as vegetables, fruits, whole grains, legumes, nuts, seeds, and lean protein sources—have been consistently associated with a reduced risk of obesity, type 2 diabetes, hypertension, and cardiovascular disease [164,165,166,167].”
From Lifestyle Medicine for Obesity in the Era of Highly Effective Anti-Obesity Treatment (2025) · cites this paper as [165]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The Mediterranean diet, rich in olive oil, vegetables, legumes, nuts, and fish, promotes weight maintenance and cardiovascular health even without strict calorie limits [100].”
From Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies (2025) · cites this paper as [100]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“a Mediterranean-style eating pattern intervention enriched with olive oil or nuts significantly reduced CVD incidence in both people with and without diabetes (91).”
From Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report (2019) · cites this paper as [91]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“To date, improvements in dietary quality rather than restrictive dietary counseling have shown benefits in primary and secondary CVD prevention,98,99”
From Malnutrition and Cachexia in Inpatients With Acute Cardiac Conditions: A Scientific Statement From the American Heart Association (2026) · cites this paper as [99]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“provided bene fi ts for cardiovascular health (76,77).”
The cited source says what the claim attributes to it.
In the citing paper
“A healthy lifestyle is the basis to optimise health outcomes regardless of WL – increased levels of physical activity have multiple health benefits including improvement of body composition, physical function and cardiorespiratory fitness, and a balanced Mediterranean diet may be associated with cardiovascular benefits [105].”
From What is the pipeline for future medications for obesity? (2025) · cites this paper as [105]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In a systematic review of trials of > 6 months ' duration, compared with a low-fat diet, the Mediterranean diet demonstrated greater reductions in body weight and HbA1c levels”
From Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2022) · cites this paper as [77]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“delayed the requirement for diabetes medication”
From Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2022) · cites this paper as [77]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Studies have demonstrated that a variety of eating plans, varying in macronutrient composition, can be used effectively and safely in the short term (1-2 years) to achieve weight loss in people with diabetes.”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [120]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The Mediterranean diet, rich in fiber, polyphenols, and monounsaturated fats, exemplifies a microbiome-friendly dietary pattern. It promotes beneficial bacterial growth while reducing inflammation and metabolic disorders.”
From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [102]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Similarly, traditional diets such as the Okinawa diet—high in vegetables, soy, and fish—are associated with diverse gut microbiota and reduced chronic disease risk.”
From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [102]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“In contrast, urbanized diets, antibiotic overuse, and environmental pollution contribute to declining microbial diversity and the rise of metabolic and autoimmune disorders [7,101,102,103,104,105,106,107].”
From The Power of Environment: A Comprehensive Review of the Exposome's Role in Healthy Aging, Longevity, and Preventive Medicine-Lessons from Blue Zones and Cilento (2025) · cites this paper as [102]
Experimental — accuracy not yet measuredThe check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“However, most individuals with type 2 diabetes are asymptomatic at diagnosis, and routine screening is recommended (Box 2).14,22”
From Diagnosis and Treatment of Type 2 Diabetes in Adults (2025) · cites this paper as [22]
Experimental — accuracy not yet measuredIn the citing paper
“If this diet is supplemented with olive oil or nuts, as in the non-randomized PREvencion con Dieta MEDiterranea (PREDIMED) study in individuals at high CV risk (49% T2DM), the risk of ASCVD was reduced by 28-31%.82”
From 2023 ESC guidelines for the management of cardiovascular disease in patients with diabetes. (2023) · cites this paper as [82]
In the citing paper
“The journal's investigations led to none of the 11 test-positive papers being retracted except for one, which was subsequently republished.40,41”
From Integrity of randomized clinical trials: Performance of integrity tests and checklists requires assessment (2023) · cites this paper as [40]
In the citing paper
“The Mediterranean diet in the PREDIMED trial, which showed a 30% reduction in CVD risk, was characterized by avoidance of red meat as a protein source.36,37”
From Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women (2019) · cites this paper as [37]
In the citing paper
“Monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids (PUFAs), in forms of olive oil, nuts and seeds in plant-based dietary regimens, may function as the driving force for the amelioration of glucose metabolism, insulin sensitivity, blood lipids and CVD risk, observed either in diabetic individuals [17,40,41] or in the general population [42].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [41]
In the citing paper
“They tend to be relatively high in unsaturated fat, particularly from extravirgin olive oil.”
