New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

Potential role of lncRNA LOXL1-AS1 in human cancer development: a narrative review

Tang, M., Rong, Y., Liu, S., Wu, Z., Ma, G., Li, X., & Cai, H. (2024) · Translational Cancer Research · doi:10.21037/tcr-23-1450 · Cited by 6

Pathology-interpretable radiomic model for predicting clinical outcome in patients with osteosarcoma: a retrospective, multicenter study

Ren, Q., Zhang, X., Wu, X., Zhao, H., Zhang, Y., Yao, Y., Leng, Y., Zhang, X., Liu, W., Xiao, J., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04424-0 · Cited by 5

The integrin α2-osteoclast axis: a key driver of bone destruction and therapeutic target in osteosarcoma

Wei, H., Shi, K., Huang, D., Lin, H., Wang, S., Chen, X., & Zhang, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06906-4 · Cited by 5

LIPA-driven reprogramming of tumor-associated macrophages shapes an immunosuppressive microenvironment in osteosarcoma

Guo, Z., Zou, Y., Liao, Y., Chen, J., Chen, W., Tu, J., Wen, L. Q., Yao, H., & Xie, X. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.116110 · Cited by 5

Considerations for Clinical Trial Design in Relapsed and Refractory Osteosarcoma: An FDA Symposium

Wessel, K. M., Janeway, K. A., Davis, L. E., Drezner, N. L., Donoghue, M. B., & Helman, L. J. (2026) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-3282 · Cited by 5

Single-cell and multi-omics integrative modeling identifies mitochondrial gene HSPE1 as a therapeutic target in osteosarcoma

Pan, S., Hu, W., Xie, P., Zhang, Z., Ma, J., & Wang, C. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-025-07633-6 · Cited by 5

sB7-H3 as a prognostic biomarker in osteosarcoma: insights into clinical outcomes

Zhao, Y., Sun, K., Yu, Y., Xu, J., Wang, Y., Yang, C., Ma, H., Zhou, Y., Ren, T., Tang, X., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-40855-2 · Cited by 5

Polymeric Theragnostic Nanoplatforms for Bone Tissue Engineering

Banerjee, K., & Madhyastha, H. (2023) · Journal of Nanotheranostics · doi:10.3390/jnt4030013 · Cited by 5

Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential

Chen, C. C., & Benavente, C. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25010568 · Cited by 7

Multi-omic validation of the cuproptosis-sphingolipid metabolism network: modulating the immune landscape in osteosarcoma

Li, Q., Fang, J., Liu, K., Luo, P., & Wang, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1424806 · Cited by 5

FBXO22 promotes osteosarcoma progression via regulation of FOXO1 for ubiquitination and degradation

Zhang, H., Bai, Y., Li, J., Chen, T., & Shang, G. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70021 · Cited by 5

mir-744-5p inhibits cell growth and angiogenesis in osteosarcoma by targeting NFIX

Xie, L., Li, W., & Li, Y. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04947-x · Cited by 5

Revolutionizing Osteosarcoma Diagnosis: A Comparative Analysis of Deep Learning Models for Precise Bone Cancer Detection Using Multi-Modal Medical Imaging

Gunanithi, S., Ilavarasan, S., & Karthika, R. N. (2024) · Lecture notes in electrical engineering · doi:10.1007/978-981-97-7592-7_16 · Cited by 6

Demethylzeylasteral inhibits osteosarcoma cell proliferation by regulating METTL17-mediated mitochondrial oxidative phosphorylation

Cao, J., Zhang, H., Wang, C., He, L., Li, Y., Wang, Z., Li, X., Aziz, F., Yang, M., & Zhu, X. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117348 · Cited by 5

Identification and verification of a polyamine metabolism-related gene signature for predicting prognosis and immune infiltration in osteosarcoma

Qiu, S., Chen, T., Cheng, D., & Yang, Q. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-025-05716-0 · Cited by 5

CAFs exosomal miR-21-5p suppresses ferroptosis and promotes proliferation and migration in osteosarcoma

Niu, X., Tian, W., Ke, Y., Li, Y., & Zhang, X. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03930-8 · Cited by 5

Validation the role of desmocollin-2 in osteosarcoma based on single cell and bulk RNA seq and experimental analyses

