New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

MIR31HG, a potential lncRNA in human cancers and non-cancers

Ruan, L., Lei, J., Yuan, Y., Li, H., Yang, H., Wang, J., & Zhang, Q. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1145454 · Cited by 10

Current approaches in tissue engineering-based nanotherapeutics for osteosarcoma treatment

Shanmugavadivu, A., Lekhavadhani, S., Miranda, P. J., & Selvamurugan, N. (2024) · Biomedical Materials · doi:10.1088/1748-605x/ad270b · Cited by 10

The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization

Tang, N., Chen, Y., Yang, S., Zhang, S., & Huang, T. (2024) · Functional & Integrative Genomics · doi:10.1007/s10142-024-01504-x · Cited by 10

3D‐Printed Biomimetic Ceramic Scaffolds with Photothermal/Chemodynamic Effects and Ionic Microenvironment for Preventing Tumor Recurrence and Promoting Vascularized Bone Reconstruction

Lu, T., Xu, Z., He, Y. H., Shu, M., Wang, X., Zhang, Y., Wu, T., & He, F. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202418438 · Cited by 10

CYFIP1 coordinate with RNMT to induce osteosarcoma cuproptosis via AURKAIP1 m7G modification

Lin, Z., Wu, Z., He, Y., Li, X., & Luo, W. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01127-3 · Cited by 10

Prediction of Patients With High-Risk Osteosarcoma on the Basis of XGBoost Algorithm Using Transcriptome and Methylation Data From SGH-OS Cohort

Zhao, W., Meng, H., Dai, Z., Zhang, L., Cheng, Z., Song, X., Xu, W., Wang, Z., Tian, K., Jiang, Y., et al. (2025) · JCO Precision Oncology · doi:10.1200/po-24-00732 · Cited by 10

Molecular Crosstalk Between RUNX2 and HIF-1α in Osteosarcoma: Implications for Angiogenesis, Metastasis, and Therapy Resistance

Magar, A. G., Morya, V. K., & Noh, K.-C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157642 · Cited by 10

Hydrogel delivering antifibrotic agent and nano-sonosensitizer enhances efficacy of sonodynamic therapy in osteosarcoma treatment

Lin, S., Liu, H., Lv, L., Jin, G.-Y., Xiang, X., Yu, B., Su, Y., Zhang, S., Wang, Z., Yang, Z., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.10.001 · Cited by 10

Roles of PTEN gene methylation in Se-CQDs induced mitochondrial apoptosis of osteosarcoma cells

Su, H., Lv, Y., Zhu, L., & Wang, Y. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113757 · Cited by 10

Investigating the effect of tannin films prepared by low-energy electron beam deposition on the inhibition of bone tumors

Tan, X., Chen, H., Liu, X., Liu, Y., & Jiang, X. (2024) · Applied Surface Science · doi:10.1016/j.apsusc.2024.159811 · Cited by 10

ZCCHC12 promotes the progression of osteosarcoma via PI3K/AKT pathway

Cui, Y., & Dong, Y.-Y. (2022) · Aging · doi:10.18632/aging.204296 · Cited by 10

Exosomes loaded with miR-665 inhibit the progression of osteosarcoma in vivo and in vitro.

Zhang, B., Yang, Y., Tao, R., Chen, Y., Zhou, Z., & Zhang, Y. (2022) · PubMed Central · Cited by 10

SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression

Li, B., Dang, X., Duan, J., Zhang, G., Zhang, J., & Song, Q. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17650 · Cited by 10

Identification and validation of long noncoding RNA AC083900.1 and RP11-283C24.1 for prediction of progression of osteosarcoma

Huang, L., Jin, W., Bao, Y., Zeng, X., Zhang, Y., Zhou, J., & Peng, H. (2023) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2023.111828 · Cited by 10

ANXA2 and Rac1 negatively regulates autophagy and osteogenic differentiation in osteosarcoma cells to confer CDDP resistance

Pan, B., Pan, Y., Wang, S., Bai, Y., Hu, X., Yang, Y., Wu, L., & Liu, J. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.07.006 · Cited by 9

Essential genes analysis reveals small ribosomal subunit protein eS28 may be a prognostic factor and potential vulnerability in osteosarcoma