From Popular dietary patterns: alignment with American Heart Association 2021 dietary guidance: a scientific statement from the American Heart Association. (2023) · cites this paper as [19]
In the citing paper
“Efficacy studies of healthy dietary patterns have resulted in a significant reduction of risk factors.12,13,19,26,97,98”
From Popular dietary patterns: alignment with American Heart Association 2021 dietary guidance: a scientific statement from the American Heart Association. (2023) · cites this paper as [19]
In the citing paper
“The type of fats consumed is more important than total amount of fat when looking at metabolic goals and CVD risk, and it is recommended that the percentage of total calories from saturated fats should be limited (120,172,(200)(201)(202).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [120]
In the citing paper
“Multiple RCTs including people with type 2 diabetes have reported that a Mediterranean eating pattern (120,203-208) can improve both glycemic management and blood lipids.”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257
Self-citationRetractedEstruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmc1806491 · Cited by 1,008
Self-citationRetractedGeneral Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
D’Agostino, R. B., Vasan, R. S., Pencina, M. J., Wolf, P. A., Cobain, M., Massaro, J. M., & Kannel, W. B. (2008) · Circulation · doi:10.1161/circulationaha.107.699579 · Cited by 7,491
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
de Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910
Mediterranean diet pyramid: a cultural model for healthy eating
Willett, W., Sacks, F., Trichopoulou, A., Drescher, G., Ferro-Luzzi, A., Helsing, E., & Trichopoulos, D. (1995) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/61.6.1402s · Cited by 2,461
Weight Loss with a Low-Carbohydrate, Mediterranean, or Low-Fat Diet
Shai, I., Schwarzfuchs, D., Henkin, Y., Shahar, D. R., Witkow, S., Greenberg, I., Golan, R., Fraser, D., Bolotin, A., Vardi, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708681 · Cited by 2,143
Esposito, K., Marfella, R., Ciotola, M., Di Palo, C., Giugliano, F., Giugliano, G., D'Armiento, M., D'Andrea, F., & Giugliano, D. (2004) · JAMA · doi:10.1001/jama.292.12.1440 · Cited by 2,126
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease
de Lorgeril, M., Renaud, S., Salen, P., Monjaud, I., Mamelle, N., Martin, J. L., Guidollet, J., Touboul, P., & Delaye, J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92580-1 · Cited by 2,122
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704
Self-citation
Cited by
Sorted by citations
Items 601–700 of 1,013
Avocado Consumption and Risk of Cardiovascular Disease in US Adults
Pacheco, L. S., Li, Y., Rimm, E. B., Manson, J. E., Sun, Q., Rexrode, K. M., Hu, F. B., & Guasch‐Ferré, M. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024014 · Cited by 51
Martino, D. D. D., Avagliano, L., Ferrazzi, E. M., Fusè, F., Sterpi, V., Parasiliti, M., Stampalija, T., Zullino, S., Farina, A., Bulfamante, G., et al. (2022) · Nutrients · doi:10.3390/nu14163276 · Cited by 50
The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?
