Circadian Mechanisms in Medicine

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310

A circadian gene expression atlas in mammals: Implications for biology and medicine

Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304

Clock Mutants of Drosophila melanogaster

Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287

A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells

Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986

Circadian Variation in the Frequency of Onset of Acute Myocardial Infarction

Muller, J. E., Stone, P. H., Turi, Z. G., Rutherford, J. D., Czeisler, C. A., Parker, C., Poole, W. K., Passamani, E., Roberts, R., Robertson, T., et al. (1985) · New England Journal of Medicine · doi:10.1056/nejm198511213132103 · Cited by 1,884

Transplanted Suprachiasmatic Nucleus Determines Circadian Period

Ralph, M. R., Foster, R. G., Davis, F. C., & Menaker, M. (1990) · Science · doi:10.1126/science.2305266 · Cited by 1,853

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528

Transcriptional architecture and chromatin landscape of the core circadian clock in mammals

Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S. (2012) · Science · doi:10.1126/science.1226339 · Cited by 1,464

Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment

Liu, M., & Yang, K. (2026) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2026.101354

Seasonal variation in sleep apnea and other sleep parameters from diagnostic polysomnography data, 2003–2024

Hasan, M. R., Umbach, D. M., Shi, M., Gu, C., Yeung, D., Talukder, A., Fan, Z., & Li, L. (2026) · Communications Health · doi:10.1038/s44528-026-00013-6

Association of Daily Activity Regularity With Functional Recovery in Patients With Stroke and Spinal Cord Injury: A Prospective Actigraphy Study

Lin, Y.-H., Lin, C., Wu, C., Chang, H., Liang, H., Chen, S.-Y., Sung, K., & Hsu, W.-C. (2026) · Annals of Rehabilitation Medicine · doi:10.5535/arm.250170

Deciphering the circadian signature in acute myeloid leukemia: NPAS2 downregulation as a master predictive feature

da Cunha, L. S., de Morais, G. P., Machado, C. B., Oliveira, D. D. S., Nogueira, B. M. D., Machado, A. K. D. C., Farias, I. C., Pessoa, F. M. C. D. P., Ribeiro, R. M., de Albuquerque, K. M. C., et al. (2026) · Blood Research · doi:10.1007/s44313-026-00157-y

Light-cycle disruption promotes renal calcium oxalate crystal deposition via the NR1D1-IRS1-FOXO1 axis

Gao, S., Huang, K., Wan, S., Wang, J., Wang, J., & Bai, Y. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118361

Chronotherapy in Oncology: Aligning Cancer Treatment with Biological Time

Belančić, A., Golčić, M., Fajkić, A., Bračić, V., Skelin, M., Markotić, A., Ćavar, I., Trivanović, D., & Mikolašević, I. (2026) · Journal of Personalized Medicine · doi:10.3390/jpm16080428

Early-night core body temperature decline is associated with sleep fragmentation and early-night slow-wave sleep duration in elite swimmers

Milot, E., Bretonneau, Q., Dugué, B., Dupuy, O., Morales‐Artacho, A. J., Nédélec, M., Pla, R., Sauvet, F., D-Day Consortium, & Bosquet, L. (2026) · Temperature · doi:10.1080/23328940.2026.2717072

Biopsychosocial profile in individuals with chronic low back pain and high central sensitization symptoms: a cross-sectional comparative study

AKDENİZ, S., Akyüz, S., Ucurum, Z., & Kaya, D. Ö. (2026) · Physiotherapy Theory and Practice · doi:10.1080/09593985.2026.2719836

Natural bioactive compounds targeting the macrophage clock in asthma: evidence, challenges, and perspectives

Ni, B., Chen, R., Sun, S., Liu, Z., Zhang, X., He, H., & Wang, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1922510

Timing of Parenteral Nutrition in Neonates, Infants, and Children: Current Evidence, Circadian Considerations, and Emerging Directions

Chan, A. P., Lai, R. W., & Calkins, K. L. (2026) · Nutrients · doi:10.3390/nu18172800

Association of Operative Timing with Clinical Outcomes and Safety in Thoracic Organ Transplantation: A Meta-Analytic Synthesis of Evidence

Hussein, A. M., Hammadeh, B. M., Asassfeh, A., Yaghi, G., Alzoubi, A., Shabaneh, A., Al-Hayk, A., Rawashdeh, B., Račkauskas, M., & Aladaileh, M. (2026) · Heart & Lung · doi:10.1016/j.hrtlng.2026.102926

