New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

Downregulation of ZFP36L1 contributes to methotrexate resistance in osteosarcoma through enhanced NHEJ DNA repair mechanisms

Zhuang, J., Ma, M., Yang, B., Liu, Y., Mi, R., Yang, W., Lu, Y., Yu, H., Wu, W., Song, Y., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08217-4 · Cited by 2

Exosomal miR-20a-5p derived from cisplatin-resistant osteosarcoma cells promotes chemoresistance via Inhibition of ferroptosis through targeting RUNX3

Zhang, P., Deng, L., Chen, K., Ding, W., Niu, X., & Tian, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-29305-7 · Cited by 2

CT-assessed pectoralis major muscle measurements as risk factors for low neoadjuvant chemotherapy efficacy in osteosarcoma: a retrospective study

Li, Z., Zhang, Y., Wu, H., Zhang, C., & Ye, Z. (2025) · BMC Medical Imaging · doi:10.1186/s12880-025-02087-0 · Cited by 2

Co‐Delivery of Cisplatin and Curcumin via ROS‐Responsive Nanoparticles to Activate the cGAS‐STING Pathway for Osteosarcoma Metalloimmunotherapy

Wu, Y., Han, Y., Li, W., Han, X., Wang, W., Bi, J., Zhang, Y., Xiang, D., Gao, H., Hu, N., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202504555 · Cited by 3

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Wang, T., Bian, Y., Hu, T., Li, M., Tan, Y., Yang, Y., Jian, X., Weng, X., Tan, C., & Liang, R. (2026) · Advanced Science · doi:10.1002/advs.202524296 · Cited by 2

Emerging functionalized artificial periostea: Diverse origins, multifaceted roles and therapeutic frontiers

Luo, Y., Jiang, W., Wu, H., Zhao, C., Wei, H., & Wang, X. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124066 · Cited by 2

Reconstruction of T cell infiltration in an osteosarcoma PDX-organoid interactive biobank for personalized immunotherapy

Sun, W., Tao, Y., He, X., Zhang, Q., Yang, X., Dong, H., Wang, H., Chen, W., Yao, B., Zhang, L., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102644 · Cited by 4

A conceptual blueprint for “turning cold to hot” in Osteosarcoma: from TME stratification hypotheses to adaptive therapeutic prospects

Yang, B., Liu, S., Liu, B., Ye, T., Ma, X., & Song, T. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02883-3 · Cited by 2

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Bozzini, N., Cortini, M., Righi, A., Grigoriadis, A. E., Dack, M. R. G., Elizabeta, I., Torricelli, F., Manicardi, V., Baldini, N., & Avnet, S. (2026) · Acta Physiologica · doi:10.1111/apha.70214 · Cited by 2

UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation

Yu, L., Li, M., Liu, T., Wu, J., Meng, H., Xu, W., Zhao, W., Zhu, H., Wang, Z., Guo, S., et al. (2026) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-25-1321 · Cited by 2

Isovalerylspiramycin I inhibits proliferation, migration and invasion of osteosarcoma cells by targeting Topoisomerase 1 and suppressing the ataxia telangiectasia and Rad3‐related/checkpoint kinase 1 pathway

Liang, J., Zhang, P., He, K., Zhang, Y., Ding, X., Li, Q., Zhou, W., Hu, H., Zhang, J., & Zhou, Y. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.203 · Cited by 2

C-C Motif Chemokine Ligand 5 (CCL5): A Potential Biomarker and Immunotherapy Target for Osteosarcoma

Zheng, H., Wang, Y., & Li, F. (2023) · Current Cancer Drug Targets · doi:10.2174/1568009623666230815115755 · Cited by 2

A novel classification predicts prognosis and drug sensitivity in osteosarcoma based on alterations in gene sets

Ye, S., Wang, X., & Chen, R. (2024) · Aging · doi:10.18632/aging.205614 · Cited by 2

Targeted PLK1 suppression through RNA interference mediated by high‐fidelity Cas13d mitigates osteosarcoma progression via TGF ‐β/Smad3 signalling

Yuan, Y., Cao, D., Zhang, A., Liu, Z., Deng, Z., & Zhang, S. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18400 · Cited by 2

A Primary Telangiectatic Mandibular Osteosarcoma With Germ‐Line Malignancy‐Associated DNA Damage Repair Gene Polymorphisms: A Case Report

Tahir, M., Wei, E. X., Madelaire, C., Yu, A. S., Herrera, G. A., & Shackelford, R. E. (2024) · Case Reports in Oncological Medicine · doi:10.1155/2024/2418888 · Cited by 2