Liang, C., Zhou, J., Wang, Y., Sun, Y., Zhou, J. R., Shao, L., Zhang, Z., Yan, W., Liu, Z., & Dong, Y. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100517 · Cited by 9

FePS3-Nanosheets-Integrated multifunctional nanocomposite hydrogel for multimodal synergistic osteosarcoma therapy and enhanced bone regeneration

Ye, B., Jing, X., Su, Y., Sun, W., Gao, Q., Zeng, L., Lu, H., Tang, S., Wan, Y., Sun, T., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162175 · Cited by 9

Role of N6-methyladenosine methyltransferase component RBM15 in cancer progression and its therapeutic potential

Shen, W., Ma, Y., Yang, C., Yan, S., & Ye, K. (2025) · Discover Oncology · doi:10.1007/s12672-025-02644-7 · Cited by 9

Activation of bone tumor-eating macrophages via assembling and co-delivering 3D printed scaffold

Li, C., Ma, Z., Sun, X. S., Li, J., Liang, J., Wang, F., Deng, L., Wang, J., & Cui, W. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123495 · Cited by 9

Reshaping tumor immune microenvironment and modulating T cell function based on hierarchical nanotherapeutics for synergistically inhibiting osteosarcoma

Li, J., Ding, Z., Liu, J., Li, G., Li, G., Wang, W., Nundlall, K., Deng, Y., Miao, J., Hu, M., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102095 · Cited by 9

Generation and characterization of patient-derived xenografts from patients with osteosarcoma

Chen, F., Zhang, Z., Shen, R., Chen, M., Li, G., & Zhu, X. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101911 · Cited by 9

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Wu, X., Ma, S., Wu, Z., & Zhao, Q. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1064815 · Cited by 9

Epidemiology and nomogram of pediatric and young adulthood osteosarcoma patients with synchronous lung metastasis: A SEER analysis

Liu, T., Cui, L., He, Z., Chen, Z., Tao, H., & Yang, J. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288492 · Cited by 9

Long noncoding RNA TUG1 promotes malignant progression of osteosarcoma by enhancing ZBTB7C expression

An, X., Wu, W., Wang, P., Mahmut, A., Guo, J., Dong, J., Wang, G., Liu, B., Yang, L., Ma, Y., et al. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100651 · Cited by 9

Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

Yuan, J., Jia, J., Wu, T., Zhi, D., Chen, Q., Zhang, J., Wu, Z., Yuan, Z. K., Zhao, X., Liu, J., et al. (2023) · Cancer Cell International · doi:10.1186/s12935-023-03076-5 · Cited by 9

Chemokine Ligand 2 Promotes Migration in Osteosarcoma by Regulating the miR-3659/MMP-3 Axis

Chang, Y.-H., Huang, Y., Tsai, H., Chang, A., Ko, C., Fong, Y., & Tang, C. (2023) · Biomedicines · doi:10.3390/biomedicines11102768 · Cited by 9

A CIC-related-epigenetic factors-based model associated with prediction, the tumor microenvironment and drug sensitivity in osteosarcoma

Yu, B., Geng, C., Wu, Z., Zhang, Z., Zhang, A., Yang, Z., Huang, J., Xiong, Y., Yang, H., & Chen, Z. (2024) · Scientific Reports · doi:10.1038/s41598-023-49770-2 · Cited by 9

Disrupting YAP1-mediated glutamine metabolism induces synthetic lethality alongside ODC1 inhibition in osteosarcoma

Wang, H., Tao, Y., Han, J., Shen, J., Mu, H., Wang, Z., Wang, J., Jin, X., Zhang, Q., Yang, Y., et al. (2024) · Cellular Oncology · doi:10.1007/s13402-024-00967-1 · Cited by 9

The Cuproptosis-Related Long Noncoding RNA Signature Predicts Prognosis and Tumour Immune Analysis in Osteosarcoma

Jiang, J., Chu, D., Lai, X., Liu, L., & Tao, J. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/6314182 · Cited by 9

Exploiting biochemical data to improve osteosarcoma diagnosis with deep learning

Wang, S., Shen, Y., Zeng, F., Wang, M., Li, B., Shen, D., Tang, X., & Wang, B. (2024) · Health Information Science and Systems · doi:10.1007/s13755-024-00288-5 · Cited by 8

