New Horizons in the Treatment of Osteosarcoma

New Guidelines to Evaluate the Response to Treatment in Solid Tumors

Therasse, P., Arbuck, S. G., Eisenhauer, E. A., Wanders, J., Kaplan, R. S., Rubinstein, L., Verweij, J., Van Glabbeke, M., van Oosterom, A. T., Christian, M. C., et al. (2000) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/92.3.205 · Cited by 15,660

The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging

Amin, M. B., Greene, F. L., Edge, S. B., Compton, C. C., Gershenwald, J. E., Brookland, R. K., Meyer, L., Gress, D. M., Byrd, D. R., & Winchester, D. P. (2017) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21388 · Cited by 6,531

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

Malkin, D., Li, F. P., Strong, L. C., Fraumeni, J. F., Nelson, C. E., Kim, D. H., Kassel, J., Gryka, M. A., Bischoff, F. Z., Tainsky, M. A., et al. (1990) · Science · doi:10.1126/science.1978757 · Cited by 3,765

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

Friend, S. H., Bernards, R., Rogelj, S., Weinberg, R. A., Rapaport, J. M., Albert, D. M., & Dryja, T. P. (1986) · Nature · doi:10.1038/323643a0 · Cited by 2,948

A System for the Surgical Staging of Musculoskeletal Sarcoma

Enneking, W. F., Spanier, S. S., & GOODMAN, M. A. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198011000-00013 · Cited by 2,661

Massive genomic rearrangement acquired in a single catastrophic event during cancer development

Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S. S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.20.3.776 · Cited by 2,393

Prognostic Factors in High-Grade Osteosarcoma of the Extremities or Trunk: An Analysis of 1,702 Patients Treated on Neoadjuvant Cooperative Osteosarcoma Study Group Protocols

Bielack, S., Kempf-Bielack, B., Delling, G., Exner, G. U., Flege, S., Helmke, K., Kotz, R., Salzer-Kuntschik, M., Werner, M., Winkelmann, W., et al. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.3.776 · Cited by 2,391

Mutational Processes Molding the Genomes of 21 Breast Cancers

Nik-Zainal, S., Alexandrov, L. B., Wedge, D. C., Van Loo, P., Greenman, C. D., Raine, K., Jones, D., Hinton, J., Marshall, J., Stebbings, L. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.024 · Cited by 1,909

High-performance pyrite nano-catalyst driven photothermal/chemodynamic synergistic therapy for Osteosarcoma

Li, M., Wang, M., Huang, J., Tang, S., Yang, J., Xu, Z., Xu, G., Chen, X., Liu, J., & Yang, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02419-2 · Cited by 21

Eriodictyol-cisplatin coated nanomedicine synergistically promote osteosarcoma cells ferroptosis and chemosensitivity

Lin, Z., Li, Y., Wu, Z., Liu, Q., Li, X., & Luo, W. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03206-3 · Cited by 20

Biology-guided precision medicine in rare cancers: Lessons from sarcomas and neuroendocrine tumours

van der Graaf, W. T. A., Tesselaar, M. E. T., McVeigh, T. P., Oyen, W. J. G., & Fröhling, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.05.011 · Cited by 20

Integrated multiomic analysis and high‐throughput screening reveal potential gene targets and synergetic drug combinations for osteosarcoma therapy

Zhang, W., Qi, L., Liu, Z., He, S., Wang, C., Wu, Y., Han, L., Liu, Z., Fu, Z., Tu, C., et al. (2023) · MedComm · doi:10.1002/mco2.317 · Cited by 20

Integrating Radiogenomics and Machine Learning in Musculoskeletal Oncology Care

Kumar, R. R., Sporn, K., Khanna, A., Paladugu, P., Gowda, C., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111377 · Cited by 21

pH-responsive hydrogel with gambogic acid and calcium nanowires for promoting mitochondrial apoptosis in osteosarcoma

Yang, L., Sun, Q., Chen, S., Ma, D., Yao, Q., Liu, H., Tan, S., Qin, Y., & Cai, L. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.11.055 · Cited by 19

