Circadian Mechanisms in Medicine

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304

Clock Mutants of Drosophila melanogaster

Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986

Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction

Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464

Case-based, asynchronous sleep education outcomes among primary care nurse practitioner students

Sawyer, A. M., Saconi, B., Lyons, M. M., Lang-Gallagher, R., Renz, S. M., Watach, A. J., McPhillips, M., & Rosen, I. M. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10112 · Cited by 11

Clocking Epilepsies: A Chronomodulated Strategy-Based Therapy for Rhythmic Seizures

Sun, S., & Wang, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044223 · Cited by 12

Detecting and exploiting the circadian clock in rheumatoid arthritis

Wilantri, S., Graßhoff, H., Lange, T., Gaber, T., Besedovsky, L., & Buttgereit, F. (2023) · Acta Physiologica · doi:10.1111/apha.14028 · Cited by 11

Circadian time‐dependent effects of experimental colitis on theophylline disposition and toxicity

Yang, Y., Wu, P., Guo, J., Pan, Z., Lin, S., Zeng, W., Wang, C., Dong, Z., & Wang, S. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16440 · Cited by 10

Overexpression of NR1D1 Portends Disease Recurrence in Thyroid Cancer

Hsu, Y., Kuo, C., Chien, M.-N., Jhuang, J., Huang, S., Chang, & Cheng, S. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae687 · Cited by 10

Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms

Pertab, J. L., Merkley, T. L., Winiarski, H. R., Cramond, K. M. J., & Cramond, A. J. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15010033 · Cited by 12

Comprehensive integrative analysis of circadian rhythms in human saliva

Nelson, N., Malhan, D., Hesse, J., Aboumanify, O., Yalçın, M., Lüers, G. H., & Relógio, A. (2025) · npj Biological Timing and Sleep · doi:10.1038/s44323-025-00035-3 · Cited by 11

The secondary pocket of cryptochrome 2 is important for the regulation of its stability and localization

Parlak, G. C., Camur, B. B., Gül, Ş., Özcan, O., Barış, İ., & Kavaklı, İ. H. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102334 · Cited by 10

Using routinely collected clinical data for circadian medicine: A review of opportunities and challenges

Kervezee, L., Dashti, H. S., Pilz, L. K., Skarke, C., & Ruben, M. D. (2024) · PLOS Digital Health · doi:10.1371/journal.pdig.0000511 · Cited by 10

Circadian Variations in the Pharmacokinetics of Capecitabine in Mice

Akyel, Y. K., Civelek, D. Ö., Öztürk, N., Gül, Ş., Gazioğlu, I., Kara, Z. P., Lévi, F., Kavaklı, İ. H., & Okyar, A. (2022) · Journal of Biological Rhythms · doi:10.1177/07487304221148779 · Cited by 10

The suggestions of ancient Chinese philosophy and medicine for contemporary scientific research, and integrative care.

Bottaccioli, F., & Bottaccioli, A. G. (2023) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2023.100024 · Cited by 10

Diurnal rhythms in varicella vaccine effectiveness

Danino, D., Kalron, Y., Haspel, J. A., & Hazan, G. (2024) · JCI Insight · doi:10.1172/jci.insight.184452 · Cited by 9

The metabolic and circadian signatures of gestational diabetes in the postpartum period characterised using multiple wearable devices

Phillips, N. E., Mareschal, J., Biancolin, A. D., Sinturel, F., Umwali, S., Blanc, S., Hemmer, A., Naef, F., Salathé, M., Dibner, C., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06318-x · Cited by 10

Endothelial Dysfunction in Acute Myocardial Infarction: A Complex Association With Sleep Health, Traditional Cardiovascular Risk Factors and Prognostic Markers

Hbaieb, M. A., Charfeddine, S., Driss, T., Bosquet, L., Dugué, B., Makni, A., Turki, M., Abid, L., & Hammouda, O. (2025) · Clinical Cardiology · doi:10.1002/clc.70080 · Cited by 10

