New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

Osteosarcoma

Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660

Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

Shi, Q., Xue, C., Zeng, Y., Yuan, X., Chu, Q., Jiang, S., Wang, J., Zhang, Y., Zhu, D., & Li, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01828-x · Cited by 428

Active targeting schemes for nano-drug delivery systems in osteosarcoma therapeutics

Shi, P., Cheng, Z., Zhao, K., Chen, Y., Zhang, A., Gan, W., & Zhang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01826-1 · Cited by 216

Ewing Sarcoma and Osteosarcoma Have Distinct Immune Signatures and Intercellular Communication Networks

Cillo, A. R., Mukherjee, E., Bailey, N. G., Onkar, S., Daley, J. D., Salgado, C. M., Li, X., Liu, D., Ranganathan, S., Burgess, M. A., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1471 · Cited by 95

A tumor microenvironment-based prognostic index for osteosarcoma

Wu, C., Gong, S., Duan, Y., Deng, C., Kallendrusch, S., Berninghausen, L. K., Osterhoff, G., & Schopow, N. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00917-3 · Cited by 94

Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

Guan, Y., Zhang, W., Mao, Y., & Li, S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02161-1 · Cited by 89

Origin and Therapies of Osteosarcoma

Moukengué, B., Lallier, M., Marchandet, L., Baud’huin, M., Verrecchia, F., Ory, B., & Lamoureux, F. (2022) · Cancers · doi:10.3390/cancers14143503 · Cited by 93

Current Status and Prospects of Clinical Treatment of Osteosarcoma

Jiang, Z.-Y., Liu, J., Wang, X., Ma, Y., & Fu, D. (2022) · Technology in Cancer Research & Treatment · doi:10.1177/15330338221124696 · Cited by 79

Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment

Bian, Y., Cai, X., Lv, Z., Xu, Y., Wang, H., Tan, C., Liang, R., & Weng, X. (2023) · Advanced Science · doi:10.1002/advs.202301806 · Cited by 75

Roles and mechanisms of copper homeostasis and cuproptosis in osteoarticular diseases

Han, J., Luo, J., Wang, C., Капилевич, Л. В., & Zhang, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116570 · Cited by 79

Current Status and Prospects of Targeted Therapy for Osteosarcoma

Hu, Z., Wen, S., Huo, Z., Wang, Q., Zhao, J., Wang, Z., Chen, Y., Zhang, L., Zhou, F., Guo, Z., et al. (2022) · Cells · doi:10.3390/cells11213507 · Cited by 78

Advancements in Photothermal Therapy Using Near-Infrared Light for Bone Tumors

Xie, M., Gong, T., Wang, Y., Li, Z., Lu, M., Luo, Y. W., Min, L., Tu, C., Zhang, X., Zeng, Q., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084139 · Cited by 73

Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

Li, T., Gao, M., Wu, Z., Yang, J., Mo, B., Yu, S., Gong, X., Liu, J., Wang, W., Luo, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202206779 · Cited by 74

Bone-targeting exosome nanoparticles activate Keap1 / Nrf2 / GPX4 signaling pathway to induce ferroptosis in osteosarcoma cells

Chen, W., Li, Z., Yu, N., Zhang, L., Li, H., Chen, Y., Gong, F., Lin, W., He, X., Wang, S., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02129-1 · Cited by 71

Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence

Wang, Z., Zhai, B., Sun, J., Zhang, X., Zou, J., Shi, Y., & Guo, D. (2024) · Drug Delivery · doi:10.1080/10717544.2024.2400476 · Cited by 67

NIR Responsive Doxorubicin‐Loaded Hollow Copper Ferrite @ Polydopamine for Synergistic Chemodynamic/Photothermal/Chemo‐Therapy

Chu, X., Zhang, L., Li, Y., He, Y. H., Zhang, Y. X., & Du, C. (2022) · Small · doi:10.1002/smll.202205414 · Cited by 60

What is the role of microbial biotechnology and genetic engineering in medicine?