Zhang, Q., Zhang, L., Chen, C., Li, P., & Lu, B. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101209 · Cited by 50
Effects of Hydroxytyrosol in Endothelial Functioning: A Comprehensive Review
Vijakumaran, U., Shanmugam, J., Heng, J. W., Azman, S. S., Yazid, M. D., Abdullah, N. A. H., & Sulaiman, N. S. (2023) · Molecules · doi:10.3390/molecules28041861 · Cited by 50
Plant bioactive compounds from Mediterranean diet improve risk factors for metabolic syndrome
Farias‐Pereira, R., Zuk, J. B., & Khavaran, H. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2232949 · Cited by 50
Cardiovascular disease in low- and middle-income countries associated with environmental factors
Sliwa, K. S., Viljoen, C. A., Stewart, S., Miller, M. R., Prabhakaran, D., Kumar, R., Thienemann, F., Piniero, D., Prabhakaran, P., Narula, J., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad388 · Cited by 50
Management of autosomal-dominant polycystic kidney disease—state-of-the-art
Müller, R., & Benzing, T. R. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy103 · Cited by 50
Fernández‐Jiménez, R., Santos-Beneit, G., Tresserra‐Rimbau, A., Bodega, P., de Miguel, M., de Cos-Gandoy, A., Rodríguez, C., Carral, V., Orrit, X., Haro, D., et al. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.03.014 · Cited by 50
Self-citationOlive oil consumption and its repercussions on lipid metabolism
Tomé‐Carneiro, J., Crespo, M. C., Hazas, M. L. D. L., Visioli, F., & Dávalos, A. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa014 · Cited by 50
Veček, N. N., Mucalo, L., Dragun, R., Miličević, T., Relja, A., Patarčić, I., Hayward, C., Polašek, O., & Kolčić, I. (2020) · Nutrients · doi:10.3390/nu12041164 · Cited by 50
Díaz‐López, A., Becerra‐Tomás, N., Ruiz-García, V., Toledo, E., Babió, N., Corella, D., Fitó, M., Romaguera, D., Vioqué, J., Alonso‐Gómez, Á. M., et al. (2021) · American Journal of Nephrology · doi:10.1159/000513664 · Cited by 49
Self-citationChatzopoulou, E., Carocho, M., Gioia, F. D., & Petropoulos, S. A. (2020) · Applied Sciences · doi:10.3390/app10249144 · Cited by 49
The Treatment of Obesity in Cardiac Rehabilitation
Ades, P. A., & Savage, P. D. (2021) · Journal of Cardiopulmonary Rehabilitation and Prevention · doi:10.1097/hcr.0000000000000637 · Cited by 49
Valorization of Local Legumes and Nuts as Key Components of the Mediterranean Diet
Hernández-López, I., Ortiz-Solà, J., Alamprese, C., Barros, L., Shelef, O., Basheer, L., Rivera, A., Abadías, M., & Aguiló‐Aguayo, I. (2022) · Foods · doi:10.3390/foods11233858 · Cited by 49
Flynn, M. M., Tierney, A. C., & Itsiopoulos, C. (2023) · Nutrients · doi:10.3390/nu15132916 · Cited by 49
Gagour, J., Hallouch, O., Asbbane, A., Bijla, L., Laknifli, A., Lee, L., Zengin, G., Bouyahya, A., Sakar, E. H., & Gharby, S. (2024) · Chemistry & Biodiversity · doi:10.1002/cbdv.202301697 · Cited by 49
Review of the Relationships Between Human Gut Microbiome, Diet, and Obesity
Patloka, O., Komprda, T., & Franke, G. (2024) · Nutrients · doi:10.3390/nu16233996 · Cited by 50
Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials
Matacchione, G., Gurău, F., Baldoni, S., Prattichizzo, F., Silvestrini, A., Giuliani, A., Pugnaloni, A., Espinosa, E., Amenta, F., Bonafè, M., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101074 · Cited by 49
Kukharchuk, V. V., Владиславович, Е. М., Викторович, С. И., Arabidze, G. G., Балахонова, Т. В., Gurevich, V. S., Zelveyan, P. A., Murataliev, T. M., Myrzakhmetova, G., Александровна, С. О., et al. (2020) · Eurasian heart journal · doi:10.38109/2225-1685-2020-2-6-29 · Cited by 49