Zeng, J., Sun, Y., Man, Y.-N., Tang, H., Xie, L., & He, M. (2023) · Journal of Cancer · doi:10.7150/jca.87411 · Cited by 5

Construction of a prognostic risk score model based on the ARHGAP family to predict the survival of osteosarcoma

Liu, W., Xia, K., Zheng, D., Huang, X., Wei, Z., Wei, Z., & Guo, W. (2023) · BMC Cancer · doi:10.1186/s12885-023-11673-w · Cited by 5

Circadian rhythm-associated lncRNA RP11-414H17.5 as a key therapeutic target in osteosarcoma affects the tumor immune microenvironment and enhances malignancy

Huang, L., Liang, W., Cai, W., & Peng, H. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04442-9 · Cited by 5

Identification of a novel cellular senescence-related lncRNA signature for prognosis and immune response in osteosarcoma

Wu, H., Deng, C., Zheng, X., Huang, Y., Chen, C., & Gu, H. (2024) · Translational Cancer Research · doi:10.21037/tcr-24-163 · Cited by 5

Bibliometric analysis and visualisation of research hotspots and frontiers on omics in osteosarcoma

Wang, X., Cao, X., Dai, Z., & Dai, Z. (2024) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-024-05898-w · Cited by 5

Preparation of polycation with hydroxyls for enhanced delivery of miRNA in osteosarcoma therapy

Chen, D., Zhang, B., Cao, J., Wang, H., Luo, P., Liu, W., Niu, X., Wang, R., & Nie, J. (2022) · Biomaterials Science · doi:10.1039/d2bm00253a · Cited by 5

Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma

Zheng, K., Hou, Y., Zhang, Y., Wang, F., Sun, A., & Dong, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1111570 · Cited by 5

Osteosarcoma transcriptome data exploration reveals STC2 as a novel risk indicator in disease progression

Wang, Z., Zeng, Z., Gao, F., Gui, Z., Du, J., Shen, N., Shang, Y., Yang, Z., Shang, L., Wei, R., et al. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01456-4 · Cited by 5

Surgery Combined with Local Implantation of Doxorubicin-Functionalized Hydroxyapatite Halts Tumor Growth and Prevents Bone Destruction in an Aggressive Osteosarcoma

Liu, Y., Corbascio, T., Huang, J., Engellau, J., Lidgren, L., Tägil, M., & Raina, D. B. (2024) · Journal of Functional Biomaterials · doi:10.3390/jfb15080232 · Cited by 4

Unraveling the role of bisphenol A in osteosarcoma biology: insights into prognosis and immune microenvironment modulation

Shiyao, L., Yao, K., Jun, L., Yichen, L., Zhao, T., Longtao, Y., Zhou, H. W., & Kai, Z. (2024) · Discover Oncology · doi:10.1007/s12672-024-01280-x · Cited by 4

LncRNA OLMALINC promotes osteosarcoma progression through USP1-mediated autophagy suppression

Li, J., Yu, B., Xue, Z., Liang, Y., Chen, S., Gui, T., Liu, Z., Zhang, L., & Peng, R. (2025) · Human Cell · doi:10.1007/s13577-025-01221-y · Cited by 4

STUB1-mediated ubiquitination of SLC25A10 regulates mitochondrial function and drives osteosarcoma progression: A novel therapeutic target

Feng, J., Zhao, M., Chen, Z., Lin, C., Jin, J., Ma, N., Bai, C., Li, Z., Xu, W., & She, C. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111855 · Cited by 4

Construction of biodegradable benzobisthiazole-based conjugated polymers with pendant β-cyclodextrin for synergistic mild-temperature chemo-photothermal therapy

Lai, Q., Huang, S., Wu, Y., Hu, B., Chen, S., Zhang, K., Xu, Y., Zhang, X., Sun, G., & Ouyang, Y. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.114102 · Cited by 4

Rab27a+CAF exosomal miR-9-5p promotes osteosarcoma progression via CREBRF/MAPK signaling pathway

Niu, X., Tian, W., Li, Z., Zhang, G., & Zhang, P. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111964 · Cited by 4

SOCS1 depletion drives osteosarcoma stemness and chemoresistance by suppressing ACTN4 degradation