Avermectin B1 mediates antitumor activity and induces autophagy in osteosarcoma through the AMPK/ULK1 signaling pathway

Fei, X., Li, Z., Pan, Z., Liang, Y., Tan, C., Cheng, D., & Yang, Q. (2024) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-024-04695-z · Cited by 2

Immune-related glycosylation genes based classification predicts prognosis and therapy options of osteosarcoma

Wang, W., Jiao, Y., Du, X., & Ye, Z. (2024) · Gene · doi:10.1016/j.gene.2024.148985 · Cited by 2

Establishing a Mandibular Osteosarcoma Model in SD Rats Using Tissue Block Transplantation

ZHANG, L., LIU, J., ZHANG, H., QIAN, Y., ZHANG, L., & WANG, W. (2024) · In Vivo · doi:10.21873/invivo.13743 · Cited by 2

Disulfidoptosis‐related molecular subtypes and prognostic model for optimizing drug therapy in metastatic osteosarcoma patients

Wang, X., Xie, C., & Lin, L. (2024) · The FASEB Journal · doi:10.1096/fj.202401510r · Cited by 2

Daidzin improves the cisplatin chemosensitivity for osteosarcoma via binding to β-catenin protein and suppressing the wnt pathway

Wang, P., Lu, H., Zhang, C., Wang, R., Chen, X., Qiao, L., Wang, Z., & Wang, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-89766-8 · Cited by 2

Insights into the role of histone lysine demethylases in bone homeostasis and skeletal diseases: A review

Wen, R., Huang, R., Xu, K., & Yi, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141807 · Cited by 2

Evaluation of Indoleamine 2,3-Dioxygenase (IDO) Expression in Osteosarcoma: Insights From a 10-Year Retrospective Cohort

Farooq, A., Amin, A., Bashir, S., Fatima, M., Hassan, M. J., Sheikh, A., Tahseen, M., Sheikh, U., & Asghar, K. (2025) · OncoTargets and Therapy · doi:10.2147/ott.s494899 · Cited by 2

Enhancing Doxorubicin Sensitivity in Osteosarcoma Cancer Cells: Unveiling the Role of Resveratrol-Induced Oxidative DNA Damage

Bazavar, M., Helali, H., Boukani, L. M., Yousefi, B., & Valizadeh, A. (2025) · Drug Research · doi:10.1055/a-2567-9916 · Cited by 2

miR-486-3p Suppresses Osteosarcoma Proliferation and Migration by Targeting the SPRED1-MAPK/ERK Pathway

Zhang, Y., Zhou, Y., Zhang, S., Zhang, X., Li, J., & Zhan, X. (2025) · Biochemical Genetics · doi:10.1007/s10528-025-11128-w · Cited by 2

Quinacrine induces autophagy via the Dlg5/AKT pathway to inhibit osteosarcoma cell proliferation and suppresses migration and invasion through the Dlg5/Girdin pathway

Li, H., Chen, W., Zeng, X., He, R., & Ji, G. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156981 · Cited by 2

Human osteosarcoma cell secretome impairs neonatal mouse calvarial osteogenic cells functions and modifies the nanoparticles-derived protein profile

Ucci, A., Giacchi, L., Cufaro, M. C., Puri, C., Ciocca, M., Ferdinando, F. D., Boccio, P. D., Cappariello, A., & Rucci, N. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123837 · Cited by 3

Targeting Cell‐Matrix Induced Chemoresistance With Regorafenib in a 3D Model of Osteosarcoma

Rao, R. R., Huang, M. S., Zhang, D. H., Huerta-López, C., Long, C. M., Rodriguez, G. A., Mozipo, E. A. T., Sagi, S., & Heilshorn, S. C. (2025) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37985 · Cited by 2

Individual Trajectories of Bone Mineral Density Reveal Persistent Bone Loss in Bone Sarcoma Patients: A Retrospective Study

Avnet, S., Falzetti, L., Bazzocchi, A., Gasperini, C., Taddei, F., Schileo, E., & Baldini, N. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11185412 · Cited by 2

Mg-ZIF nanozymes disrupt the level of ROS for osteosarcoma killing via POD activity

Zheng, J., Zhuo, S., Huang, L., Wang, J., & Huang, G. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1407989 · Cited by 2

Amicis Omnia Sunt Communia: NF-κB Inhibition as an Alternative to Overcome Osteosarcoma Heterogeneity

Medeiros, M., Guenka, S., Bastos, D., Oliveira, K. L., & Brassesco, M. S. (2024) · Pharmaceuticals · doi:10.3390/ph17060734 · Cited by 2