Anti-Müllerian hormone signalling sustains circadian homeostasis in zebrafish

Lin, Q., Du, X., Ren, F., Liu, Y., Gong, G., Ge, S., Li, W., Li, Z., Zhou, L., Duan, M., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59528-1 · Cited by 9

Multifaceted dynamics of circadian timing system influence aging and longevity

Jagota, A., Khan, Z. A., Sharma, S. A., & Priyanka (2025) · Biogerontology · doi:10.1007/s10522-025-10324-w · Cited by 9

Andrias Davidianus Peptide Hydrogel Enables Sustained SR9011 Release to Promote Efferocytosis and Alleviate Colitis

Chen, Y., Li, J., Li, J., Zhang, X., Liu, F., Yu, Q., Lin, R., & Zhu, L. (2025) · Small · doi:10.1002/smll.202509049 · Cited by 11

Continuous light exposure influences luteinization and luteal function of ovary in ICR mice

Li, X., Zhu, H., Zhang, Q., Li, Y., Li, Y., Feng, X., Yuan, R., Sha, Q., Ma, J., Luo, S., et al. (2022) · Journal of Pineal Research · doi:10.1111/jpi.12846 · Cited by 9

An update on the role and potential mechanisms of clock genes regulating spermatogenesis: A systematic review of human and animal experimental studies

He, M., Liu, K., Cao, J., & Chen, Q. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09783-0 · Cited by 9

Sleep Fragmentation, Electroencephalographic Slowing, and Circadian Disarray in a Mouse Model for Intensive Care Unit Delirium

Dulko, E., Jedrusiak, M., Osuru, H. P., Atluri, N., Illendula, M., Davis, E. M., Beenhakker, M. P., & Lunardi, N. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006524 · Cited by 10

Effect of circadian rhythm on NAD and other metabolites in human brain

Cuenoud, B. M., Huang, Z., Hartweg, M., Widmaier, M., Lim, S., Wenz, D., & Xin, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1285776 · Cited by 9

It’s about time: circadian medicine in the intensive care unit

Luetz, A., Spies, C., & Kervezee, L. (2023) · Intensive Care Medicine · doi:10.1007/s00134-023-07297-0 · Cited by 9

Circadian clock core component Bmal1 dictates cell cycle rhythm of proliferating hepatocytes during liver regeneration

Jiang, H., Garcia, V., Yanum, J. A., Lee, J., & Dai, G. (2021) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00204.2021 · Cited by 9

Konzepte zur Reduktion der Lärmbelastung auf der Intensivstation

Theuerkauf, N. U., Putensen, C., & Schewe, J. (2022) · AINS - Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie · doi:10.1055/a-1477-2300 · Cited by 9

A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development

Yuan, H., Xie, B., Xia, Y., Lin, C., Li, M., Zhang, Y., Zou, X., Lu, M., Zhao, M., & Wen, X. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.981311 · Cited by 9

Chrono-Endocrinology in Clinical Practice: A Journey from Pathophysiological to Therapeutic Aspects

Mercadante, S., & Bellastella, A. (2024) · Life · doi:10.3390/life14050546 · Cited by 10

Promoting health and survival through lowered body temperature

Conti, B., & de Cabo, R. (2025) · Nature Aging · doi:10.1038/s43587-025-00850-0 · Cited by 8

Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity

Kelters, I. R., Printezi, M. I., Ballesta, A., Dierickx, P., Koop, Y., Innominato, P. F., Lévi, F., van Dam, J. C., Doevendans, P. A., Huitema, A. D. R., et al. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf179 · Cited by 9

Artificial intelligence empowers gut microbiota research in neurodegenerative diseases molecular mechanisms and precision therapy

Zhu, H., He, H., Yang, M., Zhu, H., Hagiwara, A., Shu, L., Xu, J., Miao, Y., Han, X., & Wang, C. (2025) · iScience · doi:10.1016/j.isci.2025.114044 · Cited by 8