Manzano-Carrasco, S., Felipe, J. L., Sánchez‐Sánchez, J., Hernández-Martín, A., Gallardo, L., & García‐Unanue, J. (2020) · Nutrients · doi:10.3390/nu12061680 · Cited by 49
Johnson, C. S. C., Shively, C. A., Michalson, K. T., Lea, A. J., DeBo, R. J., Howard, T. D., Hawkins, G. A., Appt, S. E., Liu, Y., McCall, C. E., et al. (2021) · eLife · doi:10.7554/elife.68293 · Cited by 49
Johansson, A., Drake, I., Engström, G., & Acosta, S. (2021) · Nutrients · doi:10.3390/nu13061952 · Cited by 49
Xie, Y., Bowe, B. C., Gibson, A. K., McGill, J. B., Maddukuri, G. S., & Al‐Aly, Z. (2021) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2021.2488 · Cited by 49
Acosta, S., Johansson, A., & Drake, I. (2021) · Nutrients · doi:10.3390/nu13113822 · Cited by 49
Chew, N., Ng, C. H., Muthiah, M. D., & Sanyal, A. J. (2022) · Current Atherosclerosis Reports · doi:10.1007/s11883-022-01027-5 · Cited by 49
Dairy consumption, plasma metabolites, and risk of type 2 diabetes
Drouin‐Chartier, J., Hernández‐Alonso, P., Guasch‐Ferré, M., Ruiz‐Canela, M., Li, J., Wittenbecher, C., Razquín, C., Toledo, E., Dennis, C., Corella, D., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab047 · Cited by 48
Self-citationDietary Management of Type 2 Diabetes in the MENA Region: A Review of the Evidence
Hwalla, N. C., Jaafar, Z. A., & Sawaya, S. (2021) · Nutrients · doi:10.3390/nu13041060 · Cited by 49
The Association Between a Mediterranean Diet and Symptoms of Irritable Bowel Syndrome
Chen, E. Y., Mahurkar‐Joshi, S., Liu, C., Jaffe, N., Labus, J. S., Dong, T. S., Gupta, A., Patel, S., Mayer, E. A., & Chang, L. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.07.012 · Cited by 48
HDL-Cholesterol and Triglycerides Dynamics: Essential Players in Metabolic Syndrome
Alcover, S., Ramos-Regalado, L., Girón, G., Muñoz‐García, N., & Vilahur, G. (2025) · Antioxidants · doi:10.3390/antiox14040434 · Cited by 50
Papandreou, C., Li, J., Liang, L., Bulló, M., Zheng, Y., Ruiz‐Canela, M., Yu, E., Guasch‐Ferré, M., Razquín, C., Clish, C. B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39441-6 · Cited by 48
Self-citationBardagjy, A. S., & Steinberg, F. M. (2019) · Nutrients · doi:10.3390/nu11061231 · Cited by 48
Kim, C., Sung, J., Lee, J. H., Kim, W., Lee, G. J., Jee, S., Jung, I., Rah, U. W., Kim, B. O., Choi, K. H., et al. (2019) · Korean Circulation Journal · doi:10.4070/kcj.2019.0194 · Cited by 48
Hirahatake, K. M., Jiang, L., Wong, N. D., Shikany, J. M., Eaton, C. B., Allison, M., Martin, L. W., García, L., Zaslavsky, O., & Odegaard, A. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013249 · Cited by 48
Butler, M., Bastiaanssen, T. F. S., Long-Smith, C. M., Berding, K., Mörkl, S., Cusack, A.-M., Strain, C., Busca, K., Porteous-Allen, P., Claesson, M. J., et al. (2020) · Nutrients · doi:10.3390/nu12051468 · Cited by 48
Liu, G., Li, J., Li, Y., Hu, Y., Franke, A. A., Liang, L., Hu, F. B., Chan, A. T., Mukamal, K. J., Rimm, E. B., et al. (2021) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab053 · Cited by 48
Di Rosa, C., Lattanzi, G., Spiezia, C., Imperia, E., Piccirilli, S., Beato, I., Gaspa, G., Micheli, V., De Joannon, F., Vallecorsa, N., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192013040 · Cited by 47
A Clinical Tool to Predict Low Serum Selenium in Patients with Worsening Heart Failure
Al‐Mubarak, A. A., Beverborg, N. G., Anker, S. D., Samani, N. J., Dickstein, K., Filippatos, G. S., van Veldhuisen, D. J., Voors, A. A., Bömer, N., & van der Meer, P. (2020) · Nutrients · doi:10.3390/nu12092541 · Cited by 47
Hashim, H. M., & Makpol, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1007166 · Cited by 47
Cavallo, M., Morgana, G., Dozzani, I., Gatti, A., Vandoni, M., Pippi, R., Pucci, G., Vaudo, G., & Fanelli, C. G. (2023) · Nutrients · doi:10.3390/nu15153473 · Cited by 47