Development and experimental validation of hypoxia-related gene signatures for osteosarcoma diagnosis and prognosis based on WGCNA and machine learning

Wen, B., Chen, J., Ding, T., Mao, Z., Jin, R., Wang, Y., Shi, M., Zhao, L., Yang, A., Qin, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-69638-3 · Cited by 8

Recent advances in nanoagents delivery system-based phototherapy for osteosarcoma treatment

Ji, L., Huang, J., Yu, L., Jin, H., Hu, X., Sun, Y., Yin, F., & Cai, Y. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124633 · Cited by 9

Osteosarcoma Exosome Priming of Primary Human Lung Fibroblasts Induces an Immune Modulatory and Protumorigenic Phenotype

Palmer, E. P., Cronise, K. E., Haines, L. A., Das, S., Offermann, A., Easton, C. P., & Regan, D. P. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-24-0371 · Cited by 8

Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry‐Mediated Enrichment of Extracellular Vesicles

Ji, Y., Lee, J., Kim, H. Y., Kong, H., Zhao, C., Ju, Y., Zhang, R., Kim, J., Qian, A., Gonzalez, D. S. B., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202422469 · Cited by 8

Enhanced sequential osteosarcoma therapy using a 3D-Printed bioceramic scaffold combined with 2D nanosheets via NIR-II photothermal-chemodynamic synergy

Jian, G., Wang, S., Wang, X., Lu, Q., Zhu, X., Wan, S., Wang, S., Li, D., Wang, C., He, Q., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.04.029 · Cited by 8

A Web-Based Prediction Model for Overall Survival of Elderly Patients With Malignant Bone Tumors: A Population-Based Study

Tang, J., Wang, J., & Pan, X. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2021.812395 · Cited by 8

Pan-Cancer analysis of TERT and Validation in Osteosarcoma Cell Lines

Xie, L., Yin, W., Tang, F., & He, M. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.11.068 · Cited by 8

Controlled domain gels with a wide stiffness gradient simultaneously promote bone regeneration and suppress tumor recurrence through DAPK activity

Wang, Y., Zhang, J., Shu, X., Wu, F., & He, J. H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149018 · Cited by 8

METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4

Huo, X., Lu, D., Chen, D., Ye, M., Wang, X., & Shang, F. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2903120 · Cited by 8

Plumbagin induces G2/M arrest and apoptosis and ferroptosis via ROS/p38 MAPK pathway in human osteosarcoma cells

Li, J., Gao, H., Wang, P., Sun, C., Wei, Z., Yi, X., Yu, S., Zhang, Y., & Li, S. (2024) · Alexandria Engineering Journal · doi:10.1016/j.aej.2024.06.015 · Cited by 8

Prognostic and clinicopathological value of systemic immune-inflammation index in patients with osteosarcoma: a meta-analysis

Wang, X., Zhong, W., Zhang, Z., & Jiang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416068 · Cited by 8

Tongguanteng injection exerts anti-osteosarcoma effects through the ER stress-associated IRE1/CHOP pathway

Xue, X.-C., Zhou, Y.-Y., Xu, L., Wei, L.-Y., Hu, Y., Yang, J., Zhang, X., Wang, M., Han, Y., & Chen, J.-J. (2024) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-024-04689-7 · Cited by 8

Osteosarcoma Tumor Detection using Different Transfer Learning Models

Meem, R. F., & Hasan, K. T. (2019) · Clinical Imaging and Case Reports · doi:10.52338/cicasrep.2024.3962 · Cited by 8

Development of multifunctional PAA-alginate-carboxymethyl cellulose hydrogel-loaded fiber-reinforced biomimetic scaffolds for controlled release of curcumin

Fatema, K. N., Li, L., Ahmad, K., Kim, J., & Lee, D. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.140449 · Cited by 8

Characteristics and significance of T lymphocyte subsets in peripheral blood of osteosarcoma mice

Liu, Q., Xu, R. C., Xu, X., Huang, Y., & Ma, Z. (2022) · Translational Cancer Research · doi:10.21037/tcr-22-264 · Cited by 8

LncRNA SCAMP1 disrupts the balance between miR-26a-5p and ZEB2 to promote osteosarcoma cell viability and invasion

Li, R., Chen, Z., Zhou, Y., Maimaitirexiati, G., Qi, Y., Li, Y., Maimaitiyimin, A., Zhou, C., Ren, J., Liu, C., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.967000 · Cited by 8

Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity

Wang, H., Jin, X., Zhang, Y., Wang, Z., Zhang, T., Xu, J., Shen, J., Zan, P., Sun, M., Wang, C., et al. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00900-9 · Cited by 8

Chemical bonding of Epigallocatechin-3-gallate to the surface of nano-hydroxyapatite to enhance its biological activity for anti-osteosarcoma

Ren, J. M., Sun, L., Xiao, C., Zhou, S., Liang, Q., Sun, S., & Deng, C. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.12.003 · Cited by 8

Schisandrin B Inhibits Osteosarcoma Cell Proliferation and Promotes Apoptosis Through PI3K/AKT/mTOR Pathway Mediated Autophagy

Zhou, L., Zhou, L., Ma, H., Zhao, J., & Lou, D. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00391-w · Cited by 7

Single-Cell Spatial–Temporal Analysis ofZNF451in Mediating Drug Resistance and CD8+T Cell Dysfunction

Tang, N., Deng, W., Wu, Y., Deng, Z., Wu, X., Xiong, J., & Zhao, Q. (2024) · Research · doi:10.34133/research.0530 · Cited by 7

Enhancing photodynamic therapy for cancer: a two-photon excited approach with a novel mitochondrial-targeted photosensitizer

Du, W., Shang, W., Wen, W. X., Deng, X., Xie, D., Zhang, Y., Su, H., & Liu, H. (2025) · Materials Chemistry Frontiers · doi:10.1039/d4qm00870g · Cited by 7

Bone-Adhesive Peptide Hydrogel Loaded with Cisplatin for Postoperative Treatment of Osteosarcoma

Zhou, J., Huo, T., Miu, J., Wang, Z., Shan, X., Song, J., Bai, Y., Hao, S., Zhang, C., Liu, S., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c19608 · Cited by 7

pH- and redox-sensitive selenium-incorporated mesoporous silica nanoparticles for osteosarcoma-targeted treatment

He, L., Anbardan, Z. J., Habibović, P., & van Rijt, S. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.113883 · Cited by 7

A novel perspective on bone tumors: advances in organoid research

Ma, Z., Liu, Y., Chen, R., Fan, H., Kong, L., & Cao, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1550163 · Cited by 7

KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1

Cao, L., Jia, K., Tine, B. A. V., Yu, Y., Peng, Y., Chen, X., Pan, Q., Yang, W., Zhang, Z., Shao, Z., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03375-3 · Cited by 7

The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases

Cheng, Q., Li, Z., Li, Y., Chen, L., Chen, D., & Zhu, J. (2025) · Biomedicines · doi:10.3390/biomedicines13051082 · Cited by 7

Harmine exerts anticancer effects through the ROS/p38 axis to induce autophagy and apoptosis in osteosarcoma

Yu, L., Bi, K., Gu, J., Yu, Z., Li, S., & Chen, Y. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108557 · Cited by 7

Inhibition of PERK pathway promotes TAMs M1 polarization and ER stress in Osteosarcoma cells hindering tumor progression

Li, X., Guo, X., Wang, W., & Liu, P. P. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115293 · Cited by 7

The osteosarcoma immune microenvironment in progression: PLEK as a prognostic biomarker and therapeutic target

Zou, Y., Kang, J., Zhu, S., Ren, X., Zheng, L., Niu, J., Qin, X., Li, H., Xiang, L., Jiang, W., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1651858 · Cited by 7

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Dong, Y., Wang, L., Zhang, H., Li, M., Luo, Z. Y., Hu, Y., & Cai, C.-Y. (2025) · Advanced Science · doi:10.1002/advs.202512363 · Cited by 8

Integrated multi-omics reveals GABARAP-mediated mitophagy and pyruvate metabolism as key drivers of osteosarcoma progression

Han, X., Li, Y., Liu, Y., Wang, F., Li, T., Zhang, Q., Wang, G., & Feng, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680554 · Cited by 7

Zyxin Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma via Rap1-Mediated Inhibition of the MEK/ERK Signaling Pathway

Wei, Z., Xia, K., Zhou, B., Zheng, D., & Guo, W. (2023) · Biomedicines · doi:10.3390/biomedicines11082314 · Cited by 7