Santos‐Beneit, F. (2024) · MicrobiologyOpen · doi:10.1002/mbo3.1406 · Cited by 60

Deep learning models in classifying primary bone tumors and bone infections based on radiographs

Wang, H., He, Y., Wan, L., Li, C., Li, Z., Li, Z., Xu, H., & Tu, C. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00855-3 · Cited by 65

Acidity‐Triggered Transformable Polypeptide Self‐Assembly to Initiate Tumor‐Specific Biomineralization

Liu, Y., Jiang, Z., Tong, S., Sun, Y., Zhang, Y., Zhang, J., Zhao, D., Su, Y., Ding, J., & Chen, X. (2022) · Advanced Materials · doi:10.1002/adma.202203291 · Cited by 59

Surgical Treatment of Bone Sarcoma

Bläsius, F., Delbrück, H., Hildebrand, F., & Hofmann, U. K. (2022) · Cancers · doi:10.3390/cancers14112694 · Cited by 58

Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy

Ma, L., Zhou, J., Wu, Q., Luo, G., Zhao, M., Zhong, G., Zheng, Y., Meng, X., Cheng, S., & Zhang, Y. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122236 · Cited by 58

Synergetic Chemo‐Piezodynamic Therapy of Osteosarcoma Enabled by Defect‐Driven Lead‐Free Piezoelectrics

Wang, S., Chen, C., Wang, J., Li, C., Zhou, J., Liu, Y., Jiang, Y., Zhu, L., Li, C., Gong, W., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202208128 · Cited by 57

Bioactive nanocomposite hydrogel enhances postoperative immunotherapy and bone reconstruction for osteosarcoma treatment

Chu, X., Mi, B., Xiong, Y., Wang, R., Liu, T., Hu, L., Yan, C., Zeng, R., Lin, J., Fu, H., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122714 · Cited by 56

Engineering a triple-functional magnetic gel driving mutually-synergistic mild hyperthermia-starvation therapy for osteosarcoma treatment and augmented bone regeneration

Yu, K., Zhou, H., Xu, Y., Cao, Y., Zheng, Y., & Liang, B. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01955-7 · Cited by 54

The biomedical applications of nanozymes in orthopaedics based on regulating reactive oxygen species

Gao, X., Zhang, J., Gong, Y., & Yan, L. W. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02844-3 · Cited by 56

One-Dimensional Ferroelectric Nanoarrays with Wireless Switchable Static and Dynamic Electrical Stimulation for Selective Regulating Osteogenesis and Antiosteosarcoma

Xiao, C., Fan, L., Zhou, S., Kang, X., Guan, P., Fu, R., Li, C., Ren, J. M., Wang, Z., Yu, P., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c07900 · Cited by 49

NGR‐Modified CAF‐Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma

Du, J., Meng, X., Yang, M., Chen, G., Li, J., Zhu, Z., Wu, X., Hu, W., Tian, M., Li, T., et al. (2025) · Advanced Science · doi:10.1002/advs.202410918 · Cited by 48

Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling

Yu, L., Zhu, H., Wang, Z., Huang, J., Zhu, Y., Fan, G., Wang, Y., Chen, X., & Zhou, G. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01624-7 · Cited by 49

Transcriptional profiling of canine osteosarcoma identifies prognostic gene expression signatures with translational value for humans

Mannheimer, J., Tawa, G. J., Gerhold, D. L., Braisted, J. C., Sayers, C. M., McEachron, T. A., Meltzer, P. S., Mazcko, C. N., Beck, J. A., & LeBlanc, A. K. (2023) · Communications Biology · doi:10.1038/s42003-023-05208-z · Cited by 52

Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro‐Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia

Wang, Y., Zhou, X., Li, Y., Hu, Q., Liu, H., Zhao, G., Wang, K., Zeng, J., Sun, M., & Lv, C. (2024) · Small · doi:10.1002/smll.202306916 · Cited by 46

