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Circadian Mechanisms in Medicine
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Molecular insights into diurnal variations in human physiology and behavior are extending our understanding of a wide range of disease processes. Chronobiology is also providing testable hypotheses regarding the timing of treatments.
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“Chronic circadian disruption has been clearly proven to be related with an increased risk of obesity, diabetes mellitus and cardiovascular diseases, providing further support to the link between thyroid dysfunction and cardiovascular risk [8].”
From Thyroid and heart, a clinically relevant relationship (2021) · cites this paper as [8]
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Hepatocyte SREBP signaling mediates clock communication within the liver
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Metadata
- Authors
- Allada, R., & Bass, J.
- Affiliations
- Northwestern University (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-02-11
- Volume
- 384
- Issue
- 6
- Pages
- 550-561
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC8108270
- OpenAlex
- W3126193027
- Cited by
- 519
- References
- 75
- Citations by year
- 2026: 68 · 2025: 111 · 2024: 106 · 2023: 83 · 2022: 92 · 2021: 59
- FWCI
- 10.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG065988, P01AG011412)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK113011, R01DK050203, R01DK090625)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm, chronobiology, diurnal variation, clock genes, treatment timing, chronotherapy, disease processes, human physiology, behavior
- MeSH terms
- Cardiovascular Diseases, Circadian Rhythm, Humans, Infections, Neoplasms, Sleep Wake Disorders, Chronotherapy, Chronobiology Disorders, Circadian Clocks
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