Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

Elevated Serum α-Synuclein Autoantibodies in Patients with Parkinson’s Disease Relative to Alzheimer’s Disease and Controls

Shalash, A., Salama, M., Makar, M., Roushdy, T., Elrassas, H. H., Mohamed, W., El-Balkimy, M., & Abou Donia, M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00720 · Cited by 58

The Use of Biomarkers in Human Pharmacology (Phase I) Studies

Cohen, A. F., Burggraaf, J., van Gerven, J. M. A., Moerland, M., & Groeneveld, G. J. (2015) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135918 · Cited by 55

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

MacQueen, G. M., Hassel, S., Arnott, S. R., Addington, J., Bowie, C. R., Bray, S. L., Davis, A. D., Downar, J., Foster, J. A., Frey, B. N., et al. (2019) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.180036 · Cited by 57

Neurosteroids and Neurotrophic Factors: What Is Their Promise as Biomarkers for Major Depression and PTSD?

Almeida, F. B., Barros, H. M. T., & Pinna, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041758 · Cited by 57

Biomarkers Common for Inflammatory Periodontal Disease and Depression: A Systematic Review

Neupane, S. P., Virtej, A., Myhren, L. E., & Bull, V. H. (2022) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2022.100450 · Cited by 52

The meaning of significant mean group differences for biomarker discovery

Loth, E., Ahmad, J., Chatham, C., López, B., Carter, B., Crawley, D., Oakley, B., Hayward, H., Cooke, J., San José Cáceres, A., et al. (2021) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009477 · Cited by 52

Noninvasive biomarkers of endometriosis: myth or reality?

Lanišnik Rižner, T. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.899905 · Cited by 52

Molecular Biomarkers for Gestational Diabetes Mellitus and Postpartum Diabetes

Lu, W., & Hu, C. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002160 · Cited by 52

Developing retinal biomarkers of neurological disease: an analytical perspective

MacCormick, I. J., Czanner, G., & Faragher, B. (2015) · Biomarkers in Medicine · doi:10.2217/bmm.15.17 · Cited by 47

Recent advances in biomarkers and therapeutic interventions for hepatic drug safety – false dawn or new horizon?

Clarke, J. I., Dear, J. W., & Antoine, D. J. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1160057 · Cited by 46

Developing biomarkers in mood disorders research through the use of rapid-acting antidepressants

Niciu, M. J., Mathews, D. C., Nugent, A. C., Ionescu, D. F., Furey, M. L., Richards, E. M., Machado-Vieira, R., & Zarate, C. A. (2014) · Depression and Anxiety · doi:10.1002/da.22224 · Cited by 45

Combined cognitive, psychomotor and electrophysiological biomarkers in major depressive disorder

Koo, P. C., Berger, C., Kronenberg, G., Bartz, J., Wybitul, P., Reis, O., & Hoeppner, J. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-018-0952-9 · Cited by 45

Convergent Evidence from Multimodal Imaging Reveals Amygdala Abnormalities in Schizophrenic Patients and Their First-Degree Relatives

Tian, L., Meng, C., Yan, H., Zhao, Q., Liu, Q., Yan, J., Han, Y., Yuan, H., Wang, L., Yue, W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028794 · Cited by 44

Diagnostic biomarkers for obsessive-compulsive disorder: A reasonable quest or ignis fatuus?

Fullana, M. A., Abramovitch, A., Via, E., López-Sola, C., Goldberg, X., Reina, N., Fortea, L., Solanes, A., Buckley, M. J., Ramella-Cravaro, V., et al. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.08.008 · Cited by 44

Brain imaging predictors and the international study to predict optimized treatment for depression: study protocol for a randomized controlled trial

Grieve, S. M., Korgaonkar, M. S., Etkin, A., Harris, A., Koslow, S. H., Wisniewski, S., Schatzberg, A. F., Nemeroff, C. B., Gordon, E., & Williams, L. M. (2013) · Trials · doi:10.1186/1745-6215-14-224 · Cited by 44

Effects of obesity surgery on blood coagulation and fibrinolysis: a literature review

Bladbjerg, E. M., Stolberg, C. R., & Juhl, C. B. (2020) · Thrombosis and Haemostasis · doi:10.1055/s-0040-1702224 · Cited by 43

Multiplatform metabolome and proteome profiling identifies serum metabolite and protein signatures as prospective biomarkers for schizophrenia

Al Awam, K., Haußleiter, I. S., Dudley, E., Donev, R., Brüne, M., Juckel, G., & Thome, J. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-014-1224-0 · Cited by 42

Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery

McArthur, R. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.004 · Cited by 42

Why does quality of life remain an under-investigated issue in chronic kidney disease and why is it rarely set as an outcome measure in trials in this population?