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach

Schott, C. R., Koehne, A. L., Sayles, L. C., Young, E. P., Luck, C., Yu, K., Lee, A. G., Breese, M. R., Leung, S. G., Xu, H., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0873 · Cited by 47

A multifunctional nano-hydroxyapatite/MXene scaffold for the photothermal/dynamic treatment of bone tumours and simultaneous tissue regeneration

Zhang, G., Lu, Y., Song, J., An, M., An, M., Chen, W., Han, P., Yao, X., & Zhang, X. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.08.176 · Cited by 43

Redox-active vitamin C suppresses human osteosarcoma growth by triggering intracellular ROS-iron–calcium signaling crosstalk and mitochondrial dysfunction

Vaishampayan, P., & Lee, Y. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103288 · Cited by 43

Metal-organic framework-mediated siRNA delivery and sonodynamic therapy for precisely triggering ferroptosis and augmenting ICD in osteosarcoma

Sun, N., Lei, Q., Wu, M., Gao, S., Yang, Z., Lv, X., Wei, R., Yan, F., & Cai, L. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101053 · Cited by 40

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT

Zhang, W., Li, W., Yin, C., Feng, C., Liu, B., Xu, H., Jin, X., Tu, C., & Li, Z. (2024) · Cancer Research · doi:10.1158/0008-5472.can-24-0163 · Cited by 39

Single‐Atom Cu Nanozyme‐Loaded Bone Scaffolds for Ferroptosis‐Synergized Mild Photothermal Therapy in Osteosarcoma Treatment

Yan, Z., Wu, X., Tan, W., Yan, J., Zhou, J., Chen, S., Miao, J., Cheng, J., Shuai, C., & Deng, Y. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304595 · Cited by 39

Current status and future challenges of CAR-T cell therapy for osteosarcoma

Li, S., Zhang, H., & Shang, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1290762 · Cited by 37

Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

Wang, Y., Zhang, H., Qiang, H., Li, M., Cai, Y., Zhou, X., Xu, Y., Yan, Z., Dong, J., Gao, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304060 · Cited by 36

Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells

Zhang, F., Hao, Y., Yang, N., Liu, M., Luo, Y., Zhang, Y., Zhou, J., Liu, H., & Li, J. (2024) · BMC Cancer · doi:10.1186/s12885-024-11951-1 · Cited by 34

Large-Scale Comparative Analysis of Canine and Human Osteosarcomas Uncovers Conserved Clinically Relevant Tumor Microenvironment Subtypes

Patkar, S., Mannheimer, J., Harmon, S. A., Ramirez, C. J., Mazcko, C. N., Choyke, P. L., Brown, G. T., Türkbey, B., LeBlanc, A. K., & Beck, J. A. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-1854 · Cited by 35

Immunosuppressive Tumor Microenvironment of Osteosarcoma

Taylor, A. M., Sheng, J., Ng, P. K. S., Harder, J. M., Kumar, P., Ahn, J. Y., Cao, Y., Dzis, A. M., Jillette, N., Goodspeed, A. E., et al. (2025) · Cancers · doi:10.3390/cancers17132117 · Cited by 38

Deciphering the heterogeneity and immunosuppressive function of regulatory T cells in osteosarcoma using single-cell RNA transcriptome

Cheng, D., Zhang, Z., Mi, Z., Tao, W., Liu, D., Fu, J., & Fan, H. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107417 · Cited by 32

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis

Zou, Y., Guo, S., Wen, L., Lv, D., Tu, J., Liao, Y., Chen, W., Chen, Z., Li, H., Chen, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101728 · Cited by 32

Nanomaterial-assisted theranosis of bone diseases

Zheng, K., Bai, J., Yang, H., Xu, Y., Pan, G., Wang, H., & Geng, D. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.12.014 · Cited by 32