The oral immune and inflammatory network under circadian clock control

Sun, X., Ma, X., Ma, Y., Wang, X., Li, X., & Ji, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1894302

Cell-Autonomous and Systemic Circadian Regulation of Gene Expression in Adipocytes

Worthen, J. M., Frederick, A. M., Dumesic, P. A., Loros, J., & Dunlap, J. (2026) · Journal of Biological Rhythms · doi:10.1177/07487304261480978

Integrating human-smartphone interactions and actigraphy in digital phenotyping of obesity and depression: Social-physical coherence algorithm development and validation study

Lin, C., Chuang, H., Chang, H., Chen, I., Chen, T., & Lin, Y. (2026) · Chronobiology International · doi:10.1080/07420528.2026.2723200

Chronopharmacology and implications for the safety and efficacy of anticonvulsants, antipsychotics, and antidepressants: A systematic review

Tan, V. Y., Wong, S., Le, G. H., Kwan, A. T. H., Zhang, M. C., Zheng, Y. J., Teopiz, K. M., Dri, C. E., Ho, R., Bargiota, S. I., et al. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261488466

Artificial Light at Night and Hypertensive Disorders of Pregnancy: Socioeconomic Inequality in the China Birth Cohort Study

Li, Y., Hu, L.-W., Wang, L.-B., Fan, Y.-Y., Chen, Y., Li, Z., Zhang, Y.-T., Amjad, M., Gui, Z., Chu, C., et al. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.6c07362

Sex‐ and age‐specific daily and seasonal rhythms in haemoglobin and ferritin among Dutch blood donors

Wehrens, S. M. T., Meulenbeld, A., Pothast, M., Prinsze, F. J., & van den Hurk, K. (2026) · Vox Sanguinis · doi:10.1111/vox.70386

Economic Evaluation of Prolonged Hypothermic Oxygenated Machine Perfusion Enabling Daytime Liver Transplantation

Woltjes, L. C., Bonnema, M. I., Brüggenwirth, I. M. A., Lantinga, V. A., van der Hilst, C. S., de Meijer, V. E., & the DHOPE‐PRO Trial Investigators (2026) · Artificial Organs · doi:10.1111/aor.70267

Fatigue in Inflammatory Bowel Disease: The Role of Drug Therapy Within a Holistic Management Framework

Sareen, J., Prichodko, M., Graff, L. A., Keshavarzian, A., Voigt, R. M., & Bernstein, C. N. (2026) · Drugs · doi:10.1007/s40265-026-02397-9

Circadian Rhythm and Lipid Metabolism: The Role of the Gut Microbiota

Lv, X., Liu, H., Liu, M., 刘春忻, Li, Y., & Ma, J. (2026) · Life · doi:10.3390/life16101725

Salivary Dim‐Light Melatonin Onset is Associated with Functional Decline, Respiratory Symptom Emergence, and Survival in Early Amyotrophic Lateral Sclerosis

Bombaci, A., Iadarola, A., Giraudo, A., Fattori, E., Sinagra, S., Magnino, A., Falbo, M., Marco, G. D., Calvo, A., Chiò, A., et al. (2026) · Annals of Neurology · doi:10.1002/ana.78398

Tryptophan metabolism circadian regulation: clinical and pharmacological implications

Fabi, C., Balucchi, S., & Bellet, M. M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1943534

From Heart Rate Variability to Adaptive Physiological Reconfiguration: A Multisystem Hypothesis of Health and Disease

Burlacu, A., Kumar, V. D., Geman, O., & Brinza, C. (2026) · Physiologia · doi:10.3390/physiologia6040062

[Proceedings: Chronobiology of processes, depending on diurnal rhythm, and its significance in medicine].

von Mayersbach, H. (1975) · PubMed

[Chronobiology in medicine: new concepts in understanding and treatment of disease].

Zvulunov, A., & Ashkenazi, I. E. (1992) · PubMed

Circadian Rhythms, Disease and Chronotherapy

Lee, Y., Field, J. M., & Sehgal, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211044301 · Cited by 185

Circadian timekeeping in health and disease. Part 1. Basic properties of circadian pacemakers.

Moore-Ede, M., Czeisler, C. A., & Richardson, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198308253090806 · Cited by 335

Special Issue on “Research on Circadian Rhythms in Health and Disease”

Gubin, D. G., Cornélissen, G., Stefani, O., & Weinert, D. (2023) · Applied Sciences · doi:10.3390/app131910728