New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

Benzobisthiazole polymer nanocarriers for temperature-responsive controlled drug release and synergistic chemo-photothermal therapy

Tu, Y., Zheng, G., Wu, Y., Lu, M., Hu, B., Yang, K., Huang, S., Zhang, X., Sun, G., & Ouyang, Y. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116128

What’s new in pediatric bone sarcomas and benign bone tumors

von der Weid, N., Baumhoer, D., & Krieg, A. H. (2026) · Journal of Children s Orthopaedics · doi:10.1177/18632521261444250

Calpain-dependent antigen processing generates a tumor-associated epitope recognized by osteosarcoma-infiltrating T cellsPreprint

Itabashi, T., Minowa, T., Emori, M., Minami, A., Mizue, Y., Murai, A., Takaya, A., Asanuma, H., Sasaki, K., Morita, R., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9104987/v1

Prognostic and Predictive Value of CD163+ Macrophages for Neoadjuvant Chemotherapy in Osteosarcoma

Luo, Y., Wang, B., Feng, W., Xu, Z., Wu, H., Yan, Z., Guo, H., & Liu, W. T. (2026) · Biomedicines · doi:10.3390/biomedicines14050991

Effect of Osteoblast-Derived Extracellular Vesicles on Osteosarcoma Cells’ Transcriptional Profile: Role of Shuttled miRNAs

Giacchi, L., Ucci, A., Zelli, V., Compagnoni, C., Pucci, E., Tessitore, A., Ponzetti, M., & Rucci, N. (2026) · Biomedicines · doi:10.3390/biomedicines14051039

Combined Inhibition of ATR and Ribonucleotide Reductase Induces Synergistic Antineoplastic Activity in Osteosarcoma Cells

Aderhold, N., Immesberger, L., Becker, S., Milde, T., Gruhn, B., & Sonnemann, J. (2026) · Cancer Reports · doi:10.1002/cnr2.70568

Physeal breach as a potential predictor of pulmonary metastasis in paediatric osteosarcoma

Lin, Z., Huang, P., Shan, J., Qi, Z., Liang, M., Cao, B., & Ning, B. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1756381

Cavitation-Free Acoustic Sensitization Enhances PLK4-Targeted Therapy Using the Phillyrin Derivative DE02 in Osteosarcoma

Yang, J., Wang, H., He, Z., Wang, W., & Qian, J. (2026) · Cancer Biotherapy and Radiopharmaceuticals · doi:10.1177/10849785261446291

Research Progress of Cuproptosis in Orthopaedics: Opportunities and Challenges

Wang, C., & An, P. (2026) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.71175

COMPREHENSIVE IMMUNOPHENOTYPIC CHARACTERIZATION OF SARCOMA CELL CULTURES BY Five TUMOR MOLECULAR MARKERS

Bogush, T. A., Grishanina, A. N., Dorzhieva, S. S., Богуш, Е. А., Scherbakov, A. M., Kirsanov, V. Y., Kosobokova, E. N., & Melnikov, M. Y. (2026) · Lomonosov chemistry journal · doi:10.55959/msu0579-9384-2-2026-67-3-206-214

LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction via HO-1/ACSL4 axis

Yang, M., Liu, P., Zhang, H., Tang, X., Hong, X., Liu, Y., Deng, M., Tu, X., & Shao, G. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1832247

Machine learning–based integrative analysis identifies CXCL13-driven tertiary lymphoid structures as favorable immune and prognostic features in osteosarcoma

Jiang, J., Xu, J., Xie, L., Yu, Y., Sun, X., Sun, X., Yang, S., Wang, H., Ren, T., & Tang, X. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01226-1

Coupled Ionic‐Molecular Release Governed by Dissolution and Diffusion in Multicomponent Bioactive Glass Nanoparticles

Ganem, G. C. A., Chambi, J. T., Pagan, B. M., Cuffini, S. L., & Lopes, J. H. (2026) · International Journal of Applied Ceramic Technology · doi:10.1111/ijac.70210

PSIP1 Orchestrates Immune Escape in Osteosarcoma: Insights From Single‐Cell Analysis and Implications for Immunotherapy Resistance

Liu, S., Yan, H., Ku, W., & Liu, G. (2026) · International Journal of Genomics · doi:10.1155/ijog/2344901

A retrospective study on the efficacy and safety of anlotinib combined with limb salvage therapy for osteosarcoma after chemotherapy failure

Sun, Y., Fan, D., Jin, T., Li, Z., & Liu, W. T. (2026) · Medicine · doi:10.1097/md.0000000000048632