Feng, J., Wei, X., Chen, L., Yang, H.-Z., Li, Y., Wang, J., Liu, Y., Xu, Y., Zhao, Q.-Q., Li, P., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01650-3 · Cited by 4

GBP1-CDK9-STAT3 signaling axis promotes osteosarcoma PD-L1 expression and immune escape

Jing, D., Chen, B., Liang, R., Li, F., Zhao, B., Pu, F., & Wu, W. (2025) · Neoplasia · doi:10.1016/j.neo.2025.101232 · Cited by 4

Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation

Liu, Y., Han, Y., Guo, Z., Zhang, Y., Xu, X., Qi, W., Xu, M., & Li, J. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00970-0 · Cited by 4

Construction and clinical validation of a machine-learning-based consensus prognostic signature (MLPS) for osteosarcoma via multi-cohort data integration

Chen, L., Wu, H., Ren, R., Zhang, Y., Zhu, Z., Chen, X., Wang, L., Gan, X., Kang, H., Pu, H., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115831 · Cited by 4

Chest Wall Resection and Reconstruction Following Cancer

Petrella, F., Cara, A., Cassina, E. M., Libretti, L., Pirondini, E., Raveglia, F., Sibilia, M. C., & Tuoro, A. (2025) · Current Oncology · doi:10.3390/curroncol32120708 · Cited by 4

P53-Armed Oncolytic Virotherapy Promotes the Efficacy of PD1 Blockade in Murine Osteosarcoma Tumors

Kure, M., Tazawa, H., Demiya, K., Kondo, H., MOCHIZUKI, Y., Komatsubara, T., Yoshida, A., Uotani, K., Hasei, J., Fujiwara, T., et al. (2025) · Anticancer Research · doi:10.21873/anticanres.17924 · Cited by 4

Propofol Regulates ER Stress to Inhibit Tumour Growth and Sensitize Osteosarcoma to Doxorubicin

Hua, W., Du, X., Zhao, H., Sun, P., & Yang, J. (2023) · International Journal of Clinical Practice · doi:10.1155/2023/3093945 · Cited by 4

UBE2L3 Suppresses Oxidative Stress-regulated Necroptosis to Accelerate Osteosarcoma Progression

Zhao, X., Shan, G., Xing, D., Gao, H., Xiong, Z., Hui, W., & Gong, M. (2024) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/0115748928297557240212112531 · Cited by 4

Hybridized nanozymes for anti-osteosarcoma therapy via the Fenton reaction

Zheng, J., Huang, L., Wang, J., Zhuo, S., & Huang, G. (2024) · iScience · doi:10.1016/j.isci.2024.109474 · Cited by 4

Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma

Shi, Y., Wang, Z., Shao, Y., Guang, Q., Zhang, J., Liu, B., Wu, C., Wang, Y., & Sui, P. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149808 · Cited by 4

CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA

Liu, Y., Jiang, H., Hu, K., Zou, H. L., Zhang, W., Liu, J., & Jian, X. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298947 · Cited by 4

Modular Universal Tumor and Revision System Prostheses in Patients with Bone Cancer of the Lower Limbs: A Narrative Review of Functional Outcomes

Ferrara, P. E., Ariani, M., Codazza, S., Aprovitola, A., Polisano, D., & Ronconi, G. (2024) · Cancers · doi:10.3390/cancers16193357 · Cited by 4

Inhibition of discoidin domain receptor 1 as a new therapeutic strategy for osteosarcoma

Jing-lu, W., Walker, R. L., Hornicek, F. J., Shi, H., & Duan, Z. (2024) · The FASEB Journal · doi:10.1096/fj.202401508rr · Cited by 4

S100 A16 promotes the progression of osteosarcoma by activating the PI3 K/AKT signaling pathway through ANXA2

Xiang, Y.-Y., Liu, J., Yi, X., Luo, J.-Y., Yu, Y., & Yi, G.-L. (2025) · Scientific Reports · doi:10.1038/s41598-025-05293-6 · Cited by 4

Development and Validation of Nomograms to Assess Risk Factors and Overall Survival Prediction for Lung Metastasis in Young Patients with Osteosarcoma: A SEER‐Based Study