Combined use of niraparib enhanced the inhibitory effect of Anti-GD2 antibody on osteosarcoma cells

Wenyao, C., Shuai, M., Fan, Y., Li, X., & Que, X. (2024) · Discover Oncology · doi:10.1007/s12672-024-01166-y · Cited by 2

Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma

Silver, K. I., Mannheimer, J., Saba, C., Hendricks, W. P. D., Wang, G., Day, K. R., Warrier, M., Beck, J. A., Mazcko, C. N., & LeBlanc, A. K. (2024) · Veterinary oncology. · doi:10.1186/s44356-024-00004-1 · Cited by 2

The homeobox family gene signature predicts the prognosis of osteosarcoma and correlates with immune invasion

Liu, W., Xia, K., Huang, X., Wei, Z., Wei, Z., & Guo, W. (2025) · Scientific Reports · doi:10.1038/s41598-024-84924-w · Cited by 2

Paraptosis landscape reveals distinct prognoses and immune microenvironments in osteosarcoma: Experimental validation of key regulator TNK2

Zhou, L., Tang, Y. J., Chen, C., & Jiang, J. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178304 · Cited by 2

Single nucleotide mutation changes the capability of CCN3 in osteosarcoma cell invasion and differentiation

Yan, X., Yan, W., Fu, X., Xu, Y., Zhu, N., Qiu, C., Bu, M.-M., Shen, Y., & Chen, M. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101485 · Cited by 2

What Is Eating Your Bones?

Jack, K. (2023) · Physician Assistant Clinics · doi:10.1016/j.cpha.2023.07.010 · Cited by 2

Unveiling the prognostic implications of RPLP1 upregulation in osteosarcoma.

Du, X., Wei, H., Zhang, B., Pang, L. K., Zhao, R., Zhang, X. D., & Yao, W. (2023) · PubMed Central · Cited by 2

Neoadjuvant chemotherapy-induced hemoglobin decline as a prognostic factor in osteosarcoma around the knee joint: a single-center retrospective analysis of 242 patients

Yu, W., Sun, M., Wang, W. J., Shen, Z., Wang, Y., & Li, H. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08592-2 · Cited by 2

Prognositic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma.

Wang, D., Deng, Q., Peng, Y., Tong, Z., Li, Z., Huang, L., Zeng, J., Li, J., Miao, J., & Chen, S. (2024) · PubMed Central · doi:10.11817/j.issn.1672-7347.2024.230519 · Cited by 1

Transforming osteosarcoma care: from historical milestones to precision medicine advances

Wang, J., Geller, D. S., Sun, L., & Tang, X. (2024) · 中国科学通报：英文版 · doi:10.1016/j.scib.2024.11.027 · Cited by 1

ANKRD2 Knockdown as a Therapeutic Strategy in Osteosarcoma: Effects on Proliferation and Drug Response in U2OS and HOS Cells

Cenni, V., Bavelloni, A., Capanni, C., Mattioli, E., Bortolozzo, F., Kojić, S., Orlandi, G., Bertacchini, J., & Blalock, W. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041736 · Cited by 1

NEK2 promotes the progression of osteosarcoma through the AKT/p-AKT pathway and interacts with FoxM1

Tan, X., Liang, X., Feng, Y., Xie, M., Zhong, K., Luo, W., Wang, Y., Yin, Y., & Cai, Y. (2025) · Medical Oncology · doi:10.1007/s12032-025-02657-w · Cited by 1

Circular RNA rising star: new findings of circPRMT5 in cancer

Chen, D., Yin, C., Li, C., He, J., & Wu, P. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10638-5 · Cited by 1

HEY1 promotes the development and metastasis of osteosarcoma through CD44/EGFR/FAK pathway

Liu, Y., Zhang, H., Yi, X., Wang, Z., & Yu, A. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70042 · Cited by 1

Tandem High‐Dose Chemotherapy and Autologous Stem Cell Transplantation for Osteosarcoma With Initial Pulmonary Metastases

Park, H. J., Hong, K. T., Choi, J. Y., Kim, B. K., Kim, H., Park, S., Park, S., Cheon, J., & Kang, H. J. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31914 · Cited by 1

IRF2BPL inhibits proliferation, migration and invasion of osteosarcoma cells by inhibiting FOSL2-mediated PI3K/AKT pathway activation

Liu, W., Xia, K., Huang, X., Wei, Z., Wei, Z., & Guo, W. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112068 · Cited by 1

The role of everolimus in malignant bone tumor therapy: Molecular mechanisms, preclinical evidence, and advances in clinical applications