Rivera, K., Salas‐Pérez, F., Echeverría, G., Urquiaga, I., Dicenta, S., Pérez, D., de la Cerda, P., González, L., Andía, M. E., Uribe, S. A., et al. (2019) · Nutrients · doi:10.3390/nu11092135 · Cited by 47
Lombardi, R., Iuculano, F., Pallini, G., Fargion, S. R., & Fracanzani, A. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228761 · Cited by 47
Lorite-Fuentes, I., Montero‐Vílchez, T., Arias‐Santiago, S., & Molina‐Leyva, A. (2022) · Nutrients · doi:10.3390/nu14030551 · Cited by 47
Mediterranean-Style Diet and Risk of Preeclampsia by Race in the Boston Birth Cohort
Minhas, A. S., Hong, X., Wang, G., Rhee, D. K., Liu, T., Zhang, M., Michos, E. D., Wang, X., & Mueller, N. T. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.022589 · Cited by 46
Griffiths, A., Matu, J., Whyte, E., Akin-Nibosun, P., Clifford, T., Stevenson, E., & Shannon, O. M. (2021) · British Journal Of Nutrition · doi:10.1017/s0007114521003202 · Cited by 46
Stefas, D., Gyftokostas, N., Nanou, E., Kourelias, P., & Couris, S. (2021) · Molecules · doi:10.3390/molecules26164981 · Cited by 46
Nitric oxide for the prevention and treatment of viral, bacterial, protozoal and fungal infections
Bath, P. M., Coleman, C. M., Gordon, A. L., Lim, W. S., & Webb, A. J. (2021) · F1000Research · doi:10.12688/f1000research.51270.2 · Cited by 46
Dietary Patterns and All-Cause Mortality: A Systematic Review
Boushey, C. J., Ard, J. D., Bazzano, L., Heymsfield, S. B., Mayer‐Davis, E. J., Sabaté, J., Snetselaar, L., Horn, L. V., Schneeman, B. O., English, L., et al. (2020) · doi:10.52570/nesr.dgac2020.sr0108 · Cited by 46
Sood, S., Feehan, J., Itsiopoulos, C., Wilson, K., Plebanski, M., Scott, D. S., Hébert, J. R., Shivappa, N., Mousa, A., George, E. S., et al. (2022) · Nutrients · doi:10.3390/nu14204437 · Cited by 46
Dietary patterns to promote cardiometabolic health
Pagidipati, N. J., Taub, P. R., Ostfeld, R. J., & Kirkpatrick, C. F. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01061-7 · Cited by 46
Carbone, F., Després, J., Ioannidis, J. P. A., Neeland, I. J., Garruti, G., Busetto, L., Liberale, L., Ministrini, S., Vilahur, G., Schindler, T. H., et al. (2025) · European Journal of Clinical Investigation · doi:10.1111/eci.70059 · Cited by 46
Gut Microbiota-Derived Metabolites in Atherosclerosis: Pathways, Biomarkers, and Targets
Tonch-Cerbu, A.-K., Boicean, A., Stoia, O., & Teodoru, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178488 · Cited by 46
LC-MS/MS-Based Profiling of Tryptophan-Related Metabolites in Healthy Plant Foods
Vitalini, S., Dei, M., Rubino, F. M., Vigentini, I., Foschino, R. C., Iriti, M., & Paroni, R. C. (2020) · Molecules · doi:10.3390/molecules25020311 · Cited by 46
Healthy Drinks with Lovely Colors: Phenolic Compounds as Constituents of Functional Beverages
Pinto, T., & Vilela, A. (2021) · Beverages · doi:10.3390/beverages7010012 · Cited by 46
Bonaccio, M., Iacoviello, L., Donati, M. B., & de Gaetano, G. (2021) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00924-3 · Cited by 46
Treatment of Dyslipidaemia in Children
Fiorentino, R., & Chiarelli, F. (2021) · Biomedicines · doi:10.3390/biomedicines9091078 · Cited by 46
Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids
Cui, M., Chen, B., Xu, K., Rigakou, A., Diamantakos, P., Melliou, E., Logothetis, D. E., & Magiatis, P. (2021) · Scientific Reports · doi:10.1038/s41598-021-01752-y · Cited by 46
Ruiz, Z. V., Toledo, E., Vitelli‐Storelli, F., Goñi, L., Víctor de la, O., Bes‐Rastrollo, M., & Martínez‐González, M. Á. (2022) · Antioxidants · doi:10.3390/antiox11040783 · Cited by 46