Liu, Z., Li, G., Liu, H., Zhu, J., & Wang, D. (2022) · International Journal of Clinical Practice · doi:10.1155/2022/8568724 · Cited by 4

Osteogenesis in the presence of chemotherapy: A biomimetic approach

Brozovich, A., Lenna, S., Paradiso, F., Serpelloni, S., McCulloch, P. C., Weiner, B. K., Yustein, J. T., & Taraballi, F. (2022) · Journal of Tissue Engineering · doi:10.1177/20417314221138945 · Cited by 4

PSKH1 affects proliferation and invasion of osteosarcoma cells via the p38/MAPK signaling pathway

Zhu, X., Jiang, C., Wang, Z., Zhu, X., Yuan, F., & Yang, Y. (2023) · Oncology Letters · doi:10.3892/ol.2023.13730 · Cited by 4

CEP55, serving as a diagnostic marker gene for osteosarcoma, triggers the JAK2-STAT3-MMPs axis

Yan, Y., He, J., & Cheng, W. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001491 · Cited by 4

m7G-related genes predict prognosis and affect the immune microenvironment and drug sensitivity in osteosarcoma

Lin, Z., Wu, Z., Yuan, Y., Zhong, W., & Luo, W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1158775 · Cited by 4

Trifluoperazine exerts anti-osteosarcoma effect by inducing mitochondria-dependent apoptosis via AKT/TXNIP signaling pathway

Zeng, X., Chen, W., Yu, N., Li, Z., Li, H., Chen, Y., Gong, F., Jiang, X., & Ji, G. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117080 · Cited by 3

Few‐Shot Identification of Active Therapeutic Peptide Networking with Gradient Dynamics against Cancer

Xia, R., Sun, W., Liang, J., Wang, S., Gao, F., Liu, Y., Wang, L., Zhang, H., Ma, C., & Liu, K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501753 · Cited by 3

Nanomaterials for Combating Cancer while Safeguarding Organs: Safe and Effective Integrative Tumor Therapy

Ji, K., Jiang, X., Zhang, Z., Li, M., Zhu, P., Wang, Y., & Gao, J. (2025) · Biomaterials Research · doi:10.34133/bmr.0165 · Cited by 3

HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma

Ding, S.-C., Shi, C.-J., Pang, F., Wen, R., Li, N., Mai, Y., Zhou, S., & Zhang, J. (2025) · Oncology Reports · doi:10.3892/or.2025.8927 · Cited by 3

Gambogic acid suppresses osteosarcoma progression through upregulation of FOXO3a

Hu, Y., Wu, J., Ye, S., Zhang, H., Guo, Z., Han, X., & Zhou, J. (2025) · Discover Oncology · doi:10.1007/s12672-025-02776-w · Cited by 3

NovumRNA: Accurate prediction of non-canonical tumor antigens from RNA sequencing data

Außerhofer, M., Rieder, D., Facciolla, M., Gronauer, R., Lamberti, G., Lisandrelli, R., Pellegatta, S., Trajanoski, Z., & Finotello, F. (2025) · iScience · doi:10.1016/j.isci.2025.113448 · Cited by 3

RNF207 promotes the proliferation, migration and invasion of osteosarcoma through KCNQ1 mediated activation of ERK/MEK signaling pathway

Liu, W., Xia, K., Tong, K., Huang, X., Wei, Z., Wei, Z., & Guo, W. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115482 · Cited by 3

Identification and validation of stemness-related gene signatures to predict prognosis and immune infiltration in osteosarcoma reveals a critical role for S100A13

Li, J., Chang, C., Ma, Y., Zhuang, B., Ma, Q., Wang, Y., & Ji, Y. (2025) · BMC Cancer · doi:10.1186/s12885-025-14939-7 · Cited by 3

Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism–Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma

Hui, M., Zhang, H., Bajgai, J., Rahman, M. H., Pham, T. T., Mo, C., Cao, B., Choi, Y.-E., Kim, C.-S., & Lee, K. (2025) · Biomolecules · doi:10.3390/biom15121664 · Cited by 3

Personalized prediction of chemotherapy efficacy in osteosarcoma through patient-derived organoids: correlation with survival and tumor proliferation potential