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma

Kinnaman, M. D., Zaccaria, S., Makohon-Moore, A. P., Arnold, B., Levine, M. F., Gundem, G., Ossa, J. A., Głodzik, D., Rodriguez-Sanchez, I., Bouvier, N., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0385 · Cited by 31

Unraveling molecular aberrations and pioneering therapeutic strategies in osteosarcoma

Yan, P., Wang, J., Yue, B., & Wang, X. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189171 · Cited by 31

Biopolymer-based bone scaffold for controlled Pt (IV) prodrug release and synergistic photothermal-chemotherapy and immunotherapy in osteosarcoma

Yan, Z., Deng, Y., Huang, L., Zeng, J., Wang, D., Tong, Z., Fan, Q., Tan, W., Yan, J., Zang, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03253-w · Cited by 31

Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities

Du, X., Wei, H., Zhang, B., Wang, B., Li, Z., Pang, L. K., Zhao, R., & Yao, W. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1117867 · Cited by 31

Selenium-incorporated mesoporous silica nanoparticles for osteosarcoma therapy

He, L., Habibović, P., & van Rijt, S. (2023) · Biomaterials Science · doi:10.1039/d2bm02102a · Cited by 30

European standard clinical practice recommendations for children and adolescents with primary and recurrent osteosarcoma

van Ewijk, R., Herold, N., Baecklund, F., Baumhoer, D., Boye, K., Gaspar, N., Harrabi, S., Haveman, L., Hecker‐Nolting, S., Hiemcke‐Jiwa, L. S., et al. (2023) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2023.100029 · Cited by 33

Reprogramming of glucose metabolism: Metabolic alterations in the progression of osteosarcoma

An, F., Chang, W., Song, J., Zhang, J., Li, Z., Gao, P., Wang, Y., Xiao, Z., & Yan, C. (2024) · Journal of bone oncology · doi:10.1016/j.jbo.2024.100521 · Cited by 30

Multifunctional coatings of nickel-titanium implant toward promote osseointegration after operation of bone tumor and clinical application: a review

Du, T., Liu, J. S., Dong, J., Xie, H., Wang, X., Yang, X., & Yang, Y. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1325707 · Cited by 30

SLC38A5 suppresses ferroptosis through glutamine-mediated activation of the PI3K/AKT/mTOR signaling in osteosarcoma

Huang, X., Xia, K., Wei, Z., Liu, W., Wei, Z., & Guo, W. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05803-6 · Cited by 31

T2-weighted MRI radiomics in high-grade intramedullary osteosarcoma: predictive accuracy in assessing histologic response to chemotherapy, overall survival, and disease-free survival

White, L. M., Atinga, A., Naraghi, A., Lajkosz, K., Wunder, J. S., Ferguson, P. C., Tsoi, K. M., Griffin, A. M., & Haider, M. A. (2022) · Skeletal Radiology · doi:10.1007/s00256-022-04098-2 · Cited by 30

A Review of Advanced Biomaterials and Cells for the Production of Bone Organoid

Li, C., Zhang, Y., Du, Y., Hou, Z., Zhang, Y., Cui, W., & Chen, W. (2023) · Small Science · doi:10.1002/smsc.202300027 · Cited by 30

Multifunctional 3D-printed bioceramic scaffolds: Recent strategies for osteosarcoma treatment

Liu, X., Liu, Y., Qiang, L., Ya, R., Lin, Y., Li, H., Chen, Q., Gao, S., Yang, X., Zhang, C., et al. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314231170371 · Cited by 30

In vivo self-assembly and delivery of VEGFR2 siRNA-encapsulated small extracellular vesicles for lung metastatic osteosarcoma therapy

Yu, L., Fan, G., Wang, Q., Zhu, Y., Zhu, H., Chang, J., Wang, Z., Zhan, S., Hua, X., She, D., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06159-3 · Cited by 28