Self-citationMoustafa, B., Trifan, G., Isasi, C. R., Lipton, R. B., Sotres‐Alvarez, D., Cai, J., Tarraf, W., Stickel, A. M., Mattei, J., Talavera, G. A., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.21982 · Cited by 46
A Pesco-Mediterranean Diet With Intermittent Fasting
O’Keefe, J. H., Torres-Acosta, N., O’Keefe, E. L., Saeed, I. M., Lavie, C. J., Smith, S. E., & Ros, E. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.07.049 · Cited by 45
Self-citationZheng, D., Chen, L., Li, G., Jin, L., Wei, Q., Liu, Z., Yang, G., Li, Y., & Xie, X. (2022) · Food & Function · doi:10.1039/d2fo01761j · Cited by 45
Diet and Nutrition in Inflammatory Bowel Disease: A Review of the Literature
Manski, S. A., Noverati, N., Policarpo, T., Rubin, E., & Shivashankar, R. (2023) · Crohn s & Colitis 360 · doi:10.1093/crocol/otad077 · Cited by 45
Should we remove wine from the Mediterranean diet?: a narrative review
Martínez‐González, M. Á. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.12.020 · Cited by 45
Self-citationZambrano, A. K., Cadena-Ullauri, S., Ruiz‐Pozo, V. A., Tamayo‐Trujillo, R., Paz‐Cruz, E., Guevara‐Ramírez, P., Frías-Toral, E., & Simancas‐Racines, D. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05175-x · Cited by 45
Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death
Tessier, A.-J., Cortese, M., Yuan, C., Bjornevik, K., Ascherio, A., Wang, D. D., Chavarro, J. E., Stampfer, M. J., Hu, F. B., Willett, W. C., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.10021 · Cited by 44
Koo, M., & Lin, S.-C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38620 · Cited by 45
RetractedNew insights into the anorexia of ageing
Dent, E., Hoogendijk, E. O., & Wright, O. R. L. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000525 · Cited by 45
Bazal, P., Gea, A., Martínez‐González, M. Á., Salas‐Salvadó, J., Asensio, E. M., Muñoz-Bravo, C., Fiol, M., Muñoz, M. Á., Lapetra, J., Serra‐Majem, L., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.03.007 · Cited by 45
Self-citationCalahorra, J., Shenk, J. C., Wielenga, V. H., Verweij, V., Geenen, B., Dederen, P. J. W. C., Peinado, M. Á., Siles, E., Wiesmann, M., & Kiliaan, A. J. (2019) · Nutrients · doi:10.3390/nu11102430 · Cited by 45
Mantzioris, E., & Villani, A. M. (2019) · Nutrients · doi:10.3390/nu11102507 · Cited by 45
Microglia, neurodegeneration and loss of neuroendocrine control
Chowen, J. A., & García‐Segura, L. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101720 · Cited by 45
Dietary treatment to lower cholesterol and triglyceride and reduce cardiovascular risk
Welty, F. K. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000689 · Cited by 45
Michaëlsson, K., Baron, J. A., Byberg, L., Höijer, J., Larsson, S. C., Svennblad, B., Melhus, H., Wolk, A., & Lemming, E. W. (2020) · PLoS Medicine · doi:10.1371/journal.pmed.1003331 · Cited by 45
Barriers and Facilitators to Nut Consumption: A Narrative Review
Neale, E. P., Tran, G., & Brown, R. C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17239127 · Cited by 45
Novel insights in the relationship of gut microbiota and coronary artery diseases
Ramírez-Macías, I., Orenes‐Piñero, E., Camelo-Castillo, A. J., Rivera‐Caravaca, J. M., López‐García, C., & Marín, F. R. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1868397 · Cited by 45
Can Dietary Patterns Impact Fertility Outcomes? A Systematic Review and Meta-Analysis
Winter, H., Rolnik, D. L., Mol, B. W., Torkel, S., Alesi, S., Mousa, A., Habibi, N., Silva, T. R., Cheung, T. O., Tay, C. T., et al. (2023) · Nutrients · doi:10.3390/nu15112589 · Cited by 44
The role of the Mediterranean diet in modulating the gut microbiome: A review of current evidence