Dual‐Defect Nitrogen‐Rich Carbon Nitride‐Based Heterostructural Nanocatalyst for Improving the Therapeutic Efficacy of αPD‐1 via Tumor Immune Microenvironment Remodelling

Hu, T., Hu, C., Ji, Y., Lu, N., Ye, L., Li, M., Xia, J., Xie, D., Jiang, S., Li, R., et al. (2025) · Advanced Materials · doi:10.1002/adma.202506363 · Cited by 19

Targeting Mitochondrial Oxidative Stress by Calcium/Copper/Elesclomol Tri-Overloaded Nanocages for Osteosarcoma Immunotherapy via Immunogenic Cell Death

Jiang, G., Zhang, F., Wu, Z., Zhang, X., Xu, J., Peng, Z., Li, G., Zhu, G., Wang, X., & Xie, W. (2025) · ACS Nano · doi:10.1021/acsnano.5c08243 · Cited by 19

Injectable agarose hydrogels and doxorubicin-encapsulated iron-gallic acid nanoparticles for chemodynamic-photothermal synergistic therapy against osteosarcoma

Ying, H., Wang, H., Jiang, G., Tang, H., Li, L., & Zhang, J. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1045612 · Cited by 19

Sorafenib inhibits doxorubicin-induced PD-L1 upregulation to improve immunosuppressive microenvironment in Osteosarcoma

Wang, J., Hu, F., Yu, P., Wang, J., Liu, Z., Bao, Q., Zhang, W., & Wen, J. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04458-4 · Cited by 19

HOXC13-driven TIMM13 overexpression promotes osteosarcoma cell growth

Han, Q., Yan, P., Song, R., Liu, F., & Tian, Q. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05910-0 · Cited by 19

KERS‐Inspired Nanostructured Mineral Coatings Boost IFN‐γ mRNA Therapeutic Index for Antitumor Immunotherapy

Shao, Z., Chen, L., Zhang, Z., Wu, Y., Mou, H., Jin, X., Teng, W., Wang, F., Yang, Y., Zhou, H., et al. (2023) · Advanced Materials · doi:10.1002/adma.202304296 · Cited by 19

Comprehensive analysis of copper-metabolism-related genes about prognosis and immune microenvironment in osteosarcoma

Lin, Z., He, Y., Wu, Z., Yuan, Y., Li, X., & Luo, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-42053-w · Cited by 19

Construction of an ER stress-related prognostic signature for predicting prognosis and screening the effective anti-tumor drug in osteosarcoma

Chen, W., Liao, Y., Sun, P., Tu, J., Zou, Y., Ji, F., Chen, Z., Li, H., Chen, J., Peng, Y., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-023-04794-0 · Cited by 19

Advancing musculoskeletal tumor diagnosis: Automated segmentation and predictive classification using deep learning and radiomics

Wang, S., Sun, M., Sun, J., Wang, Q., Wang, G., Wang, X., Meng, X., Wang, Z., & Yu, H. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.108502 · Cited by 19

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma

Liao, Y., Chen, J., Yao, H., Zheng, T., Tu, J., Chen, W., Guo, Z., Zou, Y., Wen, L., & Xie, X. S. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06086-1 · Cited by 18

Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma

Liu, Y., Li, K., Jing, L., Yang, M., Wang, D., Ye, J., Yang, X., Wan, W., Wong, J., & Xiao, J. (2025) · Bone Research · doi:10.1038/s41413-024-00395-9 · Cited by 18

The tumor microenvironment of metastatic osteosarcoma in the human and canine lung

McGee, L. E., Pereira, J. D. S., McEachron, T. A., Mazcko, C. N., LeBlanc, A. K., & Beck, J. A. (2025) · Communications Biology · doi:10.1038/s42003-025-07992-2 · Cited by 18

Brusatol induced ferroptosis in osteosarcoma cells by modulating the Keap1/Nrf2/SLC7A11 signaling pathway