Zhang, Y., Dong, Y., Zhang, Y., Liang, G., Yu, G., Zhang, D., & Dai, C. (2025) · Oncology Reviews · doi:10.3389/or.2025.1630239 · Cited by 2

Pravastatin for Radiation‐Induced Fibrosis of the Extremity: A Single‐Center Experience

Offenbacher, R., Fabish, L., Lee, A., Yang, R., Hoang, B. H., Geller, D. S., Fox, J. L., Loeb, D. M., & Baker, A. C. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.32084 · Cited by 1

Effect of recombinant human erythropoietin on postoperative anemia in children and adolescents undergoing osteosarcoma and potential influencing factors: a single-center retrospective study

Liu, L., Lin, M., Yang, W., Yao, D., Luo, H., Yu, L., & Dai, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1637441 · Cited by 1

Doxorubicin Impairs Skeletal Muscle Regeneration by Dysregulating the Early Inflammatory Response

Kondo, S., Ishizaka, T., Yamada, M., Yonehara, S., Sasaki, H., Isaji, M., Nakagawa, T., & Horiuchi, K. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00165 · Cited by 1

hMSCs-derived exosomal MIR17HG promotes follicular helper T cell differentiation and osteosarcoma progression via the miR-372-3p/BCL6 axis

Qi, J., Xue, G., Wu, B., Zhu, P. W., & Wang, Y. Y. (2025) · Journal of bone oncology · doi:10.1016/j.jbo.2025.100726 · Cited by 1

Lower Limb Biomechanical Outcomes Following Endoprosthetic Reconstruction for Distal Femur and Proximal Tibia Bone Tumors: A Systematic Review and Meta-Analysis

Gao, Y., Yang, B., Zhang, Q., Hu, G., Liu, Y., Zhang, K., Sun, J., & Yan, S. (2025) · Bioengineering · doi:10.3390/bioengineering12121310 · Cited by 1

Stiffness-transformable photoimmune nanostimulators for remodeling tumor microenvironment of osteosarcoma and inhibiting lung metastasis

Yi, X., Tao, J., Chen, Y., Yuan, Y., Teng, Z., Li, P., & Yu, A. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168995 · Cited by 1

NIR/TME-responsive release of zoledronic acid-loaded LDHs on ZE21C magnesium alloy with multi-therapy for osteosarcoma

Li, D., Zhang, T., Jia, S., Yu, J., Sun, R., Yin, B., Wang, L., Bai, L., Chen, L., & Guan, S. (2026) · Journal of Magnesium and Alloys · doi:10.1016/j.jma.2025.101975 · Cited by 1

DLST mediates the malignant progression of osteosarcoma cells by regulating the p38 MAPK signaling pathway

Guo, C., Liao, K., Xu, K., Zhang, J., Chen, G., Luo, X., Yang, J., Dai, Z., Lv, X.-B., Zhang, F., et al. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153341 · Cited by 1

MMP10 is highly expressed in an osteosarcoma stem cell model and predicts poor prognosis

Yoshimoto, M., Tsuji, S., Hayashida, S., Sawada, Y., Tanaka, Y., Tokumura, K., & Hinoi, E. (2026) · Gene · doi:10.1016/j.gene.2026.150030 · Cited by 1

Magnesium phosphate cement modulates osteosarcoma stemness and osteogenesis via IGFBP5 activation for localized tumor therapy

Yu, L., Chen, J., Shi, D., Li, S., Chen, Z., & Guo, W. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.115643 · Cited by 1

The Role of DNA Methylation in Osteosarcoma Pathogenesis and Therapy

Zhou, X., Li, B., & Tao, P. (2026) · OncoTargets and Therapy · doi:10.2147/ott.s581744 · Cited by 1

LARS promotes osteosarcoma proliferation through leucine-dependent PRIM2 translation and DNA replication activation

Bai, G., Zhang, L., Zhao, M., Zhang, J., & Chen, W. (2026) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-026-03691-w · Cited by 1

Osteosarcoma cells promote intracellular iron detoxification to mitigate GPX4-mediated ferroptosis

Abdullah, M., Lee, D., Nipa, E., Castellanos-Gell, J., Chan, A. M., Maldonado, O. H., Salute, M. E., Nance-Richey, R., Milner, R. J., & Kim, J. H. (2026) · Cancer Gene Therapy · doi:10.1038/s41417-026-01021-y · Cited by 1

ASB7 promotes osteosarcoma lung metastasis through ubiquitin-mediated degradation of ATF2