Gündoğdu, A., & Nalbantoğlu, Ö. U. (2023) · Nutrition · doi:10.1016/j.nut.2023.112118 · Cited by 45
Obesity management: sex-specific considerations
Kantowski, T., Wiesch, C. S. Z., Aberle, J., & Lautenbach, A. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07367-0 · Cited by 44
Marrero, A. D., Quesada, A. R., Martı́nez-Poveda, B., & Medina, M. Á. (2024) · Nutrients · doi:10.3390/nu16091283 · Cited by 44
Podadera-Herreros, A., Larriva, A. P. A.-D., Gutierrez-Mariscal, F. M., Alcala-Diaz, J. F., Ojeda‐Rodríguez, A., Rodríguez-Cantalejo, F., Cardelo, M. P., Rodríguez-Cano, D., Torres-Peña, J. D., Luque, R. M., et al. (2024) · Nutrition and Diabetes · doi:10.1038/s41387-024-00285-3 · Cited by 44
Food and Medicine Homology Focus in 2026
Li, M., Wu, G.-F., Lu, F., Geng, C., Yu, S., Gao, M., Gao, Y., ZHANG, X.-F., Ling, J., Li, D.-L., et al. (2026) · Food & medicine homology. · doi:10.26599/fmh.2026.9420133 · Cited by 44
Fatty acid bioaccessibility and structural breakdown from in vitro digestion of almond particles
Swackhamer, C., Zhang, Z., Taha, A. Y., & Bornhorst, G. M. (2019) · Food & Function · doi:10.1039/c9fo00789j · Cited by 44
Sotos‐Prieto, M., Rio, D. D., Drescher, G., Estruch, R., Hanson, C., Harlan, T. S., Hu, F. B., Loi, M. A., McClung, J. P., Mojica, A., et al. (2021) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2021.1941804 · Cited by 44
Self-citationFang, X., Cao, J., Tao, Z., Yang, Z., Dai, Y., & Zhao, L. (2023) · Redox Report · doi:10.1080/13510002.2023.2187564 · Cited by 43
Montemayor, S., García, S., Monserrat-Mesquida, M., Tur, J. A., & Bouzas, C. (2023) · Nutrients · doi:10.3390/nu15183987 · Cited by 43
Lifestyle interventions for cardiometabolic health
Rutters, F., den Braver, N. R., Lakerveld, J., Mackenbach, J. D., van der Ploeg, H. P., Griffin, S. J., Elders, P. J. M., & Beulens, J. W. J. (2024) · Nature Medicine · doi:10.1038/s41591-024-03373-0 · Cited by 44
PREDIMED trial of Mediterranean diet: retracted, republished, still trusted?
Agarwal, A., & Ioannidis, J. P. A. (2019) · BMJ · doi:10.1136/bmj.l341 · Cited by 43
Spermine and gene methylation: a mechanism of lifespan extension induced by polyamine-rich diet
Soda, K. (2019) · Amino Acids · doi:10.1007/s00726-019-02733-2 · Cited by 44
O’Connor, L. E., Hu, E. A., Steffen, L. M., Selvin, E., & Rebholz, C. M. (2020) · Nutrition and Diabetes · doi:10.1038/s41387-020-0113-x · Cited by 44
Implications of personality and parental education on healthy lifestyles among adolescents
Yáñez, A. M., Bennasar‐Veny, M., Leiva, A., & Garcı́a-Toro, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-64850-3 · Cited by 43
Hu, E. A., Wu, A., Dearborn, J. L., Gottesman, R. F., Sharrett, A. R., Steffen, L. M., Coresh, J., & Rebholz, C. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200392 · Cited by 43
Metabolomic Biomarkers of Healthy Dietary Patterns and Cardiovascular Outcomes
Kim, H., & Rebholz, C. M. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00921-8 · Cited by 43
Müller, A. K., Albrecht, F., Rohrer, C., Koeberle, A., Werz, O., Schlörmann, W., Glei, M., Lorkowski, S., & Wallert, M. (2021) · Nutrients · doi:10.3390/nu13124437 · Cited by 43
Estándares SEA 2022 para el control global del riesgo cardiovascular
Mostaza, J. M., Pintó, X., Armario, P., Masana, L., Real, J. T., Valdivielso, P., Arrobas-Velilla, T., Baeza‐Trinidad, R., Calmarza, P., Cebollada, J., et al. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2021.11.003 · Cited by 43
Self-citationCaputo, M., Pigni, S., Antoniotti, V., Agosti, E., Caramaschi, A., Antonioli, A., Aimaretti, G., Manfredi, M., Bona, E., & Prodam, F. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2087593 · Cited by 43
Stroke Prevention in Older Adults
Spence, J. D., Azarpazhooh, M. R., Larsson, S. C., Bogiatzi, C., & Hankey, G. J. (2020) · Stroke · doi:10.1161/strokeaha.120.031707 · Cited by 43
Galan-Lopez, P., Sanchez-Oliver, A. J., Pihu, M., Gísladóttír, T., Domínguez, R., & Ries, F. (2019) · Nutrients · doi:10.3390/nu12010077 · Cited by 42
Chen, X., Li, Z., Smith, S. A., Chen, M., Liu, H., Zhang, J., Tang, L., Li, J., Liu, Q., & Wu, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2021.829146 · Cited by 42
Association between dietary patterns and cardiovascular diseases: A review
Lu, L., Jing, W., Qian, W., Fan, L., & Cheng, J. (2024) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2024.102412 · Cited by 42
Ratti, C., Malaguti, M., D’Aniello, E., Bellasi, A., & Sanna, G. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.120495 · Cited by 42
Association between Eating Speed and Classical Cardiovascular Risk Factors: A Cross-Sectional Study
Paz‐Graniel, I., Babió, N., Méndez, I., & Salas‐Salvadó, J. (2019) · Nutrients · doi:10.3390/nu11010083 · Cited by 42
Self-citation
Metadata
- Authors
- Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., Lamuela-Raventos, R. M., Serra-Majem, L., Pintó, X., Basora, J., Muñoz, M. A., Sorlí, J. V., Martínez, J. A., Fitó, M., Gea, A., Hernán, M. A., & Martínez-González, M. A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- From the PREDIMED (Prevención con Dieta Mediterránea) Network (RD 06/0045) (R.E., J.S.-S., F.A., E.G.-G., V.R.-G., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M.A.M.-G.) and Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (R.E., E.R., J.S.-S., M.-I.C., D.C., F.A., M. Fiol, J.L., R.M.L.-R., L.S.-M., X.P., J.B., J.V.S., J.A.M., M. Fitó, A.G., M.A.M.-G.), Instituto de Salud Carlos III, Madrid, the Department of Internal Medicine, Hospital Clinic (R.E.), the...
- Universitat de València (ES)
- ORCID
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2018-06-21
- Volume
- 378
- Issue
- 25
- Pages
- 1388-1389
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2807970930
- Semantic Scholar
- 580a209e2919f5cc97eaef2baa9bda59f3697e6b
- Cited by
- 3,616
- References
- 33
- Citations by year
- 2026: 470 · 2025: 472 · 2024: 431 · 2023: 489 · 2022: 406 · 2021: 445 · 2020: 455 · 2019: 322 · 2018: 111
- FWCI
- 317.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Funders
- Public Health Division of the Department of Health of the Autonomous Government of Catalonia (Public Health Division of the Department of Health)
- Instituto de Salud Carlos III (CIBERobn, CP06/00100, P11/02505, PI 05/2584, PI 07/0473, PI04/0954, PI07/0240, PI07/0954, PI07/1138, PI10/01407, PI10/02658, PI11/01647, RTIC G03/140, RTIC RD06/0045)
- Departamento de Educación, Gobierno de Navarra (P27/2011)
- Generalitat Valenciana (ACOMP06109, CS2010-AP-111, CS2011-AP-042, GVACOMP2010-181, GVACOMP2011-151)
- Patient-Centered Outcomes Research Institute (ME-1503-28119)
- Ministerio de Ciencia e Innovación (AGL-2009-13906-C02, AGL2010-22319-C03)
- Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007)
- Consejería de Salud de la Junta de Andalucía (PI0105/2007)
- Fundación Mapfre (Fundación Mapfre 2010)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Nuts composition and effects
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Mediterranean diet, extra virgin olive oil, mixed nuts, primary prevention, cardiovascular disease, major adverse cardiovascular events, myocardial infarction, stroke, cardiovascular mortality, high cardiovascular risk, dietary intervention, protocol deviations, propensity score, intention-to-treat analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