Hydroxyapatite coated titanium with curcumin and epigallocatechin gallate for orthopedic and dental applications

Kushram, P., Majumdar, U., & Bose, S. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213667 · Cited by 28

Probiotic Biofilm Modified 3D‐Printing Scaffolds for Improving Chemo‐Immunotherapy of Bone Tumor and Promoting Osteogenesis

Gu, H.-Y., Fan, J., Bao, P., Qu, W., Hu, Z., Qi, B., Zhang, X., & Yu, A. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202311015 · Cited by 27

Construction of Osteosarcoma Diagnosis Model by Random Forest and Artificial Neural Network

Li, S., Que, Y., Yang, R., He, P., Xu, S., & Hu, Y. S. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030447 · Cited by 26

Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways

Zeng, X., Liu, S., Yang, H., Jia, M., Liu, W., & Zhu, W. (2023) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgad070 · Cited by 26

Deprivation of methionine inhibits osteosarcoma growth and metastasis via C1orf112-mediated regulation of mitochondrial functions

Zhang, X., Zhao, Z., Wang, X., Zhang, S., Zhao, Z., Feng, W., Xu, L., Nie, J., Li, H., Liu, J., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06727-1 · Cited by 28

NIR‐II AIEgens nanosystem for fluorescence and chemiluminescence synergistic imaging‐guided precise resection in osteosarcoma surgery

Li, R., Liu, K., Hu, Q., Shen, J., Zuo, D., Wang, H., Zhu, X., & Sun, W. (2024) · Aggregate · doi:10.1002/agt2.658 · Cited by 26

Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)

Gu, S., Zheng, Y., Chen, C., Liu, J., Wang, Y., Wang, J., & Li, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5478 · Cited by 27

Sequential Therapy for Osteosarcoma and Bone Regeneration via Chemodynamic Effect and Cuproptosis Using a 3D‐Printed Scaffold with TME‐Responsive Hydrogel

Xie, D., Hu, C., Zhu, Y., Yao, J., Li, J., Xia, J., Ye, L., Jin, Y., Jiang, S., Hu, T., et al. (2024) · Small · doi:10.1002/smll.202406639 · Cited by 27

Fabrication of a composite 3D-printed titanium alloy combined with controlled in situ drug release to prevent osteosarcoma recurrence

Fan, D., Zhang, C., Wang, H., Wei, Q., Cai, H., Wei, F., Bian, Z., Liu, W., Wang, X., & Liu, Z. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100683 · Cited by 26

Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

Xu, Y., Yang, L., Li, M., Shu, H., Jia, N., Gao, Y., Shi, R., Yang, X., Zhang, Z., & Zhang, L. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.10.005 · Cited by 26

A multifunctional biomimetic nanoplatform for image-guideded photothermal-ferroptotic synergistic osteosarcoma therapy

Liu, Y., Dong, S., Hu, W., Chen, Q., Zhang, S.-F., Song, K., Han, Z.-C., Li, M., Han, Z., Liu, W., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.02.007 · Cited by 25

PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Liu, B., Li, W., Zhang, W., Feng, C., Wan, L., He, S., Xu, R., Fu, Z., Liu, Z., Xu, H., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02250-7 · Cited by 25

PLOD2 high expression associates with immune infiltration and facilitates cancer progression in osteosarcoma

Wang, Z., Fan, G., Zhu, H., Yu, L., She, D., Wei, Y., Huang, J., Li, T., Zhan, S., Zhou, S., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.980390 · Cited by 25

The roles and mechanisms of circular RNAs related to mTOR in cancers

Cao, C., Wang, Y., Wu, X., Li, Z., Guo, J., & Sun, W. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24783 · Cited by 26

The interaction between osteosarcoma and other cells in the bone microenvironment: From mechanism to clinical applications

Zeng, J., Peng, Y., Wang, D., Ayesha, K., & Chen, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1123065 · Cited by 31