Zhang, L., Luo, D., Ren, H., Fan, W., Yu, Z., Wang, S., Wu, X., Xu, Y., & Li, S. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156912 · Cited by 18

One-pot synthesized nano-heterostructure with dual-modal catalytic ROS generation ability for high-metastatic orthotopic osteosarcoma therapy

Song, H., Ji, Y., Zhu, Y., Xia, J., Hu, C., Jin, Y., Zhang, J. C., Hu, Z., & Dai, J. (2022) · Carbon · doi:10.1016/j.carbon.2022.12.053 · Cited by 18

Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma

Shi, Q., Xu, J., Chen, C., Hu, X., Wang, B., Zeng, F., Ren, T., Huang, Y., Guo, W., Tang, X., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216902 · Cited by 18

Engineering Bimetallic Polyphenol for Mild Photothermal Osteosarcoma Therapy and Immune Microenvironment Remodeling by Activating Pyroptosis and cGAS‐STING Pathway

Liu, K., Zan, P., Li, Z., Lu, H., Liu, P., Zhang, L., Wang, H., Ma, X., Chen, F., Zhao, J., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400623 · Cited by 20

CD248 promotes migration and metastasis of osteosarcoma through ITGB1-mediated FAK-paxillin pathway activation

Lu, S., Lü, T., Zhang, J., Gan, L., Wu, X., Han, D., Zhang, K., Xu, C., Liu, S., Qin, W., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-10731-7 · Cited by 17

Research Progress of Nanomaterials in Chemotherapy of Osteosarcoma

Yu, T., Cai, Z., Chang, X., Xing, C., White, S., Guo, X., & Jin, J. (2023) · Orthopaedic Surgery · doi:10.1111/os.13806 · Cited by 17

Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold: The role of glutamine metabolism

Ren, J., Zhao, C., Sun, R., Sun, J., Lu, L., Wu, J., Li, S., & Cui, L. (2024) · International Journal of Cancer · doi:10.1002/ijc.34841 · Cited by 17

Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma

Zhang, F., Chen, J., Luo, W., WEN, C., Mao, W. B., Yang, Y., Liu, C., Xu, Y., Chen, W., & Wen, L. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.123865 · Cited by 17

Identification of the shared gene signatures in retinoblastoma and osteosarcoma by machine learning

Ye, R., Yuan, Q., You, W., Huang, Y., Lin, Z., Tang, H., & Zeng, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-82789-7 · Cited by 16

EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways

Zhang, D., Han, S., Pan, X. L., Li, H., Zhao, H., Gao, X., & Wang, S. (2022) · Journal of bone oncology · doi:10.1016/j.jbo.2022.100458 · Cited by 16

Biodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophages

Luo, G., Xu, Z., Zhong, H., Shao, H., Liao, H., Liu, N., Jiang, X., Zhang, Y., & Ji, X. (2023) · Biomaterials Science · doi:10.1039/d2bm01900k · Cited by 16

Comprehensive multi-omics analysis reveals m7G-related signature for evaluating prognosis and immunotherapy efficacy in osteosarcoma

Zhang, Y., Gan, W., Ru, N., Xue, Z., Chen, W., Chen, Z., Wang, H., & Zheng, X. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100481 · Cited by 16

METTL16 promotes osteosarcoma progression by downregulating VPS33B in an m6A‐dependent manner

Cheng, J., Xu, Z., Tan, W., He, J., Pan, B., Zhang, Y., & Deng, Y. (2023) · Journal of Cellular Physiology · doi:10.1002/jcp.31068 · Cited by 16

A “biomimetic bone-magnet” with suitable mechanical properties concurrently performs accurate target collection of nanoparticles for magnetothermally driven osteosarcoma thermo-chemotherapy

Liang, B., Cao, Y., Wang, X., Zhou, H., Wang, M., Cao, Y., Lu, W., & Yu, K. (2023) · Materials & Design · doi:10.1016/j.matdes.2023.112311 · Cited by 16

Ceramide metabolism-related prognostic signature and immunosuppressive function of ST3GAL1 in osteosarcoma