Zou, Y., Zhong, J., Huo, L., Chen, J., Yu, X., Wang, J., Chen, Z., Yin, L., Zeng, C., Zhang, X., et al. (2026) · Cell Discovery · doi:10.1038/s41421-026-00890-9 · Cited by 1

Lapatinib induces ferroptosis in osteosarcoma via the SLC1A5-GPX4 axis

Miao, H., Fu, X., Liu, B., Pan, X., Han, Y., & Yu, Z. (2026) · Journal of bone oncology · doi:10.1016/j.jbo.2026.100771 · Cited by 1

The emerging role of lactate in skeletal homeostasis and disorders: Integrated mechanisms and translational opportunities

Zong, B., Yu, F., Li, S., & Sun, P. (2026) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2026.101144 · Cited by 1

Understanding and Overcoming Osteosarcoma Heterogeneity

Cho, S., Shelmidine, K., & Yustein, J. T. (2026) · Biomolecules · doi:10.3390/biom16060874 · Cited by 1

Ginsenoside Rk1 suppresses osteosarcoma progression by coordinately activating ferritinophagy and disrupting antioxidant defense to induce ferroptosis

Lin, R., Wu, J., Fang, R., Suo, Y., Lu, H., & Liu, Q. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.06.052 · Cited by 1

LncRNA SPINT1-AS1 enhances the Warburg effect and promotes the progression of osteosarcoma via the miR-135b-5p/PGAM1 axis

Wang, J., Zhang, N., Wang, Y., Chen, F., Wang, L., Wang, K., Yao, X., & Pan, X. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03761-7 · Cited by 1

T2-weighted magnetic resonance imaging radiogenomic features for the prediction of neoadjuvant chemotherapy response in patients with osteosarcoma

Yin, P., Xu, J. H., Liu, Y., Wang, S., Liu, T., Tang, X., & Hong, N. (2025) · Acta Radiologica · doi:10.1177/02841851251337849 · Cited by 1

Intelligent drug codelivery platform for immune microenvironment reconstruction and immunochemotherapy in osteosarcoma treatment

Zhang, Y., Wu, Y., Xie, Y., Liu, G., & Wang, S. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107218 · Cited by 1

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

Niu, X., Zhang, X., Li, Z., & Tian, W. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1620648 · Cited by 1

In vitro characterization of OSA-424 and OSA-55: new canine models for osteosarcoma research

Zhou, H., Wang, X., Umar, T., Li, W., He, L., Feng, W., Zhang, J., Chen, N., Deng, G., & Qiu, C. (2025) · Veterinary Quarterly · doi:10.1080/01652176.2025.2567523 · Cited by 1

Stereotactic Body Radiation Therapy Augmented Checkpoint Inhibitor Immunotherapy Response in Heavily Pretreated Metastatic Osteosarcoma

Zhu, C., Xu, Y., Wen, J., Zhang, Z., Liang, T., Chen, X., Wang, X., Liu, Q., Wang, B., Fu, Y., et al. (2025) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2025.11.042 · Cited by 1

Integrated strategies of network pharmacology, transcriptomics, and computational and experimental validation reveal the anti-osteosarcoma effects of juglone via the ROS/PI3K/AKT pathway

Miao, H., Liu, B., Pan, X., Cheng, Z., Xue, Q., Han, D. H., Yu, Z., Zhang, L., & Bai, X. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.178462 · Cited by 1

Next‐Generation Therapies for Bone Cancer: Targeted Therapy, Immunotherapy, and Nanomedicine Innovations

Wang, K., Silli, E. K., Lv, H., & Song, R. (2025) · Drug Development Research · doi:10.1002/ddr.70207 · Cited by 1

Formononetin suppresses osteosarcoma by targeting MYO1B and remodeling the tumor immune microenvironment

Liu, Y., Xiong, L., Feng, W., Xie, T., Liang, J., Yang, M., Li, S., Luo, K., Li, F., Tang, S., et al. (2025) · APL Bioengineering · doi:10.1063/5.0284083 · Cited by 1

Anti-tumor effects of Guggulsterone in osteosarcoma: Role of SIRT3-mediated PINK1-Parkin mitophagy activation

Zeng, L., Li, S., Wu, K., Bai, X., & Zhang, L. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.157860 · Cited by 1

HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

Wang, Z., Guo, Z. Q., Cao, C., Wang, Z., Huang, Z., Zhang, X., Zheng, Y., She, D., Zhu, H., Yu, L., et al. (2026) · Advanced Science · doi:10.1002/advs.202515651 · Cited by 1

Matrix micro/nano-topography drives oncogenic signaling and drug response in a 3D osteosarcoma model

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