Nie, J., Wan, C.-Y., Li, H., Zhou, J.-L., Zhong, G.-Q., Yang, T., Yao, M.-Y., Huang, W., Zhang, C., Li, S., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03541-1 · Cited by 3

Cell Membrane Biomimetic Drug Delivery Systems Based on Ferroptosis Mechanism for Anticancer Treatment

Su, L., Yang, S., Yuan, H., Cheng, Q., Wang, X., Li, N., Zhang, L., & Li, P. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202504993 · Cited by 3

Amplified ferroptosis and immunomodulation triggered by NIR-II photothermal-controllable CRISPR/Cas9 nanoplatform to treat osteosarcoma and prevent postsurgical implant-associated infections

Li, M., He, L., Wang, L., Wang, L., Pan, Q., Sun, P., Li, D., & Zhang, C. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124043 · Cited by 3

RNA Modifications: Current Understandings and Future Perspectives

Xiao, S., Xiang, T., Yang, C., Wang, X., Huang, G., Luo, F., Xie, Z., & Chen, Y. (2026) · MedComm · doi:10.1002/mco2.70734 · Cited by 3

Non-coding RNAs as master regulators of ferroptosis in cancer: mechanisms and clinical implications

Mo, H., Xie, Y., Zhang, H. Z. H., Liu, Y., Wu, W., Xia, Z., Luo, P., Liu, Z., & Cheng, Q. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02666-x · Cited by 3

A GAD1 inhibitor suppresses osteosarcoma growth through the Wnt/β-catenin signaling pathway

Jian, C., Wang, B., Mou, H., Zhang, Y., Yang, C., Huang, Q., & Ou, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31444 · Cited by 3

Bottom-up synthesis of nanoflowers for combined PTT/TDT/ST therapy of osteosarcoma

Wu, H., Xie, L., Zhu, L., Yu, T., & Zhang, Y. (2024) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2024.134346 · Cited by 3

Identification of immune-related tumor antigens and immune subtypes in osteosarcoma

Zhang, M., Xu, G., Xi, C., & Yu, E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32231 · Cited by 3

The contribution of the novel CLTC-VMP1 fusion gene to autophagy regulation and energy metabolism in cisplatin-resistant osteosarcoma

Zou, P.-A., Tao, Z., Yang, Z., Xiong, T., Deng, Z., & Chen, Q. (2024) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00302.2024 · Cited by 3

Research progress of circRNAs in bone-related diseases

Hua, X., Yu, L., Zhu, H., Zhu, Y., Fan, G., & Zhou, G. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1481322 · Cited by 3

Novel intravenous formulation for radiosensitization in osteosarcoma treatment

Zeng, H., Feng, H., Zhang, C., Kang, Z., Wu, J., Zhao, X., Huang, A., Xu, Y., Huang, Y., Xu, H., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101682 · Cited by 3

IR780-Loaded E. coli Membrane Nanovesicles Combined with Photodynamic Therapy to Enhance Immunogenicity in Osteosarcoma

Wang, H., Wang, L., Tan, Z., Wu, S., She, D., Gong, Y., Zhu, H., Wang, Y., Ren, K., Rui, X., et al. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c03230 · Cited by 3

ABLIM1 promotes the proliferation, migration and invasion of osteosarcoma through DCC mediated activation of PI3K/AKT signaling pathway

Liao, Q., Tong, S., Li, L., Wang, J., & Tong, K. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112077 · Cited by 3

Circ_0001060 Upregulates and Encourages Progression in Osteosarcoma

Liu, H., Huang, Q., Tang, H., Luo, K., Qin, Y., Li, F., Tang, F., Zheng, J., Feng, W., Li, B., et al. (2022) · DNA and Cell Biology · doi:10.1089/dna.2022.0500 · Cited by 3

Identification and validation of an anoikis-related lncRNA signature to predict prognosis and immune landscape in osteosarcoma

Zhang, J., Pan, R., & Tian, X. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1156663 · Cited by 3

Sodium fluoride (Na18F) PET Response Criteria in Solid Tumors (NAFCIST): a framework for response assessment in bone tumors

Kairemo, K., Gouda, M. A., Buschhorn, L., Wahida, A., Macapinlac, H. A., Anderson, P. M., & Subbiah, V. (2023) · ESMO Open · doi:10.1016/j.esmoop.2023.101575 · Cited by 3

Antigen processing and presentation‐related signature‐derived BNIP3 is a novel oncogene and immunotherapy determinant in osteosarcoma based on machine learning and in vitro validation

Chen, Y., Cao, Y., Wu, S., Cao, X., Cai, T., & Hu, H. (2023) · The Journal of Gene Medicine · doi:10.1002/jgm.3586 · Cited by 3

CircCRIM1 suppresses osteosarcoma progression via sponging miR146a-5p and targeting NUMB.