Zou, Y., Guo, S., Liao, Y., Chen, W., Chen, Z., Chen, J., Wen, L., & Xie, X. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101840 · Cited by 16

Harnessing ferroptosis for enhanced sarcoma treatment: mechanisms, progress and prospects

Zeng, J., Zhang, X., Lin, Z., Zhang, Y., Yang, J., Dou, P., & Liu, T. (2024) · Experimental Hematology and Oncology · doi:10.1186/s40164-024-00498-3 · Cited by 16

Targeted anti-angiogenesis therapy for advanced osteosarcoma

Zhang, Q., Xia, Y., Wang, L., Wang, Y., Bao, Y., & Zhao, G. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1413213 · Cited by 16

From conventional to cutting edge: an exploration of osteosarcoma treatments

Sellers, G. S., Poirier, M. A., Mayberry, T. G., Cowan, B. C., Wakefield, M. R., & Fang, Y. (2025) · Medical Oncology · doi:10.1007/s12032-025-02629-0 · Cited by 16

Microfluidics-based label-free SERS profiling of exosomes with machine learning for osteosarcoma diagnosis

Jin, Y., Zhang, J., Wu, X., Qu, C., Fang, X., Yang, Y., Yuan, Y., Liu, H., & Han, Z. (2025) · Talanta · doi:10.1016/j.talanta.2025.128276 · Cited by 15

SPON2 facilitates osteosarcoma development by inducing M2 macrophage polarization through activation of the NF-κB/VEGF signaling axis

Lu, X., Zhang, X., Zhang, F., Wang, W., Liu, R., Hou, Y., Shi, W., Li, J., & Peng, C. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02626-2 · Cited by 15

Osteosarcoma: A Comprehensive Morphological and Molecular Review with Prognostic Implications

Motassime, A. E., Vitiello, R., Comodo, R. M., Capece, G., Bocchino, G., Bocchi, M. B., Maccauro, G., & Meschini, C. (2025) · Biology · doi:10.3390/biology14101407 · Cited by 16

The regulatory networks and mechanisms of bone microenvironment in tumorigenesis and metastasis

Huang, G., Hou, T., Song, D., & Meng, T. (2025) · Journal of bone oncology · doi:10.1016/j.jbo.2025.100729 · Cited by 15

Molecular characterization of immunogenic cell death indicates prognosis and tumor microenvironment infiltration in osteosarcoma

Liu, Z., Liu, B., Feng, C., Li, C., Wang, H., Zhang, H., Liu, P., Li, Z., He, S., & Tu, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1071636 · Cited by 15

Naturally occurring canine sarcomas: Bridging the gap from mouse models to human patients through cross-disciplinary research partnerships

Klosowski, M. L., Haines, L. A., Alfino, L., McMellen, A. N., Leibowitz, M. J., & Regan, D. P. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1130215 · Cited by 15

Prognostic and predictive value of super-enhancer-derived signatures for survival and lung metastasis in osteosarcoma

Huang, G., Zhang, X., Xu, Y., Chen, S., Cao, Q., Liu, W., Fu, Y., Jia, Q., Shen, J., Yin, J., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-04902-8 · Cited by 15

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma

Zhou, Y., Ray, P. S., Zhu, J., Stein, F., Rettel, M., Sekaran, T., Sahadevan, S., Perez-Perri, J. I., Roth, E. K., Myklebost, O., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47031-y · Cited by 15

Bone‐Targeted Fluoropeptide Nanoparticle Inhibits NF‐κB Signaling to Treat Osteosarcoma and Tumor‐Induced Bone Destruction

Li, L., Rong, G., Gao, X. Y., Cheng, Y., Sun, Z., Cai, X., & Xiao, J. (2024) · Advanced Science · doi:10.1002/advs.202412014 · Cited by 15

Iron oxide nanoparticles coated with bioactive materials: a viable theragnostic strategy to improve osteosarcoma treatment

Benjamin, A. S., & Nayak, S. (2025) · Discover Nano · doi:10.1186/s11671-024-04163-w · Cited by 16