Mucosal Genes Encoding Clock, Inflammation and Their Mutual Regulators Are Disrupted in Pediatric Patients with Active Ulcerative Colitis

Labes, S., Froy, O., Tabach, Y., Shamir, R., Shouval, D. S., & Weintraub, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031488 · Cited by 8

Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer

Tian, Y., Xie, Y., Bai, F., Wang, J., & Zhang, D. (2024) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-024-01028-4 · Cited by 8

Comparing Human-Smartphone Interactions and Actigraphy Measurements for Circadian Rhythm Stability and Adiposity: Algorithm Development and Validation Study

Chuang, H., Lin, C., Lee, L., Chang, H., She, G.-J., & Lin, Y. (2024) · Journal of Medical Internet Research · doi:10.2196/50149 · Cited by 9

A Single-Cell Atlas of Porcine Skeletal Muscle Reveals Mechanisms That Regulate Intramuscular Adipogenesis

Xu, Z., Wu, J., Li, Y., Zhou, J., Zhang, Y., Qiao, M., Feng, Y., Sun, H., Li, Z., Li, L., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312935 · Cited by 8

How to Live on Mars With a Proper Circadian Clock?

Luo, R., Huang, Y., Ma, H., & Guo, J. (2022) · Frontiers in Astronomy and Space Sciences · doi:10.3389/fspas.2021.796943 · Cited by 9

Imidazole Propionate is Increased in Diabetes and Associated with Stool Consistency

Wu, B., Tan, L., Wang, W., Feng, X., & Yan, D. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s362715 · Cited by 8

Circadian Rhythm Sleep-Wake Disorders

Consens, F. B. (2023) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001287 · Cited by 8

The structural and functional roles of the flavin cofactor FAD in mammalian cryptochromes

Calloni, G., & Vabulas, R. M. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1081661 · Cited by 7

Circadian rhythm, epigenetics and disease interaction

Osum, M., & Kalkan, R. (2025) · Global Medical Genetics · doi:10.1016/j.gmg.2024.100006 · Cited by 8

Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality

Yang, Y., Hernandez, M. C., Chitre, S., & Jobin, C. (2025) · Current Clinical Microbiology Reports · doi:10.1007/s40588-025-00242-3 · Cited by 11

Rest–Activity Rhythm Patterns and Their Associations With Depression and Obesity: A Study Using Actigraphy and Human–Smartphone Interactions

Chen, I., Lin, C., She, G.-J., Chang, H., Chuang, H., Chen, T., & Lin, Y. (2025) · Depression and Anxiety · doi:10.1155/da/2617282 · Cited by 7

Rhythm profiling using COFE reveals multi-omic circadian rhythms in human cancers in vivo

Ananthasubramaniam, B., & Venkataramanan, R. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003196 · Cited by 9

M54 selectively stabilizes the circadian clock component of CRY1 and enhances the period of circadian rhythm at cellular level

Gül, Z. M., Aydoğan, S., Sürme, S., Efendi, S. N. H., Özcan, O., Uyanık, E., Barış, İ., Gül, Ş., & Kavaklı, İ. H. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110333 · Cited by 7

The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy

Liu, Y., Huang, Y., Luo, H., & Lin, X. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06702-0 · Cited by 8

Genetics-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism

Zhou, D., Chen, Y., Liu, P., Zhu, K., Holder-Haynes, J. G., Lloyd, S. J.-A., La, C. M., Astapova, I. I., Choa, S., Xiong, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.07.010 · Cited by 7

An amorphous zinc/copper double transition metal hydroxides for electrochemical simultaneous detection of dopamine, serotonin, and melatonin

Tang, S., Liu, M., Wang, W., Liang, A., Zhang, F., & Luo, A. (2023) · New Journal of Chemistry · doi:10.1039/d3nj02297h · Cited by 7

Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data

Zou, Z., Yoshimura, Y., Yamanishi, Y., & Oki, S. (2023) · Epigenetics & Chromatin · doi:10.1186/s13072-023-00510-w · Cited by 7

All cause and cause specific mortality associated with transition to daylight saving time in US: nationwide, time series, observational study

Zhao, S., Cao, W., Liao, G., Guo, Z., Xu, L., Shen, C., Chang, C. J., Liang, X., Wang, K., He, D., et al. (2024) · BMJ Medicine · doi:10.1136/bmjmed-2023-000771 · Cited by 6

The impact of circadian rhythm disruption on oxaliplatin tolerability and pharmacokinetics in Cry1−/−Cry2−/− mice under constant darkness

Akyel, Y. K., Öztürk, N., Gül, Ş., Çelik, M., Taşkın, A. C., Selby, C. P., Sancar, A., Kavaklı, İ. H., & Okyar, A. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-03968-7 · Cited by 7

Effects of anaesthesia and surgery on sleep–wake timing and subjective sleep quality in children: an observational study

Meewisse, A. J. G., Meijer, S. J., Choi, K. F., Kanters, S., Meekel, K. B., Burger, P., Gemke, R. J. B. J., Stenvers, D. J., Hermanides, J., van Zuylen, M. L., et al. (2025) · Anaesthesia · doi:10.1111/anae.16710 · Cited by 8

New integrative approaches to discovery of pathophysiological mechanisms triggered by night shift work

Richter, H. G., Méndez, N., Halabí, D., Torres‐Farfan, C., & Spichiger, C. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1994984 · Cited by 7

Resetting the circadian clock of Alzheimer’s mice via GLP-1 injection combined with time-restricted feeding

Dong, Y., Cheng, L., & Zhao, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.911437 · Cited by 8

Influence of Chronotypes in Respiratory Pathology

Moreno, B. R., Riolobos, C. L., Díaz-García, J. M., López, C. M., & Fernández, A. A. (2022) · Open Respiratory Archives · doi:10.1016/j.opresp.2022.100228 · Cited by 7

A Pilot Urinary Proteome Study Reveals Widespread Influences of Circadian Rhythm Disruption by Sleep Deprivation

Zhou, L. N., Lu, X., Wang, X., Huang, Z., Wu, Y., Zhou, L., Meng, L., Fu, Q., Li, X., & Meng, S. (2023) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-023-04666-9 · Cited by 8

Systematic analysis of circadian disrupting substances with a high-throughput zebrafish circadian behavior screening approach

Chen, J., Zhou, J., Li, M., Zhang, K., Dai, J., & Zhao, Y. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167037 · Cited by 7

Circadian disruption dysregulates lung gene expression associated with inflammatory lung injury

Casanova, N. G., Armond, R. L. D., Sammani, S., Sun, X., Sun, B. L., Kempf, C. L., Bime, C., Garcia, J. G. N., & Parthasarathy, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1348181 · Cited by 7

Oscillatory Dynamics and Regulatory Mechanisms of the p53–Per2 Network in DNA-Damaged Cells

Wang, C., Zhang, Y., Cao, J., & Yang, Z. (2024) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2024.3424784 · Cited by 6

Targeting the circadian modulation: novel therapeutic approaches in the management of ASD

Zhang, Y., Chen, Y. J., Li, W., Tang, L., Li, J., & Feng, X. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1451242 · Cited by 7

Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation

Liao, J., Wang, Y., Li, J., Li, P., Liu, Y., Wu, J., Zhao, M., Huang, H., Liu, P., Chen, Y., et al. (2025) · SLEEP · doi:10.1093/sleep/zsaf258 · Cited by 7

Gut microbiota, circadian rhythms and their interactions: implications for the pathogenesis and treatment of depression

Du, D., Yuan, Y., Guan, X., Xie, Q., Sun, X., & Dong, Z. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2561222 · Cited by 7

Galactose-modified small molecule modulator targets RORα to enhance circadian rhythm and alleviate periodontitis-associated alveolar bone loss