The fibrinogen-albumin ratio as a novel prognostic factor for elderly patients with osteosarcoma

Fu, Y., Yang, Y., Zhou, Y., Li, T., Xie, Y., Wang, Y., Ran, Q., Chen, Y., & Fan, X. (2023) · Medicine · doi:10.1097/md.0000000000034926 · Cited by 7

Spatiotemporal evolutionary process of osteosarcoma immune microenvironment remodeling and C1QBP‐driven drug resistance deciphered through single‐cell multi‐dimensional analysis

Wu, X., Tang, N., Zhao, Q., & Xiong, J. (2024) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10654 · Cited by 7

Inflammasome‐related gene signatures as prognostic biomarkers in osteosarcoma

Zhang, N., Han, Y., Cao, H., & Wang, Q. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18286 · Cited by 7

p53-armed oncolytic virotherapy induces abscopal effect in osteosarcoma by promoting immunogenic cell death

Demiya, K., Tazawa, H., Kondo, H., Kure, M., Mochizuki, Y., Komatsubara, T., Yoshida, A., Uotani, K., Hasei, J., Fujiwara, T., et al. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200845 · Cited by 7

The exposure to extremely low frequency electromagnetic-fields inhibits the growth and potentiates the sensitivity to chemotherapy of bidimensional and tridimensional human osteosarcoma models

Lucia, U., Bergandi, L., Grisolia, G., Fino, D., Mareschi, K., Marini, E., Niclot, A. G. S. B., Tirtei, E., Asaftei, S. D., Fagioli, F., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117162 · Cited by 7

CLG promotes mTOR / ULK1 pathway‐mediated autophagy to inhibit OS development by inhibiting TRAF6 ‐mediated FLT3 ubiquitination

Huang, X., Huang, Y., Peng, B., Wang, J., Tang, H., & Chen, Y. (2024) · Cancer Science · doi:10.1111/cas.16274 · Cited by 7

Cooperative blockade of FLT3 and ALK synergistically suppresses growth of osteosarcoma

Zhang, W., Qi, L., Xu, H., Yin, C., Yu, Z., Xu, R., Feng, C., Ren, X., Tu, C., & Li, Z. (2024) · Oncogene · doi:10.1038/s41388-024-03205-y · Cited by 7

Controllable All-in-One Biomimetic Hollow Nanoscaffold Initiating Pyroptosis-Mediated Antiosteosarcoma Targeted Therapy and Bone Defect Repair

Ma, Q., Xu, S., Wang, Q., Que, Y., He, P., Yang, R., Wang, H., Wu, Z., Xiao, L., Yuan, X., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c16287 · Cited by 7

Targeting RBM39 suppresses tumor growth and sensitizes osteosarcoma cells to cisplatin

Wang, J., Zheng, L., Chen, W., Zhang, X., Lv, D., Zeng, C., Zhang, C., Zhang, R., Kang, T., & Zhong, L. (2024) · Oncogene · doi:10.1038/s41388-024-03242-7 · Cited by 7

Decoding the role of SLC25A5 in osteosarcoma drug resistance and CD8+ T cell exhaustion: The therapeutic potential of phyllanthin

Tang, N., Deng, W., Wu, Y., Deng, Z., Wu, X., Xiong, J., & Zhao, Q. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156291 · Cited by 6

Scutellarein Inhibits Osteosarcoma Growth by Targeting the TLR4/TRAF6/NF-κB Pathway

Shi, Y., Tang, Y., Sun, Z., Sui, P., Shao, Y., Wang, Z., Zhang, J., & Gao, M. J. (2025) · Drug Design Development and Therapy · doi:10.2147/dddt.s489092 · Cited by 7

Xanthohumol Regulates Mitophagy in Osteosarcoma Cells via AMPK ‐ ULK1 ‐ FUNDC1 Signaling Pathway

Ge, Q., Yan, Z., Tian, Q., Zhang, J., Li, J., Cai, F., Zhang, L., & Zhu, Y. (2025) · Phytotherapy Research · doi:10.1002/ptr.8468 · Cited by 7

Development of a prognostic model for osteosarcoma based on macrophage polarization-related genes using machine learning: implications for personalized therapy

Zeng, J., Wang, D., Tong, Z., Li, Z., Wang, G., Du, Y., Li, J., Miao, J., & Chen, S. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01530-w · Cited by 7