Halicin-loaded injectable hyaluronic acid hydrogel for ferroptosis-driven osteosarcoma therapy via Fe2+ accumulation

Hu, X., Zhuang, H., Gao, K., Zhu, Y., Gao, F., Wang, H., Zhang, Z., Su, B., Zhang, Y., & Shen, C. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152656

NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes

Zhang, Z., Wan, L., Ai, K., Liu, J., Tang, X., 段志西, & Chen, R. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04347-7

Paget's Disease of the Spine as a Catalyst for Osteosarcoma: A Narrative Review

Montesinos, G. F. D. R., Yoon, K., Ayano, A., Lee, L., Ehioghae, M., Japa, J. P., Benn, L., & Mesfin, A. (2026) · Cureus · doi:10.7759/cureus.109625

Pulmonary Metastasectomy: Current Guidelines and Future Directions

Kossar, A., & Bonanno, A. M. (2026) · Current Surgery Reports · doi:10.1007/s40137-026-00507-w

Metabolic–immune crosstalk in osteosarcoma: mechanisms and therapeutic opportunities

Wan, X., He, W., He, B., & Chen, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1818745

Comparison of the effectiveness of neoadjuvant chemotherapy versus upfront surgery for osteosarcoma: A target trial emulation study

Zhong, G., Gu, H., Huo, Z., Zhu, M., Gingold, J. A., Lee, D., Huang, G., Shen, J., & Tu, J. (2026) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2026.111915

Comprehensive Immunophenotypic Characterization of Sarcoma Cell Cultures by Five Tumor Markers

Богуш, Т. А., Grishanina, A. N., Dorzhieva, S. S., Bogush, E. A., Scherbakov, A. M., Kirsanov, V. Y., Kosobokova, E. N., & Melnikov, M. Y. (2026) · Moscow University Chemistry Bulletin · doi:10.3103/s0027131426700112

Mitochondria-targeted photodynamic nanoparticles boost antitumor immunity by suppressing mitophagy in osteosarcoma

Deng, Q., (255117), J. L., Tong, Z., Zhang, L., Tang, Y., Liu, J., Wang, D., Zeng, J., Li, Z., Zhang, Y., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.05.028

Pre-clinical validation of OSCAR-3 mRNA-based CAR T cells for targeting osteosarcomas

Mensali, N., Joaquina, S., Montlaur, C. D., Casey, N. P., Nesset, T., Myklebost, O., McCormack, E., Pasetto, A., Gunnes, M. W., Gélébart, P., et al. (2026) · Cytotherapy · doi:10.1016/j.jcyt.2026.102930

A diagnostic nomogram for synchronous lung metastasis at initial diagnosis in osteosarcoma: A retrospective SEER database study

Ge, S., Yu, Y., Hu, L., & Niu, Y. (2026) · Journal of orthopaedic surgery · doi:10.1177/10225536261462612

Transcriptome-Inferred metabolic subtypes define prognostic and immune ecosystems in osteosarcoma at single-cell resolution

Hu, L., Zhang, D., Wang, B., Liu, Q., Liao, X., Qi, F., Chen, L., Liu, H., Zhao, Z., Liang, H., et al. (2026) · Frontiers in Pediatrics · doi:10.3389/fped.2026.1831516

The PTHR1/PKA/CREB1 axis promotes osteosarcoma progression by activating the PVT1/miR-590-3p/AXIN2 ceRNA network to induce epithelial-mesenchymal transition

Zhang, J., Li, W., Liu, F., Zhang, H., & Wang, W. (2026) · Biology Direct · doi:10.1186/s13062-026-00849-6

Radiomics-based causal machine learning for exploratory treatment-effect estimation of neoadjuvant chemotherapy cycle intensity in osteosarcoma: a proof-of-concept study

Yuan, Z., Wang, R., Zhang, H., Zheng, Z., Zhou, X., Xing, J., Zhai, W., Cao, X., Zhao, C., Zhou, T., et al. (2026) · BMC Medical Imaging · doi:10.1186/s12880-026-02533-7

Large‐scale osteosarcoma sequencing reveals age‐associated genomic architectures

Guo, Z., & Xie, X. (2026) · Cancer · doi:10.1002/cncr.70522

P53-Armed Oncolytic Virotherapy Promotes the Efficacy of PD1 Blockade in Murine Osteosarcoma Tumors

Kure, M. (2026) · Institutional Repositories DataBase (IRDB) · doi:10.18926/70666