Feng, G., Liao, Z., Wang, Y., Tang, Q., Li, N., Cheng, L., Liu, Y., Liu, R., Cui, M., Fan, W., et al. (2025) · Bone Research · doi:10.1038/s41413-025-00445-w · Cited by 6

Timing of Immunotherapy in Practice: Feasibility and Impact of Morning Checkpoint Inhibitor Administration

Innominato, P. F., Landre, T., Karaboué, A., Duchemann, B., Buchwald, Z. S., Zhang, Y., Griffiths, D., CHOUAID, C., & Lévi, F. (2025) · JCO Oncology Practice · doi:10.1200/op-25-00661 · Cited by 7

The circadian clock in inflammatory bowel diseases

Froy, O., & Weintraub, Y. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.11.008 · Cited by 6

Evaluation of the Digital Ventilated Cage® system for circadian phenotyping

Tir, S., Foster, F., & Peirson, S. N. (2025) · Scientific Reports · doi:10.1038/s41598-025-87530-6 · Cited by 8

Seeing the light: surgical circadian rhythm

Kovoor, J. G., & Maddern, G. J. (2021) · British journal of surgery · doi:10.1093/bjs/znab315 · Cited by 6

Circadian effects on UV-induced damage and mutations

Goodenow, D. A., Greer, A. J., Cone, S. J., & Gaddameedhi, S. (2022) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2022.108413 · Cited by 8

The circadian rhythm of viruses and its implications on susceptibility to infection

Blanco, J. R., Verdugo‐Sivianes, E. M., Amiama-Roig, A., & Muñoz-Galván, S. (2022) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2072296 · Cited by 6

Circadian signatures of anterior hypothalamus in time-restricted feeding

Zhou, M., Chen, J., Huang, R., Xin, H., Ma, X., Li, L., Deng, F., Zhang, Z., & Li, M. (2022) · F1000Research · doi:10.12688/f1000research.125368.1 · Cited by 6

Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions

Geng, Y., Madonna, R., Hermida, R. C., & Smolensky, M. H. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100025 · Cited by 6

Circadian Rhythm and Nuclear Receptors

Ray, D. W. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-11836-4_8 · Cited by 7

Evidence for conservation of primordial ∼12-hour ultradian gene programs in humans under free-living conditionsPreprint

Zhu, B., Liu, S., David, N. L., Dion, W. A., Doshi, N. K., Siegel, L. B., Amorim, T., Andrews, R. E., Kumar, G. N., Li, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.02.539021 · Cited by 6

The Aggravating Role of Failing Neuropeptide Networks in the Development of Sporadic Alzheimer’s Disease

Jászberényi, M., Thurzó, B., Jayakumar, A. R., & Schally, A. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313086 · Cited by 5

Chronotherapy and intervertebral disc degeneration: understanding the role of circadian rhythm in degenerative processes

Zhang, C., Zhang, R., Zhao, G., Wu, Z., Song, W., Ran, R., Zhou, K., & Zhang, H. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1586193 · Cited by 5

Noncanonical clock regulators control stress responses in digestive diseases

Zhou, D., López-Valiente, R. E., Mattar, S. G., & Guan, D. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.07.002 · Cited by 5

Emerging role of E4BP4/NFIL3 in metabolic homeostasis

Ran, S., Wang, S., Jin, Q., Liu, G., Xue, X., Qu, P., Peng, L., & Meng, H. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156390 · Cited by 5

Do circadian factors improve mortality risk prediction? A dual-cohort analysis of metabolic and circadian syndromes

Pan, D., Wang, Y., Zhang, C., Lu, Y., Yin, S., Wang, P., Xia, J., Yu, J., Gao, H., Sun, G., et al. (2025) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2025.112919 · Cited by 5

Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice

Levine, D. C., Reeh, R. H., McMahon, T., Mandrup-Poulsen, T. R., Fu, Y., & Ptáček, L. J. (2025) · Science · doi:10.1126/science.adp3065 · Cited by 8