Chen, J., Hei, R., Chen, C., Wu, X., Han, T., Bian, H., Gu, J., Lu, Y., & Zheng, Q. (2023) · PubMed Central · Cited by 3

AP003352.1/miR-141-3p axis enhances the proliferation of osteosarcoma by LPAR3

Yu, H., Zhang, B., Qi, L., Han, J., Guan, M., Li, J., & Meng, Q. (2023) · PeerJ · doi:10.7717/peerj.15937 · Cited by 3

High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma

Ma, Y., Chen, B., Zhang, B., Zhang, C., Zhu, Q., Wang, X., Liu, Z.-G., & Liu, H. (2023) · Aging · doi:10.18632/aging.205235 · Cited by 3

The role of lncRNA HCG18 in human diseases

Long, F., Zhou, X., Zhang, J., Di, C., Li, X., Ye, H., Pan, J., & Si, J. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3961 · Cited by 3

Molecular characterization of Golgi apparatus-related genes indicates prognosis and immune infiltration in osteosarcoma

Zhang, J., Liu, J., Ding, R., Miao, X., Deng, J., Zhao, X., Wu, T., & Cheng, X. (2024) · Aging · doi:10.18632/aging.205645 · Cited by 3

HOXB5 promotes the progression and metastasis of osteosarcoma cells by activating the JAK2/STAT3 signalling pathway

Ma, Q., Li, X., Wang, H., Xu, S., Que, Y., He, P., Yang, R., Wang, Q., & Hu, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30445 · Cited by 3

N-terminal histone acetyltransferase NAA40 modulates osteosarcoma progression by controlling AGR2 expression

Wu, H., Hua, X., Man, Y.-N., Huang, P., Huang, L., & He, M. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151491 · Cited by 3

Veratramine influences the proliferation of human osteosarcoma cells through modulating the PI3K/AKT signaling cascade

Zhou, X., Qu, X., Li, Z., Duan, Y., Zhu, Y., Wang, J., Han, X., Zhang, J., Luo, J., & Luo, X. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101630 · Cited by 3

Research of the Active Components and Potential Mechanisms of Qingfei Gujin Decoction in the Treatment of Osteosarcoma Based on Network Pharmacology and Molecular Docking Technology

Yan, Q., Yang, J., Yao, Y., Jia, Z. H., Wang, Y., Cheng, M., Yan, X., & Xu, Y. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/7994425 · Cited by 3

Identification of RALA as a Therapeutic Target and Prognostic Predictor of Osteosarcoma

Fan, G., Zhu, Y., Zhu, H., Yu, L., Wang, Z., Zhai, C., Zhou, G., Zhao, J., & Wang, Y. (2023) · BioMed Research International · doi:10.1155/2023/1150768 · Cited by 3

CircTNPO1 promotes the tumorigenesis of osteosarcoma by sequestering miR-578 to upregulate WNT5A expression

Shi, Y., Tian, Y., Wu, Y., & Zhao, Y. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110858 · Cited by 3

Circular RNA CircSATB2 facilitates osteosarcoma progression through regulating the miR-661/FUS-mediated mRNA of ZNFX1

Wang, Z., She, D., Liu, L., Hua, X., Zhu, H., Yu, L., Wang, H., Zhu, Y., Fan, G., Wang, Y., et al. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110977 · Cited by 3

ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in modulating the malignant biological behavior of osteosarcoma cells

Li, S., Xue, J., Zhang, H., & Shang, G. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04406-z · Cited by 3

Tandem mass tag (TMT) quantitative protein analysis‐based proteomics and parallel reaction monitoring (PRM) validation revealed that MST4 accelerates osteosarcoma proliferation by increasing MRC2 activity

