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A Molecular Basis for Nicotine as a Gateway Drug

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Kandel, Eric R., Kandel, Denise B.·2014·New England Journal of Medicine

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nejm clinical practice centerExplore a new page designed specifically for practicing clinicians, the NEJM Clinical Practice Center, at NEJM.org/clinical-practice-center.Find practice-changing research, reviews from our Clinical Practice series, a curated collection of clinical cases, and interactive features designed to hone your diagnostic skills.

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Authors: Kandel, E. R., & Kandel, D. B.
Affiliations: Howard Hughes Medical Institute (US)
New York State Psychiatric Institute (US)
ORCID: Kandel, Eric R.
Kandel, Denise B.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2014-09-04
Volume: 371
Issue: 10
Pages: 932-943
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmsa1405092
PMC: PMC4353486
OpenAlex: W2317172122
Cited by: 353
References: 32
Citations by year: 2026: 8 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 18 · 2021: 31 · 2020: 72 · 2019: 32 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 45 · 2014: 6
FWCI: 24.67
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health
National Institute on Drug Abuse (K-5 DA00081, K05DA000081, R01DA024001)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: nicotine, tobacco use, smoking initiation, nicotine dependence
MeSH terms: Animals, Brain, Cocaine, Humans, Learning, Nicotine, Substance-Related Disorders, Mice, Memory, Long-Term

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A Molecular Basis for Nicotine as a Gateway Drug

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