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A Molecular Basis for Nicotine as a Gateway Drug
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“Such findings provide substantial support for a neurobiological sensitization mechanism (Kandel & Kandel, 2014).”
From Nicotine and the adolescent brain (2015) · cites this paper as Kandel & Kandel, 2014
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“These effects are both unidirectional in that cocaine does not affect nicotine-induced responses and result from inhibition of histone deacetylase (Kandel & Kandel, 2014).”
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“These effects are both unidirectional in that cocaine does not affect nicotine-induced responses and result from inhibition of histone deacetylase (Kandel & Kandel, 2014).”
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“At the molecular level, nicotine exerts a priming effect by enhancing the ability of cocaine to induce FosB, a key mediator of addiction.”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [304]
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Metadata
- Authors
- Kandel, E. R., & Kandel, D. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- New York State Psychiatric Institute (US)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2014-09-04
- Volume
- 371
- Issue
- 10
- Pages
- 932-943
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC4353486
- OpenAlex
- W2317172122
- Cited by
- 353
- References
- 32
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 18 · 2021: 31 · 2020: 72 · 2019: 32 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 45 · 2014: 6
- FWCI
- 24.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute on Drug Abuse (K-5 DA00081, K05DA000081, R01DA024001)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- nicotine, tobacco use, smoking initiation, nicotine dependence
- MeSH terms
- Animals, Brain, Cocaine, Humans, Learning, Nicotine, Substance-Related Disorders, Mice, Memory, Long-Term
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