Analysis of a large osteosarcoma sequencing data set elucidates patterns of genomic alterations

Bender, H. G., Kuang, Z., de la Vega, L. L., Ceca, E., Schiantarelli, J., Honecker, J., Hiemenz, M., Forrest, S. J., & Janeway, K. A. (2026) · Cancer · doi:10.1002/cncr.70500

Single-cell and longitudinal transcriptomics-guided engineering of FZD1-targeting precision nanotherapy against osteosarcoma cancer stem cells

Chen, Z., Li, Z., Yu, W., Huang, H., Chen, J., Jiang, Y., Zhou, X., Zhong, L., Zhuo, H., Jia, Y., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.07.009

Integrated Bulk and Single-Cell Transcriptomics Reveals the C3–C3AR1 Axis as a Candidate Mediator of Coagulome-Immune Crosstalk in Osteosarcoma

Mu, J., Wang, Y., Liu, H., He, X., Li, Z., Lu, M., Tang, F., Luo, Y., Zhou, Y., Li, M., et al. (2026) · Biomedicines · doi:10.3390/biomedicines14081686

Focal Adhesion Kinase Activation Mediates IQ Motif-Containing GTPase-Activating Protein 3–Promoted Lung Metastasis in Osteosarcoma

Cao, J., Li, Y., He, L., pan, D., Wang, C., Li, J., Sun, K., Li, X., Aziz, F., Xiao, J., et al. (2026) · American Journal Of Pathology · doi:10.1016/j.ajpath.2026.06.011

Biomimetic multistage drug delivery system for reversing chemoresistance in osteosarcoma

Li, X., Xu, S., Peng, Y., Su, Z., Wang, S., Li, A., Du, Y., Shao, Z., & Huang, X. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180066

MiRNA-140-3p affects the proliferation and metastasis of osteosarcoma via the UBE2C/PI3K-Akt axis

Yang, X., Xiang, Y., Liu, H., Li, Z., Luo, Z., Liu, J., Bao, Y., & Yang, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1742599

Formononetin Antagonizes Osteosarcoma Metastasis by Targeting CD44: An Integrated Multi-Omics Study

Feng, W., Dai, W., Wei, G., Li, S., Teng, H., Xiao, D., Zhong, C., Li, F., & Liu, Y. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158612

Phase‐Separated Nanoarchitecture of Adhesion‐Cytoskeleton Force Coupling Reforms Nuclear Spatiotemporal Posture Conformation and Mechanotransduction of Osteosarcoma on Biofunctional Microarrays

Fan, H., Cui, X., Hou, Y., Xu, S., Lee, K., Chen, Q., Wang, N., Wang, Q., Wang, Y.-T., & Zhang, X. (2026) · Advanced Healthcare Materials · doi:10.1002/adhm.71508

Self-powered electro-activated MgxFe1-xS2 scaffold for gas-ion therapy in osteosarcoma suppression and bone regeneration

Lu, B., Chen, Z., Yan, S., Yu, D., Yue, X., Zhang, Y., Zhang, M., Guo, J., Xu, B., Li, X., et al. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.124519

A single‐molecule prodrug synergistically suppresses MYC‐amplified osteosarcoma through sequential nitric oxide release and photodynamic therapy

Peng, S., Wu, J., Wang, S., Gao, Y., Guo, X., Li, M., Wu, Y., Wang, Y., Cai, Z., Hua, Y., et al. (2026) · Smart Molecules · doi:10.1002/smo2.70084

The efficacy of whole-course nursing on malignant bone and soft tumors of lower limbs: A randomized study

Wang, L., Tian, W., Jing, J., Yin, M., & Sun, Y. (2026) · Medicine · doi:10.1097/md.0000000000049172

The prognostic value of pretreatment complete blood count parameters in primary osteosarcoma: a multicenter study of 449 patients receiving neoadjuvant therapy

Yu, W., Yixuan, K., Jin, L., Wen, J., Bao, Q., Liu, B., Tao, H., Fu, Y., & Zhang, W. (2026) · European journal of medical research · doi:10.1186/s40001-026-05003-6

Near-infrared light-triggered nitric oxide-enhanced chemodynamic and photothermal therapy on magnesium alloy implants in osteosarcoma

Wang, Y., Chen, L., Zhou, Z., Liang, Y., Zhang, T., Sun, R., Tian, Y., Liu, Y., Fu, Y., Wang, H., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.180513