Revolutionizing Bone Tumor Therapy: Biodegradable Magnesium Implant Triggers cGAS‐STING‐Dependent Synergy of Autophagic Cell Death and Alkaline Metabolic Collapse

Li, M., Wei, T., Liu, H., Wu, Z., Zhou, J., Jiang, J., He, P., Zhang, Y., & Zheng, Y. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202507822 · Cited by 7

Barriers in bone tumor treatment: the emerging role of drug delivery systems

Liu, J., Liu, X.-H., Zhong, N., Xiao, Y., Wang, G.-R., Liu, B., & Bu, L. (2025) · Medical Oncology · doi:10.1007/s12032-025-02853-8 · Cited by 7

Management of Unresectable Localized Pelvic Bone Sarcomas: Current Practice and Future Perspectives

do Brito, J. S., Esperança‐Martins, M., Abrunhosa-Branquinho, A. N., Melo-Alvim, C., Lopes-Brás, R., Janeiro, J., Lopéz‐Presa, D., Fernandes, I., Portela, J., & Costa, L. (2022) · Cancers · doi:10.3390/cancers14102546 · Cited by 7

Circ0038632 modulates MiR-186/DNMT3A axis to promote proliferation and metastasis in osteosarcoma

Tan, X., Zeng, C., Li, H., Tan, Y., & Zhu, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.939994 · Cited by 7

NEK6 Promotes the Progression of Osteosarcoma Through Activating STAT3 Signaling Pathway by Down-Regulation of miR-26a-5p

Zhu, M., Sun, Y., Xue, H., Wu, G., Wang, Z., Shi, J., Ma, J., Gu, B., & Xiao-ling, Y. A. N. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s413461 · Cited by 7

The Efficacy and Safety of Pegylated Liposomal Doxorubicin‐Based Neoadjuvant Chemotherapy in Children With Osteosarcoma: A Retrospective Real‐World Study

Wang, G., Tang, S.-Q., Chai, L., Liang, Y., Li, T., Bi, W., & Feng, C. (2025) · Cancer Innovation · doi:10.1002/cai2.162 · Cited by 6

Material-Driven Therapeutics: Functional Nanomaterial Design Paradigms Revolutionizing Osteosarcoma Treatment

Zhang, Z., He, F., Li, W., Liu, B., Deng, C. D., & Qin, X. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16060213 · Cited by 6

Nanoparticle-driven reactive oxygen species therapy: A new frontier in osteosarcoma treatment

He, L., Habibović, P., & van Rijt, S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114289 · Cited by 6

pH/ROS-responsive magnesium scaffold functionalized via hydrazone bonds for localized postoperative bone tumor therapy

Ding, Y., Fen, X., Chen, S., Zhang, Y., & Pang, Q. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.115285 · Cited by 6

Nanodynamic therapies for osteosarcoma: Recent advances and future perspectives

Xin, Y., Yao, J., Qiao, W., Liu, W., Hua, X., Zheng, X., Hui, J., & Fan, D. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.171582 · Cited by 6

Targeting high-risk MYC-overexpressed osteosarcoma with an Aurora kinase inhibitor:--results from a pilot umbrella trial

Tian, K., Jiang, Y., Sun, M., Lv, Y. B., Fan, J., Sun, C., Zhu, Y., Yu, Y., Qiang, X., Peng, P., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01219-7 · Cited by 6

Hub biomarkers in ultrasound-guided bladder cancer and osteosarcoma: Myosin light chain kinase and caldesmon

Li, H., Lin, G., Cui, M., Wang, L., Ding, D., Li, X., Fan, X., Yang, Q., Wang, Y., Kang, C., et al. (2023) · Medicine · doi:10.1097/md.0000000000036414 · Cited by 6

Integrated transcriptomic analysis systematically reveals the heterogeneity and molecular characterization of cancer-associated fibroblasts in osteosarcoma

Liu, Y., Han, X.-L., Han, Y., Bi, J., Wu, Y., Xiang, D., Zhang, Y., Bi, W., Xu, M., & Li, J. (2024) · Gene · doi:10.1016/j.gene.2024.148286 · Cited by 6

Bulk and single-cell sequencing identified a prognostic model based on the macrophage and lipid metabolism related signatures for osteosarcoma patients