CRISPR‐Cas9 screening identified lethal genes enriched in necroptosis pathway and of prognosis significance in osteosarcoma

Cheng, L., Xiong, W., Li, S., Wang, G., Zhou, J., & Li, H. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3563 · Cited by 24

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Wang, C., Zhang, Y., Kong, W., Rong, X., Zhong, Z., Jiang, L., Chen, S., Li, C., Zhang, F., & Jiang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s471900 · Cited by 25

Neoadjuvant Chemotherapy for Adults with Osteogenic Sarcoma

Robinson, M. J., & Davis, E. J. (2024) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01269-2 · Cited by 27

Towards precision medicine: design considerations for nanozymes in tumor treatment

Li, X., Hu, J., Zhao, Q., Yao, W., Jing, Z., & Jin, Z. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05845-w · Cited by 24

CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway

Cheng, J., Zhang, Y., Wan, R., Zhou, J., Wu, X., Fan, Q., He, J., Tan, W., & Deng, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.919108 · Cited by 24

P2RX7 promotes osteosarcoma progression and glucose metabolism by enhancing c-Myc stabilization

Sheng, G., Gao, Y., Ding, Q., Zhang, R., Wang, T., Jing, S., Zhao, H., Ma, T., Wu, H. K., & Yang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-03985-z · Cited by 24

Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine

Tan, L., Wang, Y., Hu, X., Du, G., Tang, X., & Min, L. (2023) · Biomolecules · doi:10.3390/biom13091362 · Cited by 24

Subtractive Nanopore Engineered MXene Photonic Nanomedicine with Enhanced Capability of Photothermia and Drug Delivery for Synergistic Treatment of Osteosarcoma

Hui, T., Fu, J., Zheng, B., Fu, C., Zhao, B., Zhang, T., Zhang, Y., Wang, C., Yu, L., Yang, Y., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c10572 · Cited by 24

Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy

Deng, X., Zhao, R., Tang, Y., Yi, M., Ge, Z., Wang, D., Fang, Q., Xiong, Z., Duan, A., Liu, W., et al. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c11749 · Cited by 24

Biomaterials‐Boosted Immunotherapy for Osteosarcoma

Sun, C., Li, S., & Ding, J. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400864 · Cited by 25

Tumor microenvironment in osteosarcoma: From cellular mechanism to clinical therapy

Yu, Y., Li, K., Peng, Y., Zhang, Z., Pu, F., Shao, Z., & Wu, W. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101569 · Cited by 26

Emerging immunotherapies in osteosarcoma: from checkpoint blockade to cellular therapies

Han, Z., Chen, G., & Wang, D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1579822 · Cited by 25

Osteosarcoma and causes of death: A report of 1520 deceased patients from the Cooperative Osteosarcoma Study Group (COSS)

Bielack, S., Blattmann, C., Borkhardt, A., Csóka, M., Hassenpflug, W. A., Kabíčková, E., Kager, L., Kessler, T., Kratz, C. P., Kühne, T., et al. (2022) · European Journal of Cancer · doi:10.1016/j.ejca.2022.09.007 · Cited by 23

CD44 expression is correlated with osteosarcoma cell progression and immune infiltration and affects the Wnt/β-catenin signaling pathway

Ji, H., Kong, L., Wang, Y., Hou, Z., Kong, W., Qi, J., & Jin, Y. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100487 · Cited by 23

Surface defect engineered-Mg-based implants enable the dual functions of superhydrophobic and synergetic photothermal/chemodynamic therapy

Zhang, D., Xu, R., Chen, S., Du, H., Shi, Q., Peng, F., & Liu, X. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.07.012 · Cited by 23

Patterns of metastatic progression and association with clinical outcomes in canine osteosarcoma: A necropsy study of 83 dogs

Silver, K. I., Patkar, S., Mazcko, C. N., Berger, E. P., Beck, J. A., & LeBlanc, A. K. (2023) · Veterinary and Comparative Oncology · doi:10.1111/vco.12927 · Cited by 22

Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases

Zhou, R., Hu, W., Ma, P. X., & Liu, C.-J. (2024) · Bone Research · doi:10.1038/s41413-024-00370-4 · Cited by 22

Ultrasound-responsive heterojunction sonosensitizers for multifunctional synergistic sonodynamic therapy

Li, Q., Wei, W., Wang, K., Shi, X., Ling, G., & Zhang, P. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.110777 · Cited by 22

Osteosarcoma immune microenvironment: cellular struggle and novel therapeutic insights

Zhang, Y., Jiang, S., Lv, J., Feng, W., Yu, Y., & Zhao, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1584450 · Cited by 22

STEAP2 promotes osteosarcoma progression by inducing epithelial–mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2

Zhang, D., Liu, H., Wang, W., Xu, G., Yin, C., & Wang, S. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2136465 · Cited by 22

Circular RNA circEMB promotes osteosarcoma progression and metastasis by sponging miR-3184-5p and regulating EGFR expression

Tan, J., Yang, B., Zhong, H., Luo, M., Su, Z., Xie, C. L., Shi, M., Sun, C., & Lin, L. (2023) · Biomarker Research · doi:10.1186/s40364-022-00442-9 · Cited by 22

Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma

Zhong, L., Wang, J., Chen, W., Lv, D., Zhang, R., Wang, X., Zeng, C., He, X., Zheng, L., Gao, Y., et al. (2023) · Science Advances · doi:10.1126/sciadv.adi0889 · Cited by 22

Intraoperative Resection Guidance and Rapid Pathological Diagnosis of Osteosarcoma using B7H3 Targeted Probe under NIR‐II Fluorescence Imaging

Zeng, F., Li, C., Wang, H., Wang, Y., Ren, T., He, F., Jiang, J., Xu, J., Wang, B., Wu, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202310167 · Cited by 23

Interaction gene set between osteoclasts and regulatory CD4+ T cells can accurately predict the prognosis of patients with osteosarcoma

Li, F., Tang, H., Luo, X., Li, X., Luo, K., Liu, S., Liang, J., Liao, S., Zhong, C., Zhan, X., et al. (2023) · Cancer Science · doi:10.1111/cas.15821 · Cited by 22

Metal ions and nanomaterials for targeted bone cancer immunotherapy

Qin, S., Hu, Y., Luo, H., Chu, W., Deng, R., & Ma, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1513834 · Cited by 21

Biodegradable Carbon Dioxide‐Derived Non‐Viral Gene Vectors for Osteosarcoma Gene Therapy

Li, M., Lin, Z., Yang, J., Huang, H., Liu, G., Liu, Q., Zhang, X., Zhang, Y., Xu, Z., Lin, H., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201306 · Cited by 21

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

Chen, W., Lin, W., Yu, N., Zhang, L., Wu, Z., Chen, Y., Li, Z., Gong, F., Li, N., Chen, X., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s379917 · Cited by 21

Schottky Heterojunction Facilitates Osteosarcoma Ferroptosis and Enhances Bone Formation in a Switchable Mode

Lv, Z., Wu, Y., Lin, J., Li, W., Weisbecker, H., Wang, P., Song, X., Sun, W. Y., Sun, Z., Xie, Y., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202312032 · Cited by 22

Osteosarcoma – conventional treatment vs. gene therapy

Tan, M. L., Choong, P., & Dass, C. R. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.2.7385 · Cited by 99

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13

The Genetics of Osteosarcoma

Martin, J. W., Squire, J. A., & Zieleńska, M. (2012) · Sarcoma · doi:10.1155/2012/627254 · Cited by 254

Making gene therapy for osteosarcoma a reality

Broadhead, M. L., Clark, J. C. M., Choong, P., & Dass, C. R. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.18 · Cited by 12

Genome-Informed Targeted Therapy for Osteosarcoma

Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452