Potential protective function and causal association of LEPR in osteosarcoma

Li, Q., Man, Q., & Zhang, H. (2026) · Medicine · doi:10.1097/md.0000000000050202

Single-cell multi-omics reveals NUF2 as a potential biomarker associated with the high-lactylation malignant state in osteosarcoma

Huang, Y., Feng, T., Yang, B., Yu, Q., Wang, Y., Feng, L., Wei, X., & Tang, F. (2026) · The International Journal of Biological Markers · doi:10.1177/03936155261465683

A universal consuming endogenous H2S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance

Lin, Y., Yuan, K., Liu, Y., Du, Y., Chang, H., Hou, L., Liang, Y., Huang, K., Yang, S., & Tang, T. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.08.011

Diagnostic et surveillance des ostéosarcomes

Hammoud, S., Larousserie, F., Charlon, S., Bourdet, C., Feydy, A., & Drapé, J. (2026) · EMC - Radiologie et imagerie médicale - Musculosquelettique - Neurologique - Maxillofaciale · doi:10.1016/s1879-8551(26)43580-0

The Role of Alveolar Pneumocytes in the Lung Microenvironment of Osteosarcoma MetastasesPreprint

Pereira, J. S., McGee, L. E., Garg, A., Silver, K. I., McEachron, T. A., Mazcko, C. N., LeBlanc, A. K., & Beck, J. A. (2026) · Research Square · doi:10.21203/rs.3.rs-10540427/v1

LNP-mediated silencing of oncogenic lncRNA PVT1 enhances chemotherapeutic efficacy in osteosarcoma

Wei, J., Zetao, Q., Qin, Q., Chen, H., Liang, W., Wang, T., Wang, S., Wang, W., Wang, Y., & Wang, Y. (2026) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2026.102732

Coordinated circRNA Silencing and Chemotherapy by pH-Responsive Nanoparticles Reprogram Cell Death in Drug-Resistant Osteosarcoma

Wang, X., Chen, C., Ma, X., Tan, S., Zhu, K., Hu, J., Zhu, J., Li, C., Du, J., & Zhang, C. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c02632

Incidence of Osteosarcoma and the Impact of Treatment on Survival: A Population‐Based Study

Cao, Y., Liu, T., Zhao, W., Li, M., Yu, L., Cai, Z., & Zhang, T. (2026) · International Journal of Clinical Practice · doi:10.1155/ijcp/3525919

TLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune Microenvironment

Zhang, X., Zeng, H., Qin, F., Wei, Y., Wan, D., & Wei, X. (2026) · MedComm – Oncology · doi:10.1002/mog2.70093

Surface and global proteomics identify ROR2 and other proteins as potentially actionable immunotherapeutic targets in osteosarcoma

Mooney, B., Chu, X., Negri, G. L., Lizardo, M. M., Song, H., Marsh, A., Delaidelli, A., Huang, Y. Z., Rouleau, M., Spencer, S. E., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117884

TSSC3 as a potential biomarker in osteosarcoma: implications for angiogenesis

Feng, H., Xu, W., Feng, Q., Wei, X., Huang, M., & Gao, Z. (2026) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.112768

Epitranscriptomic silencing of STK25 promotes ferroptosis evasion via the METTL3–YAP–GPX4 axis in osteosarcoma

Liu, Z., Zhang, Z., Hu, F., Wen, J., Fu, Y., Liu, Q., Liang, T., Wang, J., Shen, Y., Bao, Q., et al. (2026) · Cancer Letters · doi:10.1016/j.canlet.2026.218807

Dual-targeting poly(2-oxazoline)-coated porous silicon nanoparticles for improving osteosarcoma therapy

Abdelmoneem, M. A., Esser, L., Mazrad, Z. A. I., Kempe, K., & Voelcker, N. H. (2026) · Nanoscale · doi:10.1039/d6nr02152b

NQO1‑activated self‑reinforcing bimetallic nanoplatform triggers ferroptosis and cuproptosis for osteosarcoma therapy

Zhang, Y., Bai, Q., Zhong, Y., Guo, X., Wang, S., Li, W., & Li, M. C. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116120

Research advances on tetrahedral framework nucleic acids in diseases of the skeletal, joint, spinal, nervous, and muscular systems

Wang, L., & Chen, C. (2026) · Materials Today Advances · doi:10.1016/j.mtadv.2026.100960

Licochalcone B inhibits Neuritin 1-driven perineural invasion and osteosarcoma progression via the Hedgehog signaling pathway