Single-cell and spatial transcriptomics reveals the key role of MCAM+ tip-like endothelial cells in osteosarcoma metastasis

Tang, H., Cai, Y., Yang, M., Tang, S., Huang, Q., Li, H., Liu, S., Teng, H., Xie, T., He, M., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00896-8 · Cited by 15

Identification of a Solute Carrier Family-Based Signature for Predicting Overall Survival in Osteosarcoma

Zheng, D., Wei, Z., & Guo, W. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.849789 · Cited by 15

Comprehensive analysis of potential cellular communication networks in advanced osteosarcoma using single-cell RNA sequencing data

Xu, N., Wang, X., Wang, L., Song, Y., Zheng, X., & Hu, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1013737 · Cited by 15

Gadolinium-Bisphosphonate Nanoparticle-Based Low-Dose Radioimmunotherapy for Osteosarcoma

Zhang, S., Wu, Y., Yu, J., Ma, C., Wang, Y., Wang, Y., Li, L., & Zhang, L. W. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00880 · Cited by 15

Nanosized drug delivery strategies in osteosarcoma chemotherapy

Chen, C., Wang, S., Wang, J., Yao, F., Tang, X., & Guo, W. (2023) · APL Bioengineering · doi:10.1063/5.0137026 · Cited by 15

MicroRNA ‐324‐3p inhibits osteosarcoma progression by suppressing PGAM1 ‐mediated aerobic glycolysis

Weng, Y., Duan, W., Yu, X., Wu, F., Yang, D., Jiang, Y., Wu, J., Wang, M., Wang, X., Shen, Y., et al. (2023) · Cancer Science · doi:10.1111/cas.15779 · Cited by 16

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02)

Xie, L., Liang, X., Xu, J., Sun, X., Liu, K., Sun, K., Li, Y., Tang, X., Li, X., Zhan, X., et al. (2023) · BMC Cancer · doi:10.1186/s12885-023-11390-4 · Cited by 14

Advancements in Diagnosis and Treatment of Cardiac Sarcomas: A Comprehensive Review

Wang, X., Luan, X., Yin, W., Wang, Y., Li, X., Chen, R., Zhang, G., Zhao, R., Dong, X., Zhang, Z., et al. (2025) · Current Treatment Options in Oncology · doi:10.1007/s11864-024-01287-0 · Cited by 14

Osteosarcoma cell–derived CCL2 facilitates lung metastasis via accumulation of tumor-associated macrophages

Kondo, H., Tazawa, H., Fujiwara, T., Yoshida, A., Kure, M., Demiya, K., Kanaya, N., Hata, T., Uotani, K., Hasei, J., et al. (2025) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-025-04051-x · Cited by 14

Chargeable persistent luminescence 3D-printed scaffolds: A stepwise tactic for osteosarcoma treatment

Huang, R., Ni, N., Su, Y., Gu, L., Ju, Y., Zhang, D., Li, J., Chang, M., Chen, Y., Gu, P., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147436 · Cited by 14

Blocking CXCR4 – CARM1 – YAP axis overcomes osteosarcoma doxorubicin resistance by suppressing aerobic glycolysis

Li, Z., Lu, H., Zhang, Y., Lv, J., Zhang, Y., Xu, T., Dong, Y., Duan, Z., Guan, Y., Jiang, Z., et al. (2024) · Cancer Science · doi:10.1111/cas.16295 · Cited by 14

Spatial Heterogeneity of PD-1/PD-L1 Defined Osteosarcoma Microenvironments at Single-Cell Spatial Resolution

Yang, C. H., Lai, Y., Wang, J., Chen, Q., Pan, Q., Xu, C., Mo, P., Guo, G., Chen, R., Liu, N., et al. (2024) · Laboratory Investigation · doi:10.1016/j.labinv.2024.102143 · Cited by 14

Harnessing multi‑omics to revolutionize understanding and management of osteosarcoma: A pathway to precision medicine (Review)

Chen, X., Tian, B., Wang, Y., Zheng, J., & Kang, X. (2025) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2025.5533 · Cited by 14

Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma

Huang, T., Chen, Y., Zhao, Q., Wu, X., Li, H., Luo, X., Su, Y., Zhang, S., Liu, P., & Tang, N. (2025) · Research · doi:10.34133/research.0708 · Cited by 14

Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression

Shi, Y., Tian, Y., Sun, X., Qiu, Y., & Zhao, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.889583 · Cited by 14

The Future of HER2-Targeted Treatment for Osteosarcoma: Lessons from the Negative Trastuzumab Deruxtecan Results

Nakano, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316823 · Cited by 14

Analysis of intercellular communication in the osteosarcoma microenvironment based on single cell sequencing data

Chen, F., Liu, J., Yang, T., Sun, J., He, X., Fu, X., Qiao, S., An, J., & Yang, J. (2023) · Journal of bone oncology · doi:10.1016/j.jbo.2023.100493 · Cited by 14

From biology to personalized medicine: Recent knowledge in osteosarcoma

Mohr, A., Costa, M. E. M. D., Fromigué, O., Audinot, B., Balde, T., Droit, R., Abbou, S. D., Khneisser, P., Berlanga, P., Pérez, E., et al. (2024) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2024.104941 · Cited by 13

FoxG1/BNIP3 axis promotes mitophagy and blunts cisplatin resistance in osteosarcoma

Pan, B., Li, Y., Han, H., Zhang, L., Hu, X., Pan, Y., & Peng, Z. (2024) · Cancer Science · doi:10.1111/cas.16242 · Cited by 13

Ubiquitination in osteosarcoma: unveiling the impact on cell biology and therapeutic strategies

Shen, J., Lai, Y., Wu, Y., Lin, X. H., Zhang, C., & Liu, H. (2024) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2024.0231 · Cited by 13

PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma

Oyama, T., Brashears, C. B., Rathore, R., Benedict-Hamilton, H. M., Caldwell, K. E., Dirckx, N., Hawkins, W. G., & Tine, B. A. V. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07378-6 · Cited by 13

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Zhang, W., Yin, C., Qi, L., Liu, Z., Xu, R., Tu, C., & Li, Z. (2025) · Advanced Science · doi:10.1002/advs.202410937 · Cited by 13

STAT3 inhibition in combination with CD47 blockade inhibits osteosarcoma lung metastasis

Shrestha, P., Shrestha, R., Zhou, Y. L., Zielinski, R. J., Priebe, W., & Kleinerman, E. S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1608375 · Cited by 13

MARCH8/NSUN6/ROS-mediated DNA damage positive feedback loop regulates cisplatin resistance in osteosarcoma

He, M., Li, T., Wang, A., Liu, Y., Wang, X., Liu, Z., Xie, J., Wang, Y., Wang, Y., Ren, Z., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01544-1 · Cited by 13

SAR1A regulates the RhoA / YAP and autophagy signaling pathways to influence osteosarcoma invasion and metastasis

Zhan, F., Deng, Q., Chen, Z., Xie, C., Xiang, S., Qiu, S., Tian, L., Wu, C., Ou, Y., Chen, J., et al. (2022) · Cancer Science · doi:10.1111/cas.15551 · Cited by 13

Circular RNA-regulated autophagy is involved in cancer progression

Zhou, X., Lin, J., Wang, F., Chen, X., Zhang, Y., Hu, Z., & Jin, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.961983 · Cited by 13

Feasibility of machine learning–based modeling and prediction to assess osteosarcoma outcomes

Zhao, Q., Hu, W., Xia, Y., Dai, S., Wu, X., Chen, J., Yuan, X., Zhong, T., Xi, X., & Wang, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-00179-z · Cited by 12

Mitochondria-targeted MXene@MnO2-TPP nanoheterostructures for synergistic enhancement of sonodynamic therapy and immunotherapy in osteosarcoma

Zeng, J., Yan, Z., Wang, D., He, T., Tong, Z., Miao, J., Li, J., Tan, W., Chen, S., & Deng, Y. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.029 · Cited by 12

The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential

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