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New Horizons in the Treatment of Osteosarcoma
Abstract
Osteosarcoma, which is most common in people 10 to 30 years of age, is generally treated with resection and adjuvant chemotherapy. Detection of gene rearrangements, copy-number variations, and targeted disruption of tumor suppressors by whole-genome sequencing has not yet led to improved treatment.
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“Many patients later diagnosed with osteosarcoma first seek medical care with concerns for persisting pain in an extremity 101 .”
From Osteosarcoma (2022) · cites this paper as [101]
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Metadata
- Authors
- Meltzer, P. S., & Helman, L. J.
- Affiliations
- National Institutes of Health (US)
- ORCID
- Meltzer, Paul S.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2021-11-25
- Volume
- 385
- Issue
- 22
- Pages
- 2066-2076
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W3217429854
- Cited by
- 672
- References
- 67
- Citations by year
- 2026: 123 · 2025: 173 · 2024: 156 · 2023: 143 · 2022: 74
- FWCI
- 15.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone Tumor Diagnosis and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- osteosarcoma, gene rearrangement, copy number variation, tumor suppressor, targeted therapy, whole genome sequencing, adjuvant chemotherapy, pediatric bone tumors
- MeSH terms
- Antineoplastic Combined Chemotherapy Protocols, Bone Neoplasms, Humans, Immunotherapy, Prognosis, Osteosarcoma, Survival Rate, Neoadjuvant Therapy, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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