Wei, H., Shi, K., Huang, X., Zhang, F., Zhou, J., Lin, H., Zhong, N., Fang, X., Zhang, W., & Wang, S. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158785

Rule-derived preoperative inflammatory-lymphocyte recovery phenotype and pathological response in resected osteosarcoma: a retrospective cohort study

Liu, Y., Huang, H., Yang, K., Daxin, G., Hao, T., 周海宇, & Huang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1925540

Nutritional biomarkers regulating tumor immune microenvironment in osteosarcoma and as predictors of immune checkpoint inhibitor responses

Ren, H., & Shen, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1909913

Osteosarcoma Across the Age Spectrum: Why Outcomes Diverge and Trials Must Adapt

Collins, S. H., & Matushansky, I. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15187017

Integrative single-cell and bulk transcriptomics uncovers a lipid metabolism-related lncRNA signature alongside the ELFN1-AS1/LYPLA1 axis driving osteosarcoma progression

Wei, X., Wang, Z., Yang, Q., Lin, F., & Chen, L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1945005

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway

Ren, Z., Deng, L., Sun, J., Kang, Y., & Zhao, H. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1664094

circSATB2 promotes the proliferation and invasion of osteosarcoma via miR- 4306/SATB2Preprint

Huang, F., Zhan, Y., Fang, Z., Li, S., Zhou, Z., Guo, H., Yan, L., & Tang, F. (2026) · Research Square · doi:10.21203/rs.3.rs-10830655/v1

An immunocompetent, multifluorescent resource for real-time analysis of osteosarcoma progression, metastasis, and response to therapy

Leite, T. C., HOU, J., Geng, X., Mancinelli, L., Sedlacek, A. L., Nayak, D. A., Schoedel, K. E., Weiss, K. R., Binder, R. J., Lin, C. P., et al. (2026) · Science Advances · doi:10.1126/sciadv.aed6938

Nanocarrier-mediated immune microenvironment remodelling in osteosarcoma

Fu, J., Bi, Z., Wei, R., Lv, S., & Guo, Y. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103181

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Zhao, W., Cheng, Z., Tian, K., Sun, M., Wang, Z., Jiao, M., Luebeck, J., Zhu, K., Zhang, X., Zuo, D., et al. (2026) · Advanced Science · doi:10.1002/advs.78200

Surgical Indications and Planning in Cervical Spine Oncology

Winston, G. M., Sykes, D. A. W., Newman, W. C., & Bilsky, M. (2026) · Clinical Spine Surgery A Spine Publication · doi:10.1097/bsd.0000000000002192

Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300

Delahunty, I. M., Nance, S., Zhang, Y., Lamoureux, F., Liu, Q., Wright, W. C., Ritter, K., Shendy, N. A. M., Royer, B. B.-L., Kietlinska, S. J., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20251898

Ultrasound-Activated Wireless Piezoelectric Electrotherapy Platform for Osteosarcoma Treatment

Zhai, J., Sun, T., Tian, Y., Liu, Q., Li, H., Yang, X., Zeng, W., Cai, Z., Jin, H., Wang, Z., et al. (2026) · Dental Research · doi:10.1016/j.dtrs.2026.100057

FBXO17 promotes osteosarcoma progression by regulating glycolysis and macrophage polarization

Zeng, T., & Chen, H. (2026) · Journal of Molecular Histology · doi:10.1007/s10735-026-10983-0

Integrated multi-omics profiling identifies ECM-associated and systemic metabolic alterations associated with osteosarcoma metastasis

Liu, N., Wang, J., Lai, Y., Wu, Z., Xu, C., Chen, Q., & Yang, C. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1956299

Fucosyltransferase 4 as a candidate diagnostic biomarker and potential therapeutic target in osteosarcoma: a multi-dataset transcriptomic and structural bioinformatics analysisPreprint

Sun, X., Yan, H., Han, K., Zhu, H., Min, D., & Tian, C. (2026) · Research Square · doi:10.21203/rs.3.rs-11194919/v1

Osteosarcoma – conventional treatment vs. gene therapy

Tan, M. L., Choong, P., & Dass, C. R. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.2.7385 · Cited by 99

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13

The Genetics of Osteosarcoma

Martin, J. W., Squire, J. A., & Zieleńska, M. (2012) · Sarcoma · doi:10.1155/2012/627254 · Cited by 254

Making gene therapy for osteosarcoma a reality

Broadhead, M. L., Clark, J. C. M., Choong, P., & Dass, C. R. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.18 · Cited by 12

Genome-Informed Targeted Therapy for Osteosarcoma

Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452