Chong, K., & Unruh, M. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw399 · Cited by 42

Methodological and clinical challenges associated with biomarkers for psychiatric disease: A scoping review

Kirkpatrick, R. H., Munoz, D. P., Khalid-Khan, S., & Booij, L. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.11.023 · Cited by 41

Inhibition-Based Biomarkers for Autism Spectrum Disorder

Levin, A. R., & Nelson, C. A. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0350-1 · Cited by 39

Diagnosis of Irritable Bowel Syndrome: Role of Potential Biomarkers

Plavšić, I., Hauser, G., Tkalčić, M., Pletikosić, S., & Salkić, N. (2015) · Gastroenterology Research and Practice · doi:10.1155/2015/490183 · Cited by 37

A Roadmap towards Precision Periodontics

Rakic, M., Pejcic, N., Perunovic, N., & Vojvodic, D. (2021) · Medicina · doi:10.3390/medicina57030233 · Cited by 36

Brainmarker-I Differentially Predicts Remission to Various Attention-Deficit/Hyperactivity Disorder Treatments: A Discovery, Transfer, and Blinded Validation Study

Voetterl, H., van Wingen, G., Michelini, G., Griffiths, K. R., Gordon, E., DeBeus, R., Korgaonkar, M. S., Loo, S. K., Palmer, D., Breteler, R., et al. (2023) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.02.007 · Cited by 35

Dilated Cardiomyopathy: From Genetics to Clinical Management

(2019) · doi:10.1007/978-3-030-13864-6 · Cited by 32

AI Advances in ICU with an Emphasis on Sepsis Prediction: An Overview

Stylianides, C., Nicolaou, A., Sulaiman, W. A., Alexandropoulou, C.-A., Panagiotopoulos, I., Karathanasopoulou, K., Dimitrakopoulos, G., Kleanthous, S., Politi, E., Ntalaperas, D., et al. (2025) · Machine Learning and Knowledge Extraction · doi:10.3390/make7010006 · Cited by 28

A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease, Frontotemporal Dementia, and Subjective Cognitive Decline, and the Evaluation of Candidate Proteins for Immunoassay Calibration

Das, S., Dewit, N., Jacobs, D., Pijnenburg, Y. A. L., In ‘t Veld, S. G. J. G., Coppens, S., Quaglia, M., Hirtz, C., Teunissen, C. E., & Vanmechelen, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137221 · Cited by 26

Can the DSM-5 framework enhance the diagnosis of MCI?

Ganguli, M. (2013) · Neurology · doi:10.1212/01.wnl.0000436944.01023.e5 · Cited by 26

Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats

Bodié, K., Buck, W. R., Pieh, J., Liguori, M. J., & Popp, A. (2016) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2016.03.001 · Cited by 24

Methylomic Investigation of Problematic Adolescent Cannabis Use and Its Negative Mental Health Consequences

Clark, S. L., Chan, R., Zhao, M., Xie, L. Y., Copeland, W. E., Aberg, K. A., & van den Oord, E. J. C. G. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2021.02.008 · Cited by 23

Cardiovascular biomarkers in clinical studies of type 2 diabetes

Baldassarre, M. P. A., Andersen, A., Consoli, A., Knop, F. K., & Vilsbøll, T. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13247 · Cited by 22

Expediting Patients’ Access to Medicines by Improving the Predictability of Drug Development and the Regulatory Approval Process

Liberti, L., Breckenridge, A., Eichler, H. G., Peterson, R., McAuslane, N., & Walker, S. (2010) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.179 · Cited by 20

Neural processing of working memory in adults with ADHD in a visuospatial change detection task with distractors

Gu, C., Liu, Z.-X., Tannock, R., & Woltering, S. (2018) · PeerJ · doi:10.7717/peerj.5601 · Cited by 18

Converting tests of fundamental social, cognitive, and affective processes into clinically useful bio‐behavioral markers for neurodevelopmental conditions

Loth, E., & Evans, D. W. (2019) · WIREs Cognitive Science · doi:10.1002/wcs.1499 · Cited by 17

Biomarkers of post-traumatic stress disorder from emotional trauma: A systematic review

Paganin, W., & Signorini, S. (2023) · European Journal of Trauma & Dissociation · doi:10.1016/j.ejtd.2023.100328 · Cited by 16

Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?

Foss-Feig, J. H., Stavropoulos, K. K. M., McPartland, J. C., Wallace, M. T., Stone, W. L., & Key, A. P. (2018) · Developmental Neuropsychology · doi:10.1080/87565641.2017.1365869 · Cited by 16

Moving towards high density clinical signature studies with a human proteome catalogue developing multiplexing mass spectrometry assay panels

Rezeli, M., Végvári, Á., Fehniger, T. E., Laurell, T., & Marko-Varga, G. (2011) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-1-7 · Cited by 15

Can We Establish Causality with Statistical Analyses? The Example of Epidemiology

Frick, U., & Rehm, J. (2016) · Wiley Series in Probability and Statistics · doi:10.1002/9781118947074.ch17 · Cited by 14

A Golden Hour and Golden Opportunity for β-Cell Preservation

Evans-Molina, C., & Oram, R. A. (2024) · Diabetes · doi:10.2337/dbi24-0019 · Cited by 10

Interleukin-1 Beta in peripheral blood mononuclear cell lysates as a longitudinal biomarker of response to antidepressants: a pilot study

Ferentinos, P., Maratou, E., Antoniou, A., Serretti, A., Smyrnis, N., & Moutsatsou, P. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.801738 · Cited by 7

Drug-herb interactions: mechanisms involved and clinical implications of five commonly and traditionally used herbs

Ong, C. E., & Pan, Y. (2014) · TANG [HUMANITAS MEDICINE] · doi:10.5667/tang.2014.0008 · Cited by 1