Liu, Y., Zhang, X., Ren, X., Sun, J., Wen, Y., Guo, Z., & Ma, Q. (2023) · Molecular Carcinogenesis · doi:10.1002/mc.23567 · Cited by 2

Paucatalinone A from Paulownia Catalpifolia Gong Tong Elicits mitochondrial-mediated cancer cell death to combat osteosarcoma

Wang, G., Cui, Z., Tian, J., Li, X., Tang, W., Jing, W., Li, A., & Zhang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1367316 · Cited by 2

An interactive dose optimizer based on population pharmacokinetic study to guide dosing of methotrexate in Chinese patients with osteosarcoma

Zhang, Y., Qi, X., Huang, X., Liu, X., Liu, Y., Rui, J., Yin, Q., Wu, S., & Zhou, G. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04708-x · Cited by 2

Aucubin Induces Apoptotic Cell Death Through Caspase-dependent Pathways in Human Osteosarcoma MG-63 Cells

Cui, M., & Chen, P. (2024) · Pharmacognosy Magazine · doi:10.1177/09731296241277314 · Cited by 2

Inhibition of id-1 reduces osteosarcoma growth and metastasis through mediation of snail

Shu, R., Yu, Z., Wu, J., Cheng, Q., Peng, Z., Zhou, H., & Zhao, M. (2025) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05412-5 · Cited by 2

Heterogenic membrane-coated nanoparticles for targeted immunotherapy against osteosarcoma via p53-mediated ferroptosis and mTOR inhibition

Lei, T., Jiang, Z., Nan, J., Fan, H., Yang, J., Wang, Y., Hua, L., Hu, Q., & Hu, Y. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160854 · Cited by 2

Harnessing the metastatic potential of human osteosarcoma cells by natural coumarin galbanic acid

Ahmadi, A., Hosseini, F., Sarvi, Z. N., Iranshahi, M., & Rassouli, F. B. (2025) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-025-04128-5 · Cited by 2

A comprehensive clinico-pathological review of a series of pediatric, adolescents and young adults with high-grade osteosarcoma: from clinics to biomarker discovery

López, S. B., Rubio‐San‐Simón, A., Wu, J.-H., Cuadrillero, D. A., Sanz-Miguel, A., Lassaletta, Á., Sirvent-Cerdá, S. I., Rey-Portela, L., Abril, J. C., Moreno, L., et al. (2025) · Clinical & Translational Oncology · doi:10.1007/s12094-025-03901-5 · Cited by 2

Transcription factor CREB1 promotes malignant growth of osteosarcoma cells by inhibiting miRNA-183-5p and regulating PROX1 expression

Jin, F., Long, K., & Zhang, J. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10741-7 · Cited by 2

Melittin inhibits osteosarcoma growth in vitro and in vivo by inactivating the Wnt/β-catenin signaling pathway

Wang, X., Chang, J., Sun, X., Guo, S., Li, Y., Shi, Q. W., & Yang, Y. (2025) · Journal of Cancer · doi:10.7150/jca.109750 · Cited by 2

Identification of EEF1A2 as a potential therapy target of osteosarcoma using novel compound 8e

Xue, J., Li, M., Wang, Y., Sun, D., Hao, S., Liu, Z., Zhang, W., Li, L., Zhu, T., & Liu, S. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118355 · Cited by 2

Demethylase, ALKBH1, regulates osteosarcoma chemosensitivity through FZD8/Wnt/β-catenin signaling pathway in the m7G manner

Li, X., Lin, Z., Liu, Q., Yuan, Y., Luo, H., Zheng, H., & Luo, W. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.149130 · Cited by 2

Osteosarcoma – conventional treatment vs. gene therapy

Tan, M. L., Choong, P., & Dass, C. R. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.2.7385 · Cited by 99

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13

The Genetics of Osteosarcoma

Martin, J. W., Squire, J. A., & Zieleńska, M. (2012) · Sarcoma · doi:10.1155/2012/627254 · Cited by 254

Making gene therapy for osteosarcoma a reality

Broadhead, M. L., Clark, J. C. M., Choong, P., & Dass, C. R. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.18 · Cited by 12

Genome-Informed Targeted Therapy for Osteosarcoma

Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452