Lin, Z., Wu, Z., & Luo, W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26091 · Cited by 6

Peripheral Soluble Immune Checkpoint-Related Proteins Were Associated with Survival and Treatment Efficacy of Osteosarcoma Patients, a Cohort Study

Li, B., Wang, Q., Luo, Y., Wang, S., Pan, S., Zhao, W., Ye, Z., & Wu, X. (2024) · Cancers · doi:10.3390/cancers16091628 · Cited by 7

The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway

Huang, X., Zeng, J., Ruan, S., Lei, Z., Zhang, J., & Cao, H. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1338811 · Cited by 7

Camrelizumab in combination with doxorubicin, cisplatin, ifosfamide, and methotrexate in neoadjuvant treatment of resectable osteosarcoma: A prospective, single‐arm, exploratory phase II trial

Tang, Q., Zhang, X., Zhu, X., Xu, H., Song, G., Lu, J., Wu, H., Deng, C., Ai, F., Zhang, Y., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.70206 · Cited by 6

The Interplay Between the MYC Oncogene and Ribosomal Proteins in Osteosarcoma Onset and Progression: Potential Mechanisms and Indication of Candidate Therapeutic Targets

Guerrieri, A. N., Hattinger, C. M., Marchesini, F., Melloni, M., Serra, M., Ibrahim, T., & Penzo, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212031 · Cited by 6

CCL2‐CCR2 Axis Inhibition in Osteosarcoma Cell Model: The Impact of Oxygen Level on Cell Phenotype

Petrošiūtė, A., Musvicaitė, J., Petroška, D., Ščerbavičienė, A., Arnold, S., Matulienė, J., Žvirblienė, A., Matulis, D., & Lučiūnaitė, A. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31489 · Cited by 6

Machine learning-based selection of immune cell markers in osteosarcoma: prognostic determination and validation of CLK1 in disease progression

Zhang, N., Haizhen, Z., Zhang, R., & Li, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1468875 · Cited by 6

A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration

Oyama, R., Nabeshima, A., Endo, M., Novikov, A., Fujiwara, T., Phelip, C., Yokoyama, N., Oda, Y., Caroff, M., Matsumoto, Y., et al. (2025) · BJC Reports · doi:10.1038/s44276-024-00120-3 · Cited by 6

A 10-year bibliometric analysis in the field of osteosarcoma treatment from 2014 to 2023

Shen, Y., Shao, X.-B., Chen, J., & Tang, X. (2025) · Discover Oncology · doi:10.1007/s12672-025-02007-2 · Cited by 6

Multomic analysis reveals the potential of LAG3 as a prognostic and immune biomarker and its validation in osteosarcoma

Cao, Q., Zhang, Y., Cheng, C., Wang, X., Fan, P., Huang, J., & Dai, Z. (2025) · Scientific Reports · doi:10.1038/s41598-025-10290-w · Cited by 6

BSA-LDHs-cGAMP In Situ Sensitization of Osteosarcoma: Enhancing Antitumor Efficacy with CD40 Agonist Antibodies

Yan, F., Jing, C., Duan, S., Xia, Y., Xiao, R., Shao, S., Xiao, Z., Chen, W., & Li, C. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00333 · Cited by 6

Formulation and validation of a baseline prognostic score for osteosarcoma treated uniformly with a non-high dose methotrexate-based protocol from a low middle income healthcare setting: a single centre analysis of 594 patients

Ganguly, S., Sasi, A., Khan, S. A., Kumar, V. S., Kapoor, L., Sharma, M. C., Mridha, A. R., Barwad, A. W., Thulkar, S. P., Pushpam, D., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1148480 · Cited by 6

Osteosarcoma – conventional treatment vs. gene therapy

Tan, M. L., Choong, P., & Dass, C. R. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.2.7385 · Cited by 99

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13

The Genetics of Osteosarcoma

Martin, J. W., Squire, J. A., & Zieleńska, M. (2012) · Sarcoma · doi:10.1155/2012/627254 · Cited by 254

Making gene therapy for osteosarcoma a reality

Broadhead, M. L., Clark, J. C. M., Choong, P., & Dass, C. R. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.18 · Cited by 12

Genome-Informed Targeted Therapy for Osteosarcoma

Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452