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Nutrition in the Acute Phase of Critical Illness
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† No diagram showing how patients were selected was included in the study by Montejo et al. 10 ‡ No information on the way in which investigators concealed study-group assignments was included in the study by Acosta-Escribano et al. 13 § No sample-size calculation and only partial outcome data in the intention-to-treat population were included in the study by Pontes-Arruda et al., 22 and no diagram showing how patients were selected was included in the study by Umpierrez et al. 23¶ The study by Rice et al. 24 was stopped prematurely for futility at the first interim analysis.
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“These findings may also explain differences in results of nutritional trials, depending on the clinical setting with several nutritional studies in the ICU setting or in patients with advanced cancer not showing significant benefits form nutrition in regard to clinical outcomes [165,168].”
From ESPEN guideline on nutritional support for polymorbid medical inpatients (2023) · cites this paper as [168]
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“Data from studies conducted in the past 10 years challenge the appropriateness of these standard calorie and protein targets during the acute phase of critical illness.8,9”
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Nutrition support in acute cardiac care
Casaer, M. P., & den Berghe, G. V. (2021) · Oxford University Press eBooks · doi:10.1093/med/9780198849346.003.0030
Self-citation
Metadata
- Authors
- Casaer, M. P., & Van den Berghe, G.
- Affiliations
- KU Leuven (BE)
- ORCID
- Casaer, Michael P.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-03-27
- Volume
- 370
- Issue
- 13
- Pages
- 1227-1236
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2167108605
- Semantic Scholar
- 0cb329f79bd3d2161f4d43c16bc04bf14fe369d7
- Cited by
- 335
- References
- 58
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 18 · 2023: 17 · 2022: 24 · 2021: 29 · 2020: 23 · 2019: 23 · 2018: 30 · 2017: 34 · 2016: 27 · 2015: 56 · 2014: 18
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- nutrition, critical illness, acute phase, critically ill patients, nutritional support, methodological quality, reporting quality, sample size determination, blinding, early trial termination
- MeSH terms
- Amino Acids, Animals, Anorexia, Enteral Nutrition, Food, Humans, Lipids, Nutritional Requirements, Parenteral Nutrition, Time Factors, Randomized Controlled Trials as Topic, Critical Illness, Micronutrients
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