Nighttime Texting on Social Media, Sleep Parameters, and Adolescent Sadness: A Mediation Analysis

Sancho-Domingo, C., Garmy, P., & Norell‐Clarke, A. (2024) · Behavioral Sleep Medicine · doi:10.1080/15402002.2024.2314281 · Cited by 5

Shift Work Increases the Risk of Circadian Syndrome Rather than Metabolic Syndrome: A Cross-Sectional Study of NHANES 2005–2010

Wang, L., Wang, S., Wang, Y., Jiang, Y., He, J., & Li, X. (2024) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2024.0075 · Cited by 5

Association between the weight-adjusted-waist index and circadian syndrome in findings from a nationwide study

Zeng, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-70648-4 · Cited by 5

Differences in brain spindle density during sleep between patients with and without type 2 diabetes

Yeung, D., Talukder, A., Shi, M., Umbach, D. M., Li, Y., Motsinger‐Reif, A. A., Hwang, J. J., Fan, Z., & Li, L. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109484 · Cited by 8

Nightshift imposes irregular lifestyle behaviors in police academy trainees

Erickson, M. L., North, R., Counts, J. D., Wang, W., Starr, K. N. P., Wideman, L., Pieper, C. F., Dunn, J., & Kraus, W. E. (2023) · SLEEP Advances · doi:10.1093/sleepadvances/zpad038 · Cited by 6

Timing of diuretic administration effects on urine volume in hospitalized patients

McCullar, K. S., Abbaspour, S., Wang, W., Aguirre, A. D., Westover, M. B., & Klerman, E. B. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1208324 · Cited by 5

Hemodialysis-induced chronodisruption and chronotype distribution in patients with chronic kidney disease

Nunes, P. P., Resende, C. M., Silva, E. D. B., Bastos, D. C. P., Filho, M. L. M. R., Leocádio-Miguel, M. A., Pedrazzoli, M., Sobreira-Neto, M. A., de Andrade, T. G., Gitaí, L. L. G., et al. (2024) · Chronobiology International · doi:10.1080/07420528.2024.2306838 · Cited by 6

An Introductory Guide to Using Bloomington Drosophila Stock Center and FlyBase for Aging Research

Zheng, X. (2024) · Cells · doi:10.3390/cells13141192 · Cited by 5

Metformin upregulates circadian gene PER2 to inhibit growth and enhance the sensitivity of glioblastoma cell lines to radiotherapy via SIRT2/G6PD pathway

Li, H.-L., Feei, Z., Wanfu, Y., Zhang, Y., Sun, J., Jiang, H., Wang, F., Hou, L., & Xia, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1563865 · Cited by 7

Human genetic variation determines 24-hour rhythmic gene expression and disease risk

Chen, Y., Liu, P., Sabo, A., & Guan, D. (2025) · Nature Communications · doi:10.1038/s41467-025-59524-5 · Cited by 7

Supplements to treat prediabetes

Hepler, C., & Bass, J. T. (2021) · Science · doi:10.1126/science.abj0764 · Cited by 5

Running on Empty: Of Hypopinealism and Human Seasonality

Kunz, D., Wahnschaffe, A., Kämpfe, N., & Mahlberg, R. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.681582 · Cited by 5

The Impact of Vaccination Time on the Antibody Response to an Inactivated Vaccine against SARS‐CoV‐2 (IMPROVE‐2): A Randomized Controlled Trial

Lai, F., Ли, Б., Mei, J., Zhou, Q., Long, J., Liang, R., Mo, R., Peng, S., Liu, Y., & Xiao, H. (2023) · Advanced Biology · doi:10.1002/adbi.202300028 · Cited by 5

Oscillatory dynamics of the mammalian circadian clock induced by the core delayed negative feedback loop

Wang, C., Liu, H., & Zhang, Y. (2024) · Nonlinear Dynamics · doi:10.1007/s11071-024-09416-y · Cited by 5

From clock genes to exercise: shaping the field of Exercise Chronophysiology

Ciorciari, A. M., & Lamia, K. A. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100835 · Cited by 4

Targeting RBM10‐Repressed RORB Activity in Liquid Condensates Inhibits Lysosomal Biogenesis and Neuroblastoma Progression via Affecting NF‐κB Signaling

Guo, Y., Wang, X., Yang, C., Wang, Z., Wang, X., Li, X., Qu, J., Zhou, S., Zheng, L., & Tong, Q. (2025) · Advanced Science · doi:10.1002/advs.202506131 · Cited by 4

Chronotype, cognitive outcomes, and neural dynamics: recent evidence and potential mechanisms with implications for perioperative period

Liu, Y., Liu, Q., Gao, B., Fu, Q., Li, F., Yu-hu, M., & Liu, Y. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1649396 · Cited by 4

Dynamic Oxidative States: Interplay of Aging, Metabolic Stress, and Circadian Rhythms in Modulating Stroke Severity

Sun, J.-M., Jan, J., Hsieh, C.-T., Taliyan, R., Yang, C.-H., Teng, R.-D., & Yen, T. (2025) · Antioxidants · doi:10.3390/antiox15010054 · Cited by 4

Mapping the daily rhythmic transcriptome in the diabetic retina

Silk, R., Winter, H., Dkhissi‐Benyahya, O., Evans‐Molina, C., Stitt, A. W., Tiwari, V. K., Simpson, D. A. C., & Beli, E. (2023) · Vision Research · doi:10.1016/j.visres.2023.108339 · Cited by 4

The optimal measurement period of actigraphy for circadian rhythm in relation to adiposity: A retrospective case-control study

Chuang, H., Lin, Y., Lee, L.-A., Chang, H., She, G.-J., & Lin, C. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.07.025 · Cited by 4

Road traffic noise and breast cancer: DNA methylation in four core circadian genes

Thacher, J. D., Snigireva, A., Dauter, U. M., Delaval, M., Oudin, A., Mattisson, K., Sørensen, M., Borgquist, S., Albin, M. C., & Bröberg, K. (2024) · Clinical Epigenetics · doi:10.1186/s13148-024-01774-z · Cited by 4

Integrating cancer medicine into metabolic rhythms

Su, K., Zeng, D., Zhang, W., Peng, F., Cui, B., & Liu, Q. (2025) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2025.03.007 · Cited by 4

Using the diel cycle of ocean microbes to better understand their biogeochemical functions

Boyd, P. W., & Mooy, B. A. S. V. (2025) · Limnology and Oceanography Letters · doi:10.1002/lol2.70027 · Cited by 4

Effects of volatile anesthetics on circadian rhythm in mice: a comparative study of sevoflurane, desflurane, and isoflurane

Sugimura, S., Imai, R., Katoh, T., Makino, H., Hokamura, K., Kurita, T., Suzuki, Y., Aoki, Y., Kimura, T., Umemura, K., et al. (2023) · Journal of Anesthesia · doi:10.1007/s00540-023-03262-9 · Cited by 4

[Proceedings: Chronobiology of processes, depending on diurnal rhythm, and its significance in medicine].

von Mayersbach, H. (1975) · PubMed

[Chronobiology in medicine: new concepts in understanding and treatment of disease].

Zvulunov, A., & Ashkenazi, I. E. (1992) · PubMed

Circadian Rhythms, Disease and Chronotherapy

Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 185

Circadian timekeeping in health and disease. Part 1. Basic properties of circadian pacemakers.

Moore-Ede, M., Czeisler, C. A., & Richardson, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308253090806 · Cited by 335

Special Issue on “Research on Circadian Rhythms in Health and Disease”

Gubin, D. G., Cornélissen, G., Stefani, O., & Weinert, D. (2023) · Applied Sciences · doi:10